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108-694: Foula ( / ˈ f uː l ə / ), located in the Shetland archipelago of Scotland , is one of the United Kingdom 's most remote permanently inhabited islands . The liner RMS Oceanic was wrecked on the Shaalds of Foula in 1914. Foula was the location for the film The Edge of the World (1937). The name "Foula" derives from the Old Norse Fugley , meaning "bird island". Foula lies in

216-597: A White Star liner, wrecked on the Shaalds o' Foula. Holbourn embarked upon the RMS Lusitania in May 1915 and survived its sinking . The professor's grandson, Robert Holbourn, a naval architect , acted as the island's "Peat Marshal" for many years. Peat is a valuable and scarce resource for heat and fuel in Shetland. Its cutting requires skill, taking several years to master. The most able islanders become known as

324-405: A bone marrow transplant , in which (undifferentiated) hematopoietic stem cells are transferred. When B cells and T cells are activated by a pathogen, memory B-cells and T- cells develop, and the primary immune response results. Throughout the lifetime of an animal, these memory cells will "remember" each specific pathogen encountered, and can mount a strong secondary response if the pathogen

432-418: A pathogen or toxin are transferred to non- immune individuals. Passive immunization is used when there is a high risk of infection and insufficient time for the body to develop its own immune response, or to reduce the symptoms of ongoing or immunosuppressive diseases. Passive immunity provides immediate protection, but the body does not develop memory, therefore the patient is at risk of being infected by

540-557: A tsunami caused by the Storegga Slide hit Shetland, as well as the west coast of Norway, and may have created a wave of up to 25 m (82 ft) high in the voes where modern populations are highest. The highest point of Shetland is Ronas Hill at 450 m (1,480 ft). The Pleistocene glaciations entirely covered the islands. During that period, the Stanes of Stofast, a 2000-tonne glacial erratic , came to rest on

648-401: A vaccine , a substance that contains antigen. A vaccine stimulates a primary response against the antigen without causing symptoms of the disease. The term vaccination was coined by Richard Dunning, a colleague of Edward Jenner , and adapted by Louis Pasteur for his pioneering work in vaccination. The method Pasteur used entailed treating the infectious agents for those diseases, so they lost

756-404: A century to treat infectious disease, and before the advent of antibiotics , was often the only specific treatment for certain infections. Immunoglobulin therapy continued to be a first line therapy in the treatment of severe respiratory diseases until the 1930s, even after sulfonamide lot antibiotics were introduced. Passive or " adoptive transfer " of cell-mediated immunity, is conferred by

864-419: A coastline 1,679 mi (2,702 km) long. Lerwick , the capital and largest settlement, has a population of 6,958. About half of the archipelago's total population of 22,920 people live within 10 mi (16 km) of the town. Scalloway on the west coast, which was the capital until 1708, has a population of fewer than 1,000 people. Only 16 of about 100 islands are inhabited. The main island of

972-581: A curled tail: ⟨ʒ⟩) hence Zetland , the form used in the name of the pre-1975 county council . This is the source of the ZE postcode used for Shetland. Most of the individual islands have Norse names, although the derivations of some are obscure and may represent pre-Norse, Pictish , or even pre- Celtic names or elements. Shetland is around 106 miles (170 kilometres) north of Great Britain and 143 mi (230 km) west of Bergen , Norway . It covers an area of 567 sq mi (1,468 km ) and has

1080-402: A few decades before, there were confusing and conflicting claims of ownership. In 1720, a smallpox epidemic struck the two hundred people living on Foula. Because the islanders were so isolated from the rest of the world, they had no immunity to smallpox, unlike most North European peoples at that time, and nine out of ten of the island's population died in the epidemic. Foula remained on

1188-399: A full theory of immunity was Ilya Mechnikov who revealed phagocytosis in 1882. With Louis Pasteur 's germ theory of disease , the fledgling science of immunology began to explain how bacteria caused disease, and how, following infection, the human body gained the ability to resist further infections. In 1888 Emile Roux and Alexandre Yersin isolated diphtheria toxin , and following

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1296-521: A letter written by Harald, earl of Orkney, Shetland and Caithness, in ca. 1190. By 1431, the islands were being referred to as Hetland , after various intermediate transformations. It is possible that the Pictish "cat" sound contributed to this Norse name. In the 16th century, Shetland was referred to as Hjaltland . Gradually, the Scandinavian Norn language previously spoken by

1404-800: A link with the Caledones . In AD 43, the Roman author Pomponius Mela made reference in his writing to seven islands he called the Haemodae . In AD 77, Pliny the Elder called these same lands the Acmodae . Scholars have inferred that both of these references are to islands in the Shetland group. Another possible early written reference to the islands is Tacitus ' report in Agricola in AD 98. After he described

1512-430: A manner that accurately and proportionately represents their geographical location in relation to the rest of Scotland", so as make clear the islands' real distance from other areas. Shetland has an oceanic temperate maritime climate ( Köppen : Cfb ), bordering on, but very slightly above average in summer temperatures, the subpolar variety, with long but cool winters and short warm summers. The climate all year round

1620-523: A number of such records: Muness is the most northerly castle in the United Kingdom and Skaw the most northerly settlement. The geology of Shetland is complex, with numerous faults and fold axes . These islands are the northern outpost of the Caledonian orogeny , and there are outcrops of Lewisian , Dalradian and Moine metamorphic rocks with histories similar to their equivalents on

1728-541: A prominent hilltop in Lunnasting . It has been estimated that there are about 275 sea stacks in Scotland of which circa 110 are located around the coasts of Shetland. For many of them there is no record of there having been any attempt by rock climbers to ascend them. Shetland has a national scenic area which, unusually, includes a number of discrete locations: Fair Isle, Foula, South West Mainland (including

1836-635: A shortage of available resources and arable land there and led to a period of Viking expansion , so the Norse gradually shifted their attention from plundering to invasion. Shetland was colonised during the late 8th and 9th centuries, the fate of the existing indigenous Pictish population being uncertain. Modern Shetlanders still retain the Norse DNA with many family trees showing the Norse patronymic system (-sson/son, -dottir/daughter). Modern DNA studies such as

1944-454: A while during the late 19th century. He opposed the prevailing truck system and drew political cartoons lampooning its deficiencies. In one, he drew Foula as a beautiful young woman being strangled by a boa-constrictor labelled 'landlordism' watched by other reptiles called 'missionary', ' laird ' and 'truck'. The island was one of the last places where the Norn language was spoken (although it

2052-579: Is Lerwick , which has been the capital of Shetland since 1708, before which time the capital was Scalloway . The archipelago has an oceanic climate , complex geology, rugged coastline, and many low, rolling hills. The largest island, known as " the Mainland ", has an area of 373 sq mi (967 km ), and is the fifth-largest island in the British Isles . It is one of 16 inhabited islands in Shetland. Humans have lived in Shetland since

2160-479: Is acquired through the exposure to a pathogen, which triggers the production of antibodies by the immune system. Passive immunity is acquired through the transfer of antibodies or activated T-cells derived from an immune host either artificially or through the placenta; it is short-lived, requiring booster doses for continued immunity. The diagram below summarizes these divisions of immunity. Adaptive immunity recognizes more diverse patterns. Unlike innate immunity it

2268-478: Is also found in the epic poem " Pharsalia " written around 60 BC by the poet Marcus Annaeus Lucanus to describe a North African tribe's resistance to snake venom . The first clinical description of immunity which arose from a specific disease-causing organism is probably A Treatise on Smallpox and Measles ("Kitab fi al-jadari wa-al-hasbah″, translated 1848 ) written by the Islamic physician Al-Razi in

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2376-571: Is also provided through the transfer of IgA antibodies found in breast milk that are transferred to the gut of a nursing infant, protecting against bacterial infections, until the newborn can synthesize its antibodies. Colostrum present in mothers milk is an example of passive immunity. Artificially acquired passive immunity is a short-term immunization induced by the transfer of antibodies, which can be administered in several forms; as human or animal blood plasma, as pooled human immunoglobulin for intravenous ( IVIG ) or intramuscular (IG) use, and in

2484-469: Is also said to have sought to create a 'universal antidote' to protect him from all poisons. For nearly 2000 years, poisons were thought to be the proximate cause of disease, and a complicated mixture of ingredients, called Mithridate , was used to cure poisoning during the Renaissance . An updated version of this cure, Theriacum Andromachi , was used well into the 19th century. The term "immunes"

2592-413: Is associated with memory of the pathogen. For thousands of years mankind has been intrigued with the causes of disease and the concept of immunity. The prehistoric view was that disease was caused by supernatural forces, and that illness was a form of theurgic punishment for "bad deeds" or "evil thoughts" visited upon the soul by the gods or by one's enemies. In Classical Greek times, Hippocrates , who

2700-535: Is claimed that Walter Sutherland of Skaw in Unst was the last speaker), and the local dialect is strongly influenced by Old Norse . In 1774 George Low, a young Scottish clergyman, visited Foula hoping to find remnants of oral literature in Norn, then nearing extinction. He found fragments of songs, ballads and romances, and from his best source, an old farmer called William Henry, the ballad now known as " Hildina ". Henry

2808-414: Is defined as the first line of defense against pathogens, representing a critical systemic response to prevent infection and maintain homeostasis, contributing to the activation of an adaptive immune response. It does not adapt to specific external stimulus or a prior infection, but relies on genetically encoded recognition of particular patterns. Adaptive or acquired immunity is the active component of

2916-419: Is detected again. The primary and secondary responses were first described in 1921 by English immunologist Alexander Glenny although the mechanism involved was not discovered until later. This type of immunity is both active and adaptive because the body's immune system prepares itself for future challenges. Active immunity often involves both the cell-mediated and humoral aspects of immunity as well as input from

3024-508: Is moderate owing to the influence of the surrounding seas, with average night-time low temperatures a little above 1 °C (34 °F) in January and February and average daytime high temperatures of near 14 °C (57 °F) in July and August. The highest temperature on record was 27.8 °C (82.0 °F) on 6 August 1910 at Sumburgh Head and the lowest −8.9 °C (16.0 °F) in

3132-616: Is one of Europe's prolific petroleum provinces. As a result of the oil revenue and the cultural links with Norway, a small Home Rule movement developed briefly to recast the constitutional position of Shetland . It saw as its models the Isle of Man , as well as Shetland's closest neighbour, the Faroe Islands , an autonomous dependency of Denmark. The population stood at 17,814 in 1961. Immunity (medical) The immune system has innate and adaptive components. Innate immunity

3240-437: Is present in all metazoans , immune responses: inflammatory responses and phagocytosis . The adaptive component, on the other hand, involves more advanced lymphatic cells that can distinguish between specific "non-self" substances in the presence of "self". The reaction to foreign substances is etymologically described as inflammation while the non-reaction to self substances is described as immunity. The two components of

3348-559: Is regarded as the Father of Medicine, diseases were attributed to an alteration or imbalance in one of the four humors (blood, phlegm, yellow bile or black bile). The first written descriptions of the concept of immunity may have been made by the Athenian Thucydides who, in 430 BC, described that when the plague hit Athens : "the sick and the dying were tended by the pitying care of those who had recovered, because they knew

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3456-558: Is required for defense of tuberculosis in humans. Individuals with genetic defects in TNF may get recurrent and life-threatening infections with tuberculosis bacteria ( Mycobacterium tuberculosis ) but are otherwise healthy. They also seem to respond to other infections more or less normally. The condition is therefore called Mendelian susceptibility to mycobacterial disease (MSMD) and variants of it can be caused by other genes related to interferon production or signaling (e.g. by mutations in

3564-550: Is situated "on the tail of 7 Hamnafield". Foula's inhabitants preserve many Norse traditions of folklore and festivities. They still follow the Julian calendar for Christmas celebrations, with all the islanders gathering in one house on 6 January. New Year's Day falls on 13 January. Vagaland 's poem "Da Sang o da Papa men" about the fishermen of Papa Stour includes an insistent chorus chant, "Rowin Foula Doon". This refers to

3672-431: Is thought to have assumed that those animals acquired some detoxifying property, so that their blood would contain transformed components of the snake venom that could induce resistance to it instead of exerting a toxic effect. Mithridates reasoned that, by drinking the blood of these animals, he could acquire a similar resistance. Fearing assassination by poison, he took daily sub-lethal doses of venom to build tolerance. He

3780-651: Is unknown, but, about 1000 AD, the Chinese began practicing a form of immunization by drying and inhaling powders derived from the crusts of smallpox lesions. Around the 15th century in India , the Ottoman Empire , and east Africa , the practice of inoculation (poking the skin with powdered material derived from smallpox crusts) was quite common. This practice was first introduced into the west in 1721 by Lady Mary Wortley Montagu [the phrase "first introduced into

3888-501: The Atlantic Ocean , 15 nautical miles (28 kilometres) west of Walls on Mainland, Shetland . It was part of Walls civil parish and now is in the parish of Walls and Sandness. The island is about 2 + 1 ⁄ 2 by 3 + 1 ⁄ 2 miles (4 by 6 kilometres), with a low-lying coastal strip along the east side. With an area of 12.7 km ( 4 + 7 ⁄ 8  sq mi), it is the eighth largest and most westerly of

3996-547: The Centers for Disease Control and Prevention (CDC) concluded that "Multiple studies in different settings have consistently shown that infection with SARS-CoV-2 and vaccination each result in a low risk of subsequent infection with antigenically similar variants for at least 6 months. Numerous immunologic studies and a growing number of epidemiologic studies have shown that vaccinating previously infected individuals significantly enhances their immune response and effectively reduces

4104-613: The Iron Age . In addition to Mousa there are significant ruins at Clickimin , Culswick , Old Scatness and West Burrafirth , although their origin and purpose is a matter of some controversy. The later Iron Age inhabitants of the Northern Isles were probably Pictish, although the historical record is sparse. Hunter (2000) states in relation to King Bridei I of the Picts in the sixth century AD: "As for Shetland, Orkney, Skye and

4212-707: The Julian calendar when the rest of the Kingdom of Great Britain adopted the Gregorian calendar in 1752. Foula adhered to the Julian calendar by keeping 1800 as a leap year, but it did not observe a leap year in 1900. As a result, Foula is now one day ahead of the Julian calendar and 12 days behind the Gregorian, observing Christmas Day on 6 January Gregorian and New Year on 13 January Gregorian. The writer and journalist John Sands lived on Foula and Papa Stour for

4320-474: The Liberal prime minister William Gladstone emancipated crofters from the rule of the landlords. The Act enabled those who had effectively been landowners' serfs to become owner-occupiers of their own small farms. By this time fishermen from Holland , who had traditionally gathered each year off the coast of Shetland to fish for herring , triggered an industry in the islands that boomed from around 1880 until

4428-685: The Mesolithic period. Picts are known to have been the original inhabitants of the islands, before the Norse conquest and subsequent colonisation in the Early Middle Ages . From the 10th to 15th centuries, the islands formed part of the Kingdom of Norway . In 1472, the Parliament of Scotland absorbed the Lordship of Shetland into the Kingdom of Scotland , following the failure to pay a dowry promised to James III of Scotland by

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4536-568: The Out Skerries to the east. The uninhabited islands include Mousa , known for the Broch of Mousa , the finest preserved example of an Iron Age broch ; Noss to the east of Bressay , which has been a national nature reserve since 1955; St Ninian's Isle , connected to Mainland by the largest active tombolo in the United Kingdom; and Out Stack , the northernmost point of the British Isles . Shetland's location means that it provides

4644-579: The Royal Navy . Some 3,000 served during the Napoleonic wars from 1800 to 1815 and press gangs were rife. During this period 120 men were taken from Fetlar alone, and only 20 of them returned home. By the late 19th century 90% of all Shetland was owned by just 32 people, and between 1861 and 1881 more than 8,000 Shetlanders emigrated. With the passing of the Crofters' Holdings (Scotland) Act 1886

4752-496: The Scalloway Islands ), Muckle Roe, Esha Ness , Fethaland and Herma Ness . The total area covered by the designation is 41,833 ha , of which 26,347 ha is marine (i.e. below low tide). In October 2018, legislation came into force in Scotland to prevent public bodies, without good reason, showing Shetland in a separate box in maps, as had often been the practice. The legislation requires the islands to be "displayed in

4860-587: The Shetland Islands , is an archipelago in Scotland lying between Orkney , the Faroe Islands , and Norway . It is the northernmost region of the United Kingdom . The islands lie about 50 miles (80 kilometres) to the northeast of Orkney, 110 mi (170 km) from mainland Scotland and 140 mi (220 km) west of Norway. They form part of the border between the Atlantic Ocean to

4968-599: The Special Operations Executive in the autumn of 1940 with a base first at Lunna and later in Scalloway to conduct operations around the coast of Norway. About 30 fishing vessels used by Norwegian refugees were gathered and the Shetland Bus conducted covert operations, carrying intelligence agents, refugees, instructors for the resistance, and military supplies. It made over 200 trips across

5076-461: The innate immune system . Naturally acquired active immunity occurs as the result of an infection. When a person is exposed to a live pathogen and develops a primary immune response , this leads to immunological memory. Many disorders of immune system function can affect the formation of active immunity, such as immunodeficiency (both acquired and congenital forms) and immunosuppression . Artificially acquired active immunity can be induced by

5184-659: The potato famine of 1846 and the government introduced a Relief Plan for the islands under the command of Captain Robert Craigie of the Royal Navy who stayed in Lerwick to oversee the project 1847–1852. During this period Craigie also did much to improve and increase roads in the islands. Population increased to a maximum of 31,670 in 1861. However, British rule came at a price for many ordinary people as well as traders. The Shetlanders' nautical skills were sought by

5292-526: The "Shaalds o' Foula", lies just over 3 km ( 1 + 1 ⁄ 2  nmi) east of Foula between the island and the Shetland Mainland . Tides here can reach 12 knots (22 km/h; 6 m/s), and as the reef comes to within less than a metre of the surface, it poses a significant threat to shipping. BK Marine Limited operates the ferry service from Ham to Walls on Mainland, Shetland. New Advance carries up to 12 passengers and completes

5400-536: The 'Lordship of Shetland', removing it from the earldom of Orkney. From the mid-13th century onwards Scottish monarchs increasingly sought to take control of the islands surrounding their seas. The process was begun in earnest by Alexander II and was continued by his successor Alexander III . This strategy eventually led to an invasion of Scotland by Haakon IV Haakonsson , King of Norway. His fleet assembled in Bressay Sound before sailing for Scotland. After

5508-512: The 'cutters' and, in the spirit of a long-standing Foula tradition, all able-bodied men are now and then "bid to the banks" of women who "didn't have a cutter in the house". Simon Martin, who stayed in Foula for five years in the 1970s while salvaging metal from Oceanic , describes the island as follows: Foula, or Ultima Thule , as it was known as far back as the Roman times, rises impurely out of

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5616-464: The 14th century, Orkney and Shetland remained Norwegian possessions, but Scottish influence was growing. Jon Haraldsson , who was murdered in Thurso in 1231, was the last of an unbroken line of Norse jarls, and thereafter the earls were Scots noblemen of the houses of Angus and St Clair . On the death of Haakon VI in 1380, Norway formed a political union with Denmark, after which the interest of

5724-412: The 1890 discovery by Behring and Kitasato of antitoxin based immunity to diphtheria and tetanus , the antitoxin became the first major success of modern therapeutic immunology. In Europe , the induction of active immunity emerged in an attempt to contain smallpox . Immunization has existed in various forms for at least a thousand years, without the terminology. The earliest use of immunization

5832-537: The 1920s when stocks of the fish began to dwindle. The production peaked in 1905 at more than a million barrels, of which 708,000 were exported. During World War I , many Shetlanders served in the Gordon Highlanders , a further 3,000 served in the Merchant Navy, and more than 1,500 in a special local naval reserve. The 10th Cruiser Squadron was stationed at Swarbacks Minn (the stretch of water to

5940-497: The 9th century. In the treatise, Al Razi describes the clinical presentation of smallpox and measles and goes on to indicate that exposure to these specific agents confers lasting immunity (although he does not use this term). Until the 19th century, the miasma theory was also widely accepted. The theory viewed diseases such as cholera or the Black Plague as being caused by a miasma, a noxious form of "bad air". If someone

6048-457: The Atlantic Ocean. In contrast, winters are considerably milder than those expected in nearby continental areas, even comparable to winter temperatures of many parts of England and Wales much further south. The general character of the climate is windy, cloudy and often wet, with at least 2 mm (0.08 in) of rain falling on more than 250 days a year. Average yearly precipitation is 1,252 mm (49.3 in), with November through January

6156-538: The German merchants had left off, and fitted out their own ships to export fish from Shetland to the Continent. For the independent farmers of Shetland this had negative consequences, as they now had to fish for these merchant-lairds. Smallpox afflicted the islands in the 17th and 18th centuries (as it did all of Europe), but as vaccines became available after 1800, health improved. The islands were very badly hit by

6264-476: The Januaries of 1952 and 1959. The frost-free period may be as little as three months. In contrast, inland areas of nearby Scandinavia on similar latitudes experience significantly larger temperature differences between summer and winter, with the average highs of regular July days comparable to Lerwick's all-time record heat that is around 23 °C (73 °F), further demonstrating the moderating effect of

6372-600: The Mortons until 1766, when they were sold by James Douglas, 14th Earl of Morton to Laurence Dundas . The trade with the North German towns lasted until the Act of Union 1707 , after which high salt duties prevented the German merchants from trading with Shetland. Shetland then went into an economic depression, as the local traders were not as skilled in trading salted fish. However, some local merchant-lairds took up where

6480-525: The Norse heritage of the isles, including the Up Helly Aa fire festivals and a strong musical tradition, especially the traditional fiddle style. Almost all place names in the islands have Norse origin. The islands have produced a variety of prose writers and poets, who have often written in the distinctive Shetland dialect of the Scots language . Many areas on the islands have been set aside to protect

6588-511: The Roman discovery and conquest of Orkney, he added that the Roman fleet had seen " Thule , too". In early Irish literature, Shetland is referred to as Insi Catt — "the Isles of Cats" (meaning the island inhabited by the tribe called Cat ). This may have been the pre-Norse inhabitants' name for the islands. Cat was the name of a Pictish people who occupied parts of the northern Scottish mainland (see Kingdom of Cat ); and their name survives in

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6696-719: The Scottish crown for their territory on mainland Britain, which they held as the Mormaer of Caithness , but owed allegiance to the Norwegian crown for Orkney and Shetland. In 1194, when Harald Maddadsson was Earl of Orkney, a rebellion broke out against King Sverre Sigurdsson of Norway. The Eyjarskeggjar ("Island Beardies") sailed for Norway but were beaten in the Battle of Florvåg near Bergen . After his victory, King Sverre placed Shetland under direct Norwegian rule in 1195 as

6804-513: The Scottish mainland. There are also Old Red Sandstone deposits and granite intrusions. The most distinctive feature is the ophiolite in Unst and Fetlar which is a remnant of the Iapetus Ocean floor made up of ultrabasic peridotite and gabbro . Much of Shetland's economy depends on the oil-bearing sediments in the surrounding seas. Geological evidence shows that in around 6100 BC

6912-584: The Shetland Islands. It rises from low broken cliffs in the east to precipitous 150–365 m (490–1,200 ft) cliffs in the west. The island has five peaks, rising to 418 m (1,371 ft) at the Sneug and 376 m (1,234 ft) at the Kame. At the north end is Gaada Stack, a natural arch and towards the south-west is Da Sneck Ida Smaalie, a spectacular 30 m deep and 2 m wide crack in

7020-430: The Stout during a visit to Orkney and said, "I order you and all your subjects to be baptised. If you refuse, I'll have you killed on the spot and I swear I will ravage every island with fire and steel". Unsurprisingly, Sigurd agreed, and the islands became Christian at a stroke. The Scottish crown claimed the overlordship of the Caithness and Sutherland area from Norway in 1098. The jarls thereafter owed allegiance to

7128-475: The Viking Health Study are severely flawed as they account for only a tiny fraction of the population. Vikings then used the islands as a base for pirate expeditions to Norway and the coasts of mainland Scotland. In response, Norwegian king Harald Hårfagre ("Harald Fair Hair") annexed the Northern Isles (comprising Orkney and Shetland) in 875. Rognvald Eysteinsson received the Earldom of Orkney , which then included Shetland, from Harald as reparation for

7236-415: The Western Isles, their inhabitants, most of whom appear to have been Pictish in culture and speech at this time, are likely to have regarded Bridei as a fairly distant presence". In 2011, the collective site, " The Crucible of Iron Age Shetland ", including Broch of Mousa, Old Scatness and Jarlshof, joined the UKs "Tentative List" of World Heritage Sites . The expanding population of Scandinavia led to

7344-708: The ability to cause serious disease. Pasteur adopted the name vaccine as a generic term in honor of Jenner's discovery, which Pasteur's work built upon. In 1807, Bavaria became the first group to require their military recruits to be vaccinated against smallpox, as the spread of smallpox was linked to combat. Subsequently, the practice of vaccination would increase with the spread of war. There are four types of traditional vaccines : In addition, there are some newer types of vaccines in use: A variety of vaccine types are under development; see Experimental Vaccine Types . Most vaccines are given by hypodermic or intramuscular injection as they are not absorbed reliably through

7452-453: The bulk of visitors to the island. The island has been designated an Important Bird Area (IBA) by BirdLife International because it supports large colonies of cliff- and moorland -nesting seabirds . Foula was first inhabited as far back as 5,000 years ago. Between 2006 and 2008, the Bath & Camerton Archeological Society took several trips to Foula to study prehistoric standing stones . A particular sub-circular stone circle of interest

7560-401: The cliffs. Foula lies on the same latitude as Saint Petersburg . Foula has a population of 38 people, living in Hametun and Ham. Islanders previously made a living from fishing – first for whitefish , then lobster . Today, most islanders are crofters with income from sheep farming and birdwatching tourism . The island retains a post office in Ham. A hidden reef, the "Hoevdi Grund" or

7668-413: The course of the disease and were themselves free from apprehensions. For no one was ever attacked a second time, or not with a fatal result". Active immunotherapy may have begun with Mithridates VI of Pontus (120-63 BC) who, to induce active immunity for snake venom, recommended using a method similar to modern toxoid serum therapy , by drinking the blood of animals which fed on venomous snakes. He

7776-471: The death of his son in battle in Scotland, and then passed the earldom on to his brother Sigurd the Mighty . Sigurd went on to conquer further territory; by the time of his death in 892, the earldom of Orkney stretched from Shetland down to Caithness and Sutherland on mainland Britain. The islands converted to Christianity in the late 10th century. King Olaf I Tryggvasson summoned the jarl Sigurd

7884-452: The face of some opposition. However, inoculation had been reported in Wales since the early 17th century"]. In 1798, Edward Jenner introduced the far safer method of deliberate infection with cowpox virus, ( smallpox vaccine ), which caused a mild infection that also induced immunity to smallpox. By 1800, the procedure was referred to as vaccination . To avoid confusion, smallpox inoculation

7992-426: The family of his bride, Margaret of Denmark . After Scotland and England united in 1707 to form the Kingdom of Great Britain , trade between Shetland and continental Northern Europe decreased. The discovery of North Sea oil in the 1970s significantly boosted Shetland's economy, employment and public-sector revenues. Fishing has always been an important part of the islands' economy. The local way of life reflects

8100-473: The fishermen's practice of rowing their open fishing boat out to sea until the high cliffs of Foula were no longer visible. This entailed the boat's being some 96 kilometres (60 mi) west of Papa Stour. The Sneug in Foula was the origin ( meridian ) of the 6 inch and 1:2500 Ordnance Survey maps of Orkney and Shetland. 60°08′N 02°04′W  /  60.133°N 2.067°W  / 60.133; -2.067 Shetland Shetland , also called

8208-704: The following year the Northern Isles were directly absorbed by the Crown of Scotland, an action confirmed by the Parliament of Scotland in 1472. Nonetheless, Shetland's connection with Norway has proved to be enduring. From the early 15th century onward Shetlanders sold their goods through the Hanseatic League of German merchantmen. The Hansa would buy shiploads of salted fish, wool and butter, and import salt , cloth , beer and other goods. The late 16th century and early 17th century were dominated by

8316-559: The form of monoclonal antibodies (MAb). Passive transfer is used prophylactically in the case of immunodeficiency diseases, such as hypogammaglobulinemia . It is also used in the treatment of several types of acute infection, and to treat poisoning . Immunity derived from passive immunization lasts for only a short period of time, and there is also a potential risk for hypersensitivity reactions, and serum sickness , especially from gamma globulin of non-human origin. The artificial induction of passive immunity has been used for over

8424-491: The greatest concentration of services and facilities. They are the three settlements in the table above, plus Aith , Baltasound , Mid Yell , Sandwick , and Symbister . List of islands by largest population: Due to the practice, dating to at least the early Neolithic , of building in stone on virtually treeless islands, Shetland is extremely rich in physical remains of the prehistoric eras and there are over 5,000 archaeological sites all told. A midden site at West Voe on

8532-433: The group is known as Mainland . The next largest are Yell , Unst , and Fetlar , which lie to the north, and Bressay and Whalsay , which lie to the east. East and West Burra , Muckle Roe , Papa Stour , Trondra , and Vaila are smaller islands to the west of Mainland. The other inhabited islands are Foula 17 mi (28 km) west of Walls , Fair Isle 24 mi (38 km) south-west of Sumburgh Head , and

8640-477: The gut. Live attenuated polio and some typhoid and cholera vaccines are given orally in order to produce immunity based in the bowel . Hybrid immunity is the combination of natural immunity and artificial immunity. Studies of hybrid-immune people found that their blood was better able to neutralize the Beta and other variants of SARS-CoV-2 than never-infected, vaccinated people. Moreover, on 29 October 2021,

8748-567: The host immune response, mediated by antigen-specific lymphocytes . Unlike the innate immunity, the acquired immunity is highly specific to a particular pathogen, including the development of immunological memory . Like the innate system, the acquired system includes both humoral immunity components and cell-mediated immunity components. Adaptive immunity can be acquired either 'naturally' (by infection) or 'artificially' (through deliberate actions such as vaccination). Adaptive immunity can also be classified as 'active' or 'passive'. Active immunity

8856-423: The immune system create a dynamic biological environment where "health" can be seen as a physical state where the self is immunologically spared, and what is foreign is inflammatorily and immunologically eliminated. "Disease" can arise when what is foreign cannot be eliminated or what is self is not spared. Innate immunity, also known as native immunity, is a semi-specific and widely distributed form of immunity. It

8964-414: The influence of the despotic Robert Stewart , Earl of Orkney, who was granted the islands by his half-sister Mary Queen of Scots , and his son Patrick . The latter commenced the building of Scalloway Castle , but after his imprisonment in 1609, the Crown annexed Orkney and Shetland again until 1643, when Charles I granted them to William Douglas, 7th Earl of Morton . These rights were held on and off by

9072-471: The inhabitants of the islands was replaced by the Shetland dialect of Scots and Hjaltland became Ȝetland . The initial letter is the Middle Scots letter, yogh , the pronunciation of which is almost identical to the original Norn sound, /hj/ . When the use of the letter yogh was discontinued, it was often replaced by the similar-looking letter z (which at the time was usually rendered with

9180-555: The islands' latitude , on clear winter nights the northern lights can sometimes be seen in the sky, while in summer there is almost perpetual daylight , a state of affairs known locally as the "simmer dim". Annual bright sunshine averages 1110 hours, and overcast days are common. There are only three settlements with a population over 500, being the town of Lerwick and the villages of Scalloway and Brae. 6,760 1,170 750 For town planning purposes, Shetland Islands Council has identified eight 'Tier 1' settlements, being areas with

9288-622: The land be built"). The phrase is of Old Norse origin, is mentioned in Njáls saga , and was likely borrowed from provincial Norwegian laws such as the Frostathing Law . The name Shetland may derive from the Old Norse words hjalt (' hilt '), and land ('land'), the popular and traditional claim. Another possibility is that the first syllable is derived from the name of an ancient Celtic tribe . Andrew Jennings has suggested

9396-505: The local fauna and flora , including a number of important seabird nesting sites. The Shetland pony and Shetland Sheepdog are two well-known Shetland animal breeds . Other animals with local breeds include the Shetland sheep , cow , goose , and duck . The Shetland pig, or grice , has been extinct since about 1930. The islands' motto, which appears on the Council's coat of arms , is " Með lögum skal land byggja " ("By law shall

9504-681: The names of the county of Caithness and in the Scottish Gaelic name for Sutherland , Cataibh , which means "among the Cats". The oldest known version of the modern name Shetland is Hetland ; this may represent "Catland", the Germanic language softening the C- to H- according to Grimm's law (also coinciding with Jennings' hypothesis for the early sound shift necessary for descent from *kalid- to *halit- , from Caledones ). It occurs in

9612-502: The risk of subsequent infection, including in the setting of increased circulation of more infectious variants. ..." Immunity is determined genetically. Genomes in humans and animals encode the antibodies and numerous other immune response genes. While many of these genes are generally required for active and passive immune responses (see sections above), there are also many genes that appear to be required for very specific immune responses. For instance, Tumor Necrosis Factor (TNF)

9720-538: The rock with the inhabitants. The island’s surface largely consisting of a peat bog on rock. A lighthouse at the southern tip of the island was built in 1986. Originally powered by acetylene gas, it has been converted to solar and wind power. Many inhabitants of Foula attend the Presbyterian Kirk, also known as Baxter Chapel, that is part of the Church of Scotland . It is made of grey-coloured stone and

9828-415: The royal house in the islands declined. In 1469, Shetland was pledged by Christian I , in his capacity as King of Norway, as security against the payment of the dowry of his daughter Margaret , betrothed to James III of Scotland . As the money was never paid, the connection with the Crown of Scotland became permanent. In 1470, William Sinclair, 1st Earl of Caithness , ceded his title to James III, and

9936-428: The same pathogen later. A fetus naturally acquires passive immunity from its mother during pregnancy. Maternal passive immunity is antibody -mediated immunity. The mother's antibodies (MatAb) are passed through the placenta to the fetus by an FcRn receptor on placental cells. This occurs around the third month of gestation . IgG is the only antibody isotype that can pass through the placenta. Passive immunity

10044-423: The sea, and Leif Larsen , the most highly decorated allied naval officer of the war, made 52 of them. Several RAF airfields and sites were also established at Sullom Voe and several lighthouses suffered enemy air attacks. Oil reserves discovered in the later 20th century in the seas both east and west of Shetland have provided a much-needed alternative source of income for the islands. The East Shetland Basin

10152-497: The south coast of Mainland, dated to 4320–4030 BC, has provided the first evidence of Mesolithic human activity in Shetland. The same site provides dates for early Neolithic activity and finds at Scord of Brouster in Walls have been dated to 3400 BC. "Shetland knives" are stone tools that date from this period made from felsite from Northmavine . Pottery shards found at the important site of Jarlshof also indicate that there

10260-408: The south of Muckle Roe), and during a single year from March 1917 more than 4,500 ships sailed from Lerwick as part of an escorted convoy system. In total, Shetland lost more than 500 men, a higher proportion than any other part of Britain, and there were further waves of emigration in the 1920s and 1930s. During World War II , a Norwegian naval unit nicknamed the " Shetland Bus " was established by

10368-680: The stalemate of the Battle of Largs , Haakon retreated to Orkney, where he died in December 1263, entertained on his deathbed by recitations of the sagas. His death halted any further Norwegian expansion in Scotland and following this ill-fated expedition, the Hebrides and Mann were yielded to the Kingdom of Scotland as a result of the 1266 Treaty of Perth , although the Scots recognised continuing Norwegian sovereignty over Orkney and Shetland. In

10476-409: The term by referring to polio vaccine , measles vaccine etc. Passive immunity is the immunity acquired by the transfer of ready-made antibodies from one individual to another. Passive immunity can occur naturally, such as when maternal antibodies are transferred to the foetus through the placenta, and can also be induced artificially, when high levels of human (or horse ) antibodies specific for

10584-443: The transfer of "sensitized" or activated T-cells from one individual into another. It is rarely used in humans because it requires histocompatible (matched) donors, which are often difficult to find. In unmatched donors this type of transfer carries severe risks of graft versus host disease . It has, however, been used to treat certain diseases including some types of cancer and immunodeficiency . This type of transfer differs from

10692-493: The voyage in about two hours. Flights take off from Foula Airfield to Tingwall Airport . A ferry service ran from Foula to Scalloway until 2010. There is little shelter for boats in the island. The only beach is at the head of Ham Voe on the east coast. Local boats, including the mail boat , are hauled out of the water. The island's 370-metre (1,210 ft) cliffs are home to numerous birds, including Arctic terns , red-throated divers and great skuas , and birders make up

10800-623: The water, and from the Shetland Isles mainland its five peaks, the Noup, Hamnafield, the Sneug, Kame and Soberlie stand out starkly and characteristically. The cliffs on the west side vie with those of St Kilda as the highest sheer cliffs in Britain, 1,200 feet (370 metres) of solid rock towering from the sea. Foula, or Fughley as it was once also known, means literally 'Bird Island', with an estimated half million birds of various breeds sharing

10908-609: The west and the North Sea to the east. Their total area is 1,467 km (566 sq mi), and the population totalled 23,020 in 2022. The islands comprise the Shetland constituency of the Scottish Parliament . Shetland forms one of the 32 council areas of Scotland; the local authority is the Shetland Islands Council . The islands' administrative centre, largest settlement and only burgh

11016-568: The west in 1721 by lady Montagu" is quite not accurate and should be rendered "first promoted in the west, by lady Montague, in 1721". Because, as you can read here https://en.wikipedia.org/wiki/Variolation , the procedure was already known in Wales: "The method was first used in China, India, parts of Africa and the Middle East before it was introduced into England and North America in the 1720s in

11124-431: The wettest months, averaging 5.6 to 5.9 inches of precipitation, mostly rain. Snowfall is usually confined to the period November to February, and snow seldom lies on the ground for more than a day. Relatively less rain falls from April to July, although on average, no month receives less than 50 mm (2.0 in). Fog is common during summer due to the cooling effect of the sea on mild southerly airflows. Because of

11232-535: Was Neolithic activity there although the main settlement dates from the Bronze Age . This includes a smithy , a cluster of wheelhouses and a later broch. The site has provided evidence of habitation during various phases right up until Viking times. Heel-shaped cairns , are a style of chambered cairn unique to Shetland, with a particularly large example in Vementry . Numerous brochs were erected during

11340-552: Was discovered in 2006 at Da Heights in the north of Foula. A further investigation launched in 2007 revealed that the sub-circular stone construction was man-made, elliptical in shape with the axis pointing towards the mid-winter solstice , built before 1000 BC. In 1490, the Ciske family's estates were divided and Vaila and Foula became the property of Alv Knutsson. However, the Ciskes were Norwegian, and as Scotland had annexed Shetland

11448-460: Was exposed to the miasma in a swamp, in evening air, or breathing air in a sickroom or hospital ward, they could catch a disease. Since the 19th century, communicable diseases came to be viewed as being caused by germs/microbes. The modern word "immunity" derives from the Latin immunis, meaning exemption from military service, tax payments or other public services. The first scientist who developed

11556-417: Was increasingly referred to as variolation , and it became common practice to use this term without regard for chronology. The success and general acceptance of Jenner's procedure would later drive the general nature of vaccination developed by Pasteur and others towards the end of the 19th century. In 1891, Pasteur widened the definition of vaccine in honour of Jenner, and it then became essential to qualify

11664-451: Was quite poorly acquainted with the language, so that, although he had as a child memorised all 35 stanzas of the ballad in the original Norn, he could give Low only a summary of its content rather than a translation. "Hildina" is the only extant poem in Norn. Professor Ian Holbourn purchased Foula around 1900, becoming its last laird . He described the disaster of 8 September 1914, when the armed merchant cruiser HMS Oceanic , formerly

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