53-623: Mengovirus , also known as Columbia SK virus , mouse Elberfield virus , and Encephalomyocarditis virus (EMCV), belongs to the genus Cardiovirus which is a member of the Picornaviridae . Its genome is a single stranded positive-sense RNA molecule, making the Mengoviruses a class IV virus under the Baltimore classification system. The genome is approximately 8400nt in length, and has 5’ VG protein (Virus genome protein) and
106-689: A dead-end host . Examples include rabies, anthrax, tularemia, and West Nile fever. Thus, much of human exposure to infectious disease has been zoonotic. Many diseases, even epidemic ones, have zoonotic origin and measles , smallpox , influenza , HIV, and diphtheria are particular examples. Various forms of the common cold and tuberculosis also are adaptations of strains originating in other species. Some experts have suggested that all human viral infections were originally zoonotic. Zoonoses are of interest because they are often previously unrecognized diseases or have increased virulence in populations lacking immunity. The West Nile virus first appeared in
159-638: A growing human population . According to Peter Daszak, the chair of the group who produced the report, "there is no great mystery about the cause of the Covid-19 pandemic, or of any modern pandemic. The same human activities that drive climate change and biodiversity loss also drive pandemic risk through their impacts on our environment." According to a report from the United Nations Environment Programme and International Livestock Research Institute , entitled "Preventing
212-571: A 3’ polyadenine tail. Mengovirus was isolated by George W. A. Dick in 1948, in the Mengo district of Entebbe in Uganda, from a captive rhesus monkey that had developed hind limb paralysis. Mengovirus is a non-enveloped virus which has a nucleocapsid made up of 12 subunits. The virion is 30 nm in diameter and displays icosahedral symmetry. Once inside a host cell, the Mengovirus genome acts as
265-404: A Theiler-like rat virus (TRV) (which has yet to be named) and Saffold virus (SAF-V). Of these 4, only VHEV and SAF-V are thought to cause infection in humans. Thus far, Cardiovirus C has only been observed in the brown rat . Cardioviruses are single-stranded RNA, non-enveloped viruses with icosahedral or spherical geometries, and a T=pseudo3 icosahedral capsid protein geometry. The diameter
318-576: A piece of mRNA and is directly translated by the host ribosomes in the cytoplasm. There is a large un-translated region at the 5’ end of the RNA that has a ribosome binding site, removing the need of a cap. A single polypeptide is made and is cleaved into individual proteins by viral proteases. The genome is divided into three parts: P1, P2, and P3. P1 encodes the virus capsid proteins, P2 and P3 encode genes required for genome replication to occur. For replication to occur an intermediate double-stranded RNA molecule
371-409: A population, a pathogen either had to be a chronic infection, staying present and potentially infectious in the infected host for long periods, or it had to have other additional species as reservoir where it can maintain itself until further susceptible hosts are contacted and infected. In fact, for many "human" diseases, the human is actually better viewed as an accidental or incidental victim and
424-499: A results of many ecological and sociological changes globally. During most of human prehistory groups of hunter-gatherers were probably very small. Such groups probably made contact with other such bands only rarely. Such isolation would have caused epidemic diseases to be restricted to any given local population, because propagation and expansion of epidemics depend on frequent contact with other individuals who have not yet developed an adequate immune response . To persist in such
477-616: A set of measures to stop the rise. Foodborne zoonotic diseases are caused by a variety of pathogens that can affect both humans and animals. The most significant zoonotic pathogens causing foodborne diseases are: Escherichia coli O157:H7 , Campylobacter , Caliciviridae , and Salmonella . Contact with farm animals can lead to disease in farmers or others that come into contact with infected farm animals. Glanders primarily affects those who work closely with horses and donkeys. Close contact with cattle can lead to cutaneous anthrax infection, whereas inhalation anthrax infection
530-567: A significant source in at least one spillover event . The wildlife trade may increase spillover risk because it directly increases the number of interactions across animal species, sometimes in small spaces. The origin of the COVID-19 pandemic is traced to the wet markets in China . Zoonotic disease emergence is demonstrably linked to the consumption of wildlife meat, exacerbated by human encroachment into natural habitats and amplified by
583-599: Is a common infection of cats; in humans it is a mild disease although it can be dangerous to pregnant women. Dirofilariasis is caused by Dirofilaria immitis through mosquitoes infected by mammals like dogs and cats. Cat-scratch disease is caused by Bartonella henselae and Bartonella quintana , which are transmitted by fleas that are endemic to cats. Toxocariasis is the infection of humans by any of species of roundworm , including species specific to dogs ( Toxocara canis ) or cats ( Toxocara cati ). Cryptosporidiosis can be spread to humans from pet lizards, such as
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#1732780943679636-652: Is able to suppress the host's immune response by reducing the expression of Nuclear Factor kappa B using the 5’ un-translated region. Cardiovirus Cardiovirus are a group of viruses within order Picornavirales , family Picornaviridae . Vertebrates serve as natural hosts for these viruses. There are currently six species in the genus: Cardiovirus A is composed of only one serotype, encephalomyocarditis virus (EMCV). Cardiovirus B consists of four viruses that are most probably serologically distinct. These are Theiler's Murine encephalomyelitis virus (TMEV), Vilyuisk human encephalomyelitis virus (VHEV),
689-410: Is an infectious disease of humans caused by a pathogen (an infectious agent, such as a bacterium , virus , parasite , or prion ) that can jump from a non-human vertebrate to a human . When humans infect non-humans, it is called reverse zoonosis or anthroponosis. Major modern diseases such as Ebola and salmonellosis are zoonoses. HIV was a zoonotic disease transmitted to humans in
742-442: Is around 30 nm. Genomes are linear and non-segmented, around 7.8 kb in length. The T=pseudo3 icosahedral capsid of Cadiovirus is made of 60 protomers , each of which contains 4 polypeptides: VP1, VP2, VP3, and VP4. Inside the capsid of the virus there is a single linear, positive single-stranded RNA. On both the 3' and 5' ends of the genome there are untranslated regions . These untranslated regions of genome are important for
795-708: Is bringing people into closer contact with animal species they may never have been near before. The resulting transmission of disease from wildlife to humans, she says, is now "a hidden cost of human economic development". In a guest article, published by IPBES , President of the EcoHealth Alliance and zoologist Peter Daszak , along with three co-chairs of the 2019 Global Assessment Report on Biodiversity and Ecosystem Services , Josef Settele, Sandra Díaz , and Eduardo Brondizio, wrote that "rampant deforestation, uncontrolled expansion of agriculture, intensive farming , mining and infrastructure development, as well as
848-481: Is caused by a tapeworm, which can spread from infected sheep by food or water contaminated by feces or wool. Avian influenza is common in chickens, and, while it is rare in humans, the main public health worry is that a strain of avian influenza will recombine with a human influenza virus and cause a pandemic like the 1918 Spanish flu . In 2017, free-range chickens in the UK were temporarily ordered to remain inside due to
901-471: Is contact with or consumption of animals, animal products, or animal derivatives. This can occur in a companionistic (pets), economic (farming, trade, butchering, etc.), predatory (hunting, butchering, or consuming wild game), or research context. Recently, there has been a rise in frequency of appearance of new zoonotic diseases. "Approximately 1.67 million undescribed viruses are thought to exist in mammals and birds, up to half of which are estimated to have
954-588: Is intricately linked to numerous emerging infectious diseases like Ebola, HIV, and SARS , raising critical public health concerns. A review published in 2022 found evidence that zoonotic spillover linked to wildmeat consumption has been reported across all continents. Kate Jones , Chair of Ecology and Biodiversity at University College London , says zoonotic diseases are increasingly linked to environmental change and human behavior. The disruption of pristine forests driven by logging, mining, road building through remote places, rapid urbanization, and population growth
1007-418: Is made to be used as a template for the production of positive sense genomes. Mengovirus is infectious to vertebrate animals, and has been isolated from mice and other rodents. It can also cause acute fever in humans. There is no specific treatment for a Mengovirus infection; although dipyridamole has been shown to inhibit its replication. The illness is not severe enough to require vaccination. The Mengovirus
1060-411: Is more common for workers in slaughterhouses , tanneries , and wool mills . Close contact with sheep who have recently given birth can lead to infection with the bacterium Chlamydia psittaci , causing chlamydiosis (and enzootic abortion in pregnant women), as well as increase the risk of Q fever , toxoplasmosis , and listeriosis , in the pregnant or otherwise immunocompromised . Echinococcosis
1113-441: Is the outbreak of Nipah virus in peninsular Malaysia, in 1999, when intensive pig farming began within the habitat of infected fruit bats. The unidentified infection of these pigs amplified the force of infection, transmitting the virus to farmers, and eventually causing 105 human deaths. Similarly, in recent times avian influenza and West Nile virus have spilled over into human populations probably due to interactions between
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#17327809436791166-425: Is the usual source of human infection. Animal populations are the principal reservoir of the pathogen and horizontal infection in humans is rare. A few examples in this category include lyssavirus infections, Lyme borreliosis, plague, tularemia, leptospirosis , ehrlichiosis, Nipah virus, West Nile virus (WNV) and hantavirus infections. Secondary transmission encompasses a category of diseases of animal origin in which
1219-443: The 2009 swine flu . Zoonoses can be caused by a range of disease pathogens such as emergent viruses , bacteria, fungi and parasites; of 1,415 pathogens known to infect humans, 61% were zoonotic. Most human diseases originated in non-humans; however, only diseases that routinely involve non-human to human transmission, such as rabies , are considered direct zoonoses. Zoonoses have different modes of transmission. In direct zoonosis
1272-870: The National Association of State Public Health Veterinarians , include educational responsibilities of venue operators, limiting public animal contact, and animal care and management. Hunting involves humans tracking, chasing, and capturing wild animals, primarily for food or materials like fur. However, other reasons like pest control or managing wildlife populations can also exist. Transmission of zoonotic diseases, those leaping from animals to humans, can occur through various routes: direct physical contact, airborne droplets or particles, bites or vector transport by insects, oral ingestion, or even contact with contaminated environments. Wildlife activities like hunting and trade bring humans closer to dangerous zoonotic pathogens, threatening global health. According to
1325-413: The United Nations Environment Programme stated that the increase in zoonotic pandemics is directly attributable to anthropogenic destruction of nature and the increased global demand for meat and that the industrial farming of pigs and chickens in particular will be a primary risk factor for the spillover of zoonotic diseases in the future. Habitat loss of viral reservoir species has been identified as
1378-654: The World Health Organization (WHO) , any disease or infection that is primarily ‘naturally’ transmissible from vertebrate animals to humans or from humans to animals is classified as a zoonosis. Factors such as climate change, urbanization, animal migration and trade, travel and tourism, vector biology, anthropogenic factors, and natural factors have greatly influenced the emergence, re-emergence, distribution, and patterns of zoonoses. Zoonotic diseases generally refer to diseases of animal origin in which direct or vector mediated animal-to-human transmission
1431-559: The anthropogenic destruction of ecosystems for the purpose of expanding agriculture and human settlements reduces biodiversity and allows for smaller animals such as bats and rats, which are more adaptable to human pressures and also carry the most zoonotic diseases, to proliferate. This in turn can result in more pandemics. In October 2020, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services published its report on
1484-685: The leopard gecko . Encephalitozoon cuniculi is a microsporidial parasite carried by many mammals, including rabbits, and is an important opportunistic pathogen in people immunocompromised by HIV/AIDS , organ transplantation , or CD4+ T-lymphocyte deficiency. Pets may also serve as a reservoir of viral disease and contribute to the chronic presence of certain viral diseases in the human population. For instance, approximately 20% of domestic dogs, cats, and horses carry anti-hepatitis E virus antibodies and thus these animals probably contribute to human hepatitis E burden as well. For non-vulnerable populations (e.g., people who are not immunocompromised)
1537-491: The 'era of pandemics' by 22 experts in a variety of fields and concluded that anthropogenic destruction of biodiversity is paving the way to the pandemic era and could result in as many as 850,000 viruses being transmitted from animals – in particular birds and mammals – to humans. The increased pressure on ecosystems is being driven by the "exponential rise" in consumption and trade of commodities such as meat, palm oil , and metals, largely facilitated by developed nations, and by
1590-459: The Center for Diseases Control and Prevention (CDC) hunting and consuming wild animal meat ("bushmeat") in regions like Africa can expose people to infectious diseases due to the types of animals involved, like bats and primates. Unfortunately, common preservation methods like smoking or drying aren't enough to eliminate these risks. Although bushmeat provides protein and income for many, the practice
1643-582: The DNA replication, with the untranslated region on the 5' side being the location of internal ribosomal entry site (IRES) . Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the virus to host receptors, which mediates endocytosis. Replication follows the positive stranded RNA virus replication model. Positive stranded rna virus transcription is the method of transcription. Translation takes place by −1 ribosomal frameshifting, viral initiation, and ribosomal skipping. The virus exits
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1696-601: The Royal Society 's Part B journal, found that increased virus spillover events from animals to humans can be linked to biodiversity loss and environmental degradation , as humans further encroach on wildlands to engage in agriculture, hunting, and resource extraction they become exposed to pathogens which normally would remain in these areas. Such spillover events have been tripling every decade since 1980. An August 2020 study, published in Nature , concludes that
1749-605: The United States in 1999 , in the New York City area. Bubonic plague is a zoonotic disease, as are salmonellosis , Rocky Mountain spotted fever , and Lyme disease . A major factor contributing to the appearance of new zoonotic pathogens in human populations is increased contact between humans and wildlife. This can be caused either by encroachment of human activity into wilderness areas or by movement of wild animals into areas of human activity. An example of this
1802-1070: The actual transmission to humans is a rare event but, once it has occurred, human-to-human transmission maintains the infection cycle for some period of time. Some examples include human immunodeficiency virus (HIV) /acquired immune deficiency syndrome (AIDS), certain influenza A strains, Ebola virus and severe acute respiratory syndrome (SARS). One example is Ebola which is spread by direct transmission to humans from handling bushmeat (wild animals hunted for food) and contact with infected bats or close contact with infected animals, including chimpanzees, fruit bats, and forest antelope. Secondary transmission also occurs from human to human by direct contact with blood, bodily fluids, or skin of patients with or who died of Ebola virus disease. Some examples of pathogens with this pattern of secondary transmission are human immunodeficiency virus/acquired immune deficiency syndrome, influenza A, Ebola virus and severe acute respiratory syndrome. Recent infections of these emerging and re-emerging zoonotic infections have occurred as
1855-618: The associated disease burden is, however, small. Furthermore, the trade of non domestic animals such as wild animals as pets can also increase the risk of zoonosis spread. Outbreaks of zoonoses have been traced to human interaction with, and exposure to, other animals at fairs , live animal markets , petting zoos , and other settings. In 2005, the Centers for Disease Control and Prevention (CDC) issued an updated list of recommendations for preventing zoonosis transmission in public settings. The recommendations, developed in conjunction with
1908-555: The carrier host and domestic animals. Highly mobile animals, such as bats and birds, may present a greater risk of zoonotic transmission than other animals due to the ease with which they can move into areas of human habitation. Because they depend on the human host for part of their life-cycle, diseases such as African schistosomiasis , river blindness , and elephantiasis are not defined as zoonotic, even though they may depend on transmission by insects or other vectors . The first vaccine against smallpox by Edward Jenner in 1800
1961-577: The common cold, can use the pig as a zoonotic reservoir, constantly reinfecting the human population. Veterinarians are exposed to unique occupational hazards when it comes to zoonotic disease. In the US, studies have highlighted an increased risk of injuries and lack of veterinary awareness of these hazards. Research has proved the importance for continued clinical veterinarian education on occupational risks associated with musculoskeletal injuries, animal bites, needle-sticks, and cuts. A July 2020 report by
2014-492: The disease is directly transmitted from non-humans to humans through media such as air (influenza) or bites and saliva (rabies). In contrast, transmission can also occur via an intermediate species (referred to as a vector ), which carry the disease pathogen without getting sick. The term is from Ancient Greek : ζῷον zoon "animal" and νόσος nosos "sickness". Host genetics plays an important role in determining which non-human viruses will be able to make copies of themselves in
2067-433: The distribution and robustness of bat species harboring coronaviruses may have occurred in eastern Asian hotspots (southern China, Myanmar, and Laos), constituting a driver behind the evolution and spread of the virus. Zoonotic diseases contribute significantly to the burdened public health system as vulnerable groups such the elderly, children, childbearing women and immune-compromised individuals are at risk. According to
2120-401: The early part of the 20th century, though it has now evolved into a separate human-only disease. Human infection with animal influenza viruses is rare, as they do not transmit easily to or among humans. However, avian and swine influenza viruses in particular possess high zoonotic potential, and these occasionally recombine with human strains of the flu and can cause pandemics such as
2173-463: The exploitation of wild species have created a 'perfect storm' for the spillover of diseases from wildlife to people." Joshua Moon, Clare Wenham, and Sophie Harman said that there is evidence that decreased biodiversity has an effect on the diversity of hosts and frequency of human-animal interactions with potential for pathogenic spillover. An April 2020 study, published in the Proceedings of
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2226-535: The host cell by lysis, and viroporins. Human and vertebrates serve as the natural host. Transmission routes are zoonosis and fomite. The 3’ end of the genome encodes a polyA tail while the 5’ end encodes a genome-linked protein. A unique feature of this genus is the presence of the L* protein, 18kDa, that is made out of frame from the polyprotein and is present in the DA subgroup of TMEV. It has been found to be important for
2279-399: The human body. Dangerous non-human viruses are those that require few mutations to begin replicating themselves in human cells. These viruses are dangerous since the required combinations of mutations might randomly arise in the natural reservoir . The emergence of zoonotic diseases originated with the domestication of animals. Zoonotic transmission can occur in any context in which there
2332-429: The link between climate change and zoonosis found a strong link between climate change and the epidemic emergence in the last 15 years, as it caused a massive migration of species to new areas, and consequently contact between species which do not normally come in contact with one another. Even in a scenario with weak climatic changes, there will be 15,000 spillover of viruses to new hosts in the next decades. The areas with
2385-431: The most possibilities for spillover are the mountainous tropical regions of Africa and southeast Asia. Southeast Asia is especially vulnerable as it has a large number of bat species that generally do not mix, but could easily if climate change forced them to begin migrating. A 2021 study found possible links between climate change and transmission of COVID-19 through bats. The authors suggest that climate-driven changes in
2438-670: The next pandemic – Zoonotic diseases and how to break the chain of transmission", climate change is one of the 7 human-related causes of the increase in the number of zoonotic diseases. The University of Sydney issued a study, in March 2021, that examines factors increasing the likelihood of epidemics and pandemics like the COVID-19 pandemic. The researchers found that "pressure on ecosystems, climate change and economic development are key factors" in doing so. More zoonotic diseases were found in high-income countries . A 2022 study dedicated to
2491-418: The pathogenic landscape of traded wildlife is crucial for guiding effective measures to combat zoonotic diseases and documenting the societal and environmental costs associated with this practice. Pets can transmit a number of diseases. Dogs and cats are routinely vaccinated against rabies . Pets can also transmit ringworm and Giardia , which are endemic in both animal and human populations. Toxoplasmosis
2544-542: The potential to spill over into humans", says a study led by researchers at the University of California, Davis . According to a report from the United Nations Environment Programme and International Livestock Research Institute a large part of the causes are environmental like climate change , unsustainable agriculture, exploitation of wildlife, and land use change . Others are linked to changes in human society such as an increase in mobility. The organizations propose
2597-407: The threat of avian influenza. Cattle are an important reservoir of cryptosporidiosis , which mainly affects the immunocompromised. Reports have shown mink can also become infected. In Western countries, hepatitis E burden is largely dependent on exposure to animal products, and pork is a significant source of infection, in this respect. Similarly, the human coronavirus OC43 , the main cause of
2650-462: The unsanitary conditions of wildlife markets. These markets, where diverse species converge, facilitate the mixing and transmission of pathogens, including those responsible for outbreaks of HIV-1, Ebola, and mpox , and potentially even the COVID-19 pandemic. Notably, small mammals often harbor a vast array of zoonotic bacteria and viruses, yet endemic bacterial transmission among wildlife remains largely unexplored. Therefore, accurately determining
2703-844: The virus pathogenesis. In the case of Cardiovirus A , the virus can cause encephalitis and myocarditis, mostly in rodents, which are natural hosts . The virus is transmitted from rodents to other animals. Severe epidemics have been seen in swine and elephants . Replication of cardioviruses is dependent on a structured RNA element called the Cardiovirus cis-acting replication element (CRE) . Human cardioviruses were first isolated in 1981. Seven additional isolates have since been described in North America, Europe and South Asia. They have been associated with gastroenteritis, influenza-like symptoms and non- polio -associated acute flaccid paralysis . The first infection of cardiovirus in humans
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#17327809436792756-526: Was by infection of a zoonotic bovine virus which caused a disease called cowpox . Jenner had noticed that milkmaids were resistant to smallpox. Milkmaids contracted a milder version of the disease from infected cows that conferred cross immunity to the human disease. Jenner abstracted an infectious preparation of 'cowpox' and subsequently used it to inoculate persons against smallpox. As a result of vaccination, smallpox has been eradicated globally, and mass inoculation against this disease ceased in 1981. There are
2809-741: Was identified in 2007 in a stool sample of an infant that was experiencing fever of unknown origin. It was subsequently named the Saffold virus after the lead researcher, Morris Saffold Jones . Other pathogenic cardioviruses isolated from humans include the Syr-Darya valley fever virus and Vilyuisk human encephalomyelitis virus . Diseases associated with cardioviruses include: myocarditis , encephalitis , multiple sclerosis , and type 1 diabetes . Zoonosis A zoonosis ( / z oʊ ˈ ɒ n ə s ɪ s , ˌ z oʊ ə ˈ n oʊ s ɪ s / ; pl. : zoonoses ) or zoonotic disease
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