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113-463: The entry period is from December until April each year. A panel of judges from Discovery Education and its partner organizations, educators, and science professionals score qualifying entry videos and choose 10 finalists and up to 51 merit winners, one from each state and the District of Columbia , based on the following criteria: Students are required to address an everyday problem and articulate how

226-495: A cascading waterfall with Italian Renaissance -style architecture. Modern , Postmodern , contemporary , and other non-classical architectural styles are also seen in the city. The National Museum of African American History and Culture deeply contrasts the stone-based neoclassical buildings on the National Mall with a design that combines modern engineering with heavy inspiration from African art . The interior of

339-425: A public health emergency of international concern from January 30, 2020, to May 5, 2023. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is contagious in humans. SARS‑CoV‑2 is a strain of the species Betacoronavirus pandemicum (SARSr-CoV), as is SARS-CoV-1 , the virus that caused the 2002–2004 SARS outbreak . There are animal-borne coronavirus strains more closely related to SARS-CoV-2,

452-484: A 1-2 minute video clip as their form of entry. In 2017, Gitanjali Rao from Colorado won the top award for work on a lead detection in drinking water system. In 2018, Rishab Jain from Oregon won the Grand Award for a pancreatic cancer deep learning system. Kara Fan from San Diego won the 2019 top prize, with a nano-particle bandage concept. She made an anti-bacterial bandage with a silver particle solution to win

565-486: A 2023 population of 6.3 million residents. A locally elected mayor and 13-member council have governed the district since 1973, though Congress retains the power to overturn local laws. Washington, D.C., residents are, on the federal level, politically disenfranchised since the city's residents do not have voting representation in Congress; the city's residents elect a single non-voting congressional delegate to

678-487: A center of the nation's internal slave trade . After its survey, the new federal city was constructed on the north bank of the Potomac River, to the east of Georgetown centered on Capitol Hill . On September 9, 1791, three commissioners overseeing the capital's construction named the city in honor of President Washington. The same day, the federal district was named Columbia, a feminine form of Columbus , which

791-474: A family of viruses. By 12 January 2020, five genomes of SARS‑CoV‑2 had been isolated from Wuhan and reported by the Chinese Center for Disease Control and Prevention (CCDC) and other institutions; the number of genomes increased to 42 by 30 January 2020. A phylogenetic analysis of those samples showed they were "highly related with at most seven mutations relative to a common ancestor ", implying that

904-469: A federal town". In Federalist No. 43 , published January 23, 1788, James Madison argued that the new federal government would need authority over a national capital to provide for its own maintenance and safety. The Pennsylvania Mutiny of 1783 emphasized the need for the national government not to rely on any state for its own security. Article One, Section Eight of the Constitution permits

1017-408: A garden-lined grand avenue about 1 mile (1.6 km) long and 400 feet (120 m) wide in an area that is now the National Mall inspired by the grounds at Versailles and Tuileries Gardens. In March 1792, President Washington dismissed L'Enfant due to conflicts with the three commissioners appointed to supervise the capital's construction. Andrew Ellicott , who worked with L'Enfant in surveying

1130-693: A membrane protein that regulates the renin–angiotensin system. During the initial outbreak in Wuhan , China, various names were used for the virus; some names used by different sources included "the coronavirus" or "Wuhan coronavirus". In January 2020, the World Health Organization (WHO) recommended "2019 novel coronavirus" (2019-nCoV) as the provisional name for the virus. This was in accordance with WHO's 2015 guidance against using geographical locations, animal species, or groups of people in disease and virus names. On 11 February 2020,

1243-413: A mink euthanasia campaign rendering it virtually extinct. Each SARS-CoV-2 virion is 60–140 nanometres (2.4 × 10 –5.5 × 10  in) in diameter; its mass within the global human populace has been estimated as being between 0.1 and 10 kilograms. Like other coronaviruses, SARS-CoV-2 has four structural proteins, known as the S ( spike ), E ( envelope ), M ( membrane ), and N ( nucleocapsid ) proteins;

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1356-502: A modern glass exterior and heavy curvature. CityCenterDC is home to Palmer Alley, a pedestrian-only walkway, and houses several apartment buildings, restaurants, and luxury-brand storefronts with streamlined glass and metal facades. Outside Downtown D.C., architectural styles are more varied. Historic buildings are designed primarily in the Queen Anne , Châteauesque , Richardsonian Romanesque , Georgian Revival , Beaux-Arts , and

1469-527: A news conference) worth 10% of the students' total score. Students also presented a simple science experiment, known as a Whelmer, in front of cameras for 15% of their score. The remaining 5% came from teamwork, as the finalists were split into eight teams consisting of five members each for the science challenges. In 2008, the contest became the Discovery Education 3M Young Scientist Challenge. Students no longer have to be nominated and now submit

1582-421: A range of animals—such as cats, ferrets, hamsters, non-human primates, minks, tree shrews, raccoon dogs, fruit bats, and rabbits—that are susceptible and permissive to SARS-CoV-2 infection. Some institutions have advised that those infected with SARS‑CoV‑2 restrict their contact with animals. On 1   February 2020, the World Health Organization (WHO) indicated that "transmission from asymptomatic cases

1695-431: A relatively high homelessness rate, despite its high living standard compared to many American cities. Washington, D.C., is divided into four quadrants of unequal area: Northwest (NW) , Northeast (NE) , Southeast (SE) , and Southwest (SW) . The axes bounding the quadrants radiate from the U.S. Capitol. All road names include the quadrant abbreviation to indicate their location. House numbers generally correspond with

1808-430: A single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ~34%). SARS-CoV-2 is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and

1921-412: A site. The furin cleavage site PRRAR↓ is highly similar to that of the feline coronavirus , an alphacoronavirus 1 strain. Viral genetic sequence data can provide critical information about whether viruses separated by time and space are likely to be epidemiologically linked. With a sufficient number of sequenced genomes , it is possible to reconstruct a phylogenetic tree of the mutation history of

2034-595: A snowstorm in January 1772. Hurricanes or their remnants occasionally impact the area in late summer and early fall. However, they usually are weak by the time they reach Washington, partly due to the city's inland location. Flooding of the Potomac River , however, caused by a combination of high tide, storm surge, and runoff, has been known to cause extensive property damage in the Georgetown neighborhood of

2147-676: A special committee charged with beautifying Washington's ceremonial core. What became known as the McMillan Plan was finalized in 1901 and included relandscaping the Capitol grounds and the National Mall, clearing slums, and establishing a new citywide park system. The plan is thought to have largely preserved L'Enfant's intended design for the city. By law, the city's skyline is low and sprawling. The federal Height of Buildings Act of 1910 prohibits buildings with height exceeding

2260-405: A teacher or professional. Students completed an application that included several essays, which were then evaluated for communication abilities by DCYSC judges, who selected 400 semi-finalists and 40 finalists who received an all-expense-paid trip to Washington, D.C. to compete in the final competition. The finals consisted of two parts. The first was a research presentation, accounting for 20% of

2373-473: A variety of Victorian styles. Rowhouses are prominent in areas developed after the Civil War and typically follow Federal and late Victorian designs. Georgetown 's Old Stone House , built in 1765, is the oldest-standing building in the city. Founded in 1789, Georgetown University features a mix of Romanesque and Gothic Revival architecture . The Ronald Reagan Building is the largest building in

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2486-459: Is a strain of coronavirus that causes COVID-19 , the respiratory illness responsible for the COVID-19 pandemic . The virus previously had the provisional name 2019 novel coronavirus ( 2019-nCoV ), and has also been called human coronavirus 2019 ( HCoV-19 or hCoV-19 ). First identified in the city of Wuhan , Hubei, China, the World Health Organization designated the outbreak

2599-477: Is another possible cause of infection. Preliminary research indicates that the virus may remain viable on plastic ( polypropylene ) and stainless steel ( AISI 304 ) for up to three days, but it does not survive on cardboard for more than one day or on copper for more than four hours. The virus is inactivated by soap, which destabilizes its lipid bilayer . Viral RNA has also been found in stool samples and semen from infected individuals. The degree to which

2712-425: Is approximately 30,000 bases in length, relatively long for a coronavirus—which in turn carry the largest genomes among all RNA families. Its genome consists nearly entirely of protein-coding sequences, a trait shared with other coronaviruses. A distinguishing feature of SARS‑CoV‑2 is its incorporation of a polybasic site cleaved by furin , which appears to be an important element enhancing its virulence. It

2825-911: Is generally popular among tourists and locals. In 2007, six of the top ten buildings in the American Institute of Architects ' ranking of America's Favorite Architecture were in the city: the White House , Washington National Cathedral , the Jefferson Memorial , the United States Capitol , the Lincoln Memorial , and the Vietnam Veterans Memorial . The neoclassical , Georgian , Gothic , and Modern styles are reflected among these six structures and many other prominent edifices in

2938-453: Is likely not a major driver of transmission". One meta-analysis found that 17% of infections are asymptomatic, and asymptomatic individuals were 42% less likely to transmit the virus. However, an epidemiological model of the beginning of the outbreak in China suggested that "pre-symptomatic shedding may be typical among documented infections" and that subclinical infections may have been

3051-680: Is likely to have occurred in late 2019. Epidemiological studies estimate that in the period between December 2019 and September 2020 each infection resulted in an average of 2.4–3.4 new infections when no members of the community were immune and no preventive measures were taken. However, some subsequent variants have become more infectious. The virus is airborne and primarily spreads between people through close contact and via aerosols and respiratory droplets that are exhaled when talking, breathing, or otherwise exhaling, as well as those produced from coughs and sneezes. It enters human cells by binding to angiotensin-converting enzyme 2 (ACE2),

3164-501: Is water. The district is bordered by Montgomery County, Maryland , to the northwest; Prince George's County, Maryland , to the east; Arlington County, Virginia , to the west; and Alexandria, Virginia , to the south. The south bank of the Potomac River forms the district's border with Virginia and has two major tributaries, the Anacostia River and Rock Creek . Tiber Creek , a natural watercourse that once passed through

3277-633: The American Civil War in 1861 led to the expansion of the federal government and notable growth in the city's population, including a large influx of freed slaves. President Abraham Lincoln signed the Compensated Emancipation Act in 1862, which ended slavery in the district, freeing about 3,100 slaves in the district nine months before the Emancipation Proclamation . In 1868, Congress granted

3390-435: The Anacostia River to the east. Washington, D.C.'s street grid was extended, where possible, throughout the district starting in 1888. Georgetown's streets were renamed in 1895. Some streets are particularly noteworthy, including Pennsylvania Avenue , which connects the White House to the Capitol; and K Street, which houses the offices of many lobbying groups. Constitution Avenue and Independence Avenue , located on

3503-544: The Chesapeake and Ohio Canal National Historical Park , the National Mall and Memorial Parks , Theodore Roosevelt Island , Columbia Island , Fort Dupont Park , Meridian Hill Park , Kenilworth Park and Aquatic Gardens , and Anacostia Park . The District of Columbia Department of Parks and Recreation maintains the city's 900 acres (3.6 km ) of athletic fields and playgrounds, 40 swimming pools, and 68 recreation centers. The U.S. Department of Agriculture operates

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3616-584: The House of Representatives in 2021 but was not adopted by the U.S. Senate . To become law it would have to be passed by the Senate and signed by president; it would have renamed the city Washington, Douglas Commonwealth and shrunk the Federal District to about the size of the national mall. Designed in 1791 by Pierre Charles L'Enfant , the city is divided into quadrants , which are centered around

3729-725: The International Committee on Taxonomy of Viruses adopted the official name "severe acute respiratory syndrome coronavirus 2" (SARS‑CoV‑2). To avoid confusion with the disease SARS , the WHO sometimes refers to SARS‑CoV‑2 as "the COVID-19 virus" in public health communications and the name HCoV-19 was included in some research articles. Referring to COVID-19 as the "Wuhan virus" has been described as dangerous by WHO officials, and as xenophobic by many journalists and academics. Human-to-human transmission of SARS‑CoV‑2

3842-628: The International Monetary Fund , the Organization of American States , and other international organizations. Home to many of the nation's largest industry associations, non-profit organizations, and think tanks , D.C. is known as a lobbying hub, with K Street as the industry center. The city had 20.7 million domestic visitors and 1.2 million international visitors, ranking seventh among U.S. cities as of 2022. The Algonquian -speaking Piscataway people , also known as

3955-536: The National Mall , was fully enclosed underground during the 1870s. The creek also formed a portion of the now-filled Washington City Canal , which allowed passage through the city to the Anacostia River from 1815 until the 1850s. The Chesapeake and Ohio Canal starts in Georgetown and was used during the 19th century to bypass the Little Falls of the Potomac River, located at the northwest edge of

4068-623: The Washington Metro stations and the Hirshhorn Museum and Sculpture Garden are designed with strong influence from the 20th-century Brutalism movement. The Smithsonian Institution Building is built of Seneca red sandstone in the Norman Revival style. The Old Post Office building, located on Pennsylvania Avenue and completed in 1899, was the first building in the city to have a steel frame structure and

4181-607: The White House , the Capitol, the Supreme Court Building , and multiple federal departments and agencies . The city is home to many national monuments and museums , located most prominently on or around the National Mall , including the Jefferson Memorial , the Lincoln Memorial , and the Washington Monument . It hosts 177 foreign embassies and serves as the headquarters for the World Bank ,

4294-469: The index case ". The authors later published a correction that showed that shedding began earlier than first estimated, four to five days before symptoms appear. There is uncertainty about reinfection and long-term immunity. It is not known how common reinfection is, but reports have indicated that it is occurring with variable severity. The first reported case of reinfection was a 33-year-old man from Hong Kong who first tested positive on 26 March 2020,

4407-483: The nasal cavity is seemingly the dominant initial site of infection, with subsequent aspiration -mediated virus-seeding into the lungs in SARS‑CoV‑2 pathogenesis. They found that there was an infection gradient from high in proximal towards low in distal pulmonary epithelial cultures, with a focal infection in ciliated cells and type 2 pneumocytes in the airway and alveolar regions respectively. Studies have identified

4520-545: The 1830s, the district's southern territory of Alexandria declined economically, due in part to its neglect by Congress. Alexandria was a major market in the domestic slave trade and pro-slavery residents feared that abolitionists in Congress would end slavery in the district . Alexandria's citizens petitioned Virginia to retake the land it had donated to form the district, a process known as retrocession . The Virginia General Assembly voted in February 1846, to accept

4633-780: The 2019 3M Young Scientist Challenge. In 2020, 14-year-old Anika Chebrolu from Frisco, Texas won the 3M Young Scientist Challenge, due to her endeavor to identify the spike protein of the SARS-CoV-2 . In 2021, Sarah Park from Jacksonville, Florida won the Top Prize and the America's Top Young Scientist title by creating the Spark Care+, a music therapy treatment device for mental health disorders that uses AI, galvanic skin response for sweat gland response, and photoplethysmography (PPG) for heart rate monitoring. Since 2003, themes for

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4746-472: The 446-acre (1.80 km ) United States National Arboretum in Northeast Washington, D.C. Washington's climate is humid subtropical ( Köppen : Cfa ), or oceanic ( Trewartha : Do bordering Cf downtown). Winters are cool to cold with some snow of varying intensity, while summers are hot and humid. The district is in plant hardiness zone 8a near downtown, and zone 7b elsewhere in

4859-535: The 9,122 acres (36.92 km ) of city land owned by the U.S. government. Rock Creek Park is a 1,754-acre (7.10 km ) urban forest in Northwest Washington, which extends 9.3 miles (15.0 km) through a stream valley that bisects the city. Established in 1890, it is the country's fourth-oldest national park and is home to a variety of plant and animal species, including raccoon, deer, owls, and coyotes. Other National Park Service properties include

4972-641: The Canadas , the British set fire to government buildings in the city, gutting the United States Capitol , the Treasury Building , and the White House in what became known as the burning of Washington . However, a storm forced the British to evacuate the city after just 24 hours. Most government buildings were repaired quickly, but the Capitol, which was largely under construction at the time, would not be completed in its current form until 1868. In

5085-488: The Capitol Building and include 131 neighborhoods . As of the 2020 census , the city had a population of 689,545. Commuters from the city's Maryland and Virginia suburbs raise the city's daytime population to more than one million during the workweek. The Washington metropolitan area , which includes parts of Maryland, Virginia, and West Virginia , is the country's seventh-largest metropolitan area , with

5198-513: The City of Washington in 1895. However, the city had poor housing and strained public works, leading it to become the first city in the nation to undergo urban renewal projects as part of the City Beautiful movement in the early 20th century. The City Beautiful movement built heavily upon the already-implemented L'Enfant Plan , with the new McMillan Plan leading urban development in

5311-521: The Conoy, inhabited the lands around the Potomac River and present-day Washington, D.C., when Europeans first arrived and colonized the region in the early 17th century. The Nacotchtank , also called the Nacostines by Catholic missionaries , maintained settlements around the Anacostia River in present-day Washington, D.C. Conflicts with European colonists and neighboring tribes ultimately displaced

5424-723: The District of Columbia) Formerly known as the Discovery Channel Young Scientist Challenge (DCYSC), the 3M Young Scientist Challenge was created in 1999 as an engineering research and exhibit competition for students in grades 5 through 8. It was sponsored primarily by Discovery Communications , Society for Science and the Public , and Elmer's Glue . Competitors were originally qualified for DCYSC by entering an International Science and Engineering -affiliated science fair and being nominated by

5537-495: The N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope . Coronavirus S proteins are glycoproteins and also type I membrane proteins (membranes containing a single transmembrane domain oriented on the extracellular side). They are divided into two functional parts (S1 and S2). In SARS-CoV-2, the spike protein, which has been imaged at the atomic level using cryogenic electron microscopy ,

5650-645: The Piscataway people, some of whom established a new settlement in 1699 near Point of Rocks, Maryland . Nine cities served as capitals to the Continental Congress and under the Articles of Confederation . New York City was the first capital upon the adoption of the Constitution , succeeded by Philadelphia , which was capital from 1790 to 1800. On October 6, 1783, after the capital

5763-401: The SARS‑CoV‑2 genome (matches above 90 percent may sound high, but in genomic terms it is a wide evolutionary gap ). In addition, despite similarities in a few critical amino acids, pangolin virus samples exhibit poor binding to the human ACE2 receptor. SARS‑CoV‑2 belongs to the broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with

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5876-542: The U.S. House of Representatives. The city's voters choose three presidential electors in accordance with the Twenty-third Amendment , passed in 1961. Washington, D.C. anchors the southern end of the Northeast megalopolis . As the seat of the U.S. federal government , the city is an important world political capital . The city hosts the buildings that house federal government headquarters, including

5989-602: The Young Scientist Challenge have followed scientific curiosities and been built on the activities and innovations around them. District of Columbia Washington, D.C. , formally the District of Columbia and commonly known as Washington or D.C. , is the capital city and federal district of the United States . The city is on the Potomac River , across from Virginia , and shares land borders with Maryland to its north and east. It

6102-598: The amino acid sequence P RR A . This sequence is upstream of an arginine and serine which forms the S1/S2 cleavage site ( P RR A R ↓ S ) of the spike protein. Although such sites are a common naturally-occurring feature of other viruses within the Subfamily Orthocoronavirinae, it appears in few other viruses from the Beta-CoV genus, and it is unique among members of its subgenus for such

6215-504: The area. Blizzards affect Washington once every four to six years on average. The most violent storms, known as nor'easters , often impact large regions of the East Coast . From January 27 to 28, 1922 , the city officially received 28 inches (71 cm) of snowfall, the largest snowstorm since official measurements began in 1885. According to notes kept at the time, the city received between 30 and 36 inches (76 and 91 cm) from

6328-536: The borders of the federal district and placed boundary stones at every mile point; many of these stones are still standing. Both Maryland and Virginia were slave states , and slavery existed in the District from its founding. The building of Washington likely relied in significant part on slave labor, and slave receipts have been found for the White House, Capitol Building, and establishment of Georgetown University. The city became an important slave market and

6441-462: The city , primarily in the U ;Street, 14th Street, 7th Street, and H Street corridors, which were predominantly black residential and commercial areas. The riots raged for three days until more than 13,600 federal troops and Washington, D.C., Army National Guardsmen stopped the violence. Many stores and other buildings were burned, and rebuilding from the riots was not completed until

6554-480: The city at the Atlantic Seaboard fall line . The highest natural elevation in the district is 409 feet (125 m) above sea level at Fort Reno Park in upper northwest Washington, D.C. The lowest point is sea level at the Potomac River. The geographic center of Washington is near the intersection of 4th and L streets NW. The district has 7,464 acres (30.21 km ) of parkland, about 19% of

6667-490: The city but bankrupted its government. In 1874, Congress replaced the territorial government with an appointed three-member board of commissioners. In 1888, the city's first motorized streetcars began service. Their introduction generated growth in areas of the district beyond the City of Washington's original boundaries, leading to an expansion of the district over the next few decades. Georgetown's street grid and other administrative details were formally merged with those of

6780-819: The city throughout the movement. Much of the old Victorian Mall was replaced with modern Neoclassical and Beaux-Arts architecture ; these designs are still prevalent in the city's governmental buildings today. Increased federal spending under the New Deal in the 1930s led to the construction of new government buildings, memorials, and museums in the district, though the chairman of the House Subcommittee on District Appropriations, Ross A. Collins of Mississippi , justified cuts to funds for welfare and education for local residents by saying that "my constituents wouldn't stand for spending money on niggers." World War II led to an expansion of federal employees in

6893-730: The city's classical-style architecture include buildings constructed in the French Second Empire style, including the Eisenhower Executive Office Building , and the modernist Watergate complex . The Thomas Jefferson Building , the main Library of Congress building, and the historic Willard Hotel are built in Beaux-Arts style , popular throughout the world in the late nineteenth and early twentieth centuries. Meridian Hill Park contains

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7006-416: The city's total area, the second-highest among high-density U.S. cities after Philadelphia . The city's sizable parkland was a factor in the city being ranked as third in the nation for park access and quality in the 2018 ParkScore ranking of the park systems of the nation's 100 most populous cities, according to Trust for Public Land , a non-profit organization. The National Park Service manages most of

7119-421: The city, was then tasked with completing its design. Though Ellicott revised the original L'Enfant plans, including changing some street patterns, L'Enfant is still credited with the city's overall design. By the early 20th century, however, L'Enfant's vision of a grand national capital was marred by slums and randomly placed buildings in the city, including a railroad station on the National Mall. Congress formed

7232-408: The city. Summers are hot and humid with a July daily average of 79.8 °F (26.6 °C) and average daily relative humidity around 66%, which can cause moderate personal discomfort. Heat indices regularly approach 100 °F (38 °C) at the height of summer. The combination of heat and humidity in the summer brings very frequent thunderstorms, some of which occasionally produce tornadoes in

7345-530: The city. Many of the government buildings, monuments, and museums along the National Mall and surrounding areas are heavily inspired by classical Roman and Greek architecture. The designs of the White House, the U.S. Capitol, Supreme Court Building , Washington Monument , National Gallery of Art , Lincoln Memorial, and Jefferson Memorial are all heavily drawn from these classical architectural movements and feature large pediments, domes, columns in classical order, and heavy stone walls. Notable exceptions to

7458-469: The city. Precipitation occurs throughout the year. The highest recorded temperature was 106 °F (41 °C) on August 6, 1918, and on July 20, 1930. The lowest recorded temperature was −15 °F (−26 °C) on February 11, 1899 , right before the Great Blizzard of 1899 . During a typical year, the city averages about 37 days at or above 90 °F (32 °C) and 64 nights at or below

7571-680: The city; by 1950, the district's population reached its peak of 802,178 residents. The Twenty-third Amendment to the United States Constitution was ratified in 1961, granting the district three votes in the Electoral College for the election of president and vice president, but still not affording the city's residents representation in Congress. After the assassination of civil rights leader Martin Luther King Jr. on April 4, 1968, riots broke out in

7684-405: The creation of the capital district along the Potomac River. The city was founded in 1791, and the 6th Congress held the first session in the unfinished Capitol Building in 1800 after the capital moved from Philadelphia . In 1801, the District of Columbia, formerly part of Maryland and Virginia and including the existing settlements of Georgetown and Alexandria , was officially recognized as

7797-418: The differences between what was then called 2019-nCoV and the virus from the 2003 SARS outbreak were insufficient to make them separate viral species . Therefore, they identified 2019-nCoV as a virus of Severe acute respiratory syndrome–related coronavirus . In July 2020, scientists reported that a more infectious SARS‑CoV‑2 variant with spike protein variant G614 has replaced D614 as the dominant form in

7910-401: The district with a total area of about 3.1 million square feet (288,000 m ). Washington Union Station is designed in a combination of architectural styles. Its Great Hall has elaborate gold leaf designs along the ceilings and the hall includes several decorative classical-style statues. SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 ( SARS‑CoV‑2 )

8023-486: The district's African American male residents the right to vote in municipal elections. By 1870, the district's population had grown 75% in a decade to nearly 132,000 people, yet the city still lacked paved roads and basic sanitation. Some members of Congress suggested moving the capital farther west, but President Ulysses S. Grant refused to consider the proposal. In the Organic Act of 1871 , Congress repealed

8136-658: The east and north of the Potomac and the County of Alexandria to the west and south. After the Act's passage, citizens in the district were no longer considered residents of Maryland or Virginia, which ended their representation in Congress. On August 24, 1814, during the War of 1812 , British forces invaded and occupied the city after defeating an American force at Bladensburg . In retaliation for acts of destruction by American troops in

8249-604: The establishment of a "District (not exceeding ten miles square) as may, by cession of particular states, and the acceptance of Congress, become the seat of the government of the United States". However, the constitution does not specify a location for the capital. In the Compromise of 1790 , Madison, Alexander Hamilton , and Thomas Jefferson agreed that the federal government would pay each state's remaining Revolutionary War debts in exchange for establishing

8362-578: The fall travel to 3M's headquarters in Minnesota to participate in the Young Scientist Challenge Final Event. They visit 3M labs, meet 3M scientists, and tour the 3M Innovation Center, and also participate in a series of other scored challenges to demonstrate their scientific knowledge and communication abilities. For their final challenge, they then present the innovation that they developed during their mentorship. Here

8475-556: The federal district was a square measuring 10 miles (16 km) on each side and totaling 100 square miles (259 km ). Two pre-existing settlements were included in the territory, the port of Georgetown , founded in 1751, and the port city of Alexandria, Virginia , founded in 1749. In 1791 and 1792, a team led by Andrew Ellicott , including Ellicott's brothers Joseph and Benjamin and African American astronomer Benjamin Banneker , whose parents had been enslaved, surveyed

8588-408: The federal district; initially, the city was a separate settlement within the larger district. In 1846, Congress returned the land originally ceded by Virginia , including the city of Alexandria. In 1871, it created a single municipality for the remaining portion of the district. There have been several unsuccessful efforts to make the district into a state since the 1880s; a statehood bill passed

8701-553: The finalists are judged by a panel of judges selected by Discovery Education and its partner organizations according to the following guidelines: After the Final Event, participants attend an award ceremony and dinner, at which the winner of the title "America’s Top Young Scientist" is announced. First Place (America's Top Young Scientist) Two Runner-Up Prize winners Seven Second Prize winners Minor Planets Named After Finalists Up to 51 Merit Winners (one from each state and

8814-645: The first human infection occurred in November or December 2019. Examination of the topology of the phylogenetic tree at the start of the pandemic also found high similarities between human isolates. As of 21 August 2021, 3,422 SARS‑CoV‑2 genomes, belonging to 19 strains, sampled on all continents except Antarctica were publicly available. On 11 February 2020, the International Committee on Taxonomy of Viruses announced that according to existing rules that compute hierarchical relationships among coronaviruses based on five conserved sequences of nucleic acids,

8927-547: The first infection, but the mechanisms that could account for this are not known. No natural reservoir for SARS-CoV-2 has been identified. Prior to the emergence of SARS-CoV-2 as a pathogen infecting humans, there had been two previous zoonosis -based coronavirus epidemics, those caused by SARS-CoV-1 and MERS-CoV . The first known infections from SARS‑CoV‑2 were discovered in Wuhan, China. The original source of viral transmission to humans remains unclear, as does whether

9040-684: The first to use electrical wiring in its design. Notable contemporary residential buildings, restaurants, shops, and office buildings in the city include the Wharf on the Southwest Waterfront , Navy Yard along the Anacostia River , and CityCenterDC in Downtown . The Wharf has seen the construction of several high-rise office and residential buildings overlooking the Potomac River . Additionally, restaurants, bars, and shops have been opened at street level. Many of these buildings have

9153-404: The freezing mark (32 °F or 0 °C). On average, the first day with a minimum at or below freezing is November 18 and the last day is March 27. Washington, D.C., was a planned city , and many of the city's street grids were developed in that initial plan. In 1791, President George Washington commissioned Pierre Charles L'Enfant , a French-born military engineer and artist, to design

9266-436: The individual charters of the cities of Washington and Georgetown , abolished Washington County , and created a new territorial government for the whole District of Columbia. These steps made "the city of Washington...legally indistinguishable from the District of Columbia." In 1873, President Grant appointed Alexander Robey Shepherd as Governor of the District of Columbia. Shepherd authorized large projects that modernized

9379-437: The late 1990s. In 1973, Congress enacted the District of Columbia Home Rule Act providing for an elected mayor and 13-member council for the district. In 1975, Walter Washington became the district's first elected and first black mayor. Since the 1980s, the D.C. statehood movement has grown in prominence. In 2016, a referendum on D.C. statehood resulted in an 85% support among Washington, D.C., voters for it to become

9492-496: The most closely known relative being the BANAL-52 bat coronavirus. SARS-CoV-2 is of zoonotic origin; its close genetic similarity to bat coronaviruses suggests it emerged from such a bat-borne virus . Research is ongoing as to whether SARS‑CoV‑2 came directly from bats or indirectly through any intermediate hosts. The virus shows little genetic diversity , indicating that the spillover event introducing SARS‑CoV‑2 to humans

9605-617: The much larger clades . Several different clade nomenclatures have been proposed. Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, S, G, GH, and GR). Several notable variants of SARS-CoV-2 emerged in late 2020. The World Health Organization has currently declared five variants of concern , which are as follows: Other notable variants include 6 other WHO-designated variants under investigation and Cluster 5 , which emerged among mink in Denmark and resulted in

9718-497: The name Washington, Douglas Commonwealth (thus keeping the same abbreviation Washington, D.C.). The legalities, reasons, and impact of statehood have been heavily debated in the 2020s. Washington, D.C., is located in the Mid-Atlantic region of the U.S. East Coast . The city has a total area of 68.34 square miles (177 km ), of which 61.05 square miles (158.1 km ) is land and 7.29 square miles (18.9 km ) (10.67%)

9831-561: The nation's 51st state . In March 2017, the city's congressional delegate Eleanor Holmes Norton introduced a bill for statehood. Reintroduced in 2019 and 2021 as the Washington, D.C., Admission Act , the U.S. House of Representatives passed it in April 2021. After not progressing in the Senate, the statehood bill was introduced again in January 2023. The bill would have made D.C. into a state with one representative and two senators, with

9944-571: The natural reservoir of the virus that caused the 2002–2004 SARS outbreak has resulted in the discovery of many SARS-like bat coronaviruses , most originating in horseshoe bats . The closest match by far, published in Nature (journal) in February 2022, were viruses BANAL-52 (96.8% resemblance to SARS‑CoV‑2), BANAL-103 and BANAL-236, collected in three different species of bats in Feuang , Laos. An earlier source published in February 2020 identified

10057-496: The new capital. He enlisted the help of Isaac Roberdeau, Étienne Sulpice Hallet and Scottish surveyor Alexander Ralston to help lay out the city plan. The L'Enfant Plan featured broad streets and avenues radiating out from rectangles, providing room for open space and landscaping. L'Enfant was also provided a roll of maps by Thomas Jefferson depicting Frankfurt, Amsterdam, Strasbourg, Paris, Orleans, Bordeaux, Lyon, Marseille, Turin, and Milan. L'Enfant's design also envisioned

10170-604: The new national capital in the Southern United States . On July 9, 1790, Congress passed the Residence Act , which approved the creation of a national capital on the Potomac River . Under the Residence Act, the exact location was to be selected by President George Washington , who signed the bill into law on July 16, 1790. Formed from land donated by Maryland and Virginia, the initial shape of

10283-552: The north and south sides of the National Mall, respectively, are home to many of Washington's iconic museums, including many Smithsonian Institution buildings and the National Archives Building . Washington hosts 177 foreign embassies ; these maintain nearly 300 buildings and more than 1,600 residential properties, many of which are on a section of Massachusetts Avenue informally known as Embassy Row . The architecture of Washington, D.C., varies greatly and

10396-404: The number of blocks away from the Capitol. Most streets are set out in a grid pattern with east–west streets named with letters (e.g., C Street SW), north–south streets with numbers (e.g., 4th Street NW), and diagonal avenues, many of which are named after states . The City of Washington was bordered on the north by Boundary Street (renamed Florida Avenue in 1890); Rock Creek to the west, and

10509-530: The original SARS-CoV . Like the SARS-related coronavirus implicated in the 2003 SARS outbreak, SARS‑CoV‑2 is a member of the subgenus Sarbecovirus ( beta-CoV lineage B). Coronaviruses undergo frequent recombination. The mechanism of recombination in unsegmented RNA viruses such as SARS-CoV-2 is generally by copy-choice replication, in which gene material switches from one RNA template molecule to another during replication. The SARS-CoV-2 RNA sequence

10622-1819: The pandemic. Coronavirus genomes and subgenomes encode six open reading frames (ORFs). In October 2020, researchers discovered a possible overlapping gene named ORF3d , in the SARS‑CoV‑2 genome . It is unknown if the protein produced by ORF3d has any function, but it provokes a strong immune response. ORF3d has been identified before, in a variant of coronavirus that infects pangolins . A phylogenetic tree based on whole-genome sequences of SARS-CoV-2 and related coronaviruses is: ( Bat ) Rc-o319 , 81% to SARS-CoV-2, Rhinolophus cornutus , Iwate , Japan Bat SL-ZXC21 , 88% to SARS-CoV-2, Rhinolophus pusillus , Zhoushan , Zhejiang Bat SL-ZC45 , 88% to SARS-CoV-2, Rhinolophus pusillus , Zhoushan, Zhejiang Pangolin SARSr-CoV-GX, 85.3% to SARS-CoV-2, Manis javanica , smuggled from Southeast Asia Pangolin SARSr-CoV-GD, 90.1% to SARS-CoV-2, Manis javanica , smuggled from Southeast Asia Bat RshSTT182, 92.6% to SARS-CoV-2, Rhinolophus shameli , Steung Treng , Cambodia Bat RshSTT200, 92.6% to SARS-CoV-2, Rhinolophus shameli , Steung Treng, Cambodia (Bat) RacCS203 , 91.5% to SARS-CoV-2, Rhinolophus acuminatus , Chachoengsao , Thailand (Bat) RmYN02 , 93.3% to SARS-CoV-2, Rhinolophus malayanus , Mengla , Yunnan (Bat) RpYN06 , 94.4% to SARS-CoV-2, Rhinolophus pusillus , Xishuangbanna , Yunnan (Bat) RaTG13 , 96.1% to SARS-CoV-2, Rhinolophus affinis , Mojiang , Yunnan (Bat) BANAL-52 , 96.8% to SARS-CoV-2, Rhinolophus malayanus , Vientiane , Laos SARS-CoV-2 SARS-CoV-1 , 79% to SARS-CoV-2 There are many thousands of variants of SARS-CoV-2, which can be grouped into

10735-420: The problem directly impacts them, their families, their communities, and/or the global population. The idea must be a new innovation or solution, and cannot be a behavioral change or a new use for an existing product. Judges also look for the level of understanding of scientific concepts and confidence in communicating science in general exhibited in the videos. The ten finalists undergo a summer mentorship and in

10848-419: The return of Alexandria. On July 9, 1846, Congress went further, agreeing to return all territory that Virginia had ceded to the district during its formation. This left the district's area consisting only of the portion originally donated by Maryland. Confirming the fears of pro-slavery Alexandrians, the Compromise of 1850 outlawed the slave trade in the district, although not slavery itself. The outbreak of

10961-579: The role of pangolins as an intermediate host was initially posited (a study published in July 2020 suggested that pangolins are an intermediate host of SARS‑CoV‑2-like coronaviruses ), subsequent studies have not substantiated their contribution to the spillover. Evidence against this hypothesis includes the fact that pangolin virus samples are too distant to SARS-CoV-2: isolates obtained from pangolins seized in Guangdong were only 92% identical in sequence to

11074-454: The source of a majority of infections. That may explain how out of 217 on board a cruise liner that docked at Montevideo , only 24 of 128 who tested positive for viral RNA showed symptoms. Similarly, a study of ninety-four patients hospitalized in January and February 2020 estimated patients began shedding virus two to three days before symptoms appear and that "a substantial proportion of transmission probably occurred before first symptoms in

11187-558: The source. For a virus recently acquired through a cross-species transmission, rapid evolution is expected. The mutation rate estimated from early cases of SARS-CoV-2 was of 6.54 × 10 per site per year. Coronaviruses in general have high genetic plasticity , but SARS-CoV-2's viral evolution is slowed by the RNA proofreading capability of its replication machinery. For comparison, the viral mutation rate in vivo of SARS-CoV-2 has been found to be lower than that of influenza. Research into

11300-664: The total score, held at the Smithsonian 's National Museum of Natural History , the National Academy of Sciences , or another academic national association that varied from year to year. The second was a series of six science-related challenges at the National Institutes of Health or the University of Maryland . Each challenge concluded with some type of presentation (e.g., a radio show, a TV show, or

11413-498: The virus RaTG13 , collected in bats in Mojiang , Yunnan, China to be the closest to SARS‑CoV‑2, with 96.1% resemblance. None of the above are its direct ancestor. Bats are considered the most likely natural reservoir of SARS‑CoV‑2. Differences between the bat coronavirus and SARS‑CoV‑2 suggest that humans may have been infected via an intermediate host; although the source of introduction into humans remains unknown. Although

11526-550: The virus became pathogenic before or after the spillover event . Because many of the early infectees were workers at the Huanan Seafood Market , it has been suggested that the virus might have originated from the market. However, other research indicates that visitors may have introduced the virus to the market, which then facilitated rapid expansion of the infections. A March 2021 WHO-convened report stated that human spillover via an intermediate animal host

11639-426: The virus is infectious during the incubation period is uncertain, but research has indicated that the pharynx reaches peak viral load approximately four days after infection or in the first week of symptoms and declines thereafter. The duration of SARS-CoV-2 RNA shedding is generally between 3 and 46 days after symptom onset. A study by a team of researchers from the University of North Carolina found that

11752-587: The virus may be airborne as well, with aerosols potentially being able to transmit the virus. During human-to-human transmission, between 200 and 800 infectious SARS‑CoV‑2 virions are thought to initiate a new infection. If confirmed, aerosol transmission has biosafety implications because a major concern associated with the risk of working with emerging viruses in the laboratory is the generation of aerosols from various laboratory activities which are not immediately recognizable and may affect other scientific personnel. Indirect contact via contaminated surfaces

11865-422: The virus. Another case study described a 25-year-old man from Nevada who tested positive for SARS‑CoV‑2 on 18 April 2020 and on 5 June 2020 (separated by two negative tests). Since genomic analyses showed significant genetic differences between the SARS‑CoV‑2 variant sampled on those two dates, the case study authors determined this was a reinfection. The man's second infection was symptomatically more severe than

11978-541: The width of the adjacent street plus 20 feet (6.1 m). Despite popular belief, no law has ever limited buildings to the height of the United States Capitol or the 555-foot (169 m) Washington Monument , which remains the district's tallest structure. City leaders have cited the height restriction as a primary reason that the district has limited affordable housing and its metro area has suburban sprawl and traffic problems. Washington, D.C., still has

12091-419: Was a poetic name for the United States commonly used at that time. Congress held its first session there on November 17, 1800. Congress passed the District of Columbia Organic Act of 1801 , which officially organized the district and placed the entire territory under the exclusive control of the federal government. The area within the district was organized into two counties, the County of Washington to

12204-414: Was confirmed on 20 January 2020 during the COVID-19 pandemic . Transmission was initially assumed to occur primarily via respiratory droplets from coughs and sneezes within a range of about 1.8 metres (6 ft). Laser light scattering experiments suggest that speaking is an additional mode of transmission and a far-reaching one, indoors, with little air flow. Other studies have suggested that

12317-452: Was discharged on 15 April 2020 after two negative tests, and tested positive again on 15 August 2020 (142 days later), which was confirmed by whole-genome sequencing showing that the viral genomes between the episodes belong to different clades . The findings had the implications that herd immunity may not eliminate the virus if reinfection is not an uncommon occurrence and that vaccines may not be able to provide lifelong protection against

12430-583: Was forced by the Pennsylvania Mutiny of 1783 to move to Princeton, Congress resolved to consider a new location for it. The following day, Elbridge Gerry of Massachusetts moved "that buildings for the use of Congress be erected on the banks of the Delaware near Trenton , or of the Potomac , near Georgetown , provided a suitable district can be procured on one of the rivers as aforesaid, for

12543-439: Was named after George Washington , the first president of the United States . The district is named after Columbia , the female personification of the nation . The U.S. Constitution in 1789 called for the creation of a federal district under the exclusive jurisdiction of the U.S. Congress . As such, Washington, D.C., is not part of any state , and is not one itself. The Residence Act , adopted on July 16, 1790, approved

12656-496: Was suggested that the acquisition of the furin-cleavage site in the SARS-CoV-2 S protein was essential for zoonotic transfer to humans. The furin protease recognizes the canonical peptide sequence R X[ R / K ] R ↓X where the cleavage site is indicated by a down arrow and X is any amino acid . In SARS-CoV-2 the recognition site is formed by the incorporated 12 codon nucleotide sequence CCT CGG CGG GCA which corresponds to

12769-541: Was the most likely explanation, with direct spillover from bats next most likely. Introduction through the food supply chain and the Huanan Seafood Market was considered another possible, but less likely, explanation. An analysis in November 2021, however, said that the earliest-known case had been misidentified and that the preponderance of early cases linked to the Huanan Market argued for it being

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