Guale was a historic Native American chiefdom of Mississippian culture peoples located along the coast of present-day Georgia and the Sea Islands . Spanish Florida established its Roman Catholic missionary system in the chiefdom in the late 16th century.
135-562: During the late 17th century and early 18th century, Guale society was shattered by extensive epidemics of new infectious diseases and attacks by other tribes. Some of the surviving remnants migrated to the mission areas of Spanish Florida, while others remained near the Georgia coast. Joining with other survivors, they became known as the Yamasee , an ethnically mixed group that emerged in a process of ethnogenesis . Scholars have not reached
270-548: A Mississippian culture group that had a chiefdom along what is now the Georgia coast in the early period of Spanish exploration. Archaeological studies indicate that the precursors of the historically known Guale lived along the Georgia coast and Sea Islands, from at least 1150 AD . Archaeologists identify the prehistoric Guale cultures as the Savannah phase (1150 to 1300 AD) and the Irene phase (1300 to circa 1600). While
405-553: A nation primarily located in Western Europe that share a common French culture , history , and language , identified with the country of France . The French people, especially the native speakers of langues d'oïl from northern and central France, are primarily descended from Romans (or Gallo-Romans , western European Celtic and Italic peoples ), Gauls (including the Belgae ), as well as Germanic peoples such as
540-456: A prion . The benefits of identification, however, are often greatly outweighed by the cost, as often there is no specific treatment, the cause is obvious, or the outcome of an infection is likely to be benign . The diagnosis is aided by the presenting symptoms in any individual with an infectious disease, yet it usually needs additional diagnostic techniques to confirm the suspicion. Some signs are specifically characteristic and indicative of
675-422: A runny nose . In certain cases, infectious diseases may be asymptomatic for much or even all of their course in a given host. In the latter case, the disease may only be defined as a "disease" (which by definition means an illness) in hosts who secondarily become ill after contact with an asymptomatic carrier . An infection is not synonymous with an infectious disease, as some infections do not cause illness in
810-425: A colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and Viridans streptococci , prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with
945-646: A community of French Huguenots settled in South Africa . Most of these originally settled in the Cape Colony , but have since been quickly absorbed into the Afrikaner population. After Champlain's founding of Quebec City in 1608, it became the capital of New France . Encouraging settlement was difficult, and while some immigration did occur, by 1763 New France only had a population of some 65,000. From 1713 to 1787, 30,000 colonists immigrated from France to
1080-586: A consensus on how to classify the Guale language. Early claims that the Guale spoke a Muskogean language were questioned by the historian William C. Sturtevant . He has shown that recorded vocabulary, which sources had believed to be Guale, was Muscogee . Historical references note that the Jesuit Brother Domingo Agustín Váez recorded Guale grammar in 1569, but the documents have not been found. The Guale are believed to have been
1215-649: A dialect of Hitchiti , a Muskogean language , as did several towns in Apalachicola Province . The Guale language may or may not have been related. In 1675 the Spanish first used the term Yamasee to refer to the newcomer refugees. They thought them similar to the La Tama. In Guale Province, some of the Yamasee joined the existing missions, while others settled on the periphery. Between 1675 and 1684,
1350-469: A disease and are called pathognomonic signs; but these are rare. Not all infections are symptomatic. In children the presence of cyanosis , rapid breathing, poor peripheral perfusion, or a petechial rash increases the risk of a serious infection by greater than 5 fold. Other important indicators include parental concern, clinical instinct, and temperature greater than 40 °C. Many diagnostic approaches depend on microbiological culture to isolate
1485-399: A disease. This amplification of nucleic acid in infected tissue offers an opportunity to detect the infectious agent by using PCR. Third, the essential tools for directing PCR, primers , are derived from the genomes of infectious agents, and with time those genomes will be known if they are not already. Thus, the technological ability to detect any infectious agent rapidly and specifically
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#17327651693191620-423: A hospital stay. Lastly, a community-acquired infection is one in which the infection is acquired from a whole community. One manner of proving that a given disease is infectious, is to satisfy Koch's postulates (first proposed by Robert Koch ), which require that first, the infectious agent be identifiable only in patients who have the disease, and not in healthy controls, and second, that patients who contract
1755-531: A host with depressed resistance ( immunodeficiency ) or if they have unusual access to the inside of the body (for example, via trauma ). Opportunistic infection may be caused by microbes ordinarily in contact with the host, such as pathogenic bacteria or fungi in the gastrointestinal or the upper respiratory tract , and they may also result from (otherwise innocuous) microbes acquired from other hosts (as in Clostridioides difficile colitis ) or from
1890-502: A host. As bacterial and viral infections can both cause the same kinds of symptoms, it can be difficult to distinguish which is the cause of a specific infection. Distinguishing the two is important, since viral infections cannot be cured by antibiotics whereas bacterial infections can. There is a general chain of events that applies to infections, sometimes called the chain of infection or transmission chain . The chain of events involves several steps – which include
2025-434: A link between virulence and transmissibility. Diagnosis of infectious disease sometimes involves identifying an infectious agent either directly or indirectly. In practice most minor infectious diseases such as warts , cutaneous abscesses , respiratory system infections and diarrheal diseases are diagnosed by their clinical presentation and treated without knowledge of the specific causative agent. Conclusions about
2160-570: A majority of French people had other first languages (local languages such as Occitan , Catalan , Alsatian , West Flemish , Lorraine Franconian , Gallo , Picard or Ch'timi and Arpitan ). Today, many immigrants speak another tongue at home. According to historian Eric Hobsbawm , "the French language has been essential to the concept of 'France'," although in 1789, 50 percent of the French people did not speak it at all, and only 12 to 13 percent spoke it fairly well; even in oïl languages zones, it
2295-518: A number of basic dyes due to the electrostatic attraction between negatively charged cellular molecules and the positive charge on the dye. A cell is normally transparent under a microscope, and using a stain increases the contrast of a cell with its background. Staining a cell with a dye such as Giemsa stain or crystal violet allows a microscopist to describe its size, shape, internal and external components and its associations with other cells. The response of bacteria to different staining procedures
2430-404: A particular pathogen at all (no matter how little) but also is often used in a sense implying a clinically apparent infection (in other words, a case of infectious disease). This fact occasionally creates some ambiguity or prompts some usage discussion; to get around this it is common for health professionals to speak of colonization (rather than infection ) when they mean that some of
2565-493: A pathogen from the appropriate clinical specimen. In a microbial culture, a growth medium is provided for a specific agent. A sample taken from potentially diseased tissue or fluid is then tested for the presence of an infectious agent able to grow within that medium. Many pathogenic bacteria are easily grown on nutrient agar , a form of solid medium that supplies carbohydrates and proteins necessary for growth, along with copious amounts of water. A single bacterium will grow into
2700-429: A pathogen. A fluorescence microscope is then used to detect fluorescently labeled antibodies bound to internalized antigens within clinical samples or cultured cells. This technique is especially useful in the diagnosis of viral diseases, where the light microscope is incapable of identifying a virus directly. Other microscopic procedures may also aid in identifying infectious agents. Almost all cells readily stain with
2835-432: A patient's blood or other body fluids for antigens or antibodies that indicate presence of a specific pathogen that the doctor suspects. Other techniques (such as X-rays , CAT scans , PET scans or NMR ) are used to produce images of internal abnormalities resulting from the growth of an infectious agent. The images are useful in detection of, for example, a bone abscess or a spongiform encephalopathy produced by
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#17327651693192970-470: A persistent infection by infecting different cells of the body. Some viruses once acquired never leave the body. A typical example is the herpes virus, which tends to hide in nerves and become reactivated when specific circumstances arise. Persistent infections cause millions of deaths globally each year. Chronic infections by parasites account for a high morbidity and mortality in many underdeveloped countries. For infecting organisms to survive and repeat
3105-403: A result of an infectious disease with immunosuppressive activity (such as with measles , malaria or HIV disease ). Primary pathogens may also cause more severe disease in a host with depressed resistance than would normally occur in an immunosufficient host. While a primary infection can practically be viewed as the root cause of an individual's current health problem, a secondary infection
3240-471: A result of their presence or activity within the normal, healthy host, and their intrinsic virulence (the severity of the disease they cause) is, in part, a necessary consequence of their need to reproduce and spread. Many of the most common primary pathogens of humans only infect humans, however, many serious diseases are caused by organisms acquired from the environment or that infect non-human hosts. Opportunistic pathogens can cause an infectious disease in
3375-411: A severe illness affecting the brain, remain undiagnosed, despite extensive testing using the standard of care ( microbiological culture ) and state-of-the-art clinical laboratory methods. Metagenomic sequencing-based diagnostic tests are currently being developed for clinical use and show promise as a sensitive, specific, and rapid way to diagnose infection using a single all-encompassing test. This test
3510-417: A specific identification of an infectious agent only when such identification can aid in the treatment or prevention of the disease, or to advance knowledge of the course of an illness prior to the development of effective therapeutic or preventative measures. For example, in the early 1980s, prior to the appearance of AZT for the treatment of AIDS , the course of the disease was closely followed by monitoring
3645-432: A visible mound on the surface of the plate called a colony , which may be separated from other colonies or melded together into a "lawn". The size, color, shape and form of a colony is characteristic of the bacterial species, its specific genetic makeup (its strain ), and the environment that supports its growth. Other ingredients are often added to the plate to aid in identification. Plates may contain substances that permit
3780-509: Is a sequela or complication of that root cause. For example, an infection due to a burn or penetrating trauma (the root cause) is a secondary infection. Primary pathogens often cause primary infection and often cause secondary infection. Usually, opportunistic infections are viewed as secondary infections (because immunodeficiency or injury was the predisposing factor). Other types of infection consist of mixed, iatrogenic , nosocomial , and community-acquired infection. A mixed infection
3915-507: Is active but does not produce noticeable symptoms may be called inapparent, silent, subclinical , or occult . An infection that is inactive or dormant is called a latent infection . An example of a latent bacterial infection is latent tuberculosis . Some viral infections can also be latent, examples of latent viral infections are any of those from the Herpesviridae family. The word infection can denote any presence of
4050-486: Is also widely spoken, arguably the largest minority language in France as of the 21st century (a spot previously held by Breton and Occitan ). Modern French society is a melting pot . From the middle of the 19th century, it experienced a high rate of inward migration , mainly consisting of Spaniards , Portuguese , Italians , Arab-Berbers , Jews , Sub-Saharan Africans , Chinese , and other peoples from Africa ,
4185-423: Is an infection that is caused by two or more pathogens. An example of this is appendicitis , which is caused by Bacteroides fragilis and Escherichia coli . The second is an iatrogenic infection. This type of infection is one that is transmitted from a health care worker to a patient. A nosocomial infection is also one that occurs in a health care setting. Nosocomial infections are those that are acquired during
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4320-422: Is an initial site of infection from which organisms travel via the bloodstream to another area of the body. Among the many varieties of microorganisms , relatively few cause disease in otherwise healthy individuals. Infectious disease results from the interplay between those few pathogens and the defenses of the hosts they infect. The appearance and severity of disease resulting from any pathogen depend upon
4455-510: Is currently available. The only remaining blockades to the use of PCR as a standard tool of diagnosis are in its cost and application, neither of which is insurmountable. The diagnosis of a few diseases will not benefit from the development of PCR methods, such as some of the clostridial diseases ( tetanus and botulism ). These diseases are fundamentally biological poisonings by relatively small numbers of infectious bacteria that produce extremely potent neurotoxins . A significant proliferation of
4590-623: Is estimated that 20,000 settlers were living in Saigon in 1945, and there were 68,430 European settlers living in Madagascar in 1958. 1.6 million European pieds noirs settlers migrated from Algeria , Tunisia and Morocco . In just a few months in 1962, 900,000 pied noir settlers left Algeria in the most massive relocation of population in Europe since the World War II . In
4725-399: Is happening as part of a background evolution and recent studies confirmed the results of their assimilation, showing that "North Africans seem to be characterized by a high degree of cultural integration reflected in a relatively high propensity to exogamy " with rates ranging from 20% to 50%. According to Emmanuel Todd the relatively high exogamy among French Algerians can be explained by
4860-503: Is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon , and an example of the latter are the various species of staphylococcus that exist on human skin . Neither of these colonizations are considered infections. The difference between an infection and
4995-498: Is my home". Indeed, the country has long valued its openness , tolerance and the quality of services available. Application for French citizenship is often interpreted as a renunciation of previous state allegiance unless a dual citizenship agreement exists between the two countries (for instance, this is the case with Switzerland : one can be both French and Swiss). The European treaties have formally permitted movement and European citizens enjoy formal rights to employment in
5130-467: Is not an enzyme and has no metabolic function. Serological methods are highly sensitive, specific and often extremely rapid tests used to identify microorganisms. These tests are based upon the ability of an antibody to bind specifically to an antigen. The antigen, usually a protein or carbohydrate made by an infectious agent, is bound by the antibody. This binding then sets off a chain of events that can be visibly obvious in various ways, dependent upon
5265-406: Is possible that the La Tama had spent time in missions and become somewhat Christianized. They may have sought out the similarly missionized Guale. In 1702, when Carolina Governor James Moore led an invasion into Spanish Florida , his men destroyed the few "refugee missions" in Guale. By 1733, the Guale were so few in number that they showed no resistance to James Oglethorpe 's establishment of
5400-425: Is referred to as infectious diseases . Infections are caused by infectious agents ( pathogens ) including: The signs and symptoms of an infection depend on the type of disease. Some signs of infection affect the whole body generally, such as fatigue , loss of appetite, weight loss, fevers , night sweats, chills, aches and pains. Others are specific to individual body parts, such as skin rashes , coughing , or
5535-404: Is referred to as colonization. Most humans are not easily infected. Those with compromised or weakened immune systems have an increased susceptibility to chronic or persistent infections. Individuals who have a suppressed immune system are particularly susceptible to opportunistic infections . Entrance to the host at host–pathogen interface , generally occurs through the mucosa in orifices like
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5670-501: Is similar to current PCR tests; however, an untargeted whole genome amplification is used rather than primers for a specific infectious agent. This amplification step is followed by next-generation sequencing or third-generation sequencing , alignment comparisons , and taxonomic classification using large databases of thousands of pathogen and commensal reference genomes . Simultaneously, antimicrobial resistance genes within pathogen and plasmid genomes are sequenced and aligned to
5805-602: Is such a thing as a "French ethnic group". The discourse of ethno-nationalist groups such as the Front National (FN), however, advances the concept of Français de souche or "indigenous" French. The conventional conception of French history starts with Ancient Gaul, and French national identity often views the Gauls as national precursors, either as biological ancestors (hence the refrain nos ancêtres les Gaulois ), as emotional/spiritual ancestors, or both. Vercingetorix ,
5940-439: Is that microbial colonization is very common even in environments that humans think of as being nearly sterile . Because it is normal to have bacterial colonization, it is difficult to know which chronic wounds can be classified as infected and how much risk of progression exists. Despite the huge number of wounds seen in clinical practice, there are limited quality data for evaluated symptoms and signs. A review of chronic wounds in
6075-509: Is thought to have survived into the 6th century in France, despite considerable Romanization of the local material culture. Coexisting with Latin, Gaulish helped shape the Vulgar Latin dialects that developed into French, with effects including loanwords and calques (including oui , the word for "yes"), sound changes, and influences in conjugation and word order. Today, the last redoubt of Celtic language in France can be found in
6210-588: Is used in the taxonomic classification of microbes as well. Two methods, the Gram stain and the acid-fast stain, are the standard approaches used to classify bacteria and to diagnosis of disease. The Gram stain identifies the bacterial groups Bacillota and Actinomycetota , both of which contain many significant human pathogens. The acid-fast staining procedure identifies the Actinomycetota genera Mycobacterium and Nocardia . Biochemical tests used in
6345-533: The Altamaha River and south of the Savannah River . It included Ossabaw , St. Catherine's , Sapelo , Tybee , and Wassaw islands, among others. By the mid-17th century, the Spanish had established six Catholic missions in Guale territory, including Nuestra Señora de Guadalupe de Tolomato and Santa Catalina de Guale . Their largest settlements were probably on St. Catherine's Island. Guale
6480-638: The Americas , with the exception of the Huguenots , due to a lower birthrate than in the rest of Europe. However, significant emigration of mainly Roman Catholic French populations led to the settlement of the Province of Acadia , Canada (New France) and Louisiana , all (at the time) French possessions, as well as colonies in the West Indies , Mascarene islands and Africa . On 30 December 1687,
6615-525: The Danelaw in the region known today as Normandy in the 9th and 10th centuries. This later became a fiefdom of the Kingdom of France under King Charles III . The Vikings eventually intermarried with the local people, converting to Christianity in the process. The Normans, two centuries later, went on to conquer England and Southern Italy . Eventually, though, the largely autonomous Duchy of Normandy
6750-1169: The Franks , the Visigoths , the Suebi and the Burgundians who settled in Gaul from east of the Rhine after the fall of the Roman Empire , as well as various later waves of lower-level irregular migration that have continued to the present day. The Norsemen also settled in Normandy in the 10th century and contributed significantly to the ancestry of the Normans . Furthermore, regional ethnic minorities also exist within France that have distinct lineages, languages and cultures such as Bretons in Brittany , Occitans in Occitania , Basques in
6885-865: The French Basque Country , Catalans in northern Catalonia , Germans in Alsace , Corsicans in Corsica and Flemings in French Flanders . France has long been a patchwork of local customs and regional differences, and while most French people still speak the French language as their mother tongue , languages like Picard , Poitevin-Saintongeais , Franco-Provencal , Occitan , Catalan , Auvergnat , Corsican , Basque , French Flemish , Lorraine Franconian , Alsatian , Norman , and Breton remain spoken in their respective regions. Arabic
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#17327651693197020-568: The French Constitution , according to which "French" is a nationality , and not a specific ethnicity. France sits at the edge of the European peninsula and has seen waves of migration of groups that often settled owing to the presence of physical barriers preventing onward migration. This has led to language and regional cultural variegation, but the extent to which this pattern of migrations showed up in population genetics studies
7155-548: The French West Indies ( French Caribbean ), and in foreign countries with significant French-speaking population groups or not, such as the United States ( French Americans ), Canada ( French Canadians ), Argentina ( French Argentines ), Brazil ( French Brazilians ), Mexico ( French Mexicans ), Chile ( French Chileans ) and Uruguay ( French Uruguayans ). To be French, according to
7290-475: The Industrial Revolution . The pace of industrial growth attracted millions of European immigrants over the next century, with especially large numbers arriving from Poland , Belgium , Portugal , Italy , and Spain . In the period from 1915 to 1950, many immigrants came from Czechoslovakia , Hungary , Russia , Scandinavia and Yugoslavia . Small but significant numbers of Frenchmen in
7425-605: The Journal of the American Medical Association 's "Rational Clinical Examination Series" quantified the importance of increased pain as an indicator of infection. The review showed that the most useful finding is an increase in the level of pain [likelihood ratio (LR) range, 11–20] makes infection much more likely, but the absence of pain (negative likelihood ratio range, 0.64–0.88) does not rule out infection (summary LR 0.64–0.88). Disease can arise if
7560-691: The Middle East and East Asia , and the government, defining France as an inclusive nation with universal values, advocated assimilation through which immigrants were expected to adhere to French values and cultural norms. Nowadays, while the government has let newcomers retain their distinctive cultures since the mid-1980s and requires from them a mere integration , French citizens still equate their nationality with citizenship as does French law. In addition to mainland France, French people and people of French descent can be found internationally, in overseas departments and territories of France such as
7695-574: The Province of Georgia . A similar missionary province called Mocama (named for a Timucuan chiefdom) was situated just south of Guale, on the coast between the Altamaha River and St. Johns River in Florida. Infectious diseases An infection is the invasion of tissues by pathogens , their multiplication, and the reaction of host tissues to the infectious agent and
7830-677: The Saint-Domingue . In 1805, when the French were forced out of Saint-Domingue ( Haiti ), 35,000 French settlers were given lands in Cuba . By the beginning of the 17th century, some 20% of the total male population of Catalonia was made up of French immigrants. In the 18th century and early 19th century, a small migration of French emigrated by official invitation of the Habsburgs to the Austro-Hungarian Empire , now
7965-741: The Savannah River . That year, a Scottish colony called Stuarts Town was founded in South Carolina on Port Royal Sound near the Savannah River. Stuarts Town survived only about two years, but during that time the Scots residents formed a strong bond with the Yamasee-Guale. In late 1684, armed with Scots firearms, these Indians raided Timucua Province , devastating the mission Santa Catalina de Afuyca . They returned to Stuarts Town with 22 captives, whom they sold as slaves . Over
8100-543: The United States Census , French people are not asked to define their ethnic appartenance, whichever it may be. The usage of ethnic and racial categorization is avoided to prevent any case of discrimination; the same regulations apply to religious membership data that cannot be compiled under the French Census. This classic French republican non- essentialist conception of nationality is officialized by
8235-474: The Westo tribe, supported by English colonists in the colonies of Carolina and Virginia , destroyed all Spanish missions in Georgia . Attacks by English-supported pirates also contributed to the breakup of the missions. In 1680 a group of pirates sacked Mission Santa Catalina de Guale . By 1684 the Spanish and Indians had abandoned all six missions. The La Tama Yamasee, Guale, and other refugees scattered in
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#17327651693198370-468: The oral cavity , nose, eyes, genitalia, anus, or the microbe can enter through open wounds. While a few organisms can grow at the initial site of entry, many migrate and cause systemic infection in different organs. Some pathogens grow within the host cells (intracellular) whereas others grow freely in bodily fluids. Wound colonization refers to non-replicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue
8505-447: The polymerase chain reaction (PCR) method will become nearly ubiquitous gold standards of diagnostics of the near future, for several reasons. First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the human population have been identified. Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids to cause
8640-496: The second moments of area on humerus and femur bones. This is an engineering approach used to show the strength of the bone. They found that there was an increased strength of the bones due to higher repetitive usage, supporting the original statement. Indians throughout the American southeast were drawn to the Spanish mission provinces for their trade in European manufactured goods. Various non-Guale Indians settled in or near
8775-740: The toxins they produce. An infectious disease , also known as a transmissible disease or communicable disease , is an illness resulting from an infection. Infections can be caused by a wide range of pathogens , most prominently bacteria and viruses . Hosts can fight infections using their immune systems . Mammalian hosts react to infections with an innate response, often involving inflammation , followed by an adaptive response. Specific medications used to treat infections include antibiotics , antivirals , antifungals , antiprotozoals , and antihelminthics . Infectious diseases resulted in 9.2 million deaths in 2013 (about 17% of all deaths). The branch of medicine that focuses on infections
8910-403: The "strep test", they can be inexpensive. Complex serological techniques have been developed into what are known as immunoassays . Immunoassays can use the basic antibody – antigen binding as the basis to produce an electro-magnetic or particle radiation signal, which can be detected by some form of instrumentation. Signal of unknowns can be compared to that of standards allowing quantitation of
9045-401: The 1789 French Revolution . It replaced the ancient kingdom of France, ruled by the divine right of kings . The 1870 Franco-Prussian War , which led to the short-lived Paris Commune of 1871, was instrumental in bolstering patriotic feelings; until World War I (1914–1918), French politicians never completely lost sight of the disputed Alsace-Lorraine region which played a major role in
9180-590: The 1970s, over 30,000 French settlers left Cambodia during the Khmer Rouge regime as the Pol Pot government confiscated their farms and land properties. In the 1960s, a second wave of immigration came to France, which was needed for reconstruction purposes and for cheaper labour after the devastation brought on by World War II . French entrepreneurs went to Maghreb countries looking for cheap labour, thus encouraging work-immigration to France. Their settlement
9315-641: The 7th century BCE or earlier, and non-Celtic peoples including the Ligures , Aquitanians and Basques in Aquitaine. The Belgae , who lived in the northern and eastern areas, may have had Germanic admixture; many of these peoples had already spoken Gaulish by the time of the Roman conquest. Gaul was militarily conquered in 58–51 BCE by the Roman legions under the command of General Julius Caesar , except for
9450-598: The Franks, led by the Merovingian king Clovis I and his sons, had consolidated their hold on much of modern-day France. The other major Germanic people to arrive in France, after the Burgundians and the Visigoths , were the Norsemen or Northmen . Known by the shortened name " Norman " in France, these were Viking raiders from modern Denmark and Norway . They settled with Anglo-Scandinavians and Anglo-Saxons from
9585-540: The French Revolution, it divided social classes, with the peasants identifying with the native Gauls while the aristocracy identified with the Franks. During the early nineteenth century, intellectuals began using the identification with Gaul instead as a unifying force to bridge divisions within French society with a common national origin myth . Myriam Krepps of the University of Nebraska-Omaha argues that
9720-555: The Gaulish chieftain who tried to unite the various Gallic tribes of the land against Roman encroachment but was ultimately vanquished by Julius Caesar , is often revered as a "first national hero". In the famously popular French comic Asterix , the main characters are patriotic Gauls who fight against Roman invaders while in modern days the term Gaulois is used in French to distinguish the "native" French from French of immigrant origins. However, despite its occasional nativist usage,
9855-403: The Gaulish identity has also been embraced by French of non-native origins as well: notably, Napoleon III , whose family was ultimately of Corsican and Italian roots, identified France with Gaul and Vercingetorix, and declared that "New France, ancient France, Gaul are one and the same moral person." It has been noted that the French view of having Gallic origins has evolved over history. Before
9990-474: The Guale missions during the 17th century. Most were from an Indian province of north-central Georgia called La Tama by the Spanish. In the 1660s the well-armed Westo attacked La Tama and neighboring regions, dispersing the La Tama in several directions. Some migrated to the lower Chattahoochee River towns of Coweta and Cussita , the Apalachee mission provinces, and the Guale province. The La Tama spoke
10125-612: The Guale. They soon tried to bring them into their mission system . The Guale territory became one of the four primary mission provinces of Spanish Florida ; the Timucua , Mocama , and Apalachee Provinces , also named after the resident tribes of the territories, were the others. The boundaries of the Spanish Guale Province corresponded to the people's territory along the Atlantic coast and Sea Islands , north of
10260-953: The North and Northeast regions have relatives in Germany and Great Britain . Between 1956 and 1967, about 235,000 North African Jews from Algeria, Tunisia, and Morocco also immigrated to France due to the decline of the French empire and following the Six-Day War. Hence, by 1968, Jews of North African origin comprised the majority of the Jewish population of France. As these new immigrants were already culturally French they needed little time to adjust to French society. French law made it easy for thousands of settlers ( colons in French), national French from former colonies of North and East Africa , India and Indochina to live in mainland France. It
10395-478: The Roman army and obtained important commands. Their language is still spoken as a kind of Dutch ( French Flemish ) in northern France ( French Flanders ). The Alamans , another Germanic people immigrated to Alsace , hence the Alemannic German now spoken there. The Alamans were competitors of the Franks, and their name is the origin of the French word for "German": Allemand . By the early 6th century,
10530-626: The US and the UK) but as social conflicts born out of socioeconomic problems endangering proper integration. Historically, the heritage of the French people is mostly of Celtic or Gallic , Latin ( Romans ) origin, descending from the ancient and medieval populations of Gauls or Celts from the Atlantic to the Rhone Alps , Germanic tribes that settled France from east of the Rhine and Belgium after
10665-435: The ability of that pathogen to damage the host as well as the ability of the host to resist the pathogen. However, a host's immune system can also cause damage to the host itself in an attempt to control the infection. Clinicians, therefore, classify infectious microorganisms or microbes according to the status of host defenses – either as primary pathogens or as opportunistic pathogens . Primary pathogens cause disease as
10800-537: The alliance between the Yamasee and colonial South Carolina grew stronger in reaction. The "Yamasee" who migrated in 1685 to the Port Royal area were rebuilding the old La Tama chiefdom, but they also included numerous Guale, as well as other Indians of mostly Muskogean stock. The Yamasee lived in South Carolina until they were defeated in the Yamasee War of 1715, after which survivors were widely dispersed and
10935-458: The basis of a biochemical diagnosis of an infectious disease. For example, humans can make neither RNA replicases nor reverse transcriptase , and the presence of these enzymes are characteristic., of specific types of viral infections. The ability of the viral protein hemagglutinin to bind red blood cells together into a detectable matrix may also be characterized as a biochemical test for viral infection, although strictly speaking hemagglutinin
11070-463: The case of viral identification, a region of dead cells results from viral growth, and is called a "plaque". Eukaryotic parasites may also be grown in culture as a means of identifying a particular agent. In the absence of suitable plate culture techniques, some microbes require culture within live animals. Bacteria such as Mycobacterium leprae and Treponema pallidum can be grown in animals, although serological and microscopic techniques make
11205-476: The causative agent, Trypanosoma cruzi in a patient, which therefore makes it difficult to definitively make a diagnosis. In this case, xenodiagnosis involves the use of the vector of the Chagas agent T. cruzi , an uninfected triatomine bug, which takes a blood meal from a person suspected of having been infected. The bug is later inspected for growth of T. cruzi within its gut. Another principal tool in
11340-436: The cause of the disease are based upon the likelihood that a patient came in contact with a particular agent, the presence of a microbe in a community, and other epidemiological considerations. Given sufficient effort, all known infectious agents can be specifically identified. Diagnosis of infectious disease is nearly always initiated by medical history and physical examination. More detailed identification techniques involve
11475-447: The centuries to France, creating a variegated grouping of peoples. Thus the historian John F. Drinkwater states, "The French are, paradoxically, strongly conscious of belonging to a single nation, but they hardly constitute a unified ethnic group by any scientific gauge." The modern French are the descendants of mixtures including Romans , Celts , Iberians , Ligurians and Greeks in southern France, Germanic peoples arriving at
11610-529: The colonial link between France and Algeria. A small French descent group also subsequently arrived from Latin America ( Argentina , Chile and Uruguay ) in the 1970s. Most French people speak the French language as their mother tongue , but certain languages like Norman , Occitan languages , Corsican , Euskara , French Flemish and Breton remain spoken in certain regions (see Language policy in France ). There have also been periods of history when
11745-431: The composition of patient blood samples, even though the outcome would not offer the patient any further treatment options. In part, these studies on the appearance of HIV in specific communities permitted the advancement of hypotheses as to the route of transmission of the virus. By understanding how the disease was transmitted, resources could be targeted to the communities at greatest risk in campaigns aimed at reducing
11880-484: The culture of infectious agents isolated from a patient. Culture allows identification of infectious organisms by examining their microscopic features, by detecting the presence of substances produced by pathogens, and by directly identifying an organism by its genotype. Many infectious organisms are identified without culture and microscopy. This is especially true for viruses, which cannot grow in culture. For some suspected pathogens, doctors may conduct tests that examine
12015-600: The decline of the Roman Empire in Western Europe, a federation of Germanic peoples entered the picture: the Franks , from which the word "French" derives. The Franks were Germanic pagans who began to settle in northern Gaul as laeti during the Roman era. They continued to filter across the Rhine River from present-day Netherlands and Germany between the 3rd and 7th centuries. Initially, they served in
12150-425: The definition of the French nation and therefore of the French people. The decrees of 24 October 1870 by Adolphe Crémieux granted automatic and massive French citizenship to all Jewish people of Algeria. Successive waves of immigrants during the 19th and 20th centuries were rapidly assimilated into French culture . France's population dynamics began to change in the middle of the 19th century, as France joined
12285-400: The destruction of the virus. Instrumentation can be used to read extremely small signals created by secondary reactions linked to the antibody – antigen binding. Instrumentation can control sampling, reagent use, reaction times, signal detection, calculation of results, and data management to yield a cost-effective automated process for diagnosis of infectious disease. Technologies based upon
12420-428: The diagnosis of infectious disease is microscopy . Virtually all of the culture techniques discussed above rely, at some point, on microscopic examination for definitive identification of the infectious agent. Microscopy may be carried out with simple instruments, such as the compound light microscope , or with instruments as complex as an electron microscope . Samples obtained from patients may be viewed directly under
12555-416: The end of the Roman Empire such as the Franks and the Burgundians , and some Vikings who mixed with the Normans and settled mostly in Normandy in the 9th century. According to Dominique Schnapper , "The classical conception of the nation is that of an entity which, opposed to the ethnic group, affirms itself as an open community, the will to live together expressing itself by the acceptation of
12690-445: The environment as a result of traumatic introduction (as in surgical wound infections or compound fractures ). An opportunistic disease requires impairment of host defenses, which may occur as a result of genetic defects (such as chronic granulomatous disease ), exposure to antimicrobial drugs or immunosuppressive chemicals (as might occur following poisoning or cancer chemotherapy ), exposure to ionizing radiation , or as
12825-426: The expression of symptoms is often atypical, making a clinical diagnosis based on presentation more difficult. Thirdly, diagnostic methods that rely on the detection of antibodies are more likely to fail. A rapid, sensitive, specific, and untargeted test for all known human pathogens that detects the presence of the organism's DNA rather than antibodies is therefore highly desirable. There is usually an indication for
12960-473: The fall of the Roman Empire such as the Franks , Burgundians , Allemanni , Visigoths , and Suebi , Latin and Roman tribes such as Ligurians and Gallo-Romans , Basques , and Norse populations largely settling in Normandy at the beginning of the 10th century as well as " Bretons " (Celtic Britons) settling in Brittany in Western France . The name "France" etymologically derives from
13095-560: The first article of the French Constitution , is to be a citizen of France, regardless of one's origin, race, or religion ( sans distinction d'origine, de race ou de religion ). According to its principles, France has devoted itself to the destiny of a proposition nation , a generic territory where people are bounded only by the French language and the assumed willingness to live together, as defined by Ernest Renan 's " plébiscite de tous les jours " ('everyday plebiscite') on
13230-403: The growth of some bacteria and not others, or that change color in response to certain bacteria and not others. Bacteriological plates such as these are commonly used in the clinical identification of infectious bacterium. Microbial culture may also be used in the identification of viruses : the medium, in this case, being cells grown in culture that the virus can infect, and then alter or kill. In
13365-484: The host's protective immune mechanisms are compromised and the organism inflicts damage on the host. Microorganisms can cause tissue damage by releasing a variety of toxins or destructive enzymes. For example, Clostridium tetani releases a toxin that paralyzes muscles, and staphylococcus releases toxins that produce shock and sepsis . Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop disease. On
13500-598: The host, preventing infection and speeding wound healing . The variables involved in the outcome of a host becoming inoculated by a pathogen and the ultimate outcome include: As an example, several staphylococcal species remain harmless on the skin, but, when present in a normally sterile space, such as in the capsule of a joint or the peritoneum , multiply without resistance and cause harm. An interesting fact that gas chromatography–mass spectrometry , 16S ribosomal RNA analysis, omics , and other advanced technologies have made more apparent to humans in recent decades
13635-532: The identification of infectious agents include the detection of metabolic or enzymatic products characteristic of a particular infectious agent. Since bacteria ferment carbohydrates in patterns characteristic of their genus and species , the detection of fermentation products is commonly used in bacterial identification. Acids , alcohols and gases are usually detected in these tests when bacteria are grown in selective liquid or solid media. The isolation of enzymes from infected tissue can also provide
13770-413: The infection cycle in other hosts, they (or their progeny) must leave an existing reservoir and cause infection elsewhere. Infection transmission can take place via many potential routes: The relationship between virulence versus transmissibility is complex; with studies have shown that there were no clear relationship between the two. There is still a small number of evidence that partially suggests
13905-438: The infectious agent also develop the disease. These postulates were first used in the discovery that Mycobacteria species cause tuberculosis . French people France: 67,413,000 French diaspora and ancestry : c. 30 million Asia Middle East Europe North America South America Oceania The French people ( French : Les Français , lit. 'The French') are
14040-399: The infectious agent does not occur, this limits the ability of PCR to detect the presence of any bacteria. Given the wide range of bacterial, viral, fungal, protozoal, and helminthic pathogens that cause debilitating and life-threatening illnesses, the ability to quickly identify the cause of infection is important yet often challenging. For example, more than half of cases of encephalitis ,
14175-402: The infectious agent, reservoir, entering a susceptible host, exit and transmission to new hosts. Each of the links must be present in a chronological order for an infection to develop. Understanding these steps helps health care workers target the infection and prevent it from occurring in the first place. Infection begins when an organism successfully enters the body, grows and multiplies. This
14310-509: The island of Saint-Martin hold French nationality even though they do not speak French as a first language, while their neighbouring French-speaking Haitian immigrants (who also speak a French-creole) remain foreigners. Large numbers of people of French ancestry outside Europe speak other first languages, particularly English, throughout most of North America (with Quebec and Acadians in the Canadian Maritimes being notable, not
14445-537: The levels of C4 molecules in the natives' bones to determine the corn intake levels. By comparison, their intake of other foods such as fish, animals, other plants, etc. decreased. These changes were not for the better, as a corn-dominated diet is poor for overall health. The Guale Indians were forced to work under the Europeans in ways they never had had to before. It was labor-intensive. Spencer Larsen and Christopher Ruff concluded this based on their analysis of
14580-425: The light microscope, and can often rapidly lead to identification. Microscopy is often also used in conjunction with biochemical staining techniques, and can be made exquisitely specific when used in combination with antibody based techniques. For example, the use of antibodies made artificially fluorescent (fluorescently labeled antibodies) can be directed to bind to and identify a specific antigens present on
14715-709: The mounds for ceremonial, religious and burial purposes. French explorers under Jean Ribault contacted the Guale, whom they called the Oade after their chief, during their voyage to the Atlantic coast of North America in 1562. The Guale maintained good relations with the ephemeral French settlement known as Charlesfort on Parris Island in what is now South Carolina . When the Spanish later established themselves in St. Augustine in Spanish Florida , they also contacted
14850-656: The nations of Austria , Czech Republic , Hungary , Slovakia , Serbia and Romania . Some of them, coming from French-speaking communes in Lorraine or being French Swiss Walsers from the Valais canton in Switzerland , maintained for some generations the French language and a specific ethnic identity, later labelled as Banat (French: Français du Banat ). By 1788, there were eight villages populated by French colonists. The French First Republic appeared following
14985-599: The next two years, word of similar successes of the Stuarts Town-allied Yamasee-Guale carried throughout the region. The population of "Yamasee" Indians near Port Royal Sound grew rapidly. Although the Indians became known collectively as "Yamasee", the Guale continued to be a significant portion of the population. Spanish forces destroyed Stuarts Town. In the old Guale Province, they strongly resisted counterattacks by South Carolina. Nonetheless,
15120-476: The northwestern region of Brittany , although this is not the result of a survival of Gaulish language but of a 5th-century AD migration of Brythonic speaking Celts from Britain . The Vulgar Latin in the region of Gallia took on a distinctly local character, some of which is attested in graffiti, which evolved into the Gallo-Romance dialects which include French and its closest relatives. With
15255-531: The number of new infections. The specific serological diagnostic identification, and later genotypic or molecular identification, of HIV also enabled the development of hypotheses as to the temporal and geographical origins of the virus, as well as a myriad of other hypothesis. The development of molecular diagnostic tools have enabled physicians and researchers to monitor the efficacy of treatment with anti-retroviral drugs . Molecular diagnostics are now commonly used to identify HIV in healthy people long before
15390-467: The only, exceptions), Spanish or Portuguese in southern South America , and Afrikaans in South Africa . The adjective "French" can be used to mean either "French citizen" or "French-speaker", and usage varies depending on the context, with the former being common in France. The latter meaning is often used in Canada, when discussing matters internal to Canada. Generations of settlers have migrated over
15525-455: The onset of illness and have been used to demonstrate the existence of people who are genetically resistant to HIV infection. Thus, while there still is no cure for AIDS, there is great therapeutic and predictive benefit to identifying the virus and monitoring the virus levels within the blood of infected individuals, both for the patient and for the community at large. Symptomatic infections are apparent and clinical , whereas an infection that
15660-514: The other hand, some infectious agents are highly virulent. The prion causing mad cow disease and Creutzfeldt–Jakob disease invariably kills all animals and people that are infected. Persistent infections occur because the body is unable to clear the organism after the initial infection. Persistent infections are characterized by the continual presence of the infectious organism, often as latent infection with occasional recurrent relapses of active infection. There are some viruses that can maintain
15795-539: The pathogens are present but that no clinically apparent infection (no disease) is present. Different terms are used to describe how and where infections present over time. In an acute infection, symptoms develop rapidly; its course can either be rapid or protracted. In chronic infection, symptoms usually develop gradually over weeks or months and are slow to resolve. In subacute infections, symptoms take longer to develop than in acute infections but arise more quickly than those of chronic infections. A focal infection
15930-745: The people disintegrated as a polity. But while they lasted, the Yamasee exhibited multi-ethnic qualities. Their towns were described by European colonists as being Upper Yamasee or Lower Yamasee towns. The Lower Towns were populated mainly by La Tama Indians and included Altamaha (after the chief who lived there), Ocute, and Chechesee (Ichisi). The Guale were the majority in the Upper Towns, although other ethnicities were incorporated as well. Upper Yamasee Towns with mostly Guale populations likely included Pocotaligo, Pocosabo, and Huspah. Other Upper Towns, such as Tulafina, Sadketche (Salkehatchie), and Tomatley, were probably mixed, with Guale, La Tama, and others. It
16065-436: The prehistoric ancestors to the Guale shared many characteristics with regional neighbors, they left unique archaeological features that distinguished the "proto-Guale" people from other groups. The prehistoric people were organized into chiefdoms . They built Mississippian -type platform mounds , major earthworks requiring the organized labor of many people, and using highly skilled soil and engineering knowledge. They used
16200-421: The rules of a unified public domain which transcends all particularisms". This conception of the nation as being composed by a "will to live together," supported by the classic lecture of Ernest Renan in 1882, has been opposed by the French far-right , in particular the nationalist Front National ("National Front" – FN / now Rassemblement National - "National Rally" - RN) party which claims that there
16335-515: The south-east which had already been conquered about one century earlier. Over the next six centuries, the two cultures intermingled, creating a hybridized Gallo-Roman culture . In the late Roman era, in addition to colonists from elsewhere in the Empire and Gaulish natives, Gallia also became home to some immigrant populations of Germanic and Scythian origin, such as the Alans . The Gaulish language
16470-524: The southeast. Some relocated to new missions in Spanish Florida, but most rejected Spanish authority. They felt Spain had been unable to protect them and resented their failure to provide firearms. The Indians of Guale Province moved mostly to the Apalachee or Apalachicola regions. Around or before 1684, one small group of Yamasee-Guale refugees, led by Chief Altamaha, moved north to the mouth of
16605-639: The state sector (though not as trainees in reserved branches, e.g., as magistrates ). Seeing itself as an inclusive nation with universal values, France has always valued and strongly advocated assimilation . However, the success of such assimilation has recently been called into question. There is increasing dissatisfaction with, and within, growing ethno-cultural enclaves ( communautarisme ). The 2005 French riots in some troubled and impoverished suburbs ( les quartiers sensibles ) were an example of such tensions. However they should not be interpreted as ethnic conflicts (as appeared before in other countries like
16740-457: The target antigen. To aid in the diagnosis of infectious diseases, immunoassays can detect or measure antigens from either infectious agents or proteins generated by an infected organism in response to a foreign agent. For example, immunoassay A may detect the presence of a surface protein from a virus particle. Immunoassay B on the other hand may detect or measure antibodies produced by an organism's immune system that are made to neutralize and allow
16875-559: The taxonomically classified pathogen genomes to generate an antimicrobial resistance profile – analogous to antibiotic sensitivity testing – to facilitate antimicrobial stewardship and allow for the optimization of treatment using the most effective drugs for a patient's infection. Metagenomic sequencing could prove especially useful for diagnosis when the patient is immunocompromised . An ever-wider array of infectious agents can cause serious harm to individuals with immunosuppression, so clinical screening must often be broader. Additionally,
17010-503: The test. For example, " Strep throat " is often diagnosed within minutes, and is based on the appearance of antigens made by the causative agent, S. pyogenes , that is retrieved from a patient's throat with a cotton swab. Serological tests, if available, are usually the preferred route of identification, however the tests are costly to develop and the reagents used in the test often require refrigeration . Some serological methods are extremely costly, although when commonly used, such as with
17145-411: The use of live animals unnecessary. Viruses are also usually identified using alternatives to growth in culture or animals. Some viruses may be grown in embryonated eggs. Another useful identification method is Xenodiagnosis, or the use of a vector to support the growth of an infectious agent. Chagas disease is the most significant example, because it is difficult to directly demonstrate the presence of
17280-511: The view of "a unified territory (one land since the beginning of civilization) and a unified people" which de-emphasized "all disparities and the succession of waves of invaders" was first imprinted on the masses by the unified history curriculum of French textbooks in the late 1870s. Since the beginning of the Third Republic (1871–1940), the state has not categorized people according to their alleged ethnic origins. Hence, in contrast to
17415-522: The willingness to live together, in Renan's 1882 essay " Qu'est-ce qu'une nation? "). The debate concerning the integration of this view with the principles underlying the European Community remains open. France has been historically open to immigration, although this has changed in recent years. Referring to this perceived openness, Gertrude Stein , wrote: "America is my country but Paris
17550-524: The word Francia , the territory of the Franks . The Franks were a Germanic tribe that overran Roman Gaul at the end of the Roman Empire . In the pre-Roman era, Gaul (an area of Western Europe that encompassed all of what is known today as France, Belgium, part of Germany and Switzerland, and Northern Italy) was inhabited by a variety of peoples who were known collectively as the Gaulish tribes . Their ancestors were Celts who came from Central Europe in
17685-484: Was incorporated back into the royal domain (i. e. the territory under direct control of the French king) in the Middle Ages . In the crusader Kingdom of Jerusalem , founded in 1099, at most 120,000 Franks, who were predominantly French -speaking Western Christians, ruled over 350,000 Muslims, Jews, and native Eastern Christians. Unlike elsewhere in Europe, France experienced relatively low levels of emigration to
17820-500: Was not usually used except in cities, and even there not always in the outlying districts . Abroad, the French language is spoken in many different countries – in particular the former French colonies . Nevertheless, speaking French is distinct from being a French citizen. Thus, francophonie , or the speaking of French, must not be confused with French citizenship or ethnicity. For example, French speakers in Switzerland are not "French citizens". Native English-speaking Blacks on
17955-641: Was officialized with Jacques Chirac 's family regrouping act of 1976 ( regroupement familial ). Since then, immigration has become more varied, although France stopped being a major immigration country compared to other European countries. The large impact of North African and Arab immigration is the greatest and has brought racial , socio-cultural and religious questions to a country seen as homogenously European, French and Christian for thousands of years. Nevertherless, according to Justin Vaïsse , professor at Sciences Po Paris , integration of Muslim immigrants
18090-470: Was the least stable of the four major mission provinces. The first Guale rebellion, often labeled Juanillo 's Revolt, began on October 4, 1597. The Guale rebelled again 1645, nearly shaking off the missions. They kept up a clandestine trade with French privateers , which provided them with alternate sources of goods. After the arrival of Europeans and their intervention in Guale villages, the Guale increased their consumption of corn. Bioarcheaologists tested
18225-403: Was unclear until the publication of a study in 2019 that used genome wide data. The study identified six different genetic clusters that could be distinguished across populations. The study concluded that the population genetic clusters correlate with linguistic and historical divisions in France and with the presence of geographic barriers such as mountains and major rivers. A population bottleneck
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