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82-545: The Luton/Dunstable urban area , according to the Office for National Statistics , is the conurbation (continuous built up area) including the settlements of Luton , Dunstable and Houghton Regis , in Bedfordshire , East of England . Despite straddling district boundaries the conurbation shares many facilities including an integrated bus service and the large Luton and Dunstable University Hospital . The conurbation

164-437: A causal association does not exist in general. Conversely, it can be (and is in some circumstances) taken by US courts, in an individual case, to justify an inference that a causal association does exist, based upon a balance of probability . The subdiscipline of forensic epidemiology is directed at the investigation of specific causation of disease or injury in individuals or groups of individuals in instances in which causation

246-451: A duty to assess all UK government statistics. Following Gordon Brown's announcement of new constitutional arrangements for public appointments, Sir Michael also became, on 18 July, the first such nominee to appear before the House of Commons Treasury Committee and to have his nomination subject to confirmation by the House. On 7 February 2008, following the first meeting of the shadow board, it

328-832: A head office in the city of Newport , Wales, and other offices in 2 Marsham Street in London and Titchfield in Hampshire. The Family Records Centre in Myddelton Street in Islington , London, moved to the National Archives in Kew in 2008. They also have an Archive Storage site located in Christchurch , Dorset. The London (Pimlico) office was the head office until April 2006 when the corporate headquarters

410-498: A health system responds to current population health issues but also how a health system can be managed to better respond to future potential population health issues. Examples of organizations that use population-based health management that leverage the work and results of epidemiological practice include Canadian Strategy for Cancer Control, Health Canada Tobacco Control Programs, Rick Hansen Foundation, Canadian Tobacco Control Research Initiative. Each of these organizations uses

492-521: A lesser extent, basic research in the biological sciences. Major areas of epidemiological study include disease causation, transmission , outbreak investigation, disease surveillance , environmental epidemiology , forensic epidemiology , occupational epidemiology , screening , biomonitoring , and comparisons of treatment effects such as in clinical trials . Epidemiologists rely on other scientific disciplines like biology to better understand disease processes, statistics to make efficient use of

574-787: A population (endemic). The term "epidemiology" appears to have first been used to describe the study of epidemics in 1802 by the Spanish physician Joaquín de Villalba  [ es ] in Epidemiología Española . Epidemiologists also study the interaction of diseases in a population, a condition known as a syndemic . The term epidemiology is now widely applied to cover the description and causation of not only epidemic, infectious disease, but of disease in general, including related conditions. Some examples of topics examined through epidemiology include as high blood pressure, mental illness and obesity . Therefore, this epidemiology

656-520: A population-based health management framework called Life at Risk that combines epidemiological quantitative analysis with demographics, health agency operational research and economics to perform: Applied epidemiology is the practice of using epidemiological methods to protect or improve the health of a population. Applied field epidemiology can include investigating communicable and non-communicable disease outbreaks, mortality and morbidity rates, and nutritional status, among other indicators of health, with

738-480: A portrait of the country as its population evolves over time. This is often produced in ways that make comparison with other societies and economies possible. Much of the data on which policy-makers depend is produced by ONS through a combination of a decennial population census, samples and surveys and analysis of data generated by businesses and organisations such as the National Health Service and

820-422: A prospective study, and confounders are more easily controlled for. However, they are more costly, and there is a greater chance of losing subjects to follow-up based on the long time period over which the cohort is followed. Cohort studies also are limited by the same equation for number of cases as for cohort studies, but, if the base incidence rate in the study population is very low, the number of cases required

902-402: A random sample from the original population at risk. This has as a consequence that the control group can contain people with the disease under study when the disease has a high attack rate in a population. A major drawback for case control studies is that, in order to be considered to be statistically significant, the minimum number of cases required at the 95% confidence interval is related to

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984-445: A unique disease process different from any other individual ("the unique disease principle"), considering uniqueness of the exposome (a totality of endogenous and exogenous / environmental exposures) and its unique influence on molecular pathologic process in each individual. Studies to examine the relationship between an exposure and molecular pathologic signature of disease (particularly cancer ) became increasingly common throughout

1066-542: Is a stub . You can help Misplaced Pages by expanding it . Office for National Statistics The Office for National Statistics ( ONS ; Welsh : Swyddfa Ystadegau Gwladol ) is the executive office of the UK Statistics Authority , a non-ministerial department which reports directly to the UK Parliament . The ONS is responsible for the collection and publication of statistics related to

1148-399: Is a core component, that is unified with management science to provide efficient and effective health care and health guidance to a population. This task requires the forward-looking ability of modern risk management approaches that transform health risk factors, incidence, prevalence and mortality statistics (derived from epidemiological analysis) into management metrics that not only guide how

1230-428: Is based upon how the pattern of the disease causes change in the function of human beings. The Greek physician Hippocrates , taught by Democritus, was known as the father of medicine , sought a logic to sickness; he is the first person known to have examined the relationships between the occurrence of disease and environmental influences. Hippocrates believed sickness of the human body to be caused by an imbalance of

1312-479: Is beyond the domain of the science of epidemiology. Epidemiology has its limits at the point where an inference is made that the relationship between an agent and a disease is causal (general causation) and where the magnitude of excess risk attributed to the agent has been determined; that is, epidemiology addresses whether an agent can cause disease, not whether an agent did cause a specific plaintiff's disease. In United States law, epidemiology alone cannot prove that

1394-483: Is disputed or is unclear, for presentation in legal settings. Epidemiological practice and the results of epidemiological analysis make a significant contribution to emerging population-based health management frameworks. Population-based health management encompasses the ability to: Modern population-based health management is complex, requiring a multiple set of skills (medical, political, technological, mathematical, etc.) of which epidemiological practice and analysis

1476-537: Is famous for his investigations into the causes of the 19th-century cholera epidemics, and is also known as the father of (modern) Epidemiology. He began with noticing the significantly higher death rates in two areas supplied by Southwark Company. His identification of the Broad Street pump as the cause of the Soho epidemic is considered the classic example of epidemiology. Snow used chlorine in an attempt to clean

1558-499: Is in the term inference . Correlation, or at least association between two variables, is a necessary but not sufficient criterion for the inference that one variable causes the other. Epidemiologists use gathered data and a broad range of biomedical and psychosocial theories in an iterative way to generate or expand theory, to test hypotheses, and to make educated, informed assertions about which relationships are causal, and about exactly how they are causal. Epidemiologists emphasize that

1640-418: Is increasing recognition that a wide range of modern data sources, many not originating from healthcare or epidemiology, can be used for epidemiological study. Such digital epidemiology can include data from internet searching, mobile phone records and retail sales of drugs. Epidemiologists employ a range of study designs from the observational to experimental and generally categorized as descriptive (involving

1722-444: Is located in the southern part of the ceremonial county of Bedfordshire , England , and includes the unitary authority of Luton , and part of Central Bedfordshire . The current population (2021 census) is 286,803. This is an increase of 9% from the 2011 population of 258,018. The area is expected to grow due to development within and physical expansion of the three towns and large re-development of Luton, including redevelopment of

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1804-731: Is much criticism of the ONS's performance, particularly of the size and frequency of revisions, that this criticism is "not entirely justified". Following the review, the then-Chair of the Treasury Select Committee , Andrew Tyrie , criticised the ONS for being "out of touch". In 2019, the ONS admitted that EU migration to the UK may have been underestimated due to methodology of the International Passenger Survey. Epidemiology Epidemiology

1886-404: Is reduced by  1 ⁄ 2 . Although epidemiology is sometimes viewed as a collection of statistical tools used to elucidate the associations of exposures to health outcomes, a deeper understanding of this science is that of discovering causal relationships. " Correlation does not imply causation " is a common theme for much of the epidemiological literature. For epidemiologists, the key

1968-648: Is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population . It is a cornerstone of public health , and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare . Epidemiologists help with study design, collection, and statistical analysis of data, amend interpretation and dissemination of results (including peer review and occasional systematic review ). Epidemiology has helped develop methodology used in clinical research , public health studies, and, to

2050-521: Is typically determined using DNA from peripheral blood leukocytes. Since the 2000s, genome-wide association studies (GWAS) have been commonly performed to identify genetic risk factors for many diseases and health conditions. While most molecular epidemiology studies are still using conventional disease diagnosis and classification systems, it is increasingly recognized that disease progression represents inherently heterogeneous processes differing from person to person. Conceptually, each individual has

2132-439: Is used to describe the intersection of Host , Agent , and Environment in analyzing an outbreak. Case-series may refer to the qualitative study of the experience of a single patient, or small group of patients with a similar diagnosis, or to a statistical factor with the potential to produce illness with periods when they are unexposed. The former type of study is purely descriptive and cannot be used to make inferences about

2214-663: The Statistics and Registration Service Act 2007 . In July 2007, Sir Michael Scholar was nominated by the government to be the three-day-a-week non-executive chairman of the Statistics Board which, with the intention of re-establishing faith in the integrity of government statistics, was to take on statutory responsibility for oversight of UK statistics in April 2008 and oversee the Office for National Statistics; also having

2296-476: The " one cause – one effect " understanding is a simplistic mis-belief. Most outcomes, whether disease or death, are caused by a chain or web consisting of many component causes. Causes can be distinguished as necessary, sufficient or probabilistic conditions. If a necessary condition can be identified and controlled (e.g., antibodies to a disease agent, energy in an injury), the harmful outcome can be avoided (Robertson, 2015). One tool regularly used to conceptualize

2378-459: The "who, what, where and when of health-related state occurrence". However, analytical observations deal more with the 'how' of a health-related event. Experimental epidemiology contains three case types: randomized controlled trials (often used for a new medicine or drug testing), field trials (conducted on those at a high risk of contracting a disease), and community trials (research on social originating diseases). The term 'epidemiologic triad'

2460-794: The 'Head Office' of the Government Statistical Service (GSS). Its main office is in Newport near the United Kingdom Intellectual Property Office and Tredegar House , but another significant office is in Titchfield in Hampshire, and a small office is in London. ONS co-ordinates data collection with the respective bodies in Northern Ireland and Scotland, namely NISRA and NRS . The ONS was formed on 1 April 1996 by

2542-515: The 2000s. However, the use of molecular pathology in epidemiology posed unique challenges, including lack of research guidelines and standardized statistical methodologies, and paucity of interdisciplinary experts and training programs. Furthermore, the concept of disease heterogeneity appears to conflict with the long-standing premise in epidemiology that individuals with the same disease name have similar etiologies and disease processes. To resolve these issues and advance population health science in

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2624-487: The 2004 Big Brother Award for the "Most Heinous Government Organisation" from the campaigning organisation Privacy International for its Citizen Information Project . The project is one of several that led the Information Commissioner to warn that there is a danger of the country "sleepwalking" into a surveillance society . In December 2012 the organisation's new website to provide statistics to

2706-504: The 2010s. By 2012, it was recognized that many pathogens' evolution is rapid enough to be highly relevant to epidemiology, and that therefore much could be gained from an interdisciplinary approach to infectious disease integrating epidemiology and molecular evolution to "inform control strategies, or even patient treatment." Modern epidemiological studies can use advanced statistics and machine learning to create predictive models as well as to define treatment effects. There

2788-693: The Exchequer, announced on 28 November 2005, that the government intended to publish plans in early 2006 to legislate that the ONS and the statistics it generates are independent of government on a model based on the independence of the Monetary Policy Committee of the Bank of England. This was originally a 1997 Labour manifesto commitment and was also the policy of the Liberal Democrat and Conservative parties. Such independence

2870-873: The Home Office, the Department of Health , and the Department for Education and Skills . ONS is also responsible for the maintenance of the Inter-Departmental Business Register and the Business Structure Database . Before the establishment of the UK Statistics Authority , the statistical work of ONS, since June 2000, was scrutinised by the Statistics Commission , an independent body with its own chairman and small staff. This ceased to operate from 1 April 2008. The General Register Office and

2952-554: The ONS already acted independently, as per its own published guidelines, the National Statistics Code of Practice, which set out the key principles and standards that official statisticians, including those in other parts of the government statistical service, were expected to follow and uphold). The details of the plans for independence were considered in Parliament during the 2006/2007 session and resulted in

3034-642: The ONS. John Pullinger replaced Jil Matheson as National Statistician (and Chief Executive of the UK Statistics Authority) in July 2014. Pullinger retired in June 2019 and in October 2019 professor Sir Ian Diamond assumed the role of National Statistician. The work of the ONS covers the collection of data and the analysis and publication of statistics covering the economy, population, and society of

3116-560: The OR, a RR greater than 1 shows association, where the conclusion can be read "those with the exposure were more likely to develop the disease." Prospective studies have many benefits over case control studies. The RR is a more powerful effect measure than the OR, as the OR is just an estimation of the RR, since true incidence cannot be calculated in a case control study where subjects are selected based on disease status. Temporality can be established in

3198-480: The UK. Where data is broken down by geographical area, this is usually done by the areas defined in the ONS geographical coding system . The principal areas of data collection include: Statisticians are also employed by many other Government departments and agencies, and these statisticians often collect and publish data. They are members of the Government Statistical Service and are the professional responsibility of

3280-407: The assessment of data covering time, place, and person), analytic (aiming to further examine known associations or hypothesized relationships), and experimental (a term often equated with clinical or community trials of treatments and other interventions). In observational studies, nature is allowed to "take its course", as epidemiologists observe from the sidelines. Conversely, in experimental studies,

3362-414: The case control study. However, the point estimate generated is the relative risk (RR), which is the probability of disease for a person in the exposed group, P e  =  A  / ( A  +  B ) over the probability of disease for a person in the unexposed group, P u  =  C  / ( C  +  D ), i.e. RR  =  P e  /  P u . As with

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3444-429: The causation of the disease. Case-control studies are usually faster and more cost-effective than cohort studies but are sensitive to bias (such as recall bias and selection bias ). The main challenge is to identify the appropriate control group; the distribution of exposure among the control group should be representative of the distribution in the population that gave rise to the cases. This can be achieved by drawing

3526-427: The cause-and-effect hypothesis and none can be required sine qua non ." Epidemiological studies can only go to prove that an agent could have caused, but not that it did cause, an effect in any particular case: Epidemiology is concerned with the incidence of disease in populations and does not address the question of the cause of an individual's disease. This question, sometimes referred to as specific causation,

3608-445: The data and draw appropriate conclusions, social sciences to better understand proximate and distal causes, and engineering for exposure assessment . Epidemiology , literally meaning "the study of what is upon the people", is derived from Greek epi  'upon, among' demos  'people, district' and logos  'study, word, discourse', suggesting that it applies only to human populations. However,

3690-497: The disease to the cases in the series. A prospective study would involve following the case series over time to evaluate the disease's natural history. The latter type, more formally described as self-controlled case-series studies, divide individual patient follow-up time into exposed and unexposed periods and use fixed-effects Poisson regression processes to compare the incidence rate of a given outcome between exposed and unexposed periods. This technique has been extensively used in

3772-728: The economic and social policies and monitor the economic progress of the United Kingdom. It also allows international comparisons to be made. The Blue Book is published alongside the United Kingdom Balance of Payments – The Pink Book . The Office for National Statistics collaborates with the University of Southampton in the teaching of an MSc in Official Statistics; the programme has been running since 2003. The Virtual Microdata Laboratory (VML)

3854-624: The economy, population and society of the United Kingdom; responsibility for some areas of statistics in Scotland , Northern Ireland and Wales is devolved to the devolved governments for those areas. The ONS functions as the executive office of the National Statistician , who is also the UK Statistics Authority's Chief Executive and principal statistical adviser to the UK's National Statistics Institute, and

3936-612: The epidemiologist is the one in control of all of the factors entering a certain case study. Epidemiological studies are aimed, where possible, at revealing unbiased relationships between exposures such as alcohol or smoking, biological agents , stress , or chemicals to mortality or morbidity . The identification of causal relationships between these exposures and outcomes is an important aspect of epidemiology. Modern epidemiologists use informatics and infodemiology as tools. Observational studies have two components, descriptive and analytical. Descriptive observations pertain to

4018-771: The era of molecular precision medicine , "molecular pathology" and "epidemiology" was integrated to create a new interdisciplinary field of " molecular pathological epidemiology " (MPE), defined as "epidemiology of molecular pathology and heterogeneity of disease". In MPE, investigators analyze the relationships between (A) environmental, dietary, lifestyle and genetic factors; (B) alterations in cellular or extracellular molecules; and (C) evolution and progression of disease. A better understanding of heterogeneity of disease pathogenesis will further contribute to elucidate etiologies of disease. The MPE approach can be applied to not only neoplastic diseases but also non-neoplastic diseases. The concept and paradigm of MPE have become widespread in

4100-534: The fact that few of the experienced staff working in these highly technical areas were expected to relocate to Newport, resulting in a substantial loss of expertise and a consequent threat to the continued quality of the statistics. In a submission to the Parliamentary Treasury Sub Committee, the Bank of England expressed concern over the relocation of the ONS to Newport , saying, that "the relocation programme poses serious risks to

4182-571: The field and advanced methods to study cancer, a disease with patterns and mode of occurrences that could not be suitably studied with the methods developed for epidemics of infectious diseases. Geography pathology eventually combined with infectious disease epidemiology to make the field that is epidemiology today. Another breakthrough was the 1954 publication of the results of a British Doctors Study , led by Richard Doll and Austin Bradford Hill , which lent very strong statistical support to

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4264-756: The former Vauxhall Motors factory complex. The Luton & Dunstable urban area is considered part of the Milton Keynes and South Midlands Sub Region , part of the East of England . the East of England Regional Spatial Strategy has outlined the identified the urban area for growth, as part of the Sustainable Communities Plan . It is also considered part of the London Commuter Belt . This Bedfordshire location article

4346-405: The four humors (black bile, yellow bile, blood, and phlegm). The cure to the sickness was to remove or add the humor in question to balance the body. This belief led to the application of bloodletting and dieting in medicine. He coined the terms endemic (for diseases usually found in some places but not in others) and epidemic (for diseases that are seen at some times but not others). In

4428-458: The general population of patients with that disease. These types of studies, in which an astute clinician identifies an unusual feature of a disease or a patient's history, may lead to a formulation of a new hypothesis. Using the data from the series, analytic studies could be done to investigate possible causal factors. These can include case-control studies or prospective studies. A case-control study would involve matching comparable controls without

4510-624: The head of the service, who is also the National Statistician. Each department has a statistical service Head of Profession . For example, data on Agriculture, Fishing and Forestry comes primarily from the Department for the Environment, Food and Rural Affairs . Along with economic data on which the Treasury and Bank of England rely for decision-making, many of the statistics that receive widespread media attention are issued by

4592-575: The link between tobacco smoking and lung cancer . In the late 20th century, with the advancement of biomedical sciences, a number of molecular markers in blood, other biospecimens and environment were identified as predictors of development or risk of a certain disease. Epidemiology research to examine the relationship between these biomarkers analyzed at the molecular level and disease was broadly named " molecular epidemiology ". Specifically, " genetic epidemiology " has been used for epidemiology of germline genetic variation and disease. Genetic variation

4674-403: The main etiological work that brought forward the concept. His concepts were still being considered in analysing SARS outbreak by WHO in 2004 in the context of traditional Chinese medicine. Another pioneer, Thomas Sydenham (1624–1689), was the first to distinguish the fevers of Londoners in the later 1600s. His theories on cures of fevers met with much resistance from traditional physicians at

4756-444: The maintenance of the quality of macroeconomic data. If substantial numbers of ONS staff are unwilling to relocate, the loss of skilled individuals could have a severe impact on a range of statistics." The director of ONS at the time vigorously defended the implementation of government policy on civil service relocation and the decision to concentrate staff in the three locations outside London. The Office for National Statistics won

4838-603: The merger of the Central Statistical Office (CSO) and the Office of Population Censuses and Surveys (OPCS). Following the Statistics and Registration Service Act 2007 , the United Kingdom Statistics Authority became a non-ministerial department on 1 April 2008. ONS produces and publishes a wide range of the information about the United Kingdom that can be used for social and economic policy-making as well as painting

4920-448: The middle of the 16th century, a doctor from Verona named Girolamo Fracastoro was the first to propose a theory that the very small, unseeable, particles that cause disease were alive. They were considered to be able to spread by air, multiply by themselves and to be destroyable by fire. In this way he refuted Galen 's miasma theory (poison gas in sick people). In 1543 he wrote a book De contagione et contagiosis morbis , in which he

5002-506: The multicausality associated with disease is the causal pie model . In 1965, Austin Bradford Hill proposed a series of considerations to help assess evidence of causation, which have come to be commonly known as the " Bradford Hill criteria ". In contrast to the explicit intentions of their author, Hill's considerations are now sometimes taught as a checklist to be implemented for assessing causality. Hill himself said "None of my nine viewpoints can bring indisputable evidence for or against

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5084-417: The odds of exposure in the cases (A/C) to the odds of exposure in the controls (B/D), i.e. OR = (AD/BC). If the OR is significantly greater than 1, then the conclusion is "those with the disease are more likely to have been exposed", whereas if it is close to 1 then the exposure and disease are not likely associated. If the OR is far less than one, then this suggests that the exposure is a protective factor in

5166-498: The odds ratio by the equation: where N is the ratio of cases to controls. As the odds ratio approaches 1, the number of cases required for statistical significance grows towards infinity; rendering case-control studies all but useless for low odds ratios. For instance, for an odds ratio of 1.5 and cases = controls, the table shown above would look like this: For an odds ratio of 1.1: Cohort studies select subjects based on their exposure status. The study subjects should be at risk of

5248-414: The outcome under investigation at the beginning of the cohort study; this usually means that they should be disease free when the cohort study starts. The cohort is followed through time to assess their later outcome status. An example of a cohort study would be the investigation of a cohort of smokers and non-smokers over time to estimate the incidence of lung cancer. The same 2×2 table is constructed as with

5330-516: The post of Registrar-General for England and Wales ceased to be part of ONS from that date but remains subject to ministerial accountability within the Home Office . The annual United Kingdom National Accounts are published in an online publication (The Blue Book ) by the Office for National Statistics. It records and describes economic activity in the United Kingdom and as such is used by government, banks, academics and industries to formulate

5412-400: The prevailing Miasma Theory of the time, a model of disease in which poor air quality was blamed for illness. This was used to rationalize high rates of infection in impoverished areas instead of addressing the underlying issues of poor nutrition and sanitation, and was proven false by his work. Other pioneers include Danish physician Peter Anton Schleisner , who in 1849 related his work on

5494-640: The prevention of the epidemic of neonatal tetanus on the Vestmanna Islands in Iceland . Another important pioneer was Hungarian physician Ignaz Semmelweis , who in 1847 brought down infant mortality at a Vienna hospital by instituting a disinfection procedure. His findings were published in 1850, but his work was ill-received by his colleagues, who discontinued the procedure. Disinfection did not become widely practiced until British surgeon Joseph Lister 'discovered' antiseptics in 1865 in light of

5576-545: The public was described as "a disaster" by members of parliament on the Public Administration Committee. The chair of the UK Statistics Authority said that significant improvements to the website were being made, but admitted that its state at the time made it "difficult to use, difficult to navigate and difficult to search". In 2016, professor Sir Charles Bean conducted an independent review of UK Economic Statistics. He notes that although there

5658-524: The register of births, marriages and deaths. Its publications, and analyses by other users based on its published data, are reported and discussed daily in the media as the basis for the public understanding of the country in which they live. The reliance on some of these data by government (both local and national) makes ONS material central to debates about the determination of priorities, the allocation of resources and for decisions on interest rates or borrowing. The complexity and degree and speed of change in

5740-402: The same population that gave rise to the cases. The case-control study looks back through time at potential exposures that both groups (cases and controls) may have encountered. A 2×2 table is constructed, displaying exposed cases (A), exposed controls (B), unexposed cases (C) and unexposed controls (D). The statistic generated to measure association is the odds ratio (OR), which is the ratio of

5822-743: The society, combined with the challenge of measuring some of these (e.g. in relation to longevity, migration or illness patterns or fine movements in inflation or other aspects of national accounts) give rise to periodic debates about some of its indicators and portrayals. Many of these rely on sources which are outside ONS, while some of its own sources need to be supplemented, for example between censuses, by updated but less rigorously obtained information from other sources. Consequently, unexpected or incomplete data or occasional errors or disputes about its analysis can also attract considerable attention. ONS data can also be used in epidemiologic studies such as survival analysis . Gordon Brown , then Chancellor of

5904-456: The study of adverse reactions to vaccination and has been shown in some circumstances to provide statistical power comparable to that available in cohort studies. Case-control studies select subjects based on their disease status. It is a retrospective study. A group of individuals that are disease positive (the "case" group) is compared with a group of disease negative individuals (the "control" group). The control group should ideally come from

5986-439: The term is widely used in studies of zoological populations (veterinary epidemiology), although the term " epizoology " is available, and it has also been applied to studies of plant populations (botanical or plant disease epidemiology ). The distinction between "epidemic" and "endemic" was first drawn by Hippocrates , to distinguish between diseases that are "visited upon" a population (epidemic) from those that "reside within"

6068-716: The time. He was not able to find the initial cause of the smallpox fever he researched and treated. John Graunt , a haberdasher and amateur statistician, published Natural and Political Observations ... upon the Bills of Mortality in 1662. In it, he analysed the mortality rolls in London before the Great Plague , presented one of the first life tables , and reported time trends for many diseases, new and old. He provided statistical evidence for many theories on disease, and also refuted some widespread ideas on them. John Snow

6150-413: The water and removed the handle; this ended the outbreak. This has been perceived as a major event in the history of public health and regarded as the founding event of the science of epidemiology, having helped shape public health policies around the world. However, Snow's research and preventive measures to avoid further outbreaks were not fully accepted or put into practice until after his death due to

6232-637: The work of Louis Pasteur . In the early 20th century, mathematical methods were introduced into epidemiology by Ronald Ross , Janet Lane-Claypon , Anderson Gray McKendrick , and others. In a parallel development during the 1920s, German-Swiss pathologist Max Askanazy and others founded the International Society for Geographical Pathology to systematically investigate the geographical pathology of cancer and other non-infectious diseases across populations in different regions. After World War II, Richard Doll and other non-pathologists joined

6314-696: Was also sought by the Royal Statistical Society and the Statistics Commission . The National Statistician would be directly accountable to Parliament through a more widely constituted independent governing Statistics Board. The ONS would be a non-ministerial government department so that the staff, including the Director, would remain as civil servants but without being under direct ministerial control. The then National Statistician, Dame Karen Dunnell , stated that legislation would help improve public trust in official statistics (although

6396-638: Was announced that it would be known as the UK Statistics Authority (UKSA). In 2012, Andrew Dilnot replaced Michael Scholar as chairman of the Authority. Since its establishment, ONS has had five Directors: professor Tim Holt ; Len Cook ; Karen Dunnell ; Jil Matheson ; and, from October 2012, Glen Watson . Len Cook was the first Director to hold the newly created role of National Statistician. The roles of Director of ONS and National Statistician were combined until 2012 when Jil Matheson continued as National Statistician while Glen Watson became Director of

6478-424: Was established in 2004 to allow researchers access to business data. It is a secure facility within the Office for National Statistics where both government officials and academic researchers can analyse sensitive, detailed data for statistical purposes. The researchers cannot download the data or take any copies out of the laboratory and the results of the analysis is checked for statistical disclosure. The ONS has

6560-538: Was moved to Newport following the Lyons Review on public sector relocation. Between 2011 and 2022 the London office was located on the 2nd floor of the former Drummond Gate headquarters; since 2022 the London office has been located in 2 Marsham Street. The ONS asserted that recruitment and training of quality staff in South Wales, where data collection and analysis already took place, would ensure that there

6642-502: Was no risk to the quality of its services and that it managed the risks associated with the changes. However, the plan to discontinue statistical activity in London proved controversial amid claims that the shift of functions from London and the closure of the London office would have serious implications for the future of certain sets of statistics. These include health statistics, National Accounts, Retail and Consumer Prices and Labour Market Statistics. These risks were stated to derive from

6724-668: Was the first to promote personal and environmental hygiene to prevent disease. The development of a sufficiently powerful microscope by Antonie van Leeuwenhoek in 1675 provided visual evidence of living particles consistent with a germ theory of disease . During the Ming dynasty , Wu Youke (1582–1652) developed the idea that some diseases were caused by transmissible agents, which he called Li Qi (戾气 or pestilential factors) when he observed various epidemics rage around him between 1641 and 1644. His book Wen Yi Lun (瘟疫论, Treatise on Pestilence/Treatise of Epidemic Diseases) can be regarded as

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