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96-523: The impetus for NICHD came from the Task Force on the Health and Well-Being of Children, convened in 1961 and led by Dr. Robert E. Cooke, a senior medical advisor to President John F. Kennedy . Eunice Kennedy Shriver also served on the task force, which reported that more research was needed on the physical, emotional, and intellectual growth of children. The U.S. Congress established NICHD in 1962 as

192-537: A " playboy ", describing his performance in the Senate and the House as "pathetic" on another occasion, saying that he was "smart enough, but he doesn't like the grunt work". Author John T. Shaw acknowledges that while his Senate career is not associated with acts of "historic statesmanship" or "novel political thought," Kennedy made modest contributions as a legislator, drafting more than 300 bills to assist Massachusetts and

288-538: A Bachelor of Arts in government, concentrating on international affairs . That fall, he enrolled at the Stanford Graduate School of Business and audited classes, but he left after a semester to help his father complete his memoirs as an American ambassador. In early 1941, Kennedy toured South America. Kennedy planned to attend Yale Law School , but canceled when American entry into World War II seemed imminent. In 1940, Kennedy attempted to enter

384-420: A badly burned crewman to the island with a life jacket strap clenched between his teeth. From there, Kennedy and his subordinate, Ensign George Ross, made forays through the coral islands, searching for help. When they encountered an English-speaking native with a canoe, Kennedy carved his location on a coconut shell and requested a boat rescue. Seven days after the collision, with the coconut message delivered,

480-502: A brief stint in journalism, Kennedy represented a working-class Boston district in the U.S. House of Representatives from 1947 to 1953. He was subsequently elected to the U.S. Senate , serving as the junior senator for Massachusetts from 1953 to 1960. While in the Senate, Kennedy published his book, Profiles in Courage , which won a Pulitzer Prize . Kennedy ran in the 1960 presidential election . His campaign gained momentum after

576-508: A philanthropist and socialite. His paternal grandfather, P. J. Kennedy , was an East Boston ward boss and Massachusetts state legislator . Kennedy's maternal grandfather and namesake, John F. Fitzgerald , was a U.S. congressman and two-term mayor of Boston . All four of his grandparents were children of Irish immigrants. Kennedy had an older brother, Joseph Jr. , and seven younger siblings: Rosemary , Kathleen , Eunice , Patricia , Robert , Jean , and Ted . Kennedy's father amassed

672-407: A pilot study to large scale strategy may not be assumed as possible, partly due to the exceptional resources and favorable conditions that accompany a pilot study. In clinical research , studies conducted in preparation for a future randomized controlled trial are known as "pilot" and "feasibility" studies, where pilot studies are a subset of feasibility studies. A feasibility study asks whether

768-537: A politician, and at that time he suffered from extreme shyness. Kennedy found "most of his fellow congressmen boring, preoccupied as they all seemed to be with their narrow political concerns." The arcane House rules and customs, which slowed legislation, exasperated him. Kennedy served in the House for six years, joining the influential Education and Labor Committee and the Veterans' Affairs Committee . He concentrated his attention on international affairs, supporting

864-484: A preparatory boarding school in Wallingford, Connecticut . Rose had wanted John and Joe Jr. to attend a Catholic school , but Joe Sr. thought that if they were to compete in the political world, they needed to be with boys from prominent Protestant families. John spent his first years at Choate in his older brother's shadow and compensated with rebellious behavior that attracted a clique. Their most notorious stunt

960-414: A private fortune and established trust funds for his nine children that guaranteed lifelong financial independence. His business kept him away from home for long stretches, but Joe Sr. was a formidable presence in his children's lives. He encouraged them to be ambitious, emphasized political discussions at the dinner table, and demanded a high level of academic achievement. John's first exposure to politics

1056-458: A result of the first debate. The debates are now considered a milestone in American political history—the point at which the medium of television began to play a dominant role. Kennedy's campaign gained momentum after the first debate, and he pulled slightly ahead of Nixon in most polls. On Election Day, Kennedy defeated Nixon in one of the closest presidential elections of the 20th century. In

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1152-469: A senator "the most corrupting job in the world." He complained that they were all too quick to cut deals and please campaign contributors to ensure their political futures. Kennedy, with the luxury of a rich father who could finance his campaigns, could remain independent of any special interest, except for those in his home state of Massachusetts that could align against his reelection. According to Robert Caro , Majority Leader Lyndon Johnson viewed Kennedy as

1248-422: A series of televised debates . An estimated 70 million Americans, about two-thirds of the electorate, watched the first debate on September 26. Kennedy had met the day before with the producer to discuss the set design and camera placement. Nixon, just out of the hospital after a painful knee injury, did not take advantage of this opportunity and during the debate looked at the reporters asking questions and not at

1344-416: A series of " teas " at hotels and parlors across Massachusetts to reach out to women voters. In the presidential election, Republican Dwight D. Eisenhower carried Massachusetts by 208,000 votes, but Kennedy narrowly defeated Lodge by 70,000 votes for the Senate seat. The following year, he married Jacqueline Bouvier . Kennedy underwent several spinal operations over the next two years. Often absent from

1440-583: A sizable Black population, Kennedy was not particularly sensitive to the problems of African Americans. Robert Kennedy later reflected, "We weren't thinking of the Negroes of Mississippi or Alabama—what should be done for them. We were thinking of what needed to be done in Massachusetts." Most historians and political scientists who have written about Kennedy refer to his U.S. Senate years as an interlude. According to Robert Dallek , Kennedy called being

1536-552: A variety of initiatives. The "President's Task Force on Health Risks and Safety Risks to Children" recommended this federal initiative in 1999, after which Congress passed the Children's Health Act of 2000 (Title X, Section 1004). The Act charged NICHD to: The Act required this NCS to: The NCS was designed to examine the effects of the environment—broadly defined to include factors such as air, water, diet, sound, family dynamics, community, and cultural influences— and genetics on

1632-644: A village on Cape Cod , where they swam, sailed, and played touch football. Christmas and Easter holidays were spent at their winter retreat in Palm Beach, Florida . In September 1930, Kennedy, 13 years old, was sent to the Canterbury School in New Milford, Connecticut , for 8th grade. In April 1931, he had an appendectomy , after which he withdrew from Canterbury and recuperated at home. In September 1931, Kennedy started attending Choate ,

1728-430: Is a small-scale preliminary study conducted to evaluate feasibility , duration , cost , adverse events , and improve upon the study design prior to performance of a full-scale research project . Pilot experiments are frequently carried out before large-scale quantitative research , in an attempt to avoid time and money being used on an inadequately designed project. A pilot study is usually carried out on members of

1824-436: Is often claimed that television viewers overwhelmingly believed Kennedy, appearing to be the more attractive of the two, had won, while radio listeners (a smaller audience) thought Nixon had defeated him. However, only one poll split TV and radio voters like this and the methodology was poor. Pollster Elmo Roper concluded that the debates raised interest, boosted turnout, and gave Kennedy an extra two million votes, mostly as

1920-719: The 1953 Worcester tornado ), except on certain occasions when the national interest was at stake. In 1954, Kennedy voted in favor of the Saint Lawrence Seaway which would connect the Great Lakes to the Atlantic Ocean, despite opposition from Massachusetts politicians who argued that the project would hurt the Port of Boston economically. In 1954, when the Senate voted to condemn Joseph McCarthy for breaking Senate rules and abusing an Army general, Kennedy

2016-858: The American embassy in London , where his father was serving as President Franklin D. Roosevelt 's ambassador to the Court of St. James's . The following year, Kennedy traveled throughout Europe, the Soviet Union , the Balkans , and the Middle East in preparation for his Harvard senior honors thesis. He then went to Berlin, where a U.S. diplomatic representative gave him a secret message about war breaking out soon to pass on to his father, and to Czechoslovakia before returning to London on September 1, 1939,

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2112-530: The Boston Council from 1946 to 1955 as district vice chairman, member of the executive board, vice-president, and National Council Representative. To appeal to the large Italian-American voting bloc in Massachusetts, Kennedy delivered a speech in November 1947 supporting a $ 227 million aid package to Italy. He maintained that Italy was in danger from an "onslaught of the communist minority" and that

2208-499: The Democratic presidential nomination . Though some questioned Kennedy's age and experience, his charisma and eloquence earned him numerous supporters. Kennedy faced several potential challengers, including Senate Majority Leader Lyndon Johnson, Adlai Stevenson II , and Senator Hubert Humphrey . Kennedy traveled extensively to build his support. His campaign strategy was to win several primaries to demonstrate his electability to

2304-473: The Fish and Wildlife Service budget, modernizing reserve-fleet vessels , tax incentives to prevent further business relocations, and the development of hydroelectric and nuclear power in Massachusetts. Kennedy's suggestions for stimulating the region's economy appealed to both parties by offering benefits to business and labor, and promising to serve national defense. Congress would eventually enact most of

2400-569: The National Defense Education Act in 1959 to eliminate the requirement that aid recipients sign a loyalty oath and provide supporting affidavits. Kennedy cast a procedural vote against President Eisenhower's bill for the Civil Rights Act of 1957 and this was considered by some to be an appeasement of Southern Democratic opponents of the bill. Kennedy did vote for Title III of the act, which would have given

2496-864: The Naval Reserve Officer Training School in Chicago and at the Motor Torpedo Boat Squadrons Training Center in Melville, Rhode Island . His first command was PT-101 from December 7, 1942, until February 23, 1943. Unhappy to be assigned to the Panama Canal , far from the fighting, Kennedy appealed to Massachusetts senator David Walsh , who arranged for him to be assigned to the South Pacific . In April 1943, Kennedy

2592-549: The PT-109 crew were rescued. Almost immediately, the PT-109 rescue became a highly publicized event. The story was chronicled by John Hersey in The New Yorker in 1944 (decades later it was the basis of a successful film ). It followed Kennedy into politics and provided a strong foundation for his appeal as a leader. Hersey portrayed Kennedy as a modest, self-deprecating hero. For his courage and leadership, Kennedy

2688-620: The Truman Doctrine as the appropriate response to the emerging Cold War . He also supported public housing and opposed the Labor Management Relations Act of 1947 , which restricted the power of labor unions. Though not as vocally anti-communist as Joseph McCarthy , Kennedy supported the Immigration and Nationality Act of 1952 , which required communists to register with the government, and he deplored

2784-482: The U.S. Environmental Protection Agency . An independent Study Monitoring and Oversight Committee monitored study progress and participant safety. In addition to these more formal channels, the NCS solicited feedback from subject matter experts from around the world and from individuals, community advocates, and professional societies concerned with child health. The NCS Program Office also provided public forums for input on

2880-535: The party bosses , who controlled most of the delegates, and to prove to his detractors that a Catholic could win popular support. Victories over Senator Humphrey in the Wisconsin and West Virginia primaries gave Kennedy momentum as he moved on to the 1960 Democratic National Convention in Los Angeles. When Kennedy entered the convention, he had the most delegates, but not enough to ensure that he would win

2976-583: The " loss of China ." During a speech in Salem, Massachusetts on January 30, 1949, Kennedy denounced Truman and the State Department for contributing to the "tragic story of China whose freedom we once fought to preserve. What our young men had saved [in World War II], our diplomats and our President have frittered away." Having served as a boy scout during his childhood, Kennedy was active in

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3072-523: The Attorney General powers to enjoin, but Majority Leader Lyndon B. Johnson agreed to let the provision die as a compromise measure. Kennedy also voted for the "Jury Trial Amendment." Many civil rights advocates criticized that vote as one which would weaken the act. A final compromise bill, which Kennedy supported, was passed in September 1957. As a senator from Massachusetts, which lacked

3168-883: The Cuban government of Fidel Castro in the failed Bay of Pigs Invasion and Operation Mongoose . In October 1962, U.S. spy planes discovered Soviet missile bases had been deployed in Cuba. The resulting period of tensions, termed the Cuban Missile Crisis , nearly resulted in nuclear war . In August 1961, after East German troops erected the Berlin Wall , Kennedy sent an army convoy to reassure West Berliners of U.S. support, and delivered one of his most famous speeches in West Berlin in June 1963. In 1963, Kennedy signed

3264-722: The Greater Houston Ministerial Association on September 12: "I am not the Catholic candidate for president. I am the Democratic Party candidate for president who also happens to be a Catholic. I do not speak for my Church on public matters—and the Church does not speak for me." He promised to respect the separation of church and state , and not to allow Catholic officials to dictate public policy. The Kennedy and Nixon campaigns agreed to

3360-802: The McClellan Committee) with his brother Robert, who was chief counsel, to investigate racketeering in labor-management relations. The hearings attracted extensive radio and television coverage where the Kennedy brothers engaged in dramatic arguments with controversial labor leaders, including Jimmy Hoffa , of the Teamsters Union . The following year, Kennedy introduced a bill to prevent the expenditure of union dues for improper purposes or private gain; to forbid loans from union funds for illicit transactions; and to compel audits of unions, which would ensure against false financial reports. It

3456-790: The NCS Program Office engaged external advisors and scientific groups. These groups included federal partners such as the NCS Federal Advisory Committee and a Federal Consortium with representatives from multiple federal agencies including: the U.S. Department of Health and Human Services , the National Institute of Environmental Health Sciences of the National Institutes of Health , the Centers for Disease Control and Prevention , and

3552-802: The NIH Director that moving forward with the larger Main Study would not be the best way to add to the understanding of how environmental and genetic factors influence child health and development. NICHD has made numerous contributions to improving the health of children, adults, families, and communities. Selected research advances from 2015 include improving the health of infants born preterm, encouraging healthy behaviors, and optimizing rehabilitation. 39°0′12″N 77°6′16″W  /  39.00333°N 77.10444°W  / 39.00333; -77.10444 John F. Kennedy John Fitzgerald Kennedy (May 29, 1917 – November 22, 1963), also known as JFK ,

3648-556: The New England region (some of which became law). In 1958 , Kennedy was re-elected to the Senate, defeating his Republican opponent, Boston lawyer Vincent J. Celeste, with 73.6 percent of the vote, the largest winning margin in the history of Massachusetts politics. In the aftermath of his re-election, Kennedy began preparing to run for president by traveling throughout the U.S. with the aim of building his candidacy for 1960. On January 2, 1960, Kennedy announced his candidacy for

3744-484: The Pacific. He oversaw a professional advertising campaign that ensured ads went up in just the right places the campaign had a virtual monopoly on [Boston] subway space, and on window stickers ("Kennedy for Congress") for cars and homes and was the force behind the mass mailing of Hersey's PT-109 article. Though Republicans took control of the House in the 1946 elections , Kennedy defeated his Republican opponent in

3840-517: The Senate in 1952 against Republican three-term incumbent Henry Cabot Lodge Jr. with the campaign slogan "KENNEDY WILL DO MORE FOR MASSACHUSETTS". Joe Sr. again financed his son's candidacy (persuading the Boston Post to switch its support to Kennedy by promising the publisher a $ 500,000 loan), while John's younger brother Robert emerged as campaign manager. Kennedy's mother and sisters contributed as highly effective canvassers by hosting

3936-564: The Senate, he was at times critically ill and received Catholic last rites . During his convalescence in 1956, he published Profiles in Courage , a book about U.S. senators who risked their careers for their personal beliefs, for which he won the Pulitzer Prize for Biography in 1957. Rumors that this work was ghostwritten by his close adviser and speechwriter , Ted Sorensen , were confirmed in Sorensen's 2008 autobiography. At

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4032-652: The South, and blamed the right-to-work provision for giving the South an unfair advantage over Massachusetts in labor costs. In May 1953, Kennedy introduced "The Economic Problems of New England", a 36-point program to help Massachusetts industries such as fishing , textile manufacturing , watchmaking , and shipbuilding , as well as the Boston seaport. Kennedy's policy agenda included protective tariffs , preventing excessive speculation in raw wool, stronger efforts to research and market American fish products, an increase in

4128-667: The Warrior River at Choiseul Island , taking ten marines aboard and delivering them to safety. Under doctor's orders, Kennedy was relieved of his command on November 18, and sent to the hospital on Tulagi. By December 1943, with his health deteriorating, Kennedy left the Pacific front and arrived in San Francisco in early January 1944. After receiving treatment for his back injury at the Chelsea Naval Hospital in Massachusetts from May to December 1944, he

4224-701: The army's Officer Candidate School . Despite months of training, he was medically disqualified due to his chronic back problems. On September 24, 1941, Kennedy, with the help of the director of the Office of Naval Intelligence (ONI) and the former naval attaché to Joe Sr., Alan Kirk, joined the United States Naval Reserve . He was commissioned an ensign on October 26, 1941, and joined the ONI staff in Washington, D.C. In January 1942, Kennedy

4320-426: The base of Kolombangara around 2:00 a.m., and attempted to turn to attack, when PT-109 was rammed suddenly at an angle and cut in half by the destroyer Amagiri , killing two PT-109 crew members. Avoiding surrender, the remaining crew swam towards Plum Pudding Island , 3.5 miles (5.6 km) southwest of the remains of PT-109 , on August 2. Despite re-injuring his back in the collision, Kennedy towed

4416-440: The camera. Kennedy wore a blue suit and shirt to cut down on glare and appeared sharply focused against the gray studio background. Nixon wore a light-colored suit that blended into the gray background; in combination with the harsh studio lighting that left Nixon perspiring, he offered a less-than-commanding presence. By contrast, Kennedy appeared relaxed, tanned, and telegenic, looking into the camera whilst answering questions. It

4512-674: The campus newspaper, but had little involvement with campus politics, preferring to concentrate on athletics and his social life. Kennedy played football and was on the JV squad during his sophomore year, but an injury forced him off the team, and left him with back problems that plagued him for the rest of his life. He won membership in the Hasty Pudding Club and the Spee Club , one of Harvard's elite " final clubs ". In July 1938, Kennedy sailed overseas with his older brother to work at

4608-433: The chance to achieve their full potential for healthy and productive lives, free from disease or disability, and to ensure the health, productivity, independence, and well-being of all people through optimal rehabilitation. As of November 2016, the director of NICHD is Diana W. Bianchi . NICHD's budget in 2015 was an estimated $ 1.3 billion, which supported research at institutions, universities, and organizations throughout

4704-671: The country was the "initial battleground in the communist drive to capture Western Europe." To combat Soviet efforts to take control in Middle Eastern and Asian countries like Indochina , Kennedy wanted the United States to develop nonmilitary techniques of resistance that would not create suspicions of neoimperialism or add to the country's financial burden. The problem, as he saw it, was not simply to be anti-communist but to stand for something that these emerging nations would find appealing. Almost every weekend that Congress

4800-537: The day that Germany invaded Poland ; the start of World War II . Two days later, the family was in the House of Commons for speeches endorsing the United Kingdom's declaration of war on Germany. Kennedy was sent as his father's representative to help with arrangements for American survivors of the torpedoing of SS  Athenia before flying back to the U.S. on his first transatlantic flight. While Kennedy

4896-610: The fall general election campaign, the Republican nominee and incumbent Vice President Richard Nixon held a six-point lead in the polls. Major issues included how to get the economy moving again, Kennedy's Catholicism, the Cuban Revolution , and whether the space and missile programs of the Soviet Union had surpassed those of the U.S. To address fears that his being Catholic would impact his decision-making, he told

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4992-743: The first nuclear weapons treaty . He presided over the establishment of the Peace Corps , Alliance for Progress with Latin America, and the continuation of the Apollo program with the goal of landing a man on the Moon before 1970. He supported the civil rights movement but was only somewhat successful in passing his New Frontier domestic policies. On November 22, 1963, Kennedy was assassinated in Dallas . His vice president, Lyndon B. Johnson , assumed

5088-552: The first NIH institute to focus on the entire life process rather than on a specific disease or body system. NICHD became a funding source for research on birth defects and intellectual and developmental disabilities (IDDs), created a new pediatrics specialty, and established IDDs as a field of research. The institute also focused on the idea that adult health has its origins in early development and that behavior and social science were important aspects of human development. On December 21, 2007, by act of Congress (Public Law 110–54), NICHD

5184-639: The first televised presidential debates in American history, and he was elected president, narrowly defeating Republican opponent Richard Nixon , the incumbent vice president. Kennedy's presidency saw high tensions with communist states in the Cold War. He increased the number of American military advisers in South Vietnam , and the Strategic Hamlet Program began during his presidency. In 1961, he authorized attempts to overthrow

5280-436: The full-scale (and more expensive) experiment to improve the chances of a clear outcome. In sociology , pilot studies can be referred to as small-scale studies that will help identify design issues before the main research is done. Although pilot experiments have a well-established tradition, their usefulness as a strategy for change has been questioned, at least in the domain of environmental management. Extrapolation from

5376-408: The general election, taking 73 percent of the vote. As a congressman, Kennedy had a reputation for not taking much interest in the running of his office or his constituents' concerns, with one of the highest absenteeism rates in the House, although much was explained by illness. George Smathers , one of his few political friends at the time, claimed that he was more interested in being a writer than

5472-487: The general public can only regard it as a tragedy that politics has prevented the recommendations of the McClellan committee from being carried out this year," Kennedy announced. That same year, Kennedy joined the Senate's Foreign Relations Committee . There he supported Algeria's effort to gain independence from France and sponsored an amendment to the Mutual Defense Assistance Act that would provide aid to Soviet satellite nations. Kennedy also introduced an amendment to

5568-458: The general public. His personal life has been the focus of considerable sustained interest following public revelations in the 1970s of his chronic health ailments and extramarital affairs . Kennedy is the most recent U.S. president to have died in office . John Fitzgerald Kennedy was born outside Boston in Brookline, Massachusetts , on May 29, 1917, to Joseph P. Kennedy Sr. , a businessman and politician, and Rose Kennedy ( née Fitzgerald),

5664-433: The growth, development , and health of children across the United States. The NCS was designed to follow approximately 100,000 children, some from before birth, through age 21 years. The NCS planned to collect comprehensive information to: With this broad perspective, the NCS was designed to contribute to the implementation of health equity, where each individual has an opportunity to realize their health potential. The NCS

5760-567: The many factors that contribute to health and disease from before birth through age 21. This included, but was not limited to, the search for drivers of diseases with prenatal or developmental origins. The Study was closed in December 2014. Within NICHD, the NCS Program Office administered the implementation of day-to-day Study operations. The Program Office was supervised by the Study Director, Steven Hirschfeld, MD, PhD Associate Director for Clinical Research, NICHD. For advice and recommendations regarding Study framework, content, and methodologies,

5856-456: The national popular vote, by most accounts , Kennedy led Nixon by just two-tenths of one percent (49.7% to 49.5%), while in the Electoral College , he won 303 votes to Nixon's 219 (269 were needed to win). Fourteen electors from Mississippi and Alabama refused to support Kennedy because of his support for the civil rights movement ; they voted for Senator Harry F. Byrd of Virginia, as did an elector from Oklahoma. Forty-three years old, Kennedy

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5952-495: The nations of the world to join to fight what he called the "common enemies of man: tyranny, poverty, disease, and war itself." He added: All this will not be finished in the first one hundred days. Nor will it be finished in the first one thousand days, nor in the life of this Administration, nor even perhaps in our lifetime on this planet. But let us begin." In closing, he expanded on his desire for greater internationalism: "Finally, whether you are citizens of America or citizens of

6048-425: The nomination. Stevenson—the 1952 and 1956 presidential nominee—remained very popular, while Johnson also hoped to win the nomination with support from party leaders. Kennedy's candidacy also faced opposition from former President Harry S. Truman , who was concerned about Kennedy's lack of experience. Kennedy knew that a second ballot could give the nomination to Johnson or someone else, and his well-organized campaign

6144-472: The presidency . Lee Harvey Oswald was arrested for the assassination, but he was shot and killed by Jack Ruby two days later. The FBI and the Warren Commission both concluded Oswald had acted alone, but conspiracy theories about the assassination persist. After Kennedy's death, Congress enacted many of his proposals, including the Civil Rights Act of 1964 and the Revenue Act of 1964 . Kennedy ranks highly in polls of U.S. presidents with historians and

6240-468: The presidency. After Joe's death, the assignment fell to JFK as the second eldest. Boston mayor Maurice J. Tobin discussed the possibility of John becoming his running mate in 1946 as a candidate for Massachusetts lieutenant governor , but Joe Sr. preferred a congressional campaign that could send John to Washington, where he could have national visibility. At the urging of Kennedy's father, U.S. Representative James Michael Curley vacated his seat in

6336-406: The presidential nomination, Kennedy gave his well-known " New Frontier " speech: For the problems are not all solved and the battles are not all won—and we stand today on the edge of a New Frontier. ... But the New Frontier of which I speak is not a set of promises—it is a set of challenges. It sums up not what I intend to offer the American people, but what I intend to ask of them. At the start of

6432-502: The program. Kennedy, a Massachusetts Audubon Society supporter, wanted to make sure that the shorelines of Cape Cod remained unsullied by industrialization. On September 3, 1959, Kennedy co-sponsored the Cape Cod National Seashore bill with his Republican colleague Senator Leverett Saltonstall . As a senator, Kennedy quickly won a reputation for responsiveness to requests from constituents (i.e., co-sponsoring legislation to provide federal loans to help rebuild communities damaged by

6528-438: The prominent Kennedy family in Brookline, Massachusetts , Kennedy graduated from Harvard University in 1940, joining the U.S. Naval Reserve the following year. During World War II , he commanded PT boats in the Pacific theater . Kennedy's survival following the sinking of PT-109 and his rescue of his fellow sailors made him a war hero and earned the Navy and Marine Corps Medal , but left him with serious injuries. After

6624-415: The relevant population. A pilot study is used to formulate the design of the full-scale experiment which then can be adjusted. The pilot study is potentially a critical insight to clinical trial design, recruitment and sample size of participants, treatment testing, and statistical analysis to improve the power of testing the hypothesis of the study . Analysis from the pilot experiment can be added to

6720-468: The school yearbook and was voted the "most likely to succeed." Kennedy intended to study under Harold Laski at the London School of Economics , as his older brother had done. Ill health forced his return to the U.S. in October 1935, when he enrolled late at Princeton University , but had to leave after two months due to gastrointestinal illness. In September 1936, Kennedy enrolled at Harvard College . He wrote occasionally for The Harvard Crimson ,

6816-420: The southern tip of the Solomon's Kolombangara Island. Intelligence had been sent to Kennedy's Commander Thomas G. Warfield expecting the arrival of the large Japanese naval force that would pass on the evening of August 1. Of the 24 torpedoes fired that night by eight of the American PTs, not one hit the Japanese convoy. On that moonless night, Kennedy spotted a Japanese destroyer heading north on its return from

6912-566: The start of his first term, Kennedy focused on fulfilling the promise of his campaign to do "more for Massachusetts" than his predecessor. Although Kennedy's and Lodge's legislative records were similarly liberal, Lodge voted for the Taft-Hartley Act of 1947 and Kennedy voted against it. On NBC 's Meet the Press , Kennedy excoriated Lodge for not doing enough to prevent the increasing migration of manufacturing jobs from Massachusetts to

7008-552: The state delegation to the party's presidential nominee, Adlai Stevenson II , at the Democratic National Convention in August. Stevenson let the convention select the vice presidential nominee . Kennedy finished second in the balloting, losing to Senator Estes Kefauver of Tennessee, but receiving national exposure. In 1957, Kennedy joined the Senate's Select Committee on Labor Rackets (also known as

7104-737: The strongly Democratic 11th congressional district of Massachusetts to become mayor of Boston in 1946. Kennedy established legal residency at 122 Bowdoin Street across from the Massachusetts State House . Kennedy won the Democratic primary with 42 percent of the vote, defeating nine other candidates. According to Fredrik Logevall, Joe Sr. spent hours on the phone with reporters and editors, seeking information, trading confidences, and cajoling them into publishing puff pieces on John, ones that invariably played up his war record in

7200-436: The study should proceed, and if so, how. A pilot study asks the same questions, but also has a specific design feature: in a pilot study, a future study is conducted on a smaller scale, which, if having produced positive results, may lead to a Phase I clinical trial . The use of pilot and feasibility studies to estimate treatment effect is controversial, with ongoing methodologic discussion about appropriateness. A checklist

7296-539: The war and its origins, and quickly became a bestseller. In addition to addressing Britain's unwillingness to strengthen its military in the lead-up to the war, the book called for an Anglo-American alliance against the rising totalitarian powers. Kennedy became increasingly supportive of U.S. intervention in World War II, and his father's isolationist beliefs resulted in the latter's dismissal as ambassador. In 1940, Kennedy graduated cum laude from Harvard with

7392-640: The world, as well as research conducted by NICHD scientists on the NIH campus in Bethesda, MD, and at other facilities. Source: The National Children's Study (NCS) was a longitudinal cohort study that planned to recruit participants from across the United States of America. The NCS was led by the National Institutes of Health , with the NICHD serving as the scientific lead. It was intended to measure

7488-524: The world, ask of us here the same high standards of strength and sacrifice which we ask of you. The address reflected Kennedy's confidence that his administration would chart a historically significant course in both domestic policy and foreign affairs. The contrast between this optimistic vision and the pressures of managing daily political realities would be one of the main tensions of the early years of his administration. Pilot study A pilot experiment , pilot study , pilot test or pilot project

7584-533: Was a friend of William Randolph Hearst , arranged a position for his son as a special correspondent for Hearst Newspapers ; the assignment kept Kennedy's name in the public eye and "expose[d] him to journalism as a possible career." That May he went to Berlin as a correspondent, covering the Potsdam Conference and other events. Kennedy's elder brother Joe Jr. had been the family's political standard-bearer and had been tapped by their father to seek

7680-509: Was able to earn the support of just enough delegates to win the presidential nomination on the first ballot. Kennedy ignored the opposition of his brother Robert, who wanted him to choose labor leader Walter Reuther , and other liberal supporters when he chose Johnson as his vice-presidential nominee. He believed that the Texas senator could help him win support from the South . In accepting

7776-550: Was an upperclassman at Harvard, he began to take his studies more seriously and developed an interest in political philosophy . He made the dean's list in his junior year. In 1940, Kennedy completed his thesis, "Appeasement in Munich", about British negotiations during the Munich Agreement . The thesis was released on July 24, under the title Why England Slept . The book was one of the first to offer information about

7872-581: Was assigned to Motor Torpedo Squadron TWO, and on April 24 he took command of PT-109 , then based on Tulagi Island in the Solomons . On the night of August 1–2, in support of the New Georgia campaign , PT-109 and fourteen other PTs were ordered to block or repel four Japanese destroyers and floatplanes carrying food, supplies, and 900 Japanese soldiers to the Vila Plantation garrison on

7968-499: Was assigned to the ONI field office at Headquarters, Sixth Naval District , in Charleston, South Carolina . His hope was to be the commander of a PT (patrol torpedo) boat , but his health problems seemed almost certain to prevent active duty. Kennedy's father intervened by providing misleading medical records and convincing PT officers that his presence would bring publicity to the fleet. Kennedy completed six months of training at

8064-507: Was awarded the Navy and Marine Corps Medal , and the injuries he suffered during the incident qualified him for a Purple Heart . After a month's recovery Kennedy returned to duty, commanding the PT-59 . On November 2, Kennedy's PT-59 took part with two other PTs in the rescue of 40–50 marines. The 59 acted as a shield from shore fire as they escaped on two rescue landing craft at the base of

8160-565: Was easy. They cut my PT boat in half." On August 12, 1944, Kennedy's older brother, Joe Jr. , a navy pilot, was killed on an air mission. His body was never recovered. The news reached the family's home in Hyannis Port, Massachusetts, a day later. Kennedy felt that Joe Jr.'s reckless flight was partly an effort to outdo him. To console himself, Kennedy set out to assemble a privately published book of remembrances of his brother, As We Remember Joe . In April 1945, Kennedy's father, who

8256-417: Was exploding a toilet seat with a firecracker. In the next chapel assembly, the headmaster, George St. John, brandished the toilet seat and spoke of "muckers" who would "spit in our sea," leading Kennedy to name his group "The Muckers Club," which included roommate and lifelong friend Lem Billings . Kennedy graduated from Choate in June 1935, finishing 64th of 112 students. He had been the business manager of

8352-626: Was in its Vanguard, or pilot phase, which was designed to assess the feasibility, acceptability, cost, and utility of Study scientific output, logistics, and operations prior to initiating the Main Study. The Vanguard Study enrolled about 5,000 children in 40 counties across the United States. General recruitment was completed in July 2013. On December 12, 2014, the National Children's Study closed, after an expert review committee advised

8448-479: Was in session, Kennedy would fly back to Massachusetts to give speeches to veteran, fraternal, and civic groups, while maintaining an index card file on individuals who might be helpful for a campaign for statewide office. Contemplating whether to run for Massachusetts governor or the U.S. Senate , Kennedy abandoned interest in the former, believing that the governor "sat in an office, handing out sewer contracts." As early as 1949, Kennedy began preparing to run for

8544-442: Was published in 2016 to provide guidance on how to report pilot trials. In engineering , a pilot trial may be conducted to understand the design problems, learn the correct technique’s or to capture unknown requirements prior to building a prototype . It may use prototype parts or simply samples to see which are successful and which are not, prior to more significant development effort. A pilot can typically be differentiated from

8640-574: Was released from active duty. Beginning in January 1945, Kennedy spent three months recovering from his back injury at Castle Hot Springs , a resort and temporary military hospital in Arizona. On March 1, 1945, Kennedy retired from the Navy Reserve on physical disability and was honorably discharged with the full rank of lieutenant. When later asked how he became a war hero, Kennedy joked: "It

8736-508: Was renamed the Eunice Kennedy Shriver National Institute of Child Health and Human Development in honor of Mrs. Shriver's vision, dedication, and contributions to the founding of the institute. Past directors from 1963 -present The mission of NICHD is to ensure that every person is born healthy and wanted, that women suffer no harmful effects from reproductive processes, and that all children have

8832-451: Was the youngest person ever elected to the presidency (though Theodore Roosevelt was a year younger when he succeeded to the presidency after the assassination of William McKinley in 1901). Kennedy was sworn in as the 35th president at noon on January 20, 1961. In his inaugural address , he spoke of the need for all Americans to be active citizens: "Ask not what your country can do for you—ask what you can do for your country." He asked

8928-556: Was the 35th president of the United States , serving from 1961 until his assassination in 1963. He was the youngest person elected president. Kennedy served at the height of the Cold War , and the majority of his foreign policy concerned relations with the Soviet Union and Cuba . A Democrat , Kennedy represented Massachusetts in both houses of the United States Congress prior to his presidency. Born into

9024-539: Was the first major labor relations bill to pass either house since the Taft–Hartley Act of 1947 and dealt largely with the control of union abuses exposed by the McClellan Committee but did not incorporate tough Taft–Hartley amendments requested by President Eisenhower. It survived Senate floor attempts to include Taft-Hartley amendments and passed but was rejected by the House. "Honest union members and

9120-533: Was the only Democrat not to cast a vote against him. Kennedy drafted a speech supporting the censure. However, it was not delivered because Kennedy was hospitalized for back surgery in Boston. Although Kennedy never indicated how he would have voted, the episode damaged his support among members of the liberal community in the 1956 and 1960 elections. In 1956, Kennedy gained control of the Massachusetts Democratic Party , and delivered

9216-822: Was touring the Boston wards with his grandfather Fitzgerald during his 1922 failed gubernatorial campaign. With Joe Sr.'s business ventures concentrated on Wall Street and Hollywood and an outbreak of polio in Massachusetts , the family decided to move from Boston to the Riverdale neighborhood of New York City in September 1927. Several years later, his brother Robert told Look magazine that his father left Boston because of job signs that read: " No Irish Need Apply ." The Kennedys spent summers and early autumns at their home in Hyannis Port, Massachusetts ,

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