125-641: Sputnik V ( Russian : Спутник V , the brand name from the Russian Direct Investment Fund or RDIF) or Gam-COVID-Vac ( Russian : Гам-КОВИД-Вак , the name under which it is legally registered and produced) is an adenovirus viral vector vaccine for COVID-19 developed by the Gamaleya Research Institute of Epidemiology and Microbiology in Russia . It is the world's first registered combination vector vaccine for
250-674: A constitutional referendum on whether to adopt Russian as a second official language. According to the Central Election Commission, 74.8% voted against, 24.9% voted for and the voter turnout was 71.1%. Starting in 2019, instruction in Russian will be gradually discontinued in private colleges and universities in Latvia, and in general instruction in Latvian public high schools. On 29 September 2022, Saeima passed in
375-519: A new education law which requires all schools to teach at least partially in Ukrainian, with provisions while allow indigenous languages and languages of national minorities to be used alongside the national language. The law faced criticism from officials in Russia and Hungary. The 2019 Law of Ukraine "On protecting the functioning of the Ukrainian language as the state language" gives priority to
500-573: A COVID-19 vaccine or any other vaccine is evaluated in controlled clinical trials. It is an estimate of how many people who received the vaccine got the disease compared to how many people who got a placebo had the same outcome. On 2 February 2021, an interim analysis from the Moscow trial was published in The Lancet reporting an efficacy of 91.6% (95% CI , 85.6 – 95.2% ) after the second dose for all age groups, with no unusual side effects . For
625-413: A booster dose following a primary vaccination is evaluated in several ways. One way is to measure the level of antibodies specific against a disease a few years after the primary dose is given. Anamnestic response, the rapid production of antibodies after a stimulus of an antigen, is a typical way to measure the need for a booster dose of a certain vaccine. If the anamnestic response is high after receiving
750-456: A booster dose if their B and T cell count against hepatitis B decrease below a certain level. The tetanus disease requires a booster dose every 10 years, or in some circumstances immediately following infection of tetanus. Td is the name of the booster for adults, and differs from the primary dose in that it does not include immunization against pertussis (whooping cough). While the US recommends
875-580: A booster dose later in life. Both the United States Centers for Disease Control (CDC) and the Canadian National Advisory Committee on Immunization (NACI) supported these recommendations by publicly advising against the need for a hepatitis B booster dose. However, immuno-repressed individuals are advised to seek further screening to evaluate their immune response to hepatitis B, and potentially receive
1000-459: A booster for tetanus every 10 years, other countries, such as the UK, suggest just two booster shots within the first 20 years of life, but no booster after a third decade. Neonatal tetanus is a concern during pregnancy for some women, and mothers are recommended a booster against tetanus during their pregnancy in order to protect their child against the disease. Whooping cough, also called pertussis,
1125-695: A formula with V standing for the nucleus (vowel) and C for each consonant, the maximal structure can be described as follows: (C)(C)(C)(C)V(C)(C)(C)(C) Booster dose A booster dose is an extra administration of a vaccine after an earlier ( primer ) dose. After initial immunization , a booster provides a re-exposure to the immunizing antigen . It is intended to increase immunity against that antigen back to protective levels after memory against that antigen has declined through time. For example, tetanus shot boosters are often recommended every 10 years, by which point memory cells specific against tetanus lose their function or undergo apoptosis . The need for
1250-484: A language that "belongs to the European cultural space". The financing of Russian-language content by the state will cease, which the concept says create a "unified information space". However, one inevitable consequence would be the closure of public media broadcasts in Russian on LTV and Latvian Radio, as well as the closure of LSM's Russian-language service. In Lithuania , Russian has no official or legal status, but
1375-588: A lesser extent the languages to the south and the east: Uralic , Turkic , Persian , Arabic , and Hebrew . According to the Defense Language Institute in Monterey, California , Russian is classified as a level III language in terms of learning difficulty for native English speakers, requiring approximately 1,100 hours of immersion instruction to achieve intermediate fluency. Feudal divisions and conflicts created obstacles between
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#17328007520721500-730: A local trial of Sputnik V coronavirus vaccine was comparable to that of a late-stage trial done in Russia. In May 2021, a study by researchers of the National University of Córdoba , Argentina, found that the vaccine produced antibodies capable of neutralizing the Gamma variant . A study in Argentina found that neutralization is maintained against Alpha and Lambda and reduced against Gamma. The degree of reduction, however, does not necessarily imply reduced protection . A small study of 12 serum samples found that antibodies from
1625-622: A minority language under the Framework Convention for the Protection of National Minorities . 30% of the population was fluent in Russian in 2006, and 2% used it as the main language with family, friends, or at work. In Azerbaijan , Russian has no official status, but is a lingua franca of the country. 26% of the population was fluent in Russian in 2006, and 5% used it as the main language with family, friends, or at work. In Georgia , Russian has no official status, but it
1750-457: A paper suggesting that the almost identical efficacy for every age group from the Lancet paper is very unlikely to occur in genuine experimental data. The group called for a thorough investigation of the Lancet article, as well as the immediate release of anonymized individual patient data to an unbiased statistical expert, and suggested the article should be retracted. The Lancet Group recognized
1875-405: A primary vaccine many years ago, there is most likely little to no need for a booster dose. People can also measure the active B and T cell activity against that antigen after a certain amount of time that the primary vaccine was administered or determine the prevalence of the disease in vaccinated populations. If a patient receives a booster dose but already has a high level of antibody, then
2000-526: A qualitatively new entity can be said to emerge—the general language of the working class... capitalism has the tendency of creating the general urban language of a given society. In 2010, there were 259.8 million speakers of Russian in the world: in Russia – 137.5 million, in the CIS and Baltic countries – 93.7 million, in Eastern Europe – 12.9 million, Western Europe – 7.3 million, Asia – 2.7 million, in
2125-515: A reaction called an Arthus reaction could develop, a localized form of Type III hypersensitivity induced by high levels of IgG antibodies causing inflammation . The inflammation is often self-resolved over the course of a few days but could be avoided altogether by increasing the length of time between the primary vaccine and the booster dose. It is not yet fully clear why some vaccines such as hepatitis A and B are effective for life, and some such as tetanus need boosters. The prevailing theory
2250-429: A ready-to-use solution in water that is frozen at the common home-freezer storage temperature of −18 °C or 0 °F or lower, and as a freeze-dried (lyophlilized) powder, "Gam-COVID-Vac-Lyo", which can be stored at 2–8 °C or 36–46 °F. The freeze-dried powder must be reconstituted with sterile water before use. The lyophilized formulation of Gam-COVID-Vac is similar to the smallpox vaccine , circumventing
2375-534: A report from Argentina published in the New England Journal of Medicine described fatal vaccine-induced thrombocytopenia and thrombosis in a young woman after receipt of Sputnik-V. Gam-COVID-Vac is a viral vector vaccine based on two recombinant replication-defective human adenoviruses : Ad26 (serotype 26) and Ad5 (serotype 5) replicated in HEK 293 cells. The viruses contain the gene that encodes
2500-416: A rolling review of Sputnik V (Gam-COVID-Vac), a COVID-19 vaccine developed by Russia's Gamaleya National Centre of Epidemiology and Microbiology. When asked about the prospect of Austria giving Sputnik V the approval (as some other European countries chose to do), EMA management board chair Christa Wirthumer-Hoche pointed to the fact there was not yet sufficient safety data about those who had already been given
2625-644: A short-term protective effect of a third dose (relative to two doses) was suggested. In the United States, the CDC rolled out booster shots to immunocompromised individuals during the summer of 2021 and originally planned to allow adults to receive a third dose of the COVID-19 vaccine starting in September 2021, with individuals becoming eligible starting 8 months after their second dose (for those who received
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#17328007520722750-440: A slow to nonexistent rate. While these cells are long-lived, they do not typically undergo mitosis, and eventually, the rate of loss of these cells will be greater than the rate of gain. In these cases, a booster dose is required to "boost" the memory B and T cell count back up again. In the case of the polio vaccine , the memory B and T cells produced in response to the vaccine persist only six months after consumption of
2875-423: A two-dose vaccine). After further data about long-term vaccine efficacy and the delta variant came to light, the CDC ultimately made recipients eligible for boosters 6 months after the second shot, in late October. Subsequently, vaccinations in the country surged. In September 2021, the UK's Joint Committee on Vaccination and Immunisation recommended a booster shot for the over-50s and at-risk groups, preferably
3000-539: Is Belarusian, among ethnic Belarusians this share is 28.5%; the highest share of those who speak Belarusian at home is among ethnic Poles — 46.0%. In Estonia , Russian is spoken by 29.6% of the population, according to a 2011 estimate from the World Factbook, and is officially considered a foreign language. School education in the Russian language is a very contentious point in Estonian politics, and in 2022,
3125-481: Is a co-official language per article 5 of the Constitution of Kyrgyzstan . The 2009 census states that 482,200 people speak Russian as a native language, or 8.99% of the population. Additionally, 1,854,700 residents of Kyrgyzstan aged 15 and above fluently speak Russian as a second language, or 49.6% of the population in the age group. In Tajikistan , Russian is the language of inter-ethnic communication under
3250-470: Is a contagious disease that affects the respiratory tract . The infection is caused by a bacterium that sticks to the cilia of the upper respiratory tract and can be very contagious. Pertussis can be especially dangerous for babies, whose immune systems are not yet fully developed, and can develop into pneumonia or result in the baby having trouble breathing. DTaP is the primary vaccine given against pertussis, and children typically receive five doses before
3375-401: Is a high degree of mutual intelligibility between Russian, Belarusian and Ukrainian , and a moderate degree of it in all modern Slavic languages, at least at the conversational level. Russian is written using a Cyrillic alphabet. The Russian alphabet consists of 33 letters. The following table gives their forms, along with IPA values for each letter's typical sound: Older letters of
3500-557: Is a post-posed definite article -to , -ta , -te similar to that existing in Bulgarian and Macedonian. In the Southern Russian dialects , instances of unstressed /e/ and /a/ following palatalized consonants and preceding a stressed syllable are not reduced to [ɪ] (as occurs in the Moscow dialect), being instead pronounced [a] in such positions (e.g. несл и is pronounced [nʲaˈslʲi] , not [nʲɪsˈlʲi] ) – this
3625-488: Is being used less frequently by Russian-speaking typists in favor of the extension of Unicode character encoding , which fully incorporates the Russian alphabet. Free programs are available offering this Unicode extension, which allow users to type Russian characters, even on Western 'QWERTY' keyboards. The Russian language was first introduced to computing after the M-1 , and MESM models were produced in 1951. According to
3750-624: Is called yakanye ( яканье ). Consonants include a fricative /ɣ/ , a semivowel /w⁓u̯/ and /x⁓xv⁓xw/ , whereas the Standard and Northern dialects have the consonants /ɡ/ , /v/ , and final /l/ and /f/ , respectively. The morphology features a palatalized final /tʲ/ in 3rd person forms of verbs (this is unpalatalized in the Standard and Northern dialects). During the Proto-Slavic (Common Slavic) times all Slavs spoke one mutually intelligible language or group of dialects. There
3875-431: Is given in four increments (3 within their first year and a half after birth, then one booster dose between the ages 4–6). The need for a booster dose for hepatitis B has long been debated. Studies in the early 2000s that measured memory cell count of vaccinated individuals showed that fully vaccinated adults (those that received all three rounds of vaccination at the suggested time sequence during infancy) do not require
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4000-525: Is more spoken than English. Sizable Russian-speaking communities also exist in North America, especially in large urban centers of the US and Canada, such as New York City , Philadelphia , Boston , Los Angeles , Nashville , San Francisco , Seattle , Spokane , Toronto , Calgary , Baltimore , Miami , Portland , Chicago , Denver , and Cleveland . In a number of locations they issue their own newspapers, and live in ethnic enclaves (especially
4125-564: Is odd") – чу́дно ( chúdno – "this is marvellous"), молоде́ц ( molodéts – "well done!") – мо́лодец ( mólodets – "fine young man"), узна́ю ( uznáyu – "I shall learn it") – узнаю́ ( uznayú – "I recognize it"), отреза́ть ( otrezát – "to be cutting") – отре́зать ( otrézat – "to have cut"); to indicate the proper pronunciation of uncommon words, especially personal and family names, like афе́ра ( aféra , "scandal, affair"), гу́ру ( gúru , "guru"), Гарси́я ( García ), Оле́ша ( Olésha ), Фе́рми ( Fermi ), and to show which
4250-402: Is recognized as a minority language under the Framework Convention for the Protection of National Minorities . Russian is the language of 9% of the population according to the World Factbook. Ethnologue cites Russian as the country's de facto working language. In China , Russian has no official status, but it is spoken by the small Russian communities in the northeastern Heilongjiang and
4375-569: Is sometimes considered to have played a significant role in the formation of modern Russian. Also, Russian has notable lexical similarities with Bulgarian due to a common Church Slavonic influence on both languages, but because of later interaction in the 19th and 20th centuries, Bulgarian grammar differs markedly from Russian. Over the course of centuries, the vocabulary and literary style of Russian have also been influenced by Western and Central European languages such as Greek, Latin , Polish , Dutch , German, French, Italian, and English, and to
4500-585: Is spoken by 14.2% of the population according to an undated estimate from the World Factbook. In 2005, Russian was the most widely taught foreign language in Mongolia, and was compulsory in Year 7 onward as a second foreign language in 2006. Around 1.5 million Israelis spoke Russian as of 2017. The Israeli press and websites regularly publish material in Russian and there are Russian newspapers, television stations, schools, and social media outlets based in
4625-432: Is that if the immune system responds to a primary vaccine rapidly, the body does not have time to sufficiently develop immunological memory against the disease, and memory cells will not persist in high numbers for the lifetime of the human. After a primary response of the immune system against a vaccination, memory T helper cells and B cells persist at a fairly constant level in germinal centers , undergoing cell division at
4750-532: Is the most spoken native language in Europe , the most spoken Slavic language , as well as the most geographically widespread language of Eurasia . It is the world's seventh-most spoken language by number of native speakers , and the world's ninth-most spoken language by total number of speakers . Russian is one of two official languages aboard the International Space Station , one of
4875-773: Is the native language of the Russians . It was the de facto and de jure official language of the former Soviet Union . Russian has remained an official language of the Russian Federation , Belarus , Kazakhstan , Kyrgyzstan , and Tajikistan , and is still commonly used as a lingua franca in Ukraine , Moldova , the Caucasus , Central Asia , and to a lesser extent in the Baltic states and Israel . Russian has over 258 million total speakers worldwide. It
5000-518: Is the stressed word in a sentence, for example Ты́ съел печенье? ( Tý syel pechenye? – "Was it you who ate the cookie?") – Ты съе́л печенье? ( Ty syél pechenye? – "Did you eat the cookie?) – Ты съел пече́нье? ( Ty syel pechénye? "Was it the cookie you ate?"). Stress marks are mandatory in lexical dictionaries and books for children or Russian learners. The Russian syllable structure can be quite complex, with both initial and final consonant clusters of up to four consecutive sounds. Using
5125-515: Is under rolling review process by EMA, but the marketing authorisation application was not submitted yet. Emergency use has also been authorized in Algeria, Bolivia, Serbia, the Palestinian territories, and Mexico. On 25 January 2021, Iran approved the vaccine, with Foreign Minister Mohammad Javad Zarif saying the country hopes to begin purchases and start joint production of the shot "in
Sputnik V COVID-19 vaccine - Misplaced Pages Continue
5250-470: The 2011 Lithuanian census , Russian was the native language for 7.2% of the population. In Moldova , Russian was considered to be the language of interethnic communication under a Soviet-era law. On 21 January 2021, the Constitutional Court of Moldova declared the law unconstitutional and deprived Russian of the status of the language of interethnic communication. 50% of the population
5375-1000: The Apollo–Soyuz mission, which first flew in 1975. In March 2013, Russian was found to be the second-most used language on websites after English. Russian was the language of 5.9% of all websites, slightly ahead of German and far behind English (54.7%). Russian was used not only on 89.8% of .ru sites, but also on 88.7% of sites with the former Soviet Union domain .su . Websites in former Soviet Union member states also used high levels of Russian: 79.0% in Ukraine, 86.9% in Belarus, 84.0% in Kazakhstan, 79.6% in Uzbekistan, 75.9% in Kyrgyzstan and 81.8% in Tajikistan. However, Russian
5500-413: The Constitution of Tajikistan and is permitted in official documentation. 28% of the population was fluent in Russian in 2006, and 7% used it as the main language with family, friends or at work. The World Factbook notes that Russian is widely used in government and business. In Turkmenistan , Russian lost its status as the official lingua franca in 1996. Among 12% of the population who grew up in
5625-461: The FDA , WHO , and several universities and healthcare institutions, concluded that there was insufficient data to determine the long-term protective benefits of a booster dose (only short-term protective effects were observed), and recommended instead that existing vaccine stock would save most lives if made available to people who had not received any vaccine. Israel first rolled out booster doses of
5750-475: The HEK 293 cells. For the production of the vaccine, to propagate adenoviral vectors in which the E1 gene was deleted, HEK 293 cells are used, which express several adenoviral genes, including E1. However, although rare, homologous recombination between the inserted cellular sequence and the vector sequence can restore the replication capacity to the vector, with less than 100 replicating adenovirus particles per dose of
5875-640: The Oxford–AstraZeneca COVID‑19 vaccine , uses chimpanzee adenovirus ( ChAdOx1 ) as the vector. For both the Oxford-AstraZeneca COVID-19 and Gam-COVID-Vac vaccines the producer cells for the production of non-replicating adenoviral vectors were obtained from the HEK 293 cell line . Each dose of Gam-COVID-Vac contains (1.0 ± 0.5) × 10 virus particles. Both Ad26 and Ad5 were modified to remove the E1 gene to prevent replication outside
6000-750: The Pfizer–BioNTech COVID-19 vaccine for at-risk populations in July 2021. In August this was expanded for the rest of the Israeli population. Effectiveness against severe disease in Israel was lower among people vaccinated either in January or April than in those vaccinated in February or March. During the first 3 weeks of August 2021, just after booster doses were approved and began to be deployed widely,
6125-575: The Pfizer–BioNTech vaccine , meaning about 30 million adults should receive a third dose. The UK's booster rollout was extended to over-40s in November 2021. Russia's Sputnik V COVID-19 vaccine, using similar technology to AstraZeneca's COVID-19 vaccine, in November 2021 introduced a COVID-19 booster called Sputnik Light, which according to a study by the Gamaleya Research Institute of Epidemiology and Microbiology has an effectiveness of 70% against
6250-623: The Philippines (in limited quantities), and the United Arab Emirates . The Sputnik V is currently registered and certified in 71 countries. However, as of April 2022 less than 2.5% of the people vaccinated worldwide have taken a Sputnik V dose. In early 2022, as a result of the 2022 Russian invasion of Ukraine , the United States and other countries placed the Russian Direct Investment Fund (RDIF) on
6375-584: The Ukrainian language in more than 30 spheres of public life: in particular in public administration , media, education, science, culture, advertising, services . The law does not regulate private communication. A poll conducted in March 2022 by RATING in the territory controlled by Ukraine found that 83% of the respondents believe that Ukrainian should be the only state language of Ukraine. This opinion dominates in all macro-regions, age and language groups. On
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#17328007520726500-578: The United States Census , in 2007 Russian was the primary language spoken in the homes of over 850,000 individuals living in the United States. Russian is one of the official languages (or has similar status and interpretation must be provided into Russian) of the following: The Russian language is also one of two official languages aboard the International Space Station – NASA astronauts who serve alongside Russian cosmonauts usually take Russian language courses. This practice goes back to
6625-472: The deltoid muscle . Sputnik Light is a registered single-dose vaccine consisting of only the first dose of Sputnik V. It is intended for areas with acute outbreaks and it will be used as a third ( booster ) dose for those who have received Sputnik V at least 6 months earlier. On August 11, 2021, the developers of the Sputnik V vaccine offered its 'Sputnik Light' (Ad26) vaccine to Pfizer for trial against
6750-756: The list of sanctioned Russian entities and people , significantly reducing Sputnik V's future commercial prospects. The Gam-COVID-Vac vaccine itself is available in two forms: frozen ( vaccine storage : below −18 °C) and liquid (vaccine storage: from +2 to +8 °C, produced a little). In addition to the main vaccine, vaccines and its derivatives were registered: Gam-COVID-Vac-Lyo ( Russian : Гам-КОВИД-Вак-Лио , no data on use), Sputnik Light ( Russian : Спутник Лайт , used for revaccination, as well as vaccination of foreigners in Russia), Gam-COVID-Vac-M ( Russian : Гам-КОВИД-Вак-М , for vaccination of adolescents 12–17 years old). The vaccine can be formulated in two ways: as
6875-592: The 1990s, people in the US started using acellular vaccines (contained small portions of the bacterium), that had lower side effects but were also less effective at triggering an immunological memory response, due to the antigen presented to the immune system being less complete. This less effective, but safer vaccine, led to the development of the booster Tdap. As of September 2021 , protection against severe disease remained high at 6 months after vaccination despite lower efficacy in protection from COVID-19 infection. An international panel of scientists affiliated with
7000-519: The 20th century, Russian was a mandatory language taught in the schools of the members of the old Warsaw Pact and in other countries that used to be satellites of the USSR. According to the Eurobarometer 2005 survey, fluency in Russian remains fairly high (20–40%) in some countries, in particular former Warsaw Pact countries. In Armenia , Russian has no official status, but it is recognized as
7125-471: The Belarusian society the Russian language prevails, so according to the 2019 census 6,718,557 people (71.4% of the total population) stated that they speak Russian at home, for ethnic Belarusians this share is 61.4%, for Russians — 97.2%, for Ukrainians — 89.0%, for Poles — 52.4%, and for Jews — 96.6%; 2,447,764 people (26.0% of the total population) stated that the language they usually speak at home
7250-465: The Delta variant. The effectiveness of COVID-19 vaccines, or any other vaccine, is determined in a mass vaccination in a "real-world" setting (not in clinical trials). This is an assessment of how well the vaccine protects people from outcomes such as infection, symptomatic illness, hospitalization, and death. Effectiveness is evaluated outside of clinical trials, which by contrast, evaluate the efficacy of
7375-764: The European Union, according to the RDIF. On 10 February, the European Medicines Agency (EMA) said that they had "not received an application for a rolling review or a marketing authorisation for the vaccine". The developers have only expressed their interest that the vaccine be considered for a rolling review, but EMA's Human Medicines Committee (CHMP) and the COVID-19 EMA pandemic Task Force (COVID-ETF) need to give their agreement first before developers can submit their application for initiation of
7500-532: The Great and developed from the Moscow ( Middle or Central Russian ) dialect substratum under the influence of some of the previous century's Russian chancery language. Prior to the Bolshevik Revolution , the spoken form of the Russian language was that of the nobility and the urban bourgeoisie. Russian peasants, the great majority of the population, continued to speak in their own dialects. However,
7625-590: The Institute of Russian Language of the Russian Academy of Sciences, an optional acute accent ( знак ударения ) may, and sometimes should, be used to mark stress . For example, it is used to distinguish between otherwise identical words, especially when context does not make it obvious: замо́к ( zamók – "lock") – за́мок ( zámok – "castle"), сто́ящий ( stóyashchy – "worthwhile") – стоя́щий ( stoyáshchy – "standing"), чудно́ ( chudnó – "this
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#17328007520727750-526: The Middle East and North Africa – 1.3 million, Sub-Saharan Africa – 0.1 million, Latin America – 0.2 million, U.S., Canada , Australia, and New Zealand – 4.1 million speakers. Therefore, the Russian language is the seventh-largest in the world by the number of speakers , after English, Mandarin, Hindi -Urdu, Spanish, French, Arabic, and Portuguese. Russian is one of the six official languages of
7875-807: The Russian alphabet include ⟨ ѣ ⟩ , which merged to ⟨ е ⟩ ( /je/ or /ʲe/ ); ⟨ і ⟩ and ⟨ ѵ ⟩ , which both merged to ⟨ и ⟩ ( /i/ ); ⟨ ѳ ⟩ , which merged to ⟨ ф ⟩ ( /f/ ); ⟨ ѫ ⟩ , which merged to ⟨ у ⟩ ( /u/ ); ⟨ ѭ ⟩ , which merged to ⟨ ю ⟩ ( /ju/ or /ʲu/ ); and ⟨ ѧ ⟩ and ⟨ ѩ ⟩ , which later were graphically reshaped into ⟨ я ⟩ and merged phonetically to /ja/ or /ʲa/ . While these older letters have been abandoned at one time or another, they may be used in this and related articles. The yers ⟨ ъ ⟩ and ⟨ ь ⟩ originally indicated
8000-724: The Russian minister of Health Mikhail Murashko announced at a government briefing with the participation of President Vladimir Putin regulatory approval of the vaccine for widespread use. The state registration of the vaccine was carried out "conditionally" with post-marketing measures according to the decree of the Government of the Russian Federation . The registration certificate for the vaccine stated that it could not be used widely in Russia until 1 January 2021, and before that, it may be provided to "a small number of citizens from vulnerable groups", such as medical staff and
8125-458: The Russian principalities before and especially during Mongol rule. This strengthened dialectal differences, and for a while, prevented the emergence of a standardized national language. The formation of the unified and centralized Russian state in the 15th and 16th centuries, and the gradual re-emergence of a common political, economic, and cultural space created the need for a common standard language. The initial impulse for standardization came from
8250-458: The Soviet era can speak Russian, other generations of citizens that do not have any knowledge of Russian. Primary and secondary education by Russian is almost non-existent. In Uzbekistan , Russian is the language of inter-ethnic communication. It has some official roles, being permitted in official documentation and is the lingua franca of the country and the language of the elite. Russian
8375-467: The United Nations. Education in Russian is still a popular choice for both Russian as a second language (RSL) and native speakers in Russia, and in many former Soviet republics. Russian is still seen as an important language for children to learn in most of the former Soviet republics. In Belarus , Russian is a second state language alongside Belarusian per the Constitution of Belarus . 77% of
8500-545: The acute shortages of effective vaccines in Europe. German medical experts have recommended its approval also, and consider the Sputnik Vaccine "clever" and "highly safe". On 19 March 2021, the Philippine Food and Drug Administration granted emergency use authorization for Sputnik V, the fourth COVID-19 vaccine to be given authorization. The Philippine government planned to buy 20 million doses of
8625-468: The age group of 60 years and older, the reported efficacy was 91.8%. On 12 May, a group of biostatisticians from Russia, the US, France, Italy and the Netherlands questioned the efficacy results in a correspondence in The Lancet , highlighting data discrepancies , substandard reporting , apparent errors and numerical inconsistencies and a very unlikely homogeneity in vaccine efficacy across age groups. The authors responded by saying that they had provided
8750-405: The age of seven. Tdap is the booster for pertussis, and is advised in the US to be administered every ten years, and during every pregnancy for mothers. Tdap can also be used as a booster against tetanus. Upon its invention in the 1950s, the pertussis vaccine was whole-cell (contained the entire inactivated bacterium), and could cause fever and local reactions in people who received the vaccine. In
8875-403: The broader sense of expanding the use of Russian alongside or in favour of other languages. The current standard form of Russian is generally regarded as the modern Russian literary language ( современный русский литературный язык – "sovremenny russky literaturny yazyk"). It arose at the beginning of the 18th century with the modernization reforms of the Russian state under the rule of Peter
9000-498: The climate. However, in places where polio is still present, following up an OPV primary dose with an IPV booster may help eradicate the disease. In the United States, only the IPV is used. In rare cases (about 1 in 2.7 million), the OPV has reverted to a strengthened form of the illness, and caused paralysis in the recipients of the vaccine. For this reason, the US only administers IPV, which
9125-633: The concerns about the validity of data published in the article and invited the authors of the article to respond to these latest questions. Side effects are mostly mild and similar to other adenovirus vector vaccines such as the Oxford-AstraZeneca and the Janssen vaccines. However, unlike the Oxford-AstraZeneca and Janssen vaccines evidence does not suggest a risk of vaccine-induced immune thrombotic thrombocytopenia . Although
9250-519: The country. There is an Israeli TV channel mainly broadcasting in Russian with Israel Plus . See also Russian language in Israel . Russian is also spoken as a second language by a small number of people in Afghanistan . In Vietnam , Russian has been added in the elementary curriculum along with Chinese and Japanese and were named as "first foreign languages" for Vietnamese students to learn, on equal footing with English. The Russian language
9375-443: The delta variant. It can be combined with all other vaccines and may be more effective with mRNA vaccines than mRNA boosters. Booster shots can also be used after infections. In this regard, the UK's National Health Service recommends people to wait 28 days after testing positive for COVID-19 before getting their booster shots. Evidence shows that getting a vaccine after recovery from a COVID-19 infection provides added protection to
9500-526: The distinction is a prominent feature of the language, which is usually shown in writing not by a change of the consonant but rather by changing the following vowel. Another important aspect is the reduction of unstressed vowels . Stress , which is often unpredictable, is not normally indicated orthographically , though an optional acute accent may be used to mark stress – such as to distinguish between homographic words (e.g. замо́к [ zamók , 'lock'] and за́мок [ zámok , 'castle']), or to indicate
9625-501: The elderly, according to a Ministry of Health spokesperson. The license under register number No. ЛП-006395 ( LP-006395 ) was issued on 11 August by the Russian Ministry of Health. Although the announcement was made even before the vaccine candidate had been entered into Phase III trials, the practice of marketing authorization "on conditions" also exists in other countries. On 26 August, certificate No. ЛП-006423 ( LP-006423 )
9750-628: The estimate, citing an increase from 66% to 81% when adjusting the data for effectiveness against hospitalization. A large-scale study in Buenos Aires from December 29, 2020, to May 15, 2021, with 663,602 participants aged 60 and older who received Spunik V, the Oxford–AstraZeneca vaccine , or the Sinopharm BIBP vaccine observed an overall efficacy of 98% (95% CI , 95 – 99% ) against COVID-19-related deaths. The study noted that
9875-413: The factory and the industrial plant their local peasant dialects with their phonetics, grammar, and vocabulary, and the very process of recruiting workers from peasants and the mobility of the worker population generate another process: the liquidation of peasant inheritance by way of leveling the particulars of local dialects. On the ruins of peasant multilingual, in the context of developing heavy industry,
10000-456: The final reading amendments that state that all schools and kindergartens in the country are to transition to education in Latvian . From 2025, all children will be taught in Latvian only. On 28 September 2023, Latvian deputies approved The National Security Concept, according to which from 1 January 2026, all content created by Latvian public media (including LSM ) should be only in Latvian or
10125-778: The first dose of Sputnik V vaccine was administered on 14 May 2021 at Hyderabad . Argentina became the first Latin American country to produce it. Large-scale production started in June 2021. As of 31 December 2021 277 million doses were manufactured, mostly (265 million) in Russia. On 28 February 2022, as a result of the 2022 Russian invasion of Ukraine , the United States placed RDIF and its chief executive on its list of sanctioned Russian entities and people . The European Union , Ukraine, United Kingdom and Australia followed later in February and in March. This significantly reduces vaccine's future commercial prospects. The Gam-COVID-Vac vaccine
10250-522: The formulation which later obtained marketing authorization under limited conditions. This vaccine was given the trade name "Sputnik V", after the world's first artificial satellite . During preclinical and clinical trials, 38 participants who received one or two doses of the Gam-COVID-Vac vaccine had produced antibodies against SARS-CoV-2's spike protein, including potent neutralizing antibodies that inactivate viral particles. On 11 August 2020,
10375-409: The frozen liquid formulation was developed for large-scale use, it is cheaper and easier to manufacture. The production of the freeze-dried formulation takes much more time and resources, although it is more convenient for storage and transportation. It was developed with vaccine delivery to hard-to-reach regions of Russia in mind. According to Russian media, the mass production of the Gam-COVID-Vac
10500-582: The full-length spike protein (S) of SARS-CoV-2 to stimulate an immune response . Adenoviral vectors for expression of the SARS-CoV-2 spike protein have also been used in two other COVID-19 vaccines. One is the Janssen COVID-19 vaccine , which utilizes the Ad26COV2 viral vector based on the human virus Ad26. For this vaccine, the cell line PER.C6 is used to replicate the vector. Another one,
10625-692: The generation of immigrants who started arriving in the early 1960s). Only about 25% of them are ethnic Russians, however. Before the dissolution of the Soviet Union , the overwhelming majority of Russophones in Brighton Beach, Brooklyn in New York City were Russian-speaking Jews. Afterward, the influx from the countries of the former Soviet Union changed the statistics somewhat, with ethnic Russians and Ukrainians immigrating along with some more Russian Jews and Central Asians. According to
10750-480: The government bureaucracy for the lack of a reliable tool of communication in administrative, legal, and judicial affairs became an obvious practical problem. The earliest attempts at standardizing Russian were made based on the so-called Moscow official or chancery language, during the 15th to 17th centuries. Since then, the trend of language policy in Russia has been standardization in both the restricted sense of reducing dialectical barriers between ethnic Russians, and
10875-478: The near future", after Supreme Leader Ayatollah Ali Khamenei banned the government from importing vaccines from the United States and United Kingdom . The Czech Republic is also considering buying Sputnik V, and Prime Minister Andrej Babis dismissed the minister of health, Jan Blatný , who was a loud opponent to the use of Sputnik V. On 4 March 2021, EMA's human medicines committee (CHMP) has started
11000-415: The need for continuous "colder chain" or cold-chain storage – as required for the Pfizer–BioNTech and Moderna vaccines – and allowing transportation to remote locations with reduced risk of vaccine spoilage. The first dose (based on Ad26 ) is administered on the first day, and the second dose (based on Ad5 ) is administered on the 21st day to boost immune response . Both doses are administered into
11125-524: The northwestern Xinjiang Uyghur Autonomous Region . Russian was also the main foreign language taught in school in China between 1949 and 1964. In Kazakhstan , Russian is not a state language, but according to article 7 of the Constitution of Kazakhstan its usage enjoys equal status to that of the Kazakh language in state and local administration. The 2009 census reported that 10,309,500 people, or 84.8% of
11250-473: The oral polio vaccine (OPV). Booster doses of the OPV were found ineffective, as they, too, resulted in decreased immune response every six months after consumption. However, when the inactive polio vaccine (IPV) was used as a booster dose, it was found to increase the test subjects' antibody count by 39–75%. Often in developing countries, OPV is used over IPV, because IPV is expensive and hard to transport. Also, IPVs in tropical countries are hard to store due to
11375-515: The other hand, before the war, almost a quarter of Ukrainians were in favour of granting Russian the status of the state language, while after the beginning of Russia's invasion the support for the idea dropped to just 7%. In peacetime, the idea of raising the status of Russian was traditionally supported by residents of the south and east . But even in these regions, only a third of the respondents were in favour, and after Russia's full-scale invasion , their number dropped by almost half. According to
11500-461: The other three languages in the East Slavic branch. In many places in eastern and southern Ukraine and throughout Belarus, these languages are spoken interchangeably, and in certain areas traditional bilingualism resulted in language mixtures such as Surzhyk in eastern Ukraine and Trasianka in Belarus. An East Slavic Old Novgorod dialect , although it vanished during the 15th or 16th century,
11625-446: The parliament approved a bill to close up all Russian language schools and kindergartens by the school year. The transition to only Estonian language schools and kindergartens will start in the 2024-2025 school year. In Latvia , Russian is officially considered a foreign language. 55% of the population was fluent in Russian in 2006, and 26% used it as the main language with family, friends, or at work. On 18 February 2012, Latvia held
11750-453: The peasants' speech was never systematically studied, as it was generally regarded by philologists as simply a source of folklore and an object of curiosity. This was acknowledged by the noted Russian dialectologist Nikolai Karinsky , who toward the end of his life wrote: "Scholars of Russian dialects mostly studied phonetics and morphology. Some scholars and collectors compiled local dictionaries. We have almost no studies of lexical material or
11875-459: The population aged 15 and above, could read and write well in Russian, and understand the spoken language. In October 2023, Kazakhstan drafted a media law aimed at increasing the use of the Kazakh language over Russian, the law stipulates that the share of the state language on television and radio should increase from 50% to 70%, at a rate of 5% per year, starting in 2025. In Kyrgyzstan , Russian
12000-418: The population was fluent in Russian in 2006, and 67% used it as the main language with family, friends, or at work. According to the 2019 Belarusian census , out of 9,413,446 inhabitants of the country, 5,094,928 (54.1% of the total population) named Belarusian as their native language, with 61.2% of ethnic Belarusians and 54.5% of ethnic Poles declaring Belarusian as their native language. In everyday life in
12125-480: The prevention of COVID-19, having been registered on 11 August 2020 by the Russian Ministry of Health . Gam-COVID-Vac was initially approved for distribution in Russia and then in 59 other countries (as of April 2021) on the preliminary results of Phase I – II studies eventually published on 4 September 2020. Approval in early August of Gam-COVID-Vac was met with criticism in mass media and discussions in
12250-547: The production of over 100 million doses of vaccine in India was made with Dr. Reddy's Laboratories , which on 11 January 2021 submitted mid-stage trial data to the Indian regulator and recommended moving onto late-stage trials. The RDIF announced plans to sell 100 million doses to India, 35 million to Uzbekistan , and 32 million to Mexico , as well as 25 million each to Nepal and Egypt . In India,
12375-479: The pronunciation of ultra-short or reduced /ŭ/ , /ĭ/ . Because of many technical restrictions in computing and also because of the unavailability of Cyrillic keyboards abroad, Russian is often transliterated using the Latin alphabet. For example, мороз ('frost') is transliterated moroz , and мышь ('mouse'), mysh or myš' . Once commonly used by the majority of those living outside Russia, transliteration
12500-472: The proper pronunciation of uncommon words or names. Russian is an East Slavic language of the wider Indo-European family . It is a descendant of Old East Slavic , a language used in Kievan Rus' , which was a loose conglomerate of East Slavic tribes from the late 9th to the mid-13th centuries. From the point of view of spoken language , its closest relatives are Ukrainian , Belarusian , and Rusyn ,
12625-403: The regulatory authorities with all the data necessary for obtaining approval, and that the data included with the paper were enough for readers to confirm the reported vaccine efficacy. They also addressed the protocol queries, and said numerical inconsistencies were "simple typing errors that were formally corrected". In June 2022 a group of biostatisticians from Australia and Singapore published
12750-491: The respondents), while according to the 2002 census – 142.6 million people (99.2% of the respondents). In Ukraine , Russian is a significant minority language. According to estimates from Demoskop Weekly, in 2004 there were 14,400,000 native speakers of Russian in the country, and 29 million active speakers. 65% of the population was fluent in Russian in 2006, and 38% used it as the main language with family, friends, or at work. On 5 September 2017, Ukraine's Parliament passed
12875-505: The rolling review process. On 4 March 2021, the Committee for Medicinal Products for Human Use (CHMP) of the EMA started a rolling review of Sputnik V. The EU applicant is R-Pharm Germany GmbH. On 16 June, Reuters reported that approval of Sputnik V will be delayed at least until September because not all the necessary clinical data has been submitted by the deadline. As of June 2021, Sputnik V
13000-537: The scientific community as to whether approval was justified in the absence of robust scientific research confirming safety and efficacy . A large-scale Brazilian study from Dec. 2020 to May 2021 confirmed its effectiveness and safety, as of Oxford–AstraZeneca 's, i.e. above Sinopharm BIBP 's. Emergency mass-distribution of the vaccine began in December 2020 in countries including Russia, Argentina , Belarus , Hungary , Serbia , Pakistan (in limited quantities),
13125-567: The six official languages of the United Nations , as well as the fourth most widely used language on the Internet . Russian is written using the Russian alphabet of the Cyrillic script ; it distinguishes between consonant phonemes with palatal secondary articulation and those without—the so-called "soft" and "hard" sounds. Almost every consonant has a hard or soft counterpart, and
13250-679: The survey carried out by RATING in August 2023 in the territory controlled by Ukraine and among the refugees, almost 60% of the polled usually speak Ukrainian at home, about 30% – Ukrainian and Russian, only 9% – Russian. Since March 2022, the use of Russian in everyday life has been noticeably decreasing. For 82% of respondents, Ukrainian is their mother tongue, and for 16%, Russian is their mother tongue. IDPs and refugees living abroad are more likely to use both languages for communication or speak Russian. Nevertheless, more than 70% of IDPs and refugees consider Ukrainian to be their native language. In
13375-459: The syntax of Russian dialects." After 1917, Marxist linguists had no interest in the multiplicity of peasant dialects and regarded their language as a relic of the rapidly disappearing past that was not worthy of scholarly attention. Nakhimovsky quotes the Soviet academicians A.M Ivanov and L.P Yakubinsky, writing in 1930: The language of peasants has a motley diversity inherited from feudalism. On its way to becoming proletariat peasantry brings to
13500-660: The three vaccines showed a similar effectiveness against death, and that the effectiveness against infection was similar to that of the Oxford-Astrazeneca vaccine and greater than that of the Sinopharm BIBP vaccine. A large-scale study was conducted in Mexico. The study compared 793,487 adults vaccinated with different vaccines with 4,792,338 unvaccinated adults between December 24, 2020, and September 27, 2021.The results were as follows: The vaccine efficacy of
13625-553: The trial participants, but the authors responded that there was a small sample size of nine, and the measured results of titration could only take discrete values (800, 1600, 3200, 6400). Coupled with the observation that values tended to reach a plateau after three to four weeks, they contend that it is not unlikely that several participants would show identical results for days 21 to 28. In early November 2020, Israel Hadassah Medical Center director-general Zeev Rotstein stated that Hadassah's branch in Moscow's Skolkovo Innovation Center
13750-786: The two. Others divide the language into three groupings, Northern , Central (or Middle), and Southern , with Moscow lying in the Central region. The Northern Russian dialects and those spoken along the Volga River typically pronounce unstressed /o/ clearly, a phenomenon called okanye ( оканье ). Besides the absence of vowel reduction, some dialects have high or diphthongal /e⁓i̯ɛ/ in place of Proto-Slavic * ě and /o⁓u̯ɔ/ in stressed closed syllables (as in Ukrainian) instead of Standard Russian /e/ and /o/ , respectively. Another Northern dialectal morphological feature
13875-511: The use of the language has some presence in certain areas. A large part of the population, especially the older generations, can speak Russian as a foreign language. However, English has replaced Russian as lingua franca in Lithuania and around 80% of young people speak English as their first foreign language. In contrast to the other two Baltic states, Lithuania has a relatively small Russian-speaking minority (5.0% as of 2008). According to
14000-593: The vaccine effectively neutralize the Alpha variant, with moderately reduced neutralization against the E484K substitution (median 2.8 fold reduction). However, neutralization of the Beta variant was markedly reduced (median 6.1 fold reduction). In August 2020, British and American officials stated that the Gam-COVID-Vac vaccine would likely be rejected due to concerns that the normally rigorous process of vaccine clinical testing
14125-562: The vaccine. On 12 April 2021, India approved the use of Sputnik V vaccine for emergency use against COVID-19 based on strong immunogenicity data. As of 12 April 2021, 62 countries had granted Sputnik V emergency use authorization. Russian language Russian is an East Slavic language belonging to the Balto-Slavic branch of the Indo-European language family . It is one of the four extant East Slavic languages, and
14250-713: The vaccine. The other ingredients ( excipients ) are the same, both quantitatively and qualitatively, in the two doses. No adjuvants and no other components or ingredients should be included in the vaccine. Large quantities of both adenoviruses are produced by HEK 293 cells that have the E1 gene necessary for viral replication. Rarely, Ad5 can acquire the E1 gene from the HEK 293 cells, restoring its ability to replicate. Gamaleya has set an acceptable limit of 5,000 replicating virus particles per vaccine dose, and quality control documents state that tested batches contain less than 100 replicating virus particles per dose. The production of
14375-405: The vaccine. "We could have Sputnik V on the market in future, when we've examined the necessary data," she said, adding that the vaccine needed to match up to European criteria on quality control and efficacy. On 18 March 2021, German regional leaders including State Premiers and the mayor of Berlin called for the swift approval of the Russian vaccine by the European Medicines Agency to counteract
14500-416: The vaccine. A vaccine is generally considered effective if the estimate is ≥50% with a >30% lower limit of the 95% confidence interval . Effectiveness is generally expected to slowly decrease over time. On 25 August, a preliminary version of a case-control study indicated an unadjusted effectiveness of about 50% against symptomatic disease. The authors expected that adjusting for age and sex would increase
14625-477: Was collaborating on a phase III clinical trial. The ongoing phase III study is a randomised, double-blind, placebo-controlled, multi-centre clinical trial involving 40,000 volunteers in Moscow, and is scheduled to run until May 2021. In 2020–2021, phase III clinical studies were also being conducted in Belarus, UAE, India, Kazakhstan and Venezuela. On April 13, 2021, India's health ministry said its drug regulator had found that safety and immunogenicity data from
14750-765: Was developed by a cellular microbiologists team of the government-backed Gamaleya Research Institute of Epidemiology and Microbiology . The group was led by MD and RAS associate member Denis Logunov, who also worked on vaccines for the Ebolavirus and the MERS-coronavirus . In May 2020, the Gamaleya Research Institute of Epidemiology and Microbiology announced that it had developed the vaccine without serious side effects. By August 2020, phases I and II of two clinical trials (involving 38 patients each) were completed. Only one of them used
14875-405: Was first introduced in North America when Russian explorers voyaged into Alaska and claimed it for Russia during the 18th century. Although most Russian colonists left after the United States bought the land in 1867, a handful stayed and preserved the Russian language in this region to this day, although only a few elderly speakers of this unique dialect are left. In Nikolaevsk, Alaska , Russian
15000-421: Was fluent in Russian in 2006, and 19% used it as the main language with family, friends, or at work. According to the 2014 Moldovan census , Russians accounted for 4.1% of Moldova's population, 9.4% of the population declared Russian as their native language, and 14.5% said they usually spoke Russian. According to the 2010 census in Russia , Russian language skills were indicated by 138 million people (99.4% of
15125-625: Was issued for the lyophilized formulation "Gam-COVID-Vac-Lyo". On 12 June 2021, developers announced that they had developed and tested a nasal vaccine for children aged 8 to 12, with no side effects found, and that they expected to release it on 15 September 2021. A phase I safety trial began on 18 June 2020. On 4 September 2020, data on 76 participants in a phase I–II trial were published, indicating preliminary evidence of safety and an immune response. The results were challenged by international vaccine scientists as being incomplete, suspicious, and unreliable when identical data were reported for many of
15250-423: Was launched by 15 August. By that moment, the Russian Federation has already received applications from 20 countries for the supply of 1 billion doses of vaccine. Three facilities were able to produce about a million doses per month at each with a potential doubling of capacity by winter. By the end of 2020, Gamaleya Research Institute's production, according to an interview with the organization's spokesperson,
15375-531: Was not followed. As of December 2020, Belarus and Argentina granted emergency use authorization for the vector-based vaccine . On 21 January 2021, Hungary became the first European Union country to register the shot for emergency use, as well as the United Arab Emirates in the Persian Gulf region. On 19 January 2021, the Russian authorities applied for the registration of Sputnik V in
15500-504: Was planned to produce 3–5 million doses. As of March 2021, the Russian Direct Investment Fund (RDIF) has licensed production in India , China , South Korea and Brazil . In the EU , RDIF has signed production agreements. By the end of March 2021 RDIF anticipates 33 million doses will have been manufactured in Russia, less than 5% of which will have been exported. An agreement for
15625-402: Was the sixth-most used language on the top 1,000 sites, behind English, Chinese, French, German, and Japanese. Despite leveling after 1900, especially in matters of vocabulary and phonetics, a number of dialects still exist in Russia. Some linguists divide the dialects of Russian into two primary regional groupings, "Northern" and "Southern", with Moscow lying on the zone of transition between
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