14-531: [REDACTED] Look up vap in Wiktionary, the free dictionary. VAP may refer to: Venous access port , a medical port Ventilator-associated pneumonia , sub-type of hospital-acquired pneumonia (HAP) Vertical auto profile , cholesterol, lipid and lipoprotein blood test Vapour Pressure Deficit , physical effect Vascular adhesion protein VAP, Inc. ,
28-444: A Japanese entertainment company Véhicule d'Action dans la Profondeur , a military vehicle made by Panhard Virtual Access Point , a method of using multiple BSSIDs on single physical Wireless access point VAP protein family , where VAP is the umbrella term for the conserved V AMP- a ssociated p rotein, where VAMP stands for vesicle-associated membrane protein. Humans have two VAPs: VAPA and VAPB Topics referred to by
42-444: A Japanese entertainment company Véhicule d'Action dans la Profondeur , a military vehicle made by Panhard Virtual Access Point , a method of using multiple BSSIDs on single physical Wireless access point VAP protein family , where VAP is the umbrella term for the conserved V AMP- a ssociated p rotein, where VAMP stands for vesicle-associated membrane protein. Humans have two VAPs: VAPA and VAPB Topics referred to by
56-532: Is a protein that in humans is encoded by the VAPA gene . Together with VAPB and VAPC it forms the VAP protein family . They are integral endoplasmic reticulum membrane proteins of the type II and are ubiquitous among eukaryotes. VAPA is ubiquitously expressed in human tissues and is thought to be involved in membrane trafficking by interaction with SNAREs , in regulation of lipid transport and metabolism, and in
70-569: Is different from Wikidata All article disambiguation pages All disambiguation pages vap (Redirected from Vap ) [REDACTED] Look up vap in Wiktionary, the free dictionary. VAP may refer to: Venous access port , a medical port Ventilator-associated pneumonia , sub-type of hospital-acquired pneumonia (HAP) Vertical auto profile , cholesterol, lipid and lipoprotein blood test Vapour Pressure Deficit , physical effect Vascular adhesion protein VAP, Inc. ,
84-475: Is different from Wikidata All article disambiguation pages All disambiguation pages VAPA 2RR3 9218 30960 ENSG00000101558 ENSMUSG00000024091 Q9P0L0 Q9WV55 NM_003574 NM_194434 NM_013933 NM_001355402 NP_003565 NP_919415 NP_038961 NP_001342331 VAMP-Associated Protein A ( or Vesicle-Associated Membrane Protein -Associated Protein A)
98-570: The FFAT motif and viral proteins. VAPA is able to bind a range of SNARE proteins including syntaxin1A , rbet1 and rsec22. It also binds to proteins associated with membrane fusion machinery such as alphaSNAP and NSF .These interaction suggest that VAPA could have a general role in the regulation of the function of these proteins that are mainly involved in membrane fusion VAP proteins have been found to be essential host factors for several viruses. VAP proteins binds with non-structural proteins of
112-739: The Unfolded Protein Response ( UPR ). The protein is divided in three different domains. First, an N-terminal beta-sheet with an immunoglobulin-like fold that shares homology with the Nematode major sperm protein ( MSP ). Secondly, a central coiled-coil domain. Then finally a C-terminal transmembrane domain (TMD) which is usually present in proteins of the t-SNARE superfamily and has been found in other proteins associated with vesicular transport. VAPA can form homo-dimers and also hetero dimers with VAPB by interactions through their (TMD). Because of its ubiquitous expression,
126-518: The amount of stress triggered by the UPR. The VAP would regulate this process by inhibiting membrane contact. The P56S SNP in the MSP domain of VAPB is involved in the onset of Lou Gehrig's disease also called amyotrophic lateral sclerosis ( ALS ) where the patient loses muscle control and function. The degenerescence of motor neurons observed in such condition could to be due to the inability of VAPB to regulate
140-559: The hepatitis C virus NS5A and NS5B allowing the RNA replication machinery of the virus to set up on the lipid raft membrane of the host cell. VAPA also binds to several viral proteins from the Norovirus family and is important for the virus replication efficiency. The non-structural proteins NS1 and NS2 are able to bind VAPA thanks to sequence mimicry of the FFAT motif probably yielding
154-687: The intracellular localisation and function of VAPA may vary between cell types. It is however mainly located in the ER, Golgi apparatus and the Vesicular Tubular Compartment or ER-Golgi Intermediate Compartment , an organelle of eukaryotic cells consisting in fused ER-derived vesicles that transports proteins from the ER to the Golgi apparatus. VAPA has been documented to interact with three different groups of proteins: proteins associated with vesicle traffic and fusion, proteins containing
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#1732780515373168-399: The same advantage to viral replication as for hepatitis C virus. The N-terminal MSP-homologous part of VAPA is able to bind to the FFAT motif, a particular sequence motif shared by several lipid binding proteins including oxysterol-binding protein ( OSBP ). One of its proposed functions is to slow down the lipid flow back towards the ER when protein misfolding occurs, in order to reduce
182-403: The same term [REDACTED] This disambiguation page lists articles associated with the title VAP . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=VAP&oldid=1245636513 " Category : Disambiguation pages Hidden categories: Short description
196-403: The same term [REDACTED] This disambiguation page lists articles associated with the title VAP . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=VAP&oldid=1245636513 " Category : Disambiguation pages Hidden categories: Short description
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