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90-466: North Karelia has successfully reduced chronic diseases through public health measures. In the 1960s Finland led industrialized nations in heart disease mortality rates; North Karelia had Finland's highest incidence. In 1972 a long-term project was undertaken which targeted this risk in North Karelia. The resulting improvement in public health is still considered remarkable, a model for the rest of

180-456: A drink ) is a beverage containing alcohol (ethanol) . Alcoholic drinks are typically divided into three classes— beers , wines , and spirits —and typically their alcohol content is between 3% and 50%. Many cultures have a distinct drinking culture , where alcoholic drinks are integrated into parties . Most countries have laws regulating the production, sale, and consumption of alcoholic beverages. For example, some regulations may require

270-582: A 10 percent to 30 percent higher risk of cardiovascular disease. Sleep disorders such as sleep-disordered breathing and insomnia , are also associated with a higher cardiometabolic risk. An estimated 50 to 70 million Americans have insomnia, sleep apnea or other chronic sleep disorders . In addition, sleep research displays differences in race and class. Short sleep and poor sleep tend to be more frequently reported in ethnic minorities than in whites. African-Americans report experiencing short durations of sleep five times more often than whites, possibly as

360-630: A 35-40 hours week. A diet high in fruits and vegetables decreases the risk of cardiovascular disease and death . A 2021 review found that plant-based diets can provide a risk reduction for CVD if a healthy plant-based diet is consumed. Unhealthy plant-based diets do not provide benefits over diets including meat. A similar meta-analysis and systematic review also looked into dietary patterns and found "that diets lower in animal foods and unhealthy plant foods, and higher in healthy plant foods are beneficial for CVD prevention". A 2018 meta-analysis of observational studies concluded that "In most countries,

450-497: A beneficial effect. A diet high in trans fatty acids is associated with higher rates of cardiovascular disease, and in 2015 the Food and Drug Administration (FDA) determined that there was 'no longer a consensus among qualified experts that partially hydrogenated oils (PHOs), which are the primary dietary source of industrially produced trans fatty acids (IP-TFA), are generally recognized as safe (GRAS) for any use in human food'. There

540-617: A given age , from CVD are more common and have been increasing in much of the developing world , while rates have declined in most of the developed world since the 1970s. Coronary artery disease and stroke account for 80% of CVD deaths in males and 75% of CVD deaths in females. Most cardiovascular disease affects older adults. In the United States 11% of people between 20 and 40 have CVD, while 37% between 40 and 60, 71% of people between 60 and 80, and 85% of people over 80 have CVD. The average age of death from coronary artery disease in

630-891: A greater risk of cardiovascular disease. Policies that have resulted in increased socio-economic inequalities have been associated with greater subsequent socio-economic differences in cardiovascular disease implying a cause and effect relationship. Psychosocial factors, environmental exposures, health behaviours, and health-care access and quality contribute to socio-economic differentials in cardiovascular disease. The Commission on Social Determinants of Health recommended that more equal distributions of power, wealth, education, housing, environmental factors, nutrition, and health care were needed to address inequalities in cardiovascular disease and non-communicable diseases. Particulate matter has been studied for its short- and long-term exposure effects on cardiovascular disease . Currently, airborne particles under 2.5 micrometers in diameter (PM 2.5 ) are

720-508: A male with diabetes. Women who have high blood pressure and had complications in their pregnancy have three times the risk of developing cardiovascular disease compared to women with normal blood pressure who had no complications in pregnancy. Coronary heart diseases are 2 to 5 times more common among middle-aged men than women. In a study done by the World Health Organization , sex contributes to approximately 40% of

810-451: A reduction in cardiovascular events. A 2015 meta-analysis of observational studies however did not find a convincing association between saturated fat intake and cardiovascular disease. Variation in what is used as a substitute for saturated fat may explain some differences in findings. The benefit from replacement with polyunsaturated fats appears greatest, while replacement of saturated fats with carbohydrates does not appear to have

900-503: A result of social and environmental factors. Black children and children living in disadvantaged neighborhoods have much higher rates of sleep apnea. Cardiovascular disease has a greater impact on low- and middle-income countries compared to those with higher income. Although data on the social patterns of cardiovascular disease in low- and middle-income countries is limited, reports from high-income countries consistently demonstrate that low educational status or income are associated with

990-432: A risk of death as never smokers. Insufficient physical activity (defined as less than 5 x 30 minutes of moderate activity per week, or less than 3 x 20 minutes of vigorous activity per week) is currently the fourth leading risk factor for mortality worldwide. In 2008, 31.3% of adults aged 15 or older (28.2% men and 34.4% women) were insufficiently physically active. The risk of ischemic heart disease and diabetes mellitus

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1080-437: A small amount compared to usual care. However, there was some uncertainty as to whether providing these scores had any effect on cardiovascular disease events. It is unclear whether or not dental care in those with periodontitis affects their risk of cardiovascular disease. According to a 2021 WHO study, working 55+ hours a week raises the risk of stroke by 35% and the risk of dying from heart conditions by 17%, when compared to

1170-461: A small effect. Age is the most important risk factor in developing cardiovascular or heart diseases, with approximately a tripling of risk with each decade of life. Coronary fatty streaks can begin to form in adolescence. It is estimated that 82 percent of people who die of coronary heart disease are 65 and older. Simultaneously, the risk of stroke doubles every decade after age 55. Multiple explanations are proposed to explain why age increases

1260-709: A vegan diet is associated with a more favourable cardio-metabolic profile compared to an omnivorous diet." Evidence suggests that the Mediterranean diet may improve cardiovascular outcomes. There is also evidence that a Mediterranean diet may be more effective than a low-fat diet in bringing about long-term changes to cardiovascular risk factors (e.g., lower cholesterol level and blood pressure ). The DASH diet (high in nuts, fish, fruits and vegetables, and low in sweets, red meat and fat) has been shown to reduce blood pressure, lower total and low density lipoprotein cholesterol and improve metabolic syndrome ; but

1350-478: A wine last longer, so they play an important role in the aging of wine . The average number of people who drink as of 2016 was 39% for males and 25% for females (2.4 billion people in total). Females on average drink 0.7 drinks per day while males drink 1.7 drinks per day. The rates of drinking varies significantly in different areas of the world. Alcohol is used in rum-running , the illegal business of smuggling alcoholic beverages where such transportation

1440-511: Is exclusively fermented with white sugar , yeast , and water. Fermented water is clarified after the fermentation to produce a colorless or off-white liquid with no discernible taste other than that of ethanol . Mead ( / m iː d / ), also called hydromel, is an alcoholic drink made by fermenting honey with water, sometimes with various fruits , spices , grains , or hops . The alcoholic content of mead may range from as low as 3% ABV to more than 20%. The defining characteristic of mead

1530-402: Is a depressant , which in low doses causes euphoria , reduces anxiety , and increases sociability. In higher doses, it causes drunkenness , stupor , unconsciousness , or death . Long-term use can lead to an alcohol use disorder , an increased risk of developing several types of cancer , cardiovascular disease , and physical dependence . Alcohol is classified as a carcinogen . In 2023,

1620-804: Is a fermented beverage most commonly produced from grapes . Wine involves a longer fermentation process than beer and often a long aging process (months or years), resulting in an alcohol content of 9%–16% ABV . Sparkling wines such French Champagne , Catalan Cava or Italian Prosecco are also made from grapes, with a secondary fermentation . Fruit wines are made from fruits other than grapes , such as plums , cherries , or apples . Distilled beverages (also called liquors or spirit drinks) are alcoholic drinks produced by distilling (i.e., concentrating by distillation ) ethanol produced by means of fermenting grain, fruit, or vegetables. Unsweetened, distilled, alcoholic drinks that have an alcohol content of at least 20% ABV are called spirits . For

1710-407: Is a large pub that specializes in beer . A cider house is an establishment that sells alcoholic cider for consumption on the premises. Some cider houses also sell cider "to go", for consumption off the premises. A traditional cider house was often little more than a room in a farmhouse or cottage , selling locally fermented cider. An ouzeri ( Greek ουζερί IPA: [uzeˈri] )

1800-501: Is a term used in the United States to describe an improvised alcoholic beverage . It is variously made from apples , oranges , fruit cocktail , fruit juices , hard candy , sugar , high fructose syrup , and possibly other ingredients, including crumbled bread . Drinking games are games which involve the consumption of alcoholic beverages and often enduring the subsequent intoxication resulting from them. Evidence of

1890-582: Is a type of Greek tavern which serves ouzo (a Greek liquor) and mezedes (small finger foods ). Pulquerías (or pulcherías) are a type of tavern in Mexico that specialize in serving an alcoholic beverage known as pulque . A tiki bar is a themed drinking establishment that serves elaborate cocktails, especially rum -based mixed drinks such as the Mai Tai and Zombie cocktails. Tiki bars are aesthetically defined by their tiki culture décor which

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1980-409: Is also beneficial. Treating people who have strep throat with antibiotics can decrease the risk of rheumatic heart disease. The use of aspirin in people who are otherwise healthy is of unclear benefit. Cardiovascular diseases are the leading cause of death worldwide except Africa. Together CVD resulted in 17.9 million deaths (32.1%) in 2015, up from 12.3 million (25.8%) in 1990. Deaths, at

2070-1214: Is also linked to carotid artery thickening and increased risk of acute myocardial infarction. Existing cardiovascular disease or a previous cardiovascular event, such as a heart attack or stroke, is the strongest predictor of a future cardiovascular event. Age, sex, smoking, blood pressure, blood lipids and diabetes are important predictors of future cardiovascular disease in people who are not known to have cardiovascular disease. These measures, and sometimes others, may be combined into composite risk scores to estimate an individual's future risk of cardiovascular disease. Numerous risk scores exist although their respective merits are debated. Other diagnostic tests and biomarkers remain under evaluation but currently these lack clear-cut evidence to support their routine use. They include family history, coronary artery calcification score, high sensitivity C-reactive protein (hs-CRP), ankle–brachial pressure index , lipoprotein subclasses and particle concentration, lipoprotein(a), apolipoproteins A-I and B, fibrinogen , white blood cell count, homocysteine , N-terminal pro B-type natriuretic peptide (NT-proBNP), and markers of kidney function. High blood phosphorus

2160-494: Is also linked to an increased risk. There is evidence that mental health problems, in particular depression and traumatic stress, is linked to cardiovascular diseases. Whereas mental health problems are known to be associated with risk factors for cardiovascular diseases such as smoking, poor diet, and a sedentary lifestyle, these factors alone do not explain the increased risk of cardiovascular diseases seen in depression, stress, and anxiety. Moreover, posttraumatic stress disorder

2250-495: Is an unlicensed hotel , liquor-store or other vendor of alcoholic beverages, sometimes with the added connotation of selling poor-quality products. A straw purchaser may receive money or recompense from the underage person in exchange for purchasing the alcohol on their behalf. Alcohol has been used as a currency for transactional sex in South Africa, and Uganda. Pruno also known as prison hooch or prison wine,

2340-488: Is any disease involving the heart or blood vessels . CVDs constitute a class of diseases that includes: coronary artery diseases (e.g. angina , heart attack ), heart failure , hypertensive heart disease , rheumatic heart disease , cardiomyopathy , arrhythmia , congenital heart disease , valvular heart disease , carditis , aortic aneurysms , peripheral artery disease , thromboembolic disease , and venous thrombosis . The underlying mechanisms vary depending on

2430-422: Is associated with heart disease. Associations also exist for exposure to arsenic , benzopyrenes , lead , dynamite , carbon disulphide , carbon monoxide , metalworking fluids and occupational exposure to tobacco smoke . Working with the electrolytic production of aluminium or the production of paper when the sulphate pulping process is used is associated with heart disease. An association

2520-514: Is being electrolytically produced, is associated with stroke . As of 2017, evidence suggests that certain leukemia -associated mutations in blood cells may also lead to increased risk of cardiovascular disease. Several large-scale research projects looking at human genetic data have found a robust link between the presence of these mutations, a condition known as clonal hematopoiesis , and cardiovascular disease-related incidents and mortality. Radiation treatments (RT) for cancer can increase

2610-411: Is complex, and may depend on the amount of alcohol consumed. There is a direct relationship between high levels of drinking alcohol and cardiovascular disease. Drinking at low levels without episodes of heavy drinking may be associated with a reduced risk of cardiovascular disease, but there is evidence that associations between moderate alcohol consumption and protection from stroke are non-causal. At

2700-452: Is conflicting evidence concerning whether dietary supplements of omega-3 fatty acids (a type of polyunsaturated essential fatty acid) added to diet improve cardiovascular risk. The benefits of recommending a low-salt diet in people with high or normal blood pressure are not clear. In those with heart failure, after one study was left out, the rest of the trials show a trend to benefit. Another review of dietary salt concluded that there

2790-435: Is disputed. The World Health Organization attributes approximately 1.7 million deaths worldwide to low fruit and vegetable consumption. Frequent consumption of high-energy foods, such as processed foods that are high in fats and sugars, promotes obesity and may increase cardiovascular risk. The amount of dietary salt consumed may also be an important determinant of blood pressure levels and overall cardiovascular risk. There

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2880-543: Is documented as increasing cardiovascular risk in both adults and teens. Recommendations suggest that infants typically need 12 or more hours of sleep per day, adolescents at least eight or nine hours, and adults seven or eight. About one-third of adult Americans get less than the recommended seven hours of sleep per night, and in a study of teenagers, just 2.2 percent of those studied got enough sleep, many of whom did not get good quality sleep. Studies have shown that short sleepers getting less than seven hours sleep per night have

2970-488: Is estimated to account for approximately 13% of CVD deaths, while tobacco accounts for 9%, diabetes 6%, lack of exercise 6%, and obesity 5%. Rheumatic heart disease may follow untreated strep throat . It is estimated that up to 90% of CVD may be preventable. Prevention of CVD involves improving risk factors through: healthy eating , exercise, avoidance of tobacco smoke and limiting alcohol intake. Treating risk factors, such as high blood pressure, blood lipids and diabetes

3060-412: Is evidence that higher consumption of sugar is associated with higher blood pressure and unfavorable blood lipids, and sugar intake also increases the risk of diabetes mellitus. High consumption of processed meats is associated with an increased risk of cardiovascular disease, possibly in part due to increased dietary salt intake. The relationship between alcohol consumption and cardiovascular disease

3150-411: Is forbidden by law. Wine fraud relates to the commercial aspects of wine. The most prevalent type of fraud is one where wines are adulterated, usually with the addition of cheaper products (e.g. juices) and sometimes with harmful chemicals and sweeteners (compensating for color or flavor). Moonshine is illegal to produce and sell in most countries. In Australia, a sly-grog shop (or shanty)

3240-597: Is inconclusive. Additionally echocardiography , myocardial perfusion imaging , and cardiac stress testing is not recommended in those at low risk who do not have symptoms. Some biomarkers may add to conventional cardiovascular risk factors in predicting the risk of future cardiovascular disease; however, the value of some biomarkers is questionable. Ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), and coronary artery calcium , are also of unclear benefit in those without symptoms as of 2018. The NIH recommends lipid testing in children beginning at

3330-490: Is independently associated with increased risk for incident coronary heart disease, even after adjusting for depression and other covariates. Little is known about the relationship between work and cardiovascular disease, but links have been established between certain toxins, extreme heat and cold, exposure to tobacco smoke, and mental health concerns such as stress and depression. A 2015 SBU-report looking at non-chemical factors found an association for those: Specifically

3420-509: Is moderate quality evidence that reducing saturated fat intake for at least two years reduces the risk of cardiovascular disease. High trans-fat intake has adverse effects on blood lipids and circulating inflammatory markers, and elimination of trans-fat from diets has been widely advocated. In 2018 the World Health Organization estimated that trans fats were the cause of more than half a million deaths per year. There

3510-553: Is often used for medicinal purposes . It may be a grain spirit, or it may be made from other plants. It is used in mixed drinks , liqueurs , and tinctures , and also as a household solvent . In the alcoholic drinks industry, congeners are substances produced during fermentation . These substances include small amounts of chemicals such as occasionally desired alcohols, like propanol and 3-methyl-1-butanol , as well as compounds that are never desired such as acetone , acetaldehyde and glycols . Congeners are responsible for most of

3600-543: Is reduced by almost a third in adults who participate in 150 minutes of moderate physical activity each week (or equivalent). In addition, physical activity assists weight loss and improves blood glucose control, blood pressure, lipid profile and insulin sensitivity. These effects may, at least in part, explain its cardiovascular benefits. High dietary intakes of saturated fat, trans-fats and salt, and low intake of fruits, vegetables and fish are linked to cardiovascular risk, although whether all these associations indicate causes

3690-452: Is some evidence that interventions aiming to reduce more than one cardiovascular risk factor may have beneficial effects on blood pressure, body mass index and waist circumference; however, evidence was limited and the authors were unable to draw firm conclusions on the effects on cardiovascular events and mortality. There is additional evidence to suggest that providing people with a cardiovascular disease risk score may reduce risk factors by

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3780-467: Is strong evidence that high dietary salt intake increases blood pressure and worsens hypertension, and that it increases the number of cardiovascular disease events; both as a result of the increased blood pressure and probably through other mechanisms. Moderate evidence was found that high salt intake increases cardiovascular mortality; and some evidence was found for an increase in overall mortality, strokes, and left ventricular hypertrophy . Overall,

3870-653: Is that the majority of the drink's fermentable sugar is derived from honey. Mead can also be referred to as "honeywine." Pulque is the Mesoamerican fermented drink made from the "honey water" of maguey , Agave americana . Pulque can be distilled to produce tequila or Mezcal . Rice wine is an alcoholic drink fermented and possibly distilled from rice , consumed in East Asia , Southeast Asia and South Asia . Sake , huangjiu , mijiu , and cheongju are popular examples of East Asian rice wine . Wine

3960-407: Is the most life-threatening of the diabetic complications and diabetics are two- to four-fold more likely to die of cardiovascular-related causes than nondiabetics. Screening ECGs (either at rest or with exercise) are not recommended in those without symptoms who are at low risk. This includes those who are young without risk factors. In those at higher risk the evidence for screening with ECGs

4050-443: Is wine that has had a spirit added to it. Many different styles of fortified wine have been developed, including port , sherry, madeira , marsala , commandaria , and the aromatized wine vermouth . Rectified spirit , also called "neutral grain spirit", is alcohol which has been purified by means of "rectification" (i.e. repeated distillation). The term neutral refers to the spirit's lack of flavor that would have been present if

4140-602: The 2019 Finnish parliamentary election in North Karelia: The song "Pohjois-Karjala" ("North Karelia") by the Finnish pop rock band Leevi and the Leavings tells the story of an urban man who dreams of returning to his native region of North Karelia. It has become such a big hit in North Karelia that it is almost perceived as a regional song. Cardiovascular disease Cardiovascular disease ( CVD )

4230-535: The Great Rebellion . The alcohol monopoly system has a long history in various countries, often implemented to limit the availability and consumption of alcohol for public health and social welfare reasons. The alcohol monopoly was created in the Swedish town of Falun in 1850, to prevent overconsumption and reduce the profit motive for sales of alcohol. It later went all over the country in 1905 when

4320-784: The Swedish parliament ordered all sales of vodka to be done via local alcohol monopolies. In 1894, the Russian Empire established a state monopoly on vodka, which became a major source of revenue for the Russian government. Later in the nineteenth century opposition to alcohol grew in the form of the temperance movement , in the United States , United Kingdom , Canada , Scandinavia and India , and it eventually led to national prohibitions in Canada (1918 to 1920), Norway (spirits only from 1919 to 1926 ), Finland (1919 to 1932), and

4410-439: The congeners . Freeze distillation concentrates ethanol along with methanol and fusel alcohols (fermentation by-products partially removed by distillation) in applejack . Fortified wine is wine, such as port or sherry , to which a distilled beverage (usually brandy ) has been added. Fortified wine is distinguished from spirits made from wine in that spirits are produced by means of distillation , while fortified wine

4500-640: The coronary arteries . Cardiovascular disease in a person's parents increases their risk by ~3 fold, and genetics is an important risk factor for cardiovascular diseases. Genetic cardiovascular disease can occur either as a consequence of single variant (Mendelian) or polygenic influences. There are more than 40 inherited cardiovascular disease that can be traced to a single disease-causing DNA variant, although these conditions are rare. Most common cardiovascular diseases are non-Mendelian and are thought to be due to hundreds or thousands of genetic variants (known as single nucleotide polymorphisms), each associated with

4590-463: The 18th century. In 1767, the häradshövding (judge) used the name Pohjois-Karjala (North Karelia). The residents also called themselves the men of the province and drew up their own regulations in Finnish for the border guard , showing their separateness. Administratively, North Karelia belonged to different counties in the 18th century, but it had its own "North Karelia county". This self-administration set it apart from other regions. The separation

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4680-635: The Encouraging of the Distillation of Brandy and Spirits from Corn" Alcoholic beverages played an important role in the Thirteen Colonies from their early days when drinking wine and beer at that time was safer than drinking water – which was usually taken from sources also used to dispose of sewage and garbage. Drinking hard liquor was common occurrence in early nineteenth-century United States. The Whiskey Rebellion (also known as

4770-487: The United States (1920 to 1933), as well as provincial prohibition in India (1948 to present). Beer is a beverage fermented from grain mash . It is typically made from barley or a blend of several grains and flavored with hops . Most beer is naturally carbonated as part of the fermentation process. If the fermented mash is distilled, then the drink becomes a spirit . Beer is the most consumed alcoholic beverage in

4860-595: The WHO declared that 'the risk to the drinker’s health starts from the first drop of any alcoholic beverage.' Discovery of late Stone Age jugs suggests that intentionally fermented drinks existed at least as early as the Neolithic period. The oldest verifiable brewery has been found in a prehistoric burial site in a cave near Haifa in modern-day Israel . Researchers have found residue of 13,000-year-old beer that they think might have been used for ritual feasts to honor

4950-478: The Whiskey Insurrection) was a violent tax protest in the United States beginning in 1791 and ending in 1794 during the presidency of George Washington . The so-called "whiskey tax" was the first tax imposed on a domestic product by the newly formed federal government. Beer was difficult to transport and spoiled more easily than rum and whiskey. The Rum Rebellion of 1808 was a coup d'état in

5040-420: The age of 2 if there is a family history of heart disease or lipid problems. It is hoped that early testing will improve lifestyle factors in those at risk such as diet and exercise. Screening and selection for primary prevention interventions has traditionally been done through absolute risk using a variety of scores (ex. Framingham or Reynolds risk scores). This stratification has separated people who receive

5130-443: The current body of scientific evidence is uncertain on whether intermittent fasting could prevent cardiovascular disease. Intermittent fasting may help people lose more weight than regular eating patterns, but was not different from energy restriction diets. Alcoholic beverage This is an accepted version of this page An alcoholic beverage (also called an adult beverage , alcoholic drink , strong drink , or simply

5220-459: The dead. The traces of a wheat-and-barley-based alcohol were found in stone mortars carved into the cave floor. The Carmona Wine Urn is a first century Roman glass urn containing intact wine . Discovered in 2019 in Carmona, Spain during excavations of the city's western Roman necropolis , analysis of the urn's contents five years after has deemed the vessel as the oldest surviving wine in

5310-859: The developed world is around 80, while it is around 68 in the developing world. CVD is typically diagnosed seven to ten years earlier in men than in women. There are many cardiovascular diseases involving the blood vessels. They are known as vascular diseases . There are also many cardiovascular diseases that involve the heart. There are many risk factors for heart diseases: age, sex, tobacco use, physical inactivity, non-alcoholic fatty liver disease , excessive alcohol consumption, unhealthy diet, obesity, genetic predisposition and family history of cardiovascular disease, raised blood pressure ( hypertension ), raised blood sugar ( diabetes mellitus ), raised blood cholesterol ( hyperlipidemia ), undiagnosed celiac disease , psychosocial factors, poverty and low educational status, air pollution , and poor sleep . While

5400-426: The disease. It is estimated that dietary risk factors are associated with 53% of CVD deaths. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis . This may be caused by high blood pressure , smoking , diabetes mellitus , lack of exercise , obesity , high blood cholesterol , poor diet, excessive alcohol consumption, and poor sleep , among other things. High blood pressure

5490-575: The distillation of various substances. The distillation of wine is attested in Arabic works attributed to al-Kindī ( c.  801 –873 CE) and to al-Fārābī ( c.  872 –950), and in the 28th book of al-Zahrāwī 's (Latin: Abulcasis, 936–1013) Kitāb al-Taṣrīf (later translated into Latin as Liber servatoris ). 12th century: The process of distillation spread from the Middle East to Italy, where distilled alcoholic drinks were recorded in

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5580-417: The existence of drinking games dates back to antiquity. Drinking games have been banned at some institutions, particularly colleges and universities. A drinking song is a song sung while drinking an alcoholic beverage. A beer garden (German: Biergarten ) is an outdoor area in which beer and food are served, typically at shared tables shaded by trees. A beer hall ( German : Bierpalast, Bierhalle )

5670-482: The female lipid metabolism toward a more atherogenic form by decreasing the HDL cholesterol level while increasing LDL and total cholesterol levels. Among men and women, there are differences in body weight, height, body fat distribution, heart rate, stroke volume, and arterial compliance. In the very elderly, age-related large artery pulsatility and stiffness are more pronounced among women than men. This may be caused by

5760-528: The individual contribution of each risk factor varies between different communities or ethnic groups the overall contribution of these risk factors is very consistent. Some of these risk factors, such as age, sex or family history/genetic predisposition, are immutable; however, many important cardiovascular risk factors are modifiable by lifestyle change, social change, drug treatment (for example prevention of hypertension, hyperlipidemia, and diabetes). People with obesity are at increased risk of atherosclerosis of

5850-464: The intermediate and low risk groups. As a result, future preventative screening appears to shift toward applying prevention according to randomized trial results of each intervention rather than large-scale risk assessment. Up to 90% of cardiovascular disease may be preventable if established risk factors are avoided. Currently practised measures to prevent cardiovascular disease include: Most guidelines recommend combining preventive strategies. There

5940-428: The labeling of the percentage alcohol content (as ABV or proof ) and the use of a warning label . Some countries ban the consumption of alcoholic drinks , but they are legal in most parts of the world. The temperance movement advocates against the consumption of alcoholic beverages. The global alcoholic drink industry exceeded $ 1.5 trillion in 2017. Alcohol is one of the most widely used recreational drugs in

6030-425: The lifestyle interventions (generally lower and intermediate risk) from the medication (higher risk). The number and variety of risk scores available for use has multiplied, but their efficacy according to a 2016 review was unclear due to lack of external validation or impact analysis. Risk stratification models often lack sensitivity for population groups and do not account for the large number of negative events among

6120-616: The long-term benefits have been questioned. A high- fiber diet is associated with lower risks of cardiovascular disease. Worldwide, dietary guidelines recommend a reduction in saturated fat , and although the role of dietary fat in cardiovascular disease is complex and controversial there is a long-standing consensus that replacing saturated fat with unsaturated fat in the diet is sound medical advice. Total fat intake has not been found to be associated with cardiovascular risk. A 2020 systematic review found moderate quality evidence that reducing saturated fat intake for at least 2 years caused

6210-412: The loss of arterial elasticity and reduced arterial compliance and may subsequently lead to coronary artery disease. Men are at greater risk of heart disease than pre-menopausal women. Once past menopause , it has been argued that a woman's risk is similar to a man's although more recent data from the WHO and UN disputes this. If a female has diabetes, she is more likely to develop heart disease than

6300-600: The major focus, in which gradients are used to determine CVD risk. Overall, long-term PM exposure increased rate of atherosclerosis and inflammation. In regards to short-term exposure (2 hours), every 25 μg/m of PM 2.5 resulted in a 48% increase of CVD mortality risk. In addition, after only 5 days of exposure, a rise in systolic (2.8 mmHg) and diastolic (2.7 mmHg) blood pressure occurred for every 10.5 μg/m of PM 2.5 . Other research has implicated PM 2.5 in irregular heart rhythm, reduced heart rate variability (decreased vagal tone), and most notably heart failure. PM 2.5

6390-510: The major precursor of cardiovascular disease, begins in childhood. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study demonstrated that intimal lesions appear in all the aortas and more than half of the right coronary arteries of youths aged 7–9 years. Obesity and diabetes mellitus are linked to cardiovascular disease, as are a history of chronic kidney disease and hypercholesterolaemia . In fact, cardiovascular disease

6480-425: The mash ingredients had been distilled to a lower level of alcoholic purity. Rectified spirit also lacks any flavoring added to it after distillation (as is done, for example, with gin ). Other kinds of spirits, such as whiskey , (or whisky) are distilled to a lower alcohol percentage to preserve the flavor of the mash. Rectified spirit is a clear, colorless, flammable liquid that may contain as much as 95% ABV . It

6570-575: The mid-12th century. In Italy, the works of Taddeo Alderotti (1223–1296) describe a method for concentrating alcohol involving repeated fractional distillation through a water-cooled still. By the early 14th century, distilled alcoholic drinks had spread throughout the European continent . Distillation spread to Ireland and Scotland no later than the 15th century, as did the common European practice of distilling " aqua vitae ", primarily for medicinal purposes. in 1690, England passed "An Act for

6660-495: The most common distilled drinks, such as whisky (or whiskey) and vodka, the alcohol content is around 40%. The term hard liquor is used in North America to distinguish distilled drinks from undistilled ones (implicitly weaker). Brandy , gin , mezcal , rum , tequila , vodka , whisky (or wiskey) , baijiu , shōchū and soju are examples of distilled drinks. Distilling concentrates the alcohol and eliminates some of

6750-605: The nation. North Karelia is also known as the most sociable region in Finland. The borders of remote North Karelia were formed gradually. Important border foundations were the Treaty of Stolbovo (1617) for the eastern border and the Treaty of Teusina (1595) for the western border. The border was finally established in the Treaty of Nystad (1721), where North Karelia was separated from the "other Karelias" that remained on Russia 's side. Regional identity began to form gradually in

6840-784: The neolithic village of Jiahu in the Henan province of northern China revealed residue left behind by the alcoholic drinks they had once contained. According to a study published in the Proceedings of the National Academy of Sciences , chemical analysis of the residue confirmed that a fermented drink made of grape and hawthorn fruit wine, honey mead and rice beer was being produced in 7000–5600 BC (McGovern et al., 2005; McGovern 2009). The results of this analysis were published in December 2004. The earliest evidence of winemaking

6930-418: The population level, the health risks of drinking alcohol exceed any potential benefits. Untreated celiac disease can cause the development of many types of cardiovascular diseases, most of which improve or resolve with a gluten-free diet and intestinal healing. However, delays in recognition and diagnosis of celiac disease can cause irreversible heart damage. A lack of good sleep, in amount or quality,

7020-443: The risk of stroke was also increased by exposure to ionizing radiation. Hypertension develops more often in those who experience job strain and who have shift-work. Differences between women and men in risk are small, however men risk having and dying of heart attacks or stroke twice as often as women during working life. A 2017 SBU report found evidence that workplace exposure to silica dust , engine exhaust or welding fumes

7110-423: The risk of cardiovascular/heart diseases. One of them relates to serum cholesterol level. In most populations, the serum total cholesterol level increases as age increases. In men, this increase levels off around age 45 to 50 years. In women, the increase continues sharply until age 60 to 65 years. Aging is also associated with changes in the mechanical and structural properties of the vascular wall, which leads to

7200-955: The risk of heart disease and death, as observed in breast cancer therapy. Therapeutic radiation increases the risk of a subsequent heart attack or stroke by 1.5 to 4 times; the increase depends on the dose strength, volume, and location. Use of concomitant chemotherapy, e.g. anthracyclines, is an aggravating risk factor. The occurrence rate of RT induced cardiovascular disease is estimated between 10% and 30%. Side-effects from radiation therapy for cardiovascular diseases have been termed radiation-induced heart disease or radiation-induced cardiovascular disease . Symptoms are dose-dependent and include cardiomyopathy , myocardial fibrosis , valvular heart disease , coronary artery disease , heart arrhythmia and peripheral artery disease . Radiation-induced fibrosis, vascular cell damage and oxidative stress can lead to these and other late side-effect symptoms. Population-based studies show that atherosclerosis,

7290-439: The taste and aroma of distilled alcoholic drinks and contribute to the taste of non-distilled drinks. It has been suggested that these substances contribute to the symptoms of a hangover . Tannins are congeners found in wine in the presence of phenolic compounds. Wine tannins add bitterness, have a drying sensation, taste herbaceous, and are often described as astringent . Wine tannins add balance, complexity, structure and make

7380-528: The then-British penal colony of New South Wales , staged by the New South Wales Corps in order to depose Governor William Bligh . Australia's first and only military coup, its name derives from the illicit rum trade of early Sydney , over which the 'Rum Corps', as it became known, maintained a monopoly. During the first half of the 19th century, it was widely referred to in Australia as

7470-592: The variation in sex ratios of coronary heart disease mortality. Another study reports similar results finding that sex differences explains nearly half the risk associated with cardiovascular diseases One of the proposed explanations for sex differences in cardiovascular diseases is hormonal difference. Among women, estrogen is the predominant sex hormone. Estrogen may have protective effects on glucose metabolism and hemostatic system, and may have direct effect in improving endothelial cell function. The production of estrogen decreases after menopause, and this may change

7560-406: The women's smaller body size and arterial dimensions which are independent of menopause. Cigarettes are the major form of smoked tobacco. Risks to health from tobacco use result not only from direct consumption of tobacco, but also from exposure to second-hand smoke. Approximately 10% of cardiovascular disease is attributed to smoking; however, people who quit smoking by age 30 have almost as low

7650-444: The world, and about 33% of all humans currently drink alcohol. In 2015, among Americans , 86% of adults had consumed alcohol at some point, with 70% drinking it in the last year and 56% in the last month. Several other animals are affected by alcohol similarly to humans and, once they consume it, will consume it again if given the opportunity, though humans are the only species known to produce alcoholic drinks intentionally. Alcohol

7740-617: The world, surpassing the previous record holder, the Speyer wine bottle (discovered in 1867) by three centuries. Beer was likely brewed from barley as early as 13,000 years ago in the Middle East. Pliny the Elder wrote about the golden age of winemaking in Rome , the 2nd century BCE (200–100 BCE), when vineyards were planted. Examination and analysis of ancient pottery jars from

7830-504: The world. Cider or cyder ( / ˈ s aɪ d ər / SY -dər ) is a fermented alcoholic drink made from any fruit juice ; apple juice (traditional and most common), peaches , pears (" Perry " cider) or other fruit. Cider alcohol content varies from 1.2% ABV to 8.5% or more in traditional English ciders. In some regions, cider may be called " apple wine ". Fermented water is an ethanol -based water solution with approximately 15-17% ABV without sweet reserve . Fermented water

7920-459: Was also found between heart disease and exposure to compounds which are no longer permitted in certain work environments, such as phenoxy acids containing TCDD (dioxin) or asbestos . Workplace exposure to silica dust or asbestos is also associated with pulmonary heart disease . There is evidence that workplace exposure to lead, carbon disulphide, phenoxyacids containing TCDD, as well as working in an environment where aluminum

8010-629: Was dated at 6,000 to 5,800 BCE in Georgia in the South Caucasus . Celtic people were known to have been making types of alcoholic cider as early as 3000 BC. and wine was consumed in Classical Greece at breakfast or at symposia , and in the 1st century BC. Medieval Muslim chemists such as Jābir ibn Ḥayyān (Latin: Geber, ninth century) and Abū Bakr al-Rāzī (Latin: Rhazes, c.  865–925 ) experimented extensively with

8100-674: Was further strengthened when North Karelia was formed into its own province in 1960. North Karelia became its own region in 1994. Instead, North Karelia province was abolished in 1997 and its functions were transferred to the Eastern Finland province . The coat of arms of North Karelia is composed of the arms of Karelia . The region of North Karelia consists of 13 municipalities , five of which have city status (marked in bold). Joensuu sub-region Central Karelia sub-region Pielinen Karelia sub-region Institutions of higher education in North Karelia include: Results of

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