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125-454: The current clubhouse was constructed in 1880. The first meeting of the club was at Mr. John Heard's house in Boston on March 5, 1870. A club house location committee was led by B.W. Crowninshield, and a site on Marblehead neck was purchased. A new structure was built and officially opened on June 9, 1881. Construction began in 1880, and was designed in the popular stick style. Inside features

250-491: A herbicide ), reduction of spoilage, or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents , biofuels , and other industrially useful goods, as well as for bioremediation . Farmers have widely adopted GM technology. Between 1996 and 2011, the total surface area of land cultivated with GM crops had increased by a factor of 94, from 17,000 to 1,600,000 square kilometers (4,200,000 to 395,400,000 acres). 10% of

375-474: A plasmid vector inserted into the bacterium Escherichia coli . Insulin, widely used for the treatment of diabetes, was previously extracted from the pancreas of abattoir animals (cattle or pigs). The genetically engineered bacteria are able to produce large quantities of synthetic human insulin at relatively low cost. Biotechnology has also enabled emerging therapeutics like gene therapy . The application of biotechnology to basic science (for example through

500-698: A Unified Database System) database is intended to help companies, interested private users and competent authorities to find precise information on the presence, detection and identification of GMOs used in the European Union . The information is provided in English. In 1988, after prompting from the United States Congress , the National Institute of General Medical Sciences ( National Institutes of Health ) (NIGMS) instituted

625-461: A bacterium (of the genus Pseudomonas ) capable of breaking down crude oil, which he proposed to use in treating oil spills. (Chakrabarty's work did not involve gene manipulation but rather the transfer of entire organelles between strains of the Pseudomonas bacterium). The MOSFET invented at Bell Labs between 1955 and 1960, Two years later, Leland C. Clark and Champ Lyons invented

750-490: A cannon barrage for two hours, but their shot could not reach the colonists' cannons at such a height. The British gave up, boarded their ships, and sailed away. This has become known as " Evacuation Day ", which Boston still celebrates each year on March 17. After this, Washington was so impressed that he made Rufus Putnam his chief engineer. After the Revolution, Boston's long seafaring tradition helped make it one of

875-438: A child's parentage (genetic mother and father) or in general a person's ancestry . In addition to studying chromosomes to the level of individual genes, genetic testing in a broader sense includes biochemical tests for the possible presence of genetic diseases, or mutant forms of genes associated with increased risk of developing genetic disorders. Genetic testing identifies changes in chromosomes , genes, or proteins. Most of

1000-413: A consortium could be used as industrial microbes to produce precursors of the chemotherapeutic agent paclitaxel by applying the metabolic engineering in a co-culture approach to exploit the benefits from the two microbes. Another example of synthetic biology applications in industrial biotechnology is the re-engineering of the metabolic pathways of E. coli by CRISPR and CRISPRi systems toward

1125-422: A drug's efficacy or toxicity . The purpose of pharmacogenomics is to develop rational means to optimize drug therapy, with respect to the patients' genotype , to ensure maximum efficacy with minimal adverse effects . Such approaches promise the advent of " personalized medicine "; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Biotechnology has contributed to

1250-410: A food source into another form. Before the time of Charles Darwin 's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection. For thousands of years, humans have used selective breeding to improve

1375-417: A funding mechanism for biotechnology training. Universities nationwide compete for these funds to establish Biotechnology Training Programs (BTPs). Each successful application is generally funded for five years then must be competitively renewed. Graduate students in turn compete for acceptance into a BTP; if accepted, then stipend, tuition and health insurance support are provided for two or three years during

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1500-536: A harmful microbe are examples of environmental implications of biotechnology. Many cities have installed CityTrees , which use biotechnology to filter pollutants from urban atmospheres. The regulation of genetic engineering concerns approaches taken by governments to assess and manage the risks associated with the use of genetic engineering technology, and the development and release of genetically modified organisms (GMO), including genetically modified crops and genetically modified fish . There are differences in

1625-624: A lively port , and the then-town primarily engaged in shipping and fishing during its colonial days. Boston was a primary stop on a Caribbean trade route and imported large amounts of molasses, which led to the creation of Boston baked beans . Boston's economy stagnated in the decades prior to the Revolution. By the mid-18th century, New York City and Philadelphia had surpassed Boston in wealth. During this period, Boston encountered financial difficulties even as other cities in New England grew rapidly. The weather continuing boisterous

1750-460: A million residents, and the most densely populated state capital. Some 1.2 million persons may be within Boston's boundaries during work hours, and as many as 2 million during special events. This fluctuation of people is caused by hundreds of thousands of suburban residents who travel to the city for work, education, health care, and special events. Biotechnology Biotechnology

1875-481: A model room, with full and half hull models of member yachts through the years.Later additions are wing and a tower, staff and guest overnight rooms, a main dining room and bar. and would expand the complex to include tennis courts and a swimming pool. The club suffered a few fires over years losing the right tower tower portion. Source: When the United States entered the war, Commodore Herbert Sears called

2000-415: A notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies. Krimsky, Sheldon (2015). "An Illusory Consensus behind GMO Health Assessment". Science, Technology, & Human Values . 40 (6): 883–914. doi : 10.1177/0162243915598381 . S2CID   40855100 . I began this article with the testimonials from respected scientists that there

2125-513: A number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm. The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken

2250-434: A number of ecological benefits, if not used in excess. Insect-resistant crops have proven to lower pesticide usage, therefore reducing the environmental impact of pesticides as a whole. However, opponents have objected to GM crops per se on several grounds, including environmental concerns, whether food produced from GM crops is safe, whether GM crops are needed to address the world's food needs, and economic concerns raised by

2375-475: A pair of bombs near the finish line of the Boston Marathon , killing three people and injuring roughly 264. The subsequent search for the bombers led to a lock-down of Boston and surrounding municipalities. The region showed solidarity during this time as symbolized by the slogan Boston Strong . In 2016, Boston briefly shouldered a bid as the U.S. applicant for the 2024 Summer Olympics . The bid

2500-565: A project to improve the historic West End neighborhood. Extensive demolition was met with strong public opposition, and thousands of families were displaced. The BRA continued implementing eminent domain projects, including the clearance of the vibrant Scollay Square area for construction of the modernist style Government Center . In 1965, the Columbia Point Health Center opened in the Dorchester neighborhood,

2625-602: A promising method to combat malnutrition in India and other countries. Industrial biotechnology (known mainly in Europe as white biotechnology) is the application of biotechnology for industrial purposes, including industrial fermentation . It includes the practice of using cells such as microorganisms , or components of cells like enzymes , to generate industrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles and biofuels . In

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2750-478: A pure microbiological culture in an industrial process, that of manufacturing corn starch using Clostridium acetobutylicum , to produce acetone , which the United Kingdom desperately needed to manufacture explosives during World War I . Biotechnology has also led to the development of antibiotics. In 1928, Alexander Fleming discovered the mold Penicillium . His work led to the purification of

2875-531: A significant impact on many areas of society, from medicine to agriculture to environmental science . One of the key techniques used in biotechnology is genetic engineering , which allows scientists to modify the genetic makeup of organisms to achieve desired outcomes. This can involve inserting genes from one organism into another, and consequently, create new traits or modifying existing ones. Other important techniques used in biotechnology include tissue culture, which allows researchers to grow cells and tissues in

3000-401: A violent tornado , the city itself has experienced many tornado warnings . Damaging storms are more common to areas north, west, and northwest of the city. See or edit raw graph data . In 2020, Boston was estimated to have 691,531 residents living in 266,724 households —a 12% population increase over 2010. The city is the third-most densely populated large U.S. city of over half

3125-414: A wide range of procedures for modifying living organisms for human purposes, going back to domestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization . Modern usage also includes genetic engineering, as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as

3250-505: Is 2 °F (−17 °C) on December 30, 1917, while the record warm daily minimum is 83 °F (28 °C) on both August 2, 1975 and July 21, 2019. Boston averages 43.6 in (1,110 mm) of precipitation a year, with 49.2 in (125 cm) of snowfall per season. Most snowfall occurs from mid-November through early April, and snow is rare in May and October. There is also high year-to-year variability in snowfall; for instance,

3375-508: Is July, with a mean temperature of 74.1 °F (23.4 °C). The coldest month is January, with a mean temperature of 29.9 °F (−1.2 °C). Periods exceeding 90 °F (32 °C) in summer and below freezing in winter are not uncommon but tend to be fairly short, with about 13 and 25 days per year seeing each, respectively. Sub- 0 °F (−18 °C) readings usually occur every 3 to 5 years. The most recent sub- 0 °F (−18 °C) reading occurred on February 4, 2023, when

3500-570: Is a multidisciplinary field that involves the integration of natural sciences and engineering sciences in order to achieve the application of organisms and parts thereof for products and services. The term biotechnology was first used by Károly Ereky in 1919 to refer to the production of products from raw materials with the aid of living organisms. The core principle of biotechnology involves harnessing biological systems and organisms, such as bacteria, yeast , and plants, to perform specific tasks or produce valuable substances. Biotechnology had

3625-507: Is a rapidly evolving field with significant potential to address pressing global challenges and improve the quality of life for people around the world; however, despite its numerous benefits, it also poses ethical and societal challenges, such as questions around genetic modification and intellectual property rights . As a result, there is ongoing debate and regulation surrounding the use and application of biotechnology in various industries and fields. The concept of biotechnology encompasses

3750-547: Is an intellectual, technological, and political center. However, it has lost some important regional institutions, including the loss to mergers and acquisitions of local financial institutions such as FleetBoston Financial , which was acquired by Charlotte -based Bank of America in 2004. Boston-based department stores Jordan Marsh and Filene's have both merged into the New York City –based Macy's . The 1993 acquisition of The Boston Globe by The New York Times

3875-635: Is based on the basic biological sciences (e.g., molecular biology , biochemistry , cell biology , embryology , genetics , microbiology ) and conversely provides methods to support and perform basic research in biology. Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation, and production from any living organisms and any source of biomass by means of biochemical engineering where high value-added products could be planned (reproduced by biosynthesis , for example), forecasted, formulated, developed, manufactured, and marketed for

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4000-638: Is considered one of the essential cornerstones in industrial biotechnology due to its financial and sustainable contribution to the manufacturing sector. Jointly biotechnology and synthetic biology play a crucial role in generating cost-effective products with nature-friendly features by using bio-based production instead of fossil-based. Synthetic biology can be used to engineer model microorganisms , such as Escherichia coli , by genome editing tools to enhance their ability to produce bio-based products, such as bioproduction of medicines and biofuels . For instance, E. coli and Saccharomyces cerevisiae in

4125-865: Is expected to be good news for the biotechnology sector, with the Department of Energy estimating ethanol usage could reduce U.S. petroleum-derived fuel consumption by up to 30% by 2030. The biotechnology sector has allowed the U.S. farming industry to rapidly increase its supply of corn and soybeans—the main inputs into biofuels—by developing genetically modified seeds that resist pests and drought. By increasing farm productivity, biotechnology boosts biofuel production. Biotechnology has applications in four major industrial areas, including health care (medical), crop production and agriculture, non-food (industrial) uses of crops and other products (e.g., biodegradable plastics , vegetable oil , biofuels ), and environmental uses. For example, one application of biotechnology

4250-588: Is in Roxbury . Due north of the center we find the South End. This is not to be confused with South Boston which lies directly east from the South End. North of South Boston is East Boston and southwest of East Boston is the North End Unknown, A local colloquialism Boston has an area of 89.63 sq mi (232.1 km ). Of this area, 48.4 sq mi (125.4 km ), or 54%, of it

4375-410: Is land and 41.2 sq mi (106.7 km ), or 46%, of it is water. The city's elevation, as measured at Logan International Airport , is 19 ft (5.8 m) above sea level . The highest point in Boston is Bellevue Hill at 330 ft (100 m) above sea level, and the lowest point is at sea level. The city is adjacent to Boston Harbor , an arm of Massachusetts Bay , and by extension,

4500-572: Is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story. And contrast: Panchin, Alexander Y.; Tuzhikov, Alexander I. (January 14, 2016). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology . 37 (2): 213–217. doi : 10.3109/07388551.2015.1130684 . ISSN   0738-8551 . PMID   26767435 . S2CID   11786594 . Here, we show that

4625-673: Is the application of the principles of engineering and natural sciences to tissues, cells, and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals. Relatedly, biomedical engineering is an overlapping field that often draws upon and applies biotechnology (by various definitions), especially in certain sub-fields of biomedical or chemical engineering such as tissue engineering , biopharmaceutical engineering , and genetic engineering . Although not normally what first comes to mind, many forms of human-derived agriculture clearly fit

4750-708: Is the directed use of microorganisms for the manufacture of organic products (examples include beer and milk products). Another example is using naturally present bacteria by the mining industry in bioleaching . Biotechnology is also used to recycle, treat waste, clean up sites contaminated by industrial activities ( bioremediation ), and also to produce biological weapons . A series of derived terms have been coined to identify several branches of biotechnology, for example: In medicine, modern biotechnology has many applications in areas such as pharmaceutical drug discoveries and production, pharmacogenomics , and genetic testing (or genetic screening ). In 2021, nearly 40% of

4875-488: Is widely used in biomedical applications, such as the detection of DNA hybridization , biomarker detection from blood , antibody detection, glucose measurement, pH sensing, and genetic technology . By the mid-1980s, other BioFETs had been developed, including the gas sensor FET (GASFET), pressure sensor FET (PRESSFET), chemical field-effect transistor (ChemFET), reference ISFET (REFET), enzyme-modified FET (ENFET) and immunologically modified FET (IMFET). By

5000-453: The Arbella ) and John Cotton (grandfather of Cotton Mather ) had emigrated to New England . The name of the English town ultimately derives from its patron saint, St. Botolph , in whose church John Cotton served as the rector until his emigration with Johnson. In early sources, Lincolnshire's Boston was known as "St. Botolph's town", later contracted to "Boston". Before this renaming,

5125-815: The American Revolution occurred in or near Boston. The then-town's mob presence, along with the colonists' growing lack of faith in either Britain or its Parliament , fostered a revolutionary spirit there. When the British parliament passed the Stamp Act in 1765, a Boston mob ravaged the homes of Andrew Oliver , the official tasked with enforcing the Act, and Thomas Hutchinson , then the Lieutenant Governor of Massachusetts. The British sent two regiments to Boston in 1768 in an attempt to quell

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5250-585: The Boston Garden opening in 1928. Logan International Airport opened on September 8, 1923. Boston went into decline by the early to mid-20th century, as factories became old and obsolete and businesses moved out of the region for cheaper labor elsewhere. Boston responded by initiating various urban renewal projects, under the direction of the Boston Redevelopment Authority (BRA) established in 1957. In 1958, BRA initiated

5375-625: The Boston Public Library , Trinity Church, single-family homes and wooden/brick multi-family row houses. The South End Historic District is the largest surviving contiguous Victorian-era neighborhood in the US. The geography of downtown and South Boston was particularly affected by the Central Artery/Tunnel Project (which ran from 1991 to 2007, and was known unofficially as the " Big Dig "). That project removed

5500-634: The DNA of which has been modified with genetic engineering techniques. In most cases, the main aim is to introduce a new trait that does not occur naturally in the species. Biotechnology firms can contribute to future food security by improving the nutrition and viability of urban agriculture. Furthermore, the protection of intellectual property rights encourages private sector investment in agrobiotechnology. Examples in food crops include resistance to certain pests, diseases, stressful environmental conditions, resistance to chemical treatments (e.g. resistance to

5625-470: The Human Genome Project ) has also dramatically improved our understanding of biology and as our scientific knowledge of normal and disease biology has increased, our ability to develop new medicines to treat previously untreatable diseases has increased as well. Genetic testing allows the genetic diagnosis of vulnerabilities to inherited diseases , and can also be used to determine

5750-612: The Massachusetts Bay Colony and was signed by its first governor John Winthrop . Puritan ethics and their focus on education also influenced the early history of the city. America's first public school, Boston Latin School , was founded in Boston in 1635. Boston was the largest town in the Thirteen Colonies until Philadelphia outgrew it in the mid-18th century. Boston's oceanfront location made it

5875-537: The North End , and the Seaport . Boston is sometimes called a "city of neighborhoods" because of the profusion of diverse subsections. The city government's Office of Neighborhood Services has officially designated 23 neighborhoods: More than two-thirds of inner Boston's modern land area did not exist when the city was founded. Instead, it was created via the gradual filling in of the surrounding tidal areas over

6000-652: The South End , the West End , the Financial District , and Chinatown . After the Great Boston fire of 1872 , workers used building rubble as landfill along the downtown waterfront. During the mid-to-late 19th century, workers filled almost 600 acres (240 ha) of brackish Charles River marshlands west of Boston Common with gravel brought by rail from the hills of Needham Heights. The city annexed

6125-682: The Under Secretary of the Navy , Franklin Roosevelt , and offered the use of the Eastern clubhouse to the Navy as a base. Roosevelt accepted and the clubhouse was used as a training station for the final year of World War I, primarily for training ashore and aviation training. A group of 14 members wanting to contribute to the war effort, ordered and personally financed boats to be used by the Navy as patrol craft and built with Navy approval of

6250-412: The 1970s, the city's economy had begun to recover after 30 years of economic downturn. A large number of high-rises were constructed in the Financial District and in Boston's Back Bay during this period. This boom continued into the mid-1980s and resumed after a few pauses. Hospitals such as Massachusetts General Hospital , Beth Israel Deaconess Medical Center , and Brigham and Women's Hospital lead

6375-457: The 19th century, Boston's core neighborhoods had become enclaves of ethnically distinct immigrants with their residence yielding lasting cultural change. Italians became the largest inhabitants of the North End , Irish dominated South Boston and Charlestown , and Russian Jews lived in the West End . Irish and Italian immigrants brought with them Roman Catholicism. Currently, Catholics make up Boston's largest religious community, and

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6500-643: The 20th century: Horticultural Hall , the Tennis and Racquet Club , Isabella Stewart Gardner Museum , Fenway Studios , Jordan Hall , and the Boston Opera House .  The Longfellow Bridge , built in 1906, was mentioned by Robert McCloskey in Make Way for Ducklings , describing its "salt and pepper shakers" feature. Fenway Park , home of the Boston Red Sox , opened in 1912, with

6625-598: The Atlantic Ocean. Boston is surrounded by the Greater Boston metropolitan region. It is bordered to the east by the town of Winthrop and the Boston Harbor Islands , to the northeast by the cities of Revere , Chelsea and Everett , to the north by the cities of Somerville and Cambridge , to the northwest by Watertown , to the west by the city of Newton and town of Brookline , to

6750-458: The EU and approval for import and processing. While only a few GMOs have been approved for cultivation in the EU a number of GMOs have been approved for import and processing. The cultivation of GMOs has triggered a debate about the coexistence of GM and non-GM crops. Depending on the coexistence regulations, incentives for the cultivation of GM crops differ. The EUginius (European GMO Initiative for

6875-512: The Irish have played a major role in Boston politics since the early 20th century; prominent figures include the Kennedys , Tip O'Neill , and John F. Fitzgerald . Between 1631 and 1890, the city tripled its area through land reclamation by filling in marshes, mud flats, and gaps between wharves along the waterfront. Reclamation projects in the middle of the century created significant parts of

7000-579: The John Hancock Tower is the old John Hancock Building with its prominent illuminated beacon , the color of which forecasts the weather. Downtown and its immediate surroundings (including the Financial District, Government Center, and South Boston ) consist largely of low-rise masonry buildings – often federal style and Greek revival – interspersed with modern high-rises. Back Bay includes many prominent landmarks, such as

7125-563: The Native people, as many had died of European diseases brought by early settlers and traders. Archaeological excavations unearthed one of the oldest fishweirs in New England on Boylston Street , which Native people constructed as early as 7,000 years before European arrival in the Western Hemisphere. The first European to live in what would become Boston was a Cambridge -educated Anglican cleric named William Blaxton . He

7250-547: The Northeast after New York City and Philadelphia . The larger Greater Boston metropolitan statistical area has a population of 4.9 million as of 2023, making it the largest in New England and the eleventh-largest in the country . Boston was founded on the Shawmut Peninsula in 1630 by Puritan settlers. The city was named after Boston, Lincolnshire , England. During the American Revolution , Boston

7375-735: The Renew Boston Whole Building Incentive which reduces the cost of living in buildings that are deemed energy efficient. Under the Köppen climate classification , Boston has either a hot-summer humid continental climate (Köppen Dfa ) under the 0 °C (32.0 °F) isotherm or a humid subtropical climate (Köppen Cfa ) under the −3 °C (26.6 °F) isotherm. Summers are warm to hot and humid, while winters are cold and stormy, with occasional periods of heavy snow. Spring and fall are usually cool and mild, with varying conditions dependent on wind direction and

7500-681: The act as an attempt to force them to accept the taxes established by the Townshend Acts . The act prompted the Boston Tea Party , where a group of angered Bostonians threw an entire shipment of tea sent by the East India Company into Boston Harbor . The Boston Tea Party was a key event leading up to the revolution, as the British government responded furiously with the Coercive Acts , demanding compensation for

7625-535: The adjacent towns of South Boston (1804), East Boston (1836), Roxbury (1868), Dorchester (including present-day Mattapan and a portion of South Boston ) (1870), Brighton (including present-day Allston ) (1874), West Roxbury (including present-day Jamaica Plain and Roslindale ) (1874), Charlestown (1874), and Hyde Park (1912). Other proposals were unsuccessful for the annexation of Brookline , Cambridge, and Chelsea . Many architecturally significant buildings were built during these early years of

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7750-572: The angry colonists. This did not sit well with the colonists, however. In 1770, during the Boston Massacre , British troops shot into a crowd that had started to violently harass them. The colonists compelled the British to withdraw their troops. The event was widely publicized and fueled a revolutionary movement in America. In 1773, Parliament passed the Tea Act . Many of the colonists saw

7875-518: The antibiotic compound formed by the mold by Howard Florey , Ernst Boris Chain and Norman Heatley – to form what we today know as penicillin . In 1940, penicillin became available for medicinal use to treat bacterial infections in humans. The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced

8000-511: The application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms, such as pharmaceuticals, crops, and livestock . As per the European Federation of Biotechnology , biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services. Biotechnology

8125-426: The area. Nevertheless, the city experienced conflict starting in 1974 over desegregation busing , which resulted in unrest and violence around public schools throughout the mid-1970s. Boston has also experienced gentrification in the latter half of the 20th century, with housing prices increasing sharply since the 1990s when the city's rent control regime was struck down by statewide ballot proposition . Boston

8250-471: The broad definition of "utilizing a biotechnological system to make products". Indeed, the cultivation of plants may be viewed as the earliest biotechnological enterprise. Agriculture has been theorized to have become the dominant way of producing food since the Neolithic Revolution . Through early biotechnology, the earliest farmers selected and bred the best-suited crops (e.g., those with

8375-605: The centuries. This was accomplished using earth from the leveling or lowering of Boston's three original hills (the "Trimountain", after which Tremont Street is named), as well as with gravel brought by train from Needham to fill the Back Bay . Christian Science Center , Copley Square , Newbury Street , and New England's two tallest buildings: the John Hancock Tower and the Prudential Center . Near

8500-460: The city government. A climate action plan from 2019 anticipates 2 ft (1 m) to more than 7 ft (2 m) of sea-level rise in Boston by the end of the 21st century. Many older buildings in certain areas of Boston are supported by wooden piles driven into the area's fill; these piles remain sound if submerged in water, but are subject to dry rot if exposed to air for long periods. Groundwater levels have been dropping in many areas of

8625-464: The city often receives sea breezes , especially in the late spring, when water temperatures are still quite cold and temperatures at the coast can be more than 20 °F (11 °C) colder than a few miles inland, sometimes dropping by that amount near midday. Thunderstorms typically occur from May to September; occasionally, they can become severe, with large hail , damaging winds, and heavy downpours. Although downtown Boston has never been struck by

8750-443: The city's economy, and the city's industrial manufacturing overtook international trade in economic importance by the mid-19th century. The small rivers bordering the city and connecting it to the surrounding region facilitated shipment of goods and led to a proliferation of mills and factories. Later, a dense network of railroads furthered the region's industry and commerce. During this period, Boston flourished culturally as well. It

8875-414: The city, due in part to an increase in the amount of rainwater discharged directly into sewers rather than absorbed by the ground. The Boston Groundwater Trust coordinates monitoring groundwater levels throughout the city via a network of public and private monitoring wells. The city developed a climate action plan covering carbon reduction in buildings, transportation, and energy use. The first such plan

9000-526: The commander-in-chief of the British forces in North America, led the British army in the siege. On June 17, the British captured Charlestown (now part of Boston) during the Battle of Bunker Hill . The British army outnumbered the militia stationed there, but it was a pyrrhic victory for the British because their army suffered irreplaceable casualties. It was also a testament to the skill and training of

9125-509: The course of their PhD thesis work. Nineteen institutions offer NIGMS supported BTPs. Biotechnology training is also offered at the undergraduate level and in community colleges. But see also: Domingo, José L.; Bordonaba, Jordi Giné (2011). "A literature review on the safety assessment of genetically modified plants" (PDF) . Environment International . 37 (4): 734–742. Bibcode : 2011EnInt..37..734D . doi : 10.1016/j.envint.2011.01.003 . PMID   21296423 . Archived (PDF) from

9250-445: The current decades, significant progress has been done in creating genetically modified organisms (GMOs) that enhance the diversity of applications and economical viability of industrial biotechnology. By using renewable raw materials to produce a variety of chemicals and fuels, industrial biotechnology is actively advancing towards lowering greenhouse gas emissions and moving away from a petrochemical-based economy. Synthetic biology

9375-684: The design independently: Boston Boston is the capital and most populous city in the Commonwealth of Massachusetts in the United States . The city serves as the cultural and financial center of the New England region of the Northeastern United States . It has an area of 48.4 sq mi (125 km ) and a population of 675,647 as of the 2020 census , making it the third-largest city in

9500-608: The design. Known as "The Eastern Yacht Club 62 footers", the boats were designed by Albert Loring Swasey and Nathanael Greene Herreshoff . The nine nearly identical motor boats built by the Herreshoff Manufacturing Company in Bristol , Rhode Island .The boats bore names under construction chosen by the owners and were then given their Section Patrol numbers once accepted by the Navy. The Eastern Yacht Club boats with sponsors were: Plus one built to

9625-664: The destroyed tea from the Bostonians. This angered the colonists further and led to the American Revolutionary War . The war began in the area surrounding Boston with the Battles of Lexington and Concord . Boston itself was besieged for almost a year during the siege of Boston , which began on April 19, 1775. The New England militia impeded the movement of the British Army . Sir William Howe , then

9750-488: The difference between beneficial biotechnology (e.g., bioremediation is to clean up an oil spill or hazard chemical leak) versus the adverse effects stemming from biotechnological enterprises (e.g., flow of genetic material from transgenic organisms into wild strains) can be seen as applications and implications, respectively. Cleaning up environmental wastes is an example of an application of environmental biotechnology ; whereas loss of biodiversity or loss of containment of

9875-458: The discovery and manufacturing of traditional small molecule pharmaceutical drugs as well as drugs that are the product of biotechnology – biopharmaceutics . Modern biotechnology can be used to manufacture existing medicines relatively easily and cheaply. The first genetically engineered products were medicines designed to treat human diseases. To cite one example, in 1978 Genentech developed synthetic humanized insulin by joining its gene with

10000-402: The early 2000s, BioFETs such as the DNA field-effect transistor (DNAFET), gene-modified FET (GenFET) and cell-potential BioFET (CPFET) had been developed. A factor influencing the biotechnology sector's success is improved intellectual property rights legislation—and enforcement—worldwide, as well as strengthened demand for medical and pharmaceutical products. Rising demand for biofuels

10125-466: The elevated Central Artery and incorporated new green spaces and open areas. Boston is located within the Boston Basin ecoregion , which is characterized by low and rolling hills with a number of ponds, lakes, and reservoirs. Forests are mainly transition hardwoods such as oak - hickory mixed with white pine . As a coastal city built largely on fill , sea-level rise is of major concern to

10250-607: The fact these organisms are subject to intellectual property law. Biotechnology has several applications in the realm of food security. Crops like Golden rice are engineered to have higher nutritional content, and there is potential for food products with longer shelf lives. Though not a form of agricultural biotechnology, vaccines can help prevent diseases found in animal agriculture. Additionally, agricultural biotechnology can expedite breeding processes in order to yield faster results and provide greater quantities of food. Transgenic biofortification in cereals has been considered as

10375-541: The first Community Health Center in the United States. It mostly served the massive Columbia Point public housing complex adjoining it, which was built in 1953. The health center is still in operation and was rededicated in 1990 as the Geiger-Gibson Community Health Center. The Columbia Point complex itself was redeveloped and revitalized from 1984 to 1990 into a mixed-income residential development called Harbor Point Apartments. By

10500-468: The first biosensor in 1962. Biosensor MOSFETs were later developed, and they have since been widely used to measure physical , chemical , biological and environmental parameters. The first BioFET was the ion-sensitive field-effect transistor (ISFET), invented by Piet Bergveld in 1970. It is a special type of MOSFET, where the metal gate is replaced by an ion -sensitive membrane , electrolyte solution and reference electrode . The ISFET

10625-416: The first forms of biotechnology. These processes also were included in early fermentation of beer . These processes were introduced in early Mesopotamia , Egypt , China and India , and still use the same basic biological methods. In brewing , malted grains (containing enzymes ) convert starch from grains into sugar and then adding specific yeasts to produce beer. In this process, carbohydrates in

10750-461: The first wave of European immigrants . Irish immigrants dominated the first wave of newcomers during this period, especially following the Great Famine ; by 1850, about 35,000 Irish lived in Boston . In the latter half of the 19th century, the city saw increasing numbers of Irish, Germans , Lebanese , Syrians, French Canadians , and Russian and Polish Jews settling there. By the end of

10875-461: The fortifications and dozens of cannons on Dorchester Heights that Henry Knox had laboriously brought through the snow from Fort Ticonderoga . The astonished British awoke the next morning to see a large array of cannons bearing down on them. General Howe is believed to have said that the Americans had done more in one night than his army could have done in six months. The British Army attempted

11000-416: The grains broke down into alcohols, such as ethanol. Later, other cultures produced the process of lactic acid fermentation , which produced other preserved foods, such as soy sauce . Fermentation was also used in this time period to produce leavened bread . Although the process of fermentation was not fully understood until Louis Pasteur 's work in 1857, it is still the first use of biotechnology to convert

11125-558: The highest average rate of philanthropy in the nation, and the city's businesses and institutions rank among the top in the nation for environmental sustainability and new investment. Isaac Johnson , in one of his last official acts as the leader of the Charlestown community before he died on September 30, 1630, named the then-new settlement across the river "Boston". The settlement's name came from Johnson's hometown of Boston, Lincolnshire , from which he, his wife (namesake of

11250-478: The highest yields) to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectively fertilize , restore nitrogen , and control pests . Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments and breeding them with other plants — one of

11375-511: The lab for research and medical purposes, and fermentation , which is used to produce a wide range of products such as beer, wine, and cheese. The applications of biotechnology are diverse and have led to the development of essential products like life-saving drugs, biofuels , genetically modified crops, and innovative materials. It has also been used to address environmental challenges, such as developing biodegradable plastics and using microorganisms to clean up contaminated sites. Biotechnology

11500-718: The market, but in 2015 the FDA approved the first GM salmon for commercial production and consumption. There is a scientific consensus that currently available food derived from GM crops poses no greater risk to human health than conventional food, but that each GM food needs to be tested on a case-by-case basis before introduction. Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe. The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation. GM crops also provide

11625-815: The methods of genetic engineering . These techniques have allowed for the introduction of new crop traits as well as a far greater control over a food's genetic structure than previously afforded by methods such as selective breeding and mutation breeding . Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its Flavr Savr delayed ripening tomato. To date most genetic modification of foods have primarily focused on cash crops in high demand by farmers such as soybean , corn , canola , and cotton seed oil . These have been engineered for resistance to pathogens and herbicides and better nutrient profiles. GM livestock have also been experimentally developed; in November 2013 none were available on

11750-536: The militia, as their stubborn defense made it difficult for the British to capture Charlestown without suffering further irreplaceable casualties. Several weeks later, George Washington took over the militia after the Continental Congress established the Continental Army to unify the revolutionary effort. Both sides faced difficulties and supply shortages in the siege, and the fighting

11875-634: The nation in medical innovation and patient care. Schools such as the Boston Architectural College , Boston College , Boston University , the Harvard Medical School , Tufts University School of Medicine , Northeastern University , Massachusetts College of Art and Design , Wentworth Institute of Technology , Berklee College of Music , the Boston Conservatory , and many others attract students to

12000-572: The nation's busiest ports for both domestic and international trade. Boston's harbor activity was significantly curtailed by the Embargo Act of 1807 (adopted during the Napoleonic Wars ) and the War of 1812 . Foreign trade returned after these hostilities, but Boston's merchants had found alternatives for their capital investments in the meantime. Manufacturing became an important component of

12125-542: The new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the United States Supreme Court ruled that a genetically modified microorganism could be patented in the case of Diamond v. Chakrabarty . Indian-born Ananda Chakrabarty , working for General Electric , had modified

12250-453: The next day and night, giving the enemy time to improve their works, to bring up their cannon, and to put themselves in such a state of defence, that I could promise myself little success in attacking them under all the disadvantages I had to encounter. William Howe, 5th Viscount Howe , in a letter to William Legge, 2nd Earl of Dartmouth , about the British army's decision to leave Boston, dated March 21, 1776. Many crucial events of

12375-419: The official name from the "Town of Boston" to the "City of Boston", and on March 19, 1822, the people of Boston accepted the charter incorporating the city. At the time Boston was chartered as a city, the population was about 46,226, while the area of the city was only 4.8 sq mi (12 km ). In the 1820s, Boston's population grew rapidly, and the city's ethnic composition changed dramatically with

12500-400: The original peninsula by filling in land and annexing neighboring towns. Boston's many firsts include the United States' first public park ( Boston Common , 1634), the first public school ( Boston Latin School , 1635), and the first subway system ( Tremont Street subway , 1897). Boston has emerged as a global leader in higher education and research and the largest biotechnology hub in

12625-404: The original on October 9, 2022. In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as

12750-461: The position of the jet stream . Prevailing wind patterns that blow offshore minimize the influence of the Atlantic Ocean. However, in winter, areas near the immediate coast often see more rain than snow, as warm air is sometimes drawn off the Atlantic. The city lies at the border between USDA plant hardiness zones 6b (away from the coastline) and 7a (close to the coastline). The hottest month

12875-463: The production of a chemical known as 1,4-butanediol , which is used in fiber manufacturing. In order to produce 1,4-butanediol, the authors alter the metabolic regulation of the Escherichia coli by CRISPR to induce point mutation in the glt A gene, knockout of the sad gene, and knock-in six genes ( cat 1, suc D, 4hbd , cat 2, bld , and bdh ). Whereas CRISPRi system used to knockdown

13000-460: The production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops. In the early twentieth century scientists gained a greater understanding of microbiology and explored ways of manufacturing specific products. In 1917, Chaim Weizmann first used

13125-441: The products). The utilization of biological processes, organisms or systems to produce products that are anticipated to improve human lives is termed biotechnology. By contrast, bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materials directly ) for interfacing with and utilizing living things. Bioengineering

13250-422: The purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on the pharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using

13375-422: The regulation of GMOs between countries, with some of the most marked differences occurring between the US and Europe. Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety. The European Union differentiates between approval for cultivation within

13500-404: The respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents

13625-528: The settlement on the peninsula had been known as "Shawmut" by William Blaxton and "Tremontaine" by the Puritan settlers he had invited. Prior to European colonization , the region surrounding present-day Boston was inhabited by the Massachusett people who had small, seasonal communities. When a group of settlers led by John Winthrop arrived in 1630, the Shawmut Peninsula was nearly empty of

13750-606: The southwest by the town of Dedham and small portions of Needham and Canton , and to the southeast by the town of Milton , and the city of Quincy . The Charles River separates Boston's Allston-Brighton , Fenway-Kenmore and Back Bay neighborhoods from Watertown and Cambridge, and most of Boston from its own Charlestown neighborhood. The Neponset River forms the boundary between Boston's southern neighborhoods and Quincy and Milton . The Mystic River separates Charlestown from Chelsea and Everett, and Chelsea Creek and Boston Harbor separate East Boston from Downtown ,

13875-509: The temperature dipped down to −10 °F (−23 °C); this was the lowest temperature reading in the city since 1957. In addition, several decades may pass between 100 °F (38 °C) readings; the last such reading occurred on July 24, 2022. The city's average window for freezing temperatures is November 9 through April 5. Official temperature records have ranged from −18 °F (−28 °C) on February 9, 1934, up to 104 °F (40 °C) on July 4, 1911. The record cold daily maximum

14000-534: The three competing genes ( gab D, ybg C, and tes B) that affect the biosynthesis pathway of 1,4-butanediol. Consequently, the yield of 1,4-butanediol significantly increased from 0.9 to 1.8 g/L. Environmental biotechnology includes various disciplines that play an essential role in reducing environmental waste and providing environmentally safe processes, such as biofiltration and biodegradation . The environment can be affected by biotechnologies, both positively and adversely. Vallero and others have argued that

14125-542: The time, testing is used to find changes that are associated with inherited disorders. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on a genetic disorder . As of 2011 several hundred genetic tests were in use. Since genetic testing may open up ethical or psychological problems, genetic testing is often accompanied by genetic counseling . Genetically modified crops ("GM crops", or "biotech crops") are plants used in agriculture ,

14250-570: The total company value of pharmaceutical biotech companies worldwide were active in Oncology with Neurology and Rare Diseases being the other two big applications. Pharmacogenomics (a combination of pharmacology and genomics ) is the technology that analyses how genetic makeup affects an individual's response to drugs. Researchers in the field investigate the influence of genetic variation on drug responses in patients by correlating gene expression or single-nucleotide polymorphisms with

14375-467: The winter of 2011–12 saw only 9.3 in (23.6 cm) of accumulating snow, but the previous winter, the corresponding figure was 81.0 in (2.06 m). The city's coastal location on the North Atlantic makes the city very prone to nor'easters , which can produce large amounts of snow and rain. Fog is fairly common, particularly in spring and early summer. Due to its coastal location,

14500-507: The world's crop lands were planted with GM crops in 2010. As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the US, Brazil , Argentina , India , Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain. Genetically modified foods are foods produced from organisms that have had specific changes introduced into their DNA with

14625-440: The world. The city is also a national leader in scientific research, law, medicine, engineering, and business. With nearly 5,000 startup companies, the city is considered a global pioneer in innovation and entrepreneurship , and more recently in artificial intelligence . Boston's economy also includes finance , professional and business services, information technology , and government activities. Boston households provide

14750-736: Was admired for its rarefied literary life and generous artistic patronage . Members of old Boston families—eventually dubbed the Boston Brahmins —came to be regarded as the nation's social and cultural elites. They are often associated with the American upper class , Harvard University , and the Episcopal Church . Boston was a prominent port of the Atlantic slave trade in the New England Colonies , but

14875-549: Was commissioned in 2007, with updates released in 2011, 2014, and 2019. This plan includes the Building Energy Reporting and Disclosure Ordinance, which requires the city's larger buildings to disclose their yearly energy and water use statistics and to partake in an energy assessment every five years. A separate initiative, Resilient Boston Harbor, lays out neighborhood-specific recommendations for coastal resilience . In 2013, Mayor Thomas Menino introduced

15000-548: Was home to several events that proved central to the revolution and subsequent Revolutionary War , including the Boston Massacre (1770), the Boston Tea Party (1773), Paul Revere's Midnight Ride (1775), the Battle of Bunker Hill (1775), and the Siege of Boston (1775–1776). Following American independence from Great Britain , the city continued to play an important role as a port, manufacturing hub, and center for education and culture. The city also expanded significantly beyond

15125-433: Was limited to small-scale raids and skirmishes. The narrow Boston Neck, which at that time was only about a hundred feet wide, impeded Washington's ability to invade Boston, and a long stalemate ensued. A young officer, Rufus Putnam , came up with a plan to make portable fortifications out of wood that could be erected on the frozen ground under cover of darkness. Putnam supervised this effort, which successfully installed both

15250-614: Was reversed in 2013 when it was resold to Boston businessman John W. Henry . In 2016, it was announced General Electric would be moving its corporate headquarters from Connecticut to the Seaport District in Boston, joining many other companies in this rapidly developing neighborhood. The city also saw the completion of the Central Artery/Tunnel Project, known as the Big Dig , in 2007 after many delays and cost overruns. On April 15, 2013, two Chechen Islamist brothers detonated

15375-535: Was soon overtaken by Salem, Massachusetts and Newport, Rhode Island . Boston eventually became a center of the American abolitionist movement . The city reacted largely negatively to the Fugitive Slave Act of 1850 , contributing to President Franklin Pierce 's attempt to make an example of Boston after Anthony Burns 's attempt to escape to freedom. In 1822, the citizens of Boston voted to change

15500-543: Was supported by the mayor and a coalition of business leaders and local philanthropists, but was eventually dropped due to public opposition. The USOC then selected Los Angeles to be the American candidate with Los Angeles ultimately securing the right to host the 2028 Summer Olympics . Nevertheless, Boston is one of eleven U.S. cities which will host matches during the 2026 FIFA World Cup , with games taking place at Gillette Stadium . The geographical center of Boston

15625-504: Was the person most directly responsible for the foundation of Boston by Puritan colonists in 1630. This occurred after Blaxton invited one of their leaders, Isaac Johnson , to cross Back Bay from the failing colony of Charlestown and share the peninsula. The Puritans made the crossing in September 1630. Puritan influence on Boston began even before the settlement was founded with the 1629 Cambridge Agreement . This document created

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