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138-612: The cemetery was first established for British soldiers from the Crimean War, who died mostly as the result of a cholera epidemic in the first organized military hospital in modern history created by Florence Nightingale . On the 16th of May 1855, the burial ground was consecrated by the Bishop of Gibraltar according to the rites of the Church of England , in the presence of Lord Stratford de Redcliffe . Around 6,000 soldiers died during

276-618: A reservoir of infection, and seafood shipped long distances can spread the disease. Mediterranean Theatre of World War II Allied victory Asia-Pacific Mediterranean and Middle East Other campaigns Coups The Mediterranean and Middle East Theatre was a major theatre of operations during the Second World War . The vast size of the Mediterranean and Middle East theatre saw interconnected naval, land, and air campaigns fought for control of

414-436: A temperate bacteriophage called CTXφ . Microbiologists have studied the genetic mechanisms by which the V. cholerae bacteria turn off the production of some proteins and turn on the production of other proteins as they respond to the series of chemical environments they encounter, passing through the stomach, through the mucous layer of the small intestine, and on to the intestinal wall. Of particular interest have been

552-428: A day. Severe cholera, without treatment, kills about half of affected individuals. If the severe diarrhea is not treated, it can result in life-threatening dehydration and electrolyte imbalances. Estimates of the ratio of asymptomatic to symptomatic infections have ranged from 3 to 100. Cholera has been nicknamed the "blue death" because a person's skin may turn bluish-gray from extreme loss of fluids. Fever

690-906: A diplomatic mission to channel support to the Rashid Ali regime but the British quickly learned of the German arrangements through intercepted Italian diplomatic transmissions. On 6 May, in accordance with the Paris Protocols , Germany concluded a deal with the Vichy French government to release war materials, including aircraft, from sealed stockpiles in the French Mandate of Syria and transport them to Iraq. The French also agreed to allow passage of other weapons and material and loaned several airbases in northern Syria to Germany, for

828-446: A further several hundred thousand captured during the process of the various campaigns. British losses amount to over 300,000 men killed, wounded, or captured, and total American losses in the region amounted to 130,000. During the late 1920s, Benito Mussolini claimed that Italy needed an outlet for its " surplus population " and that it would be in other countries' best interests to aid in this expansion. The regime wanted "hegemony in

966-428: A greatly reduced pathogen count—though it will not necessarily be perfectly safe, it is an improvement for poor people with limited options. In Bangladesh this practice was found to decrease rates of cholera by nearly half. It involves folding a sari four to eight times. Between uses the cloth should be rinsed in clean water and dried in the sun to kill any bacteria on it. A nylon cloth appears to work as well but

1104-534: A massive inoculation program in British India . Persons who survive an episode of cholera have long-lasting immunity for at least 3 years (the period tested.) A number of safe and effective oral vaccines for cholera are available. The World Health Organization (WHO) has three prequalified oral cholera vaccines (OCVs): Dukoral, Sanchol, and Euvichol. Dukoral , an orally administered, inactivated whole-cell vaccine , has an overall efficacy of about 52% during

1242-541: A non-toxic B-subunit of cholera toxin and providing protection against V. cholerae O1; and two vaccines developed using the same transfer of technology—ShanChol (Shantha Biotec) and Euvichol (EuBiologics Co.), which have bivalent O1 and O139 oral killed cholera vaccines. Oral cholera vaccination could be deployed in a diverse range of situations from cholera-endemic areas and locations of humanitarian crises, but no clear consensus exists. Developed for use in Bangladesh ,

1380-408: A one-million fold increase in numbers of V. cholerae in the environment. The source of the contamination is typically other people with cholera when their untreated diarrheal discharge is allowed to get into waterways, groundwater or drinking water supplies. Drinking any contaminated water and eating any foods washed in the water, as well as shellfish living in the affected waterway , can cause

1518-430: A person to contract an infection. Cholera is rarely spread directly from person to person . V. cholerae also exists outside the human body in natural water sources, either by itself or through interacting with phytoplankton , zooplankton , or biotic and abiotic detritus. Drinking such water can also result in the disease, even without prior contamination through fecal matter. Selective pressures exist however in

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1656-535: A plot to arrest him and fled Baghdad for RAF Habbaniya , from whence he was flown to Basra and given refuge on the Insect-class gunboat HMS  Cockchafer . On 1 April, Rashid Ali, along with four senior Army and Air Force officers known as the " Golden Square ", seized power via a coup d'état and Rashid Ali proclaimed himself Chief of the "National Defence Government." The Golden Square deposed al-Hashimi and restored Rashid Ali. Ali did not overthrow

1794-530: A result of transmission by food, while in developing countries it is more often water. Food transmission can occur when people harvest seafood such as oysters in waters infected with sewage , as Vibrio cholerae accumulates in planktonic crustaceans and the oysters eat the zooplankton . People infected with cholera often have diarrhea, and disease transmission may occur if this highly liquid stool, colloquially referred to as "rice-water", contaminates water used by others. A single diarrheal event can cause

1932-519: A second land grant. An obelisk was erected in 1857 by Queen Victoria (1819–1901) within the cemetery to commemorate the British soldiers from the Crimean War. A bronze plaque, attached by the British community in Turkey on the plinth of the Crimean Memorial and unveiled on Empire Day , 1954, to celebrate the 100th anniversary of Florence Nightingale ’s nursing service in this region, bears

2070-421: A severe case if they become infected. Any individual, even a healthy adult in middle age, can undergo a severe case, and each person's case should be measured by the loss of fluids, preferably in consultation with a professional health care provider . The cystic fibrosis genetic mutation known as delta-F508 in humans has been said to maintain a selective heterozygous advantage : heterozygous carriers of

2208-701: A strong escort for convoys to and from the Malta. Malta was 60 miles (97 km) from Sicily and one of the first targets of the Italian army and the Regia Aeronautica ; the air defence of Malta comprised six obsolescent Gloster Gladiator biplanes. After the first Italian air attacks it became clear that Malta could be defended and in early July, the Gladiators were reinforced by twelve Hawker Hurricane fighters. The Kriegsmarine began operations in

2346-691: A weak force garrisoning the gains made from Operation Compass. In March, the Battle of Kufra ended with the Italians losing the desert oasis of Kufra—a vital link between Italian east and north Africa—which was located in south-eastern Libya. In North Africa, the Italians responded to the defeat of their Tenth Army by dispatching armour and motorised divisions. Germany dispatched the Afrika Korps in Operation Sonnenblume , to bolster

2484-442: A year (uncertainty range: 21,000–143,000) as of 2015 . This occurs mainly in the developing world. In the early 1980s, death rates are believed to have still been higher than three million a year. It is difficult to calculate exact numbers of cases, as many go unreported due to concerns that an outbreak may have a negative impact on the tourism of a country. As of 2004, cholera remained both epidemic and endemic in many areas of

2622-555: A year. To date, seven cholera pandemics have occurred, with the most recent beginning in 1961, and continuing today. The illness is rare in high-income countries , and affects children most severely. Cholera occurs as both outbreaks and chronically in certain areas . Areas with an ongoing risk of disease include Africa and Southeast Asia . The risk of death among those affected is usually less than 5%, given improved treatment, but may be as high as 50% without such access to treatment. Descriptions of cholera are found as early as

2760-596: Is endemic . If people are immunized broadly, herd immunity results, with a decrease in the amount of contamination in the environment. WHO recommends that oral cholera vaccination be considered in areas where the disease is endemic (with seasonal peaks), as part of the response to outbreaks, or in a humanitarian crisis during which the risk of cholera is high. Oral Cholera Vaccine (OCV) has been recognized as an adjunct tool for prevention and control of cholera. The World Health Organization (WHO) has prequalified three bivalent cholera vaccines—Dukoral (SBL Vaccines), containing

2898-547: Is oral rehydration salts (ORS), the replacement of fluids and electrolytes by using slightly sweet and salty solutions. Rice-based solutions are preferred. In children, zinc supplementation has also been found to improve outcomes. In severe cases, intravenous fluids , such as Ringer's lactate , may be required, and antibiotics may be beneficial. The choice of antibiotic is aided by antibiotic sensitivity testing . Cholera continues to affect an estimated 3–5 million people worldwide and causes 28,800–130,000 deaths

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3036-422: Is a common problem. Stool and swab samples collected in the acute stage of the disease, before antibiotics have been administered, are the most useful specimens for laboratory diagnosis. If an epidemic of cholera is suspected, the most common causative agent is V. cholerae O1. If V. cholerae serogroup O1 is not isolated, the laboratory should test for V. cholerae O139. However, if neither of these organisms

3174-503: Is a common source. Humans are the only known host for the bacteria . Risk factors for the disease include poor sanitation , insufficient clean drinking water , and poverty . Cholera can be diagnosed by a stool test , or a rapid dipstick test , although the dipstick test is less accurate. Prevention methods against cholera include improved sanitation and access to clean water . Cholera vaccines that are given by mouth provide reasonable protection for about six months, and confer

3312-442: Is available to determine the presence of V. cholerae . In those samples that test positive, further testing should be done to determine antibiotic resistance. In epidemic situations, a clinical diagnosis may be made by taking a patient history and doing a brief examination. Treatment via hydration and over-the-counter hydration solutions can be started without or before confirmation by laboratory analysis, especially where cholera

3450-446: Is effective for adults aged 18–64 as a single dose. One injectable vaccine was found to be effective for two to three years. The protective efficacy was 28% lower in children less than five years old. However, as of 2010 , it has limited availability. Work is under way to investigate the role of mass vaccination. The WHO recommends immunization of high-risk groups, such as children and people with HIV , in countries where this disease

3588-416: Is increasing within cholera bacteria. In Bangladesh , for example, most cases are resistant to tetracycline , trimethoprim-sulfamethoxazole , and erythromycin . Rapid diagnostic assay methods are available for the identification of multi-drug resistant cases. New generation antimicrobials have been discovered which are effective against cholera bacteria in in vitro studies. A rapid dipstick test

3726-487: Is isolated, it is necessary to send stool specimens to a reference laboratory. Infection with V. cholerae O139 should be reported and handled in the same manner as that caused by V. cholerae O1. The associated diarrheal illness should be referred to as cholera and must be reported in the United States. The World Health Organization (WHO) recommends focusing on prevention, preparedness, and response to combat

3864-460: Is less in those with lowered gastric acidity (for instance those using proton pump inhibitors ). Children are also more susceptible, with two- to four-year-olds having the highest rates of infection. Individuals' susceptibility to cholera is also affected by their blood type , with those with type O blood being the most susceptible. Persons with lowered immunity , such as persons with AIDS or malnourished children, are more likely to develop

4002-754: Is maintained. The WHO only recommends antibiotics in those with severe dehydration. Doxycycline is typically used first line, although some strains of V. cholerae have shown resistance . Testing for resistance during an outbreak can help determine appropriate future choices. Other antibiotics proven to be effective include cotrimoxazole , erythromycin , tetracycline , chloramphenicol , and furazolidone . Fluoroquinolones , such as ciprofloxacin , also may be used, but resistance has been reported. Antibiotics improve outcomes in those who are both severely and not severely dehydrated. Azithromycin and tetracycline may work better than doxycycline or ciprofloxacin . In Bangladesh zinc supplementation reduced

4140-469: Is not as affordable. Continued eating speeds the recovery of normal intestinal function. The WHO recommends this generally for cases of diarrhea no matter what the underlying cause. A CDC training manual specifically for cholera states: "Continue to breastfeed your baby if the baby has watery diarrhea, even when traveling to get treatment. Adults and older children should continue to eat frequently." The most common error in caring for patients with cholera

4278-442: Is rapid and thready, and urine output decreases with time. Muscle cramping and weakness, altered consciousness, seizures , or even coma due to electrolyte imbalances are common, especially in children. Cholera bacteria have been found in shellfish and plankton . Transmission is usually through the fecal-oral route of contaminated food or water caused by poor sanitation . Most cholera cases in developed countries are

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4416-412: Is rare and should raise suspicion for secondary infection. Patients can be lethargic and might have sunken eyes, dry mouth, cold clammy skin, or wrinkled hands and feet. Kussmaul breathing , a deep and labored breathing pattern, can occur because of acidosis from stool bicarbonate losses and lactic acidosis associated with poor perfusion . Blood pressure drops due to dehydration, peripheral pulse

4554-406: Is rare. For example, the last major outbreak of cholera in the United States occurred in 1910–1911. Cholera is mainly a risk in developing countries in those areas where access to WASH (water, sanitation and hygiene) infrastructure is still inadequate. Effective sanitation practices, if instituted and adhered to in time, are usually sufficient to stop an epidemic. There are several points along

4692-586: Is the preferred solution, often with added potassium. Large volumes and continued replacement until diarrhea has subsided may be needed. Ten percent of a person's body weight in fluid may need to be given in the first two to four hours. This method was first tried on a mass scale during the Bangladesh Liberation War , and was found to have much success. Despite widespread beliefs, fruit juices and commercial fizzy drinks like cola are not ideal for rehydration of people with serious infections of

4830-404: Is to underestimate the speed and volume of fluids required. In most cases, cholera can be successfully treated with oral rehydration therapy (ORT), which is highly effective, safe, and simple to administer. Rice-based solutions are preferred to glucose-based ones due to greater efficiency. In severe cases with significant dehydration, intravenous rehydration may be necessary. Ringer's lactate

4968-669: The Battle of Taranto on the night of 12/13 November. After assembling enough forces the British launched a counter-attack upon the Italians in Egypt. Operation Compass drove the Italians out of Egypt and resulted in the destruction of the Italian 10th Army in February 1941. Following this success, British forces adopted a defensive position in North Africa and redeployed most troops to Greece in Operation Lustre , leaving

5106-800: The Battle of the Kasserine Pass and a temporary defensive success at the Battle of the Mareth Line . After shattering the Axis defence on the Mareth Line, the Allies squeezed Axis forces into a pocket around Tunis. Axis resistance in Africa ended on 13 May 1943, with the unconditional surrender of nearly 240,000 men, who became prisoners of war . Following the Allied victory in North Africa. The Allies now turn their attention in knocking out Italy from

5244-624: The Commonwealth War Graves Commission has taken over the duty on behalf of the British Government. The cemetery is situated today between the military hospital and the Port of Haydarpaşa next to the marshalling yard down on the street Tıbbiye Caddesi from Üsküdar to Kadıköy . Cholera Cholera ( / ˈ k ɒ l ər ə / ) is an infection of the small intestine by some strains of

5382-606: The European part of Istanbul), and later transferred here together with the graves of 18 personnel of the Royal Navy and Royal Marines who died in the sultan’s mansion in Therapia, which had been converted into a military hospital. Since 1867, more than 700 civilians are interred in a separate section within the cemetery. Among them is the grave of Sir Edward Barton , British ambassador of Queen Elizabeth I (1533–1603) to

5520-795: The First Battle of El Alamein , which had stalled the Axis advance into Egypt, British forces went onto the offensive in October. The Second Battle of El Alamein marked a watershed in the Western Desert Campaign and turned the tide in the North African Campaign . It ended the Axis threat to Egypt, the Suez Canal and of gaining access to the Middle Eastern and Persian oil fields via North Africa. As

5658-606: The German invasion of the United Kingdom . While his generals did not believe they were prepared, they were ordered to push forward without any solid objectives. On 9 September, Italian aircraft start preparation bombardments for the invasion of Egypt. Four days later, Italian infantry attacked and advanced as far as Sidi Barrani before digging in, 80 mi (130 km) west of the main British position at Mersa Matruh . In East Africa, after some initial offensive actions,

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5796-662: The Greek Civil War . The British referred to this theatre as the Mediterranean and Middle East Theatre (so called due to the location of the fighting and the name of Middle East Command ), the Americans called it the Mediterranean Theater of War and the German informal official history of the fighting is the Mediterranean, South-East Europe, and North Africa 1939–1941. Despite the large size of

5934-449: The Gs alpha subunit of the heterotrimeric G protein . This results in constitutive cAMP production, which in turn leads to the secretion of water, sodium, potassium, and bicarbonate into the lumen of the small intestine and rapid dehydration. The gene encoding the cholera toxin was introduced into V. cholerae by horizontal gene transfer . Virulent strains of V. cholerae carry a variant of

6072-543: The Indian Army who died between 1919 and 1920 in the prisoner-of-war camps in southern Turkey near Adana and were interred in the Maslak and Osmaniye Indian Cemeteries. In 1961, when those cemeteries could not be further maintained, the earth with the ashes of the cremated remains of these men was transferred here and scattered near the monument, and the remains of their Muslim comrades were re-interred. In addition to

6210-718: The Italian conquest of British Somaliland began in August and annexed the colony. After crossing the Albanian border, Italian forces began the Greco-Italian War by invading Greece on 28 October. The Greek army repulsed the Italian attack and commenced a counter-offensive on 14 November, which pushed Italian forces back into Albania. The Royal Navy inflicted a major setback upon the Italian Royal Navy during

6348-819: The Italian invasion of France , just before the end of the Battle of France . During June, the East African Campaign began with Italian attacks in East Africa, although ground combat did not start until July. On 22 June, France signed an armistice at Compiegne with Germany and on 24 June, the Franco-Italian Armistice was signed. Italy gained a 50 kilometres (31 mi) demilitarised zone inside France (as well as similar zones where Italian and French colonies met). Italian occupation forces took over an 832 km (321 sq mi) area of France, which included 28,500 people and

6486-569: The Shah was widely viewed as pro-German by the allies. Following the Shah's refusal to open Iran up as a supply route for war materiel to the USSR; the allies invaded and occupied Iran in August 1941. The Shah, who urged his military not to resist the invasion, was deposed and his young son placed on the throne as titular head of an allied controlled puppet government . Iranian oil fields were secured and

6624-627: The Soviet Union . Devastating losses in the Magreb , Egypt , and Tunisia halted Axis interference in North Africa by May 1943. The Allies then invaded Italy , resulting in an armistice authorized by the royal government, causing a civil war . A prolonged battle for Italy commenced between the Allied-aligned Kingdom of Italy in the south and Axis-aligned Italian Social Republic in the north, lasting until 2 May 1945 with

6762-574: The Spanish Civil War " began. On 7 April 1939, Mussolini began the Italian invasion of Albania and within two days had occupied the country. In May 1939, Italy formally allied to Nazi Germany in the Pact of Steel . Italian foreign policy went through two stages during the Fascist regime. Until 1934–35, Mussolini followed a "modest ... and responsible" course and following that date there

6900-772: The Sublime Porte between 1588 and 1596, who died in 1598 on the island of Heybeliada in the Sea of Marmara , and his remains were transferred later here. A chapel in memory of Sir Nicholas O’Conor-Don , British ambassador to the Ottoman Empire from 1898 to 1908, is another historic monument in this plot. Some military graves outside of the World War periods are also located in this section. There are just over 400 graves of military personnel from World War I , who died in Turkey mostly as prisoners of war or some during

7038-622: The Surrender at Caserta . The Mediterranean and Middle East theatre had the longest duration of the World War II, resulted in the destruction of the Italian Empire , and severely undermined the strategic position of Germany, resulting in German divisions being deployed to Africa and Italy and total German losses (including those captured upon final surrender) being over two million. Italian losses amounted to around 177,000 men with

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7176-412: The bacterium Vibrio cholerae . Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea lasting a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance . This may result in sunken eyes , cold skin, decreased skin elasticity, and wrinkling of

7314-406: The human stomach . The few surviving bacteria conserve their energy and stored nutrients during the passage through the stomach by shutting down protein production. When the surviving bacteria exit the stomach and reach the small intestine , they must propel themselves through the thick mucus that lines the small intestine to reach the intestinal walls where they can attach and thrive. Once

7452-500: The monarchy and named a new Regent to King Faisal II , Sherif Sharaf . The leaders of the "National Defence Government" proceeded to arrest many pro-British citizens and politicians but many escaped through Amman in Transjordan. The new regime planned to refuse further concessions to the United Kingdom, to retain diplomatic links with Fascist Italy and to expel the most prominent pro-British politicians. The plotters considered

7590-459: The occupation of Istanbul (1918 to 1923) after the Armistice of Mudros . Two other memorials of World War I are found in the cemetery, one bearing the names of a little over 200 soldiers of United Kingdom and Undivided India , who fell in various parts of Russia or on the borders of Turkey, and whose burial grounds could not be maintained. The other memorial is dedicated to the servicemen of

7728-479: The potassium level may be normal, even though large losses have occurred. As the dehydration is corrected, potassium levels may decrease rapidly, and thus need to be replaced. This is best done by Oral Rehydration Solution (ORS). Antibiotic treatments for one to three days shorten the course of the disease and reduce the severity of the symptoms. Use of antibiotics also reduces fluid requirements. People will recover without them, however, if sufficient hydration

7866-411: The "sari filter" is a simple and cost-effective appropriate technology method for reducing the contamination of drinking water. Used sari cloth is preferable but other types of used cloth can be used with some effect, though the effectiveness will vary significantly. Used cloth is more effective than new cloth, as the repeated washing reduces the space between the fibers. Water collected in this way has

8004-512: The 5th century BC in Sanskrit . In Europe, cholera was a term initially used to describe any kind of gastroenteritis, and was not used for this disease until the early 19th century. The study of cholera in England by John Snow between 1849 and 1854 led to significant advances in the field of epidemiology because of his insights about transmission via contaminated water, and a map of the same

8142-519: The Axis forces in Libya. During 1941, the British launched several offensives to push back the Axis forces in North Africa. Operation Brevity failed as did Operation Battleaxe but Operation Crusader , the third and larger offensive was launched at the end of the year. Over December 1941 into early 1942, Allied forces pushed the Italian-German forces back through Libya to roughly the limit of

8280-704: The Axis war effort in the North African theatre . Enno von Rintelen, who was the military attaché in Rome, emphasises, from the German point of view, the strategic mistake of not taking Malta . When Italy entered the war the Iraqi government did not break off diplomatic relations, as they had done with Germany. The Italian Legation in Baghdad became the centre for Axis propaganda and for fomenting anti-British feeling. In this they were aided by Mohammad Amin al-Husayni ,

8418-643: The British appointee as the Grand Mufti of Jerusalem , who had fled from the British Mandate of Palestine shortly before the outbreak of war and later received asylum in Baghdad. In January 1941, there was a political crisis within Iraq as Rashid Ali resigned as Prime Minister of Iraq and was replaced by Taha al-Hashimi ; civil war loomed. On 31 March, the Regent of Iraq, Prince 'Abd al-Ilah , learnt of

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8556-703: The British decided "that Italy could not now be regarded as a reliable friend" and preparations began to bring "the defences of the Mediterranean and the Red Sea ports up-to-date". In 1938, a weak armoured division was established in Egypt and further army and air force reinforcements were dispatched from Britain. With rising tension in Europe, in June 1939, the United Kingdom established Middle East Command (MEC) in Cairo to provide centralised command for British army units in

8694-601: The British forces and forced the British and Commonwealth forces into retreat. The Australian 9th Infantry Division fell back to the fortress port of Tobruk and the remaining British and Commonwealth forces withdrew a further 100 mi (160 km) east to Sollum on the Libyan–Egyptian border. </ref> The main Axis force began the Siege of Tobruk , and a small German force pressed eastwards, retaking all territory lost to Operation Compass, and advanced into Egypt. By

8832-414: The Caucasus and the Indian Ocean. The purpose of the command was to be "the western bastion of defence of India", keep British supply lines open to India and the Far East , and keep the Middle Eastern oilfields out of Axis hands. Upon the establishment of MEC, it was ordered to co-ordinate with the French military in the Middle East and Africa as well as liaise with the Turkish General Staff and possibly

8970-410: The Eighth Army pushed west across the desert, capturing Libya, German and Italian forces occupied southern France and landed in Tunisia. On 8 November, Allied forces launched Operation Torch landing in various places across French North Africa. In December 1942, after a 101-day British blockade, French Somaliland fell to the Allies. Following the Japanese attack on Pearl Harbor on 7 December 1941,

9108-424: The German attack. The Greek army found itself outnumbered in its effort to defend against both Italian and German troops. As a result, the Metaxas defensive line did not receive adequate troop reinforcements and was quickly overrun by the Germans, who then outflanked the Greek forces at the Albanian border, forcing their surrender. British, Australian and New Zealand forces were overwhelmed and forced to retreat, with

9246-406: The Greek General Staff. On 19 October 1939, the Treaty of Mutual Assistance was signed between the United Kingdom, France and Turkey and British military forces were authorised to begin discussions with the Turkish general staff; a further conference was held during March 1940. Within a week of the Italian occupation of Albania, France and the United Kingdom "announced they had promised to give all

9384-453: The Indian Ocean through the Sudan and Abyssinia, or to the Atlantic by way of French North Africa". On 2 October 1935, the Second Italo–Ethiopian War began when Italian forces invaded Abyssinia. Mussolini lauded the conquest as a new source of raw materials and location for emigration and speculated that a native army could be raised there to "help conquer the Sudan . "Almost as soon as the Abyssinian campaign ended, Italian intervention in

9522-485: The Iraqi army and British reinforcements were dispatched to Iraq from Transjordan and India. The larger but poorly trained Iraqi force was defeated and Baghdad and Mosul were captured. Ali and his supporters fled the country and an armistice was signed, restoring the monarchy of Faisal II, the Kingdom of Iraq and a pro-British government. The defeat of the rebellion saw the defeat of the German-Italian attempt to entrench an Axis state in Iraq and worsened relations between

9660-416: The Italian colonies, the Allies sought to bring the entire French empire effectively into the war against the Axis powers. They reopened the Mediterranean route to the Middle East. They went on from Africa to liberate Sicily, Sardinia, and Corsica. They caused Mussolini to topple from power, and they brought his successors to surrender. They drew more and more German military resources into a stubborn defence of

9798-419: The Italian peninsula, and helped the Yugoslavs to pin down within their spirited country thousands of Axis troops. Eventually, the Allies delivered a solid blow from southern France against the German forces which were opposing the Allied drive from the beaches of Normandy! They made Marseilles available for Allied use and they occupied northern Italy and Greece." Howe further notes that "Hitler had always accepted

9936-454: The Italians with a mission to block further Allied attempts to drive the Italians out of the region. It's commander was General Erwin Rommel and Rommel himself was subordinated to the Italian command. But Rommel seized on the weakness of his opponents and without waiting for his forces to fully assemble, rapidly went on the offensive. In March–April 1941, the German and Italian forces defeated

10074-553: The Mediterranean . The siege of Malta soon began, with the first Italian air attack on 11 June. In the Western Desert , Royal Air Force (RAF) aircraft attacked Italian positions inside Libya. On 11 June, the Western Desert Campaign began, as the British launched minor raids and conducted patrols along the Libyan–Egyptian border and on 17 June, Fort Capuzzo was captured. On 20 June, Mussolini began

10212-489: The Mediterranean and Middle East theatre. All three branches of the British military were made equally responsible for the defence of the area. The authority of MEC included Aden , British Somaliland , Cyprus, Egypt, Eritrea , Ethiopia, Kenya , Greece, Libya , Palestine , Iraq , Sudan, Tanganyika , Transjordan , Uganda and the shores of the Persian Gulf . If necessary, command would be exerted as far away as

10350-819: The Mediterranean with establishment of the 23rd U-boat Flotilla at a base on Salamis Island in Greece in September 1941. The flotilla was to operate against British supply convoys to Allied forces on Malta and in Tobruk. On 7 December, control of the 23rd Flotilla was transferred from Kernével to Field Marshal Albert Kesselring , Commander in Chief South ( OB Süd ) in Italy. Additional bases were established in Pola and La Spezia in northern Italy, as more U-boats were sent to

10488-618: The Mediterranean, North Africa , the Horn of Africa, the Middle East and Southern Europe . The fighting started from 10 June 1940, when Italy declared war on United Kingdom and France , until 2 May 1945 when all Axis forces in Italy surrendered. However, fighting would continue in Greece – where British troops had been dispatched to aid the Greek government – during the early stages of

10626-413: The Mediterranean. Bombing and the naval blockade led to food and commodity shortages and rationing was imposed on the inhabitants. Luftwaffe reinforcements in the Mediterranean joined in the bombing but during a lull in early 1942, 61 Supermarine Spitfires were delivered, which very much improved the defensive situation, although food, ammunition, and fuel were still short. Supply runs during lulls in

10764-672: The Mediterranean–Danubian–Balkan region" and the gaining of world power by the conquest "of an empire stretching from the Strait of Gibraltar to the Strait of Hormuz ". The Fascists had designs on Albania , Dalmatia , large parts of Slovenia , Croatia , Bosnia and Herzegovina , Macedonia and Greece and harked back to the Roman empire. The regime also sought to establish protectorates with Austria , Hungary , Romania and Bulgaria . Covert motives were for Italy to become

10902-592: The RAF in their war with the Italians in Albania. As it became likely Germany would attack Greece, four British divisions were switched from North Africa to reinforce Greek Army. The advanced guards of these troops began arriving in March 1941, triggering the entry of German forces into Bulgaria, which made clear the German intent to invade Greece. In April 1941, Germans, Italians, Hungarians and Bulgarians made quick work of

11040-737: The Royal Yugoslav army . They captured Yugoslavia in 11 days and partitioned it among themselves and newly formed client states: The Independent State of Croatia and Nedić's Serbia . In spring 1941, Italy created a Montenegrin client state and annexed most of the Dalmatian coast as the Governorship of Dalmatia ( Governatorato di Dalmazia ). A complex guerrilla uprising of communist -led Partisans , commanded by Josip Broz Tito , soon broke out. A more ambivalent, predominantly Serb paramilitary movement of royalist Chetniks both fought

11178-736: The UK and Vichy France, culminating in the Syria-Lebanon Campaign . In Operation Exporter, Australian, Free French , British and Indian units invaded Syria and Lebanon from Palestine in the south on 8 June 1941. Vigorous resistance was met from the Vichy French but superior Allied infantry equipment and numbers overwhelmed the defenders. More attacks were launched at the end of June and early July from Iraq into northern and central Syria, by Iraqforce . By 8 July, north-east Syria had been captured and elements of Iraqforce had advanced up

11316-493: The United Kingdom "disclaimed any desire to modify or see modified the national sovereignty of any country in the Mediterranean area, and agreed to discourage any activities liable to impair mutual relations." Italian diplomatic and military moves did not reflect this agreement. In the aftermath of the Italian invasion of Abyssinia, British and Italian forces in North Africa were reinforced. Due to various Italian moves, in July 1937,

11454-499: The United Kingdom to be weak and believed that its government would negotiate with their new government regardless of its legality. On 17 April, Rashid Ali, on behalf of the "National Defence Government" asked Germany for military assistance in the event of war with the British. Ali attempted to restrict British rights guaranteed under Article 5 of the 1930 Anglo-Iraqi Treaty, when he insisted that newly arrived British troops quickly be transported through Iraq and to Palestine. Before

11592-405: The United States joined the war. On 8 November 1942, American forces entered combat in North Africa with Operation Torch, which "transformed the Mediterranean from a British to an Allied theater of war", "succeeding operations in the Mediterranean area proved far more extensive than intended. One undertaking was to lead to the next". After liberating French North Africa and clearing the enemy from

11730-566: The added benefit of protecting against another type of diarrhea caused by E. coli . In 2017, the US Food and Drug Administration (FDA) approved a single-dose, live, oral cholera vaccine called Vaxchora for adults aged 18–64 who are travelling to an area of active cholera transmission. It offers limited protection to young children. People who survive an episode of cholera have long-lasting immunity for at least three years (the period tested). The primary treatment for affected individuals

11868-474: The aquatic environment that may reduce the virulence of V. cholerae . Specifically, animal models indicate that the transcriptional profile of the pathogen changes as it prepares to enter an aquatic environment. This transcriptional change results in a loss of ability of V. cholerae to be cultured on standard media, a phenotype referred to as ' viable but non-culturable ' (VBNC) or more conservatively ' active but non-culturable ' (ABNC). One study indicates that

12006-459: The assumption that Britain would soon be at war with Italy, planning began for attacks to capture Bardia and Jaghbub (Giarabub) in Libya and arrangements began in Egypt, to accommodate a much larger force. Preparations to reinforce the Iraqi army were made and Palestinian security forces were to be reduced to the minimum. British forces in East Africa were to study operations to destroy the Italian forces and support local risings, all in support of

12144-400: The bombing kept Malta in being but many ships like SS  Ohio were damaged too severely to leave. The defence of the island ensured that the Allies had an advantage in the fight to control the Mediterranean and as the garrison recovered from periods of intense bombing, aircraft, submarines and light surface ships resumed attacks on Axis supply ships, leading to fuel and supply shortages for

12282-749: The burials of World War I, graves of 38 servicemen of the Royal Navy and Royal Air Force and one pilot of the Australian Imperial Force , who were all killed in action in the Mediterranean Theatre of World War II at the borders of then neutral Turkey, are found in the Haydarpaşa Cemetery. Until 1925, the British Government was directly responsible for the maintenance of the cemetery. From then on,

12420-783: The campaign, allowing the Empire of Ethiopia to be re-established under Haile Selassie . A number of Italian garrisons continued to hold out, but the last of these, at Gondar , surrendered in November. Small groups of Italian troops carried out the Italian guerrilla war in Ethiopia until October 1943. In the Balkans , the Greeks had been reluctant to allow British troops into the country, because Britain could not spare enough forces to guarantee victory. They had, however, accepted aid from

12558-422: The cholera bacteria reach the intestinal wall, they no longer need the flagella to move. The bacteria stop producing the protein flagellin to conserve energy and nutrients by changing the mix of proteins that they express in response to the changed chemical surroundings. On reaching the intestinal wall, V. cholerae start producing the toxic proteins that give the infected person a watery diarrhea. This carries

12696-612: The cholera transmission path at which its spread may be halted: Handwashing with soap or ash after using a toilet and before handling food or eating is also recommended for cholera prevention by WHO Africa. Surveillance and prompt reporting allow for containing cholera epidemics rapidly. Cholera exists as a seasonal disease in many endemic countries, occurring annually mostly during rainy seasons . Surveillance systems can provide early alerts to outbreaks, therefore leading to coordinated response and assist in preparation of preparedness plans. Efficient surveillance systems can also improve

12834-613: The commandos. Three of the participants were arrested by the Transjordan Frontier Force a few days after their landing. The German commander was captured in 1946 and the fifth, Hasan Salama , succeeded in escaping. In 1943 a small team of German agents parachuted into Iraqi Kurdistan with the goal of covertly sabotaging Kirkuk oil fields and create a Kurdish uprising against the British with assistance from local Kurds who were seeking to create an independent Kurdistan . Further reinforcements of Nazis with weapons

12972-516: The coup, Rashid Ali's supporters had been informed that Germany would recognise the independence of Iraq from the British Empire. There had also been discussions on war material being sent to support the Iraqis and other Arab factions in fighting the British. On 3 May, German Foreign Minister Joachim von Ribbentrop persuaded Adolf Hitler to secretly return Dr. Fritz Grobba to Iraq to lead

13110-424: The culturability of V. cholerae drops 90% within 24 hours of entering the water, and furthermore that this loss in culturability is associated with a loss in virulence. Both toxic and non-toxic strains exist. Non-toxic strains can acquire toxicity through a temperate bacteriophage . About 100   million bacteria must typically be ingested to cause cholera in a normal healthy adult. This dose, however,

13248-684: The dominant power in the Mediterranean, capable of challenging France or Britain and gaining access to the Atlantic and Indian Oceans . On 30 November 1938, Mussolini addressed the Fascist Grand Council on the goal of capturing Albania, Tunisia , Corsica , the Ticino canton of Switzerland and "French territory east of the River Var (to include Nice , but not Savoy )". Mussolini alleged that Italy required uncontested access to

13386-433: The duration and severity of diarrhea in children with cholera when given with antibiotics and rehydration therapy as needed. It reduced the length of disease by eight hours and the amount of diarrhea stool by 10%. Supplementation appears to be also effective in both treating and preventing infectious diarrhea due to other causes among children in the developing world. If people with cholera are treated quickly and properly,

13524-560: The end of April, Sollum had fallen and the important Halfaya Pass captured. In East Africa , the British launched a counter-attack against the Italians from Kenya Colony in February 1941. Landings were subsequently conducted in British Somaliland and Italian Ethiopia , while an expedition from the Sudan moved on Addis Ababa . The Italian Viceroy, Duke Amedeo d'Aosta , was forced to surrender by 18 May which effectively ended

13662-438: The first to immunize humans against a bacterial disease. His vaccine and inoculation was rather controversial and was rejected by his peers and several investigation commissions but it ended up demonstrating its effectiveness and being recognized for it: out of the 30 thousand people he vaccinated only 54 died. Russian-Jewish bacteriologist Waldemar Haffkine also developed a human cholera vaccine in July 1892. He conducted

13800-480: The first year after being given and 62% in the second year, with minimal side effects. It is available in over 60 countries. However, it is not currently recommended by the Centers for Disease Control and Prevention (CDC) for most people traveling from the United States to endemic countries. The vaccine that the US Food and Drug Administration (FDA) recommends, Vaxchora , is an oral attenuated live vaccine , that

13938-420: The genetic mechanisms by which cholera bacteria turn on the protein production of the toxins that interact with host cell mechanisms to pump chloride ions into the small intestine, creating an ionic pressure which prevents sodium ions from entering the cell. The chloride and sodium ions create a salt-water environment in the small intestines, which through osmosis can pull up to six liters of water per day through

14076-462: The genetic structure. Two clusters have been identified: Cluster I and Cluster II. For the most part, Cluster I consists of strains from the 1960s and 1970s, while Cluster II largely contains strains from the 1980s and 1990s, based on the change in the clone structure. This grouping of strains is best seen in the strains from the African continent. In many areas of the world, antibiotic resistance

14214-401: The hands and feet. Dehydration can cause the skin to turn bluish . Symptoms start two hours to five days after exposure. Cholera is caused by a number of types of Vibrio cholerae , with some types producing more severe disease than others. It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. Undercooked shellfish

14352-545: The help in their power if Greek and Romanian independence were threatened and if the Greek Government or Romanian Government considered it vital to resist." British forces in the Middle East were ordered to avoid provocation. Following the defeat of Poland , the threat of an Axis attack from the Balkans against British positions in the Middle East and Eastern Mediterranean region increased. In late 1939, with

14490-562: The initial Italian attack and a counter-attack in March 1941. When the German invasion, known as Operation Marita , began on 6 April, the bulk of the Greek Army was on the Greek border with Albania , then a vassal of Italy, from which the Italian troops had attacked. German troops invaded from Bulgaria , creating a second front. Greece received a small reinforcement from British , Australian and New Zealand forces in anticipation of

14628-547: The inscription: "To Florence Nightingale, whose work near this Cemetery a century ago relieved much human suffering and laid the foundations for the nursing profession." Other monuments in the cemetery include a symbolic broken column in memorial of German Jäger officers who fell in the Crimea , and a British memorial, which was erected in 1855 initially in the Therapia Crimean Cemetery (today Tarabya in

14766-466: The intestinal cells, creating the massive amounts of diarrhea. The host can become rapidly dehydrated unless treated properly. By inserting separate, successive sections of V. cholerae DNA into the DNA of other bacteria, such as E. coli that would not naturally produce the protein toxins, researchers have investigated the mechanisms by which V. cholerae responds to the changing chemical environments of

14904-400: The intestines, and their excessive sugar content may even harm water uptake. If commercially produced oral rehydration solutions are too expensive or difficult to obtain, solutions can be made. One such recipe calls for 1 liter of boiled water, 1/2 teaspoon of salt, 6 teaspoons of sugar, and added mashed banana for potassium and to improve taste. As there frequently is initially acidosis ,

15042-956: The line of supply to Russia established and maintained for the remainder of the war. Operation Atlas was carried out by a special commando unit of the Waffen SS and took place in October 1944. It involved five soldiers: three who were previously members of the Templer religious sect in Mandatory Palestine , and two Palestinian Arabs who were close collaborators of the mufti of Jerusalem , Amin al-Husseini . Atlas aimed at establishing an intelligence-gathering base in Mandatory Palestine, radioing information back to Germany, and recruiting and arming anti-British Palestinians by buying their support with gold. The plan failed utterly, and no meaningful action could be undertaken by

15180-482: The main Allied offensive, which was planned to be launched from French Somaliland . Troops in Sudan were also asked to consider launching operations against Kufra in southern Libya. On 10 June 1940, Italy declared war on France and the United Kingdom and next day the British Commonwealth declared war on Italy. The fleets of Italy, France and the United Kingdom began the hostilities of the Battle of

15318-505: The mortality rate is less than 1%; however, with untreated cholera, the mortality rate rises to 50–60%. For certain genetic strains of cholera, such as the one present during the 2010 epidemic in Haiti and the 2004 outbreak in India, death can occur within two hours of becoming ill. Cholera affects an estimated 2.8 million people worldwide, and causes approximately 95,000 deaths

15456-448: The multiplying new generations of V. cholerae bacteria out into the drinking water of the next host if proper sanitation measures are not in place. The cholera toxin (CTX or CT) is an oligomeric complex made up of six protein subunits : a single copy of the A subunit (part A), and five copies of the B subunit (part B), connected by a disulfide bond . The five B subunits form a five-membered ring that binds to GM1 gangliosides on

15594-400: The mutation (who are not affected by cystic fibrosis) are more resistant to V. cholerae infections. In this model, the genetic deficiency in the cystic fibrosis transmembrane conductance regulator channel proteins interferes with bacteria binding to the intestinal epithelium , thus reducing the effects of an infection. When consumed, most bacteria do not survive the acidic conditions of

15732-585: The occupying forces and collaborated with them against the communists. The Partisans eventually gained recognition from the Allies as the sole resistance movement. With help from both the Soviets and the Western Allies, they turned into a formidable fighting force and successfully liberated the country. Following the Italian invasion on 28 October 1940, which is usually known as the Greco-Italian War , Greece, with British air and material support, repelled

15870-483: The oceans and shipping lanes to ensure its national sovereignty. Italy was a "prisoner in the Mediterranean" and had to break the chains of British and French control. Corsica, Cyprus , Gibraltar , Malta , Suez and Tunisia would need to be taken and Egypt , France, Greece, Turkey and the United Kingdom had to be challenged. Through armed conquest, the north and east African colonies would be linked and this 'prison' destroyed. Italy would be able to march "either to

16008-419: The previous Operation Compass advance. Taking advantage of the Allied position, German and Italian forces counter-attacked and pushed back the Allies to Gazala, west of Tobruk. As both sides prepared offensives, the Axis forces struck first and inflicted a big defeat upon the Allied forces during the Battle of Gazala . The routed Allied forces retreated to Egypt where they made a stand at El Alamein. Following

16146-494: The principle that the Mediterranean was an area of paramount Italian interest just as, farther north, German interests were exclusive. Allied forces were placed under the command of a Supreme Allied Commander AFHQ Mediterranean, General Dwight D. Eisenhower . Axis forces were caught between the Allied armies during the Tunisia Campaign but managed to delay the Allied advance by defensive operations, most notably with

16284-583: The rest of the island by 1 June. With their victory in the Battle of Crete the Germans had secured their southern flank and turned their attention towards the Soviet Union. Hitler later blamed the failure of his invasion of the Soviet Union on Mussolini 's failed conquest of Greece. Andreas Hillgruber has accused Hitler of trying to deflect blame for his country's defeat from himself to his ally, Italy. It nevertheless had serious consequences for

16422-399: The risk assessment for potential cholera outbreaks. Understanding the seasonality and location of outbreaks provides guidance for improving cholera control activities for the most vulnerable. For prevention to be effective, it is important that cases be reported to national health authorities. Spanish physician Jaume Ferran i Clua developed the first successful cholera inoculation in 1885,

16560-815: The river Euphrates towards Aleppo , the rear of the Vichy forces defending Beirut from the advance from the south. Negotiations for an armistice were started on 11 July and surrender terms signed on 14 July. Supplies to the Soviet Union had been sent via the North Cape to Murmansk and Archangel soon after the German invasion but the number of ships available was limited and convoys were vulnerable to German air and submarine attack. Supplies were also sent from American pacific ports to Vladivostok in Soviet-flagged ships but Allied planners wished to open another supply route through Iran . Though officially neutral,

16698-406: The spread of cholera. They also stress the importance of an effective surveillance system. Governments can play a role in all of these areas. Although cholera may be life-threatening, prevention of the disease is normally straightforward if proper sanitation practices are followed. In developed countries , due to their nearly universal advanced water treatment and sanitation practices, cholera

16836-646: The stomach, mucous layers, and intestinal wall. Researchers have discovered a complex cascade of regulatory proteins controls expression of V. cholerae virulence determinants. In responding to the chemical environment at the intestinal wall, the V. cholerae bacteria produce the TcpP/TcpH proteins, which, together with the ToxR/ToxS proteins, activate the expression of the ToxT regulatory protein. ToxT then directly activates expression of virulence genes that produce

16974-613: The surface of the intestinal epithelium cells. The A1 portion of the A subunit is an enzyme that ADP-ribosylates G proteins , while the A2 chain fits into the central pore of the B subunit ring. Upon binding, the complex is taken into the cell via receptor-mediated endocytosis . Once inside the cell, the disulfide bond is reduced, and the A1 subunit is freed to bind with a human partner protein called ADP-ribosylation factor 6 (Arf6). Binding exposes its active site, allowing it to permanently ribosylate

17112-428: The theatre, the various campaigns were not seen as neatly separated areas of operations but part of a vast, contiguous theatre of war. Fascist Italy aimed to carve out a new Roman Empire, while the Allies aimed to retain the status quo. Italy entered the war on 10 June 1940, and immediately invaded France and bombed Malta , which would remain under siege for over 2 years. Italian forces then attacked Greece , but it

17250-780: The town of Menton . The Royal Navy attacked the French fleet in the North African port of Mers-el-Kébir on 3 July 1940, after it refused to sail to Britain or the French West Indies and demobilise, as part of a larger plan to stop the French fleet from falling into German or Italian hands. When Italy entered the war, there were no plans for an invasion of Egypt while France was still able to resist. When France surrendered, Mussolini gave instructions for his generals to prepare an offensive. On 10 August, he instructed his forces to be prepared to attack in conjunction with

17388-410: The toxins, causing diarrhea in the infected person and allowing the bacteria to colonize the intestine. Current research aims at discovering "the signal that makes the cholera bacteria stop swimming and start to colonize (that is, adhere to the cells of) the small intestine." Amplified fragment length polymorphism fingerprinting of the pandemic isolates of V. cholerae has revealed variation in

17526-466: The transport of German aircraft to Iraq. Between 9 May and the end of the month, about 100 German and about 20 Italian aircraft landed on Syrian airfields. On 30 April, the Iraqi Army surrounded and besieged RAF Habbaniya; the base had no operational aircraft but the RAF converted trainers to carry weapons and a battalion of infantry reinforcements was flown in. German and Italian aircraft supported

17664-555: The ultimate goal of evacuation. After moving through south-eastern Yugoslavia, the Germans had been able to turn the Allied flank, cutting off Greek units in the east of the country. Greek forces in central Macedonia were isolated from the Commonwealth forces moving up in an attempt stabilise the front, with the Germans then falling on the rear of the main Greek army facing the Italians in Macedonia. The German advance into Greece

17802-529: The war and force Germany to disperse its forces, the Allies invaded Sicily in Operation Husky on 10 July 1943, with amphibious and airborne landings. The German and Italian forces were unable to prevent the Allied capture of the island but evacuated most of their troops and equipment to the mainland before the Allies entered Messina on 17 August. On 25 July, the Italian government deposed Mussolini,

17940-631: The war in the Selimiye Barracks (aka Scutari Barracks) in Istanbul, which was converted into a military hospital. The graves of the dead, of which only a few are marked today, were placed at two separate plots on a hillside close to the Sea of Marmara next to the military hospital. The land, formerly owned by Sultan Suleiman the Magnificent (1495–1566), was donated to the British Government in 1855. The two plots were linked in 1867 by

18078-451: The world. Recent major outbreaks are the 2010s Haiti cholera outbreak and the 2016–2022 Yemen cholera outbreak . In October 2016, an outbreak of cholera began in war-ravaged Yemen . WHO called it "the worst cholera outbreak in the world". In 2019, 93% of the reported 923,037 cholera cases were from Yemen (with 1911 deaths reported). Between September 2019 and September 2020, a global total of over 450,000 cases and over 900 deaths

18216-466: Was "ceaseless activity and aggression". "Prior to the Italian invasion of Ethiopia, Mussolini had made military agreements with the French and formed a coalition with the British and French to prevent German aggression in Europe." The Ethiopian War "exposed vulnerabilities and created opportunities that Mussolini seized to realise his imperial vision" At the Nyon Conference of 1937, Italy and

18354-574: Was made easier because the bulk of the Greek Army was engaged fighting the Italians on the Albanian front in the north of the country. The Greeks were forced to capitulate, ending resistance on the mainland by the end of the month. Abandoning most of its equipment, the Commonwealth force retreated to the island of Crete. From 20 May, the Germans attacked the island by using paratroops to secure an air bridgehead despite suffering heavy casualties. They then flew in more troops and were able to capture

18492-420: Was not until the introduction of German forces that it and neighbouring Yugoslavia were overrun . Allied and Axis forces fought back and forth across North Africa , while Axis interference in the Middle East caused fighting to spread as far as Palestine and Iraq . With confidence high from early gains, German forces planned to capture the Middle East with a view to possibly attacking the southern border of

18630-575: Was published in Germany in 1959. Gibraltar commanded the entrance to the Mediterranean and had been a British fortress since the early 18th century. The territory provided a strongly defended harbour, from which ships could operate in the Atlantic and the Mediterranean. Force H ( Vice-Admiral James Somerville ) was based in Gibraltar and had the task of maintaining naval superiority and providing

18768-629: Was reported; however, the accuracy of these numbers suffer from over-reporting from countries that report suspected cases (and not laboratory confirmed cases), as well as under-reporting from countries that do not report official cases (such as Bangladesh, India and Philippines). Although much is known about the mechanisms behind the spread of cholera, researchers still do not have a full understanding of what makes cholera outbreaks happen in some places and not others. Lack of treatment of human feces and lack of treatment of drinking water greatly facilitate its spread. Bodies of water have been found to serve as

18906-580: Was supposed to be sent but the mission failed within days as the Nazi commandos landed 300 km away from their target destination and lost their weapons. They were soon arrested by the British and faced execution as spies, however they were released several years after World War II ended. Gottfried Müller, one of the Nazi parachuters, would later write and publish a book describing his experiences in Kurdistan named “Im brennenden Orient” ('The Burning Orient'), which

19044-440: Was the first recorded incidence of epidemiological tracking. The primary symptoms of cholera are profuse diarrhea and vomiting of clear fluid. These symptoms usually start suddenly, half a day to five days after ingestion of the bacteria. The diarrhea is frequently described as "rice water" in nature and may have a fishy odor. An untreated person with cholera may produce 10 to 20 litres (3 to 5 US gal) of diarrhea

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