112-401: Chemical warfare ( CW ) involves using the toxic properties of chemical substances as weapons . This type of warfare is distinct from nuclear warfare , biological warfare and radiological warfare , which together make up CBRN , the military acronym for chemical, biological, radiological, and nuclear (warfare or weapons), all of which are considered " weapons of mass destruction " (WMDs),
224-453: A "plop" rather than exploding, being initially dismissed as dud high explosive or shrapnel shells, giving the gas time to work before the soldiers were alerted and took precautions. The major drawback of artillery delivery was the difficulty of achieving a killing concentration. Each shell had a small gas payload and an area would have to be subjected to saturation bombardment to produce a cloud to match cylinder delivery. A British solution to
336-529: A 14-day period; or causes inflammation which lasts for 14 days in two test subjects. Mild skin irritation is minor damage (less severe than irritation) within 72 hours of application or for three consecutive days after application. Serious eye damage involves tissue damage or degradation of vision which does not fully reverse in 21 days. Eye irritation involves changes to the eye which do fully reverse within 21 days. An Environmental hazard can be defined as any condition, process, or state adversely affecting
448-401: A broad sense but are generally called pathogens rather than toxicants. The biological toxicity of pathogens can be difficult to measure because the threshold dose may be a single organism. Theoretically one virus , bacterium or worm can reproduce to cause a serious infection . If a host has an intact immune system , the inherent toxicity of the organism is balanced by the host's response;
560-558: A cult figure after his death. The control by one single party began the period of "political tutelage", whereby the party was to lead the government while instructing the people on how to participate in a democratic system. The topic of reorganizing the army, brought up at a military conference in 1929, sparked the Central Plains War . The cliques, some of them former warlords, demanded to retain their army and political power within their own territories. Although Chiang finally won
672-424: A deeply rooted history of not only being aware of toxicity, but also taking advantage of it as a tool. Archaeologists studying bone arrows from caves of Southern Africa have noted the likelihood that some aging 72,000 to 80,000 years old were dipped in specially prepared poisons to increase their lethality. Although scientific instrumentation limitations make it difficult to prove concretely, archaeologists hypothesize
784-415: A dose, whereas for even a very toxic substance such as snake venom there is a dose below which there is no detectable toxic effect. Toxicity is species-specific, making cross-species analysis problematic. Newer paradigms and metrics are evolving to bypass animal testing , while maintaining the concept of toxicity endpoints. In Ancient Greek medical literature, the adjective τoξικόν (meaning "toxic")
896-442: A few minutes or hours or even only a few seconds. Purely gaseous agents such as chlorine are nonpersistent, as are highly volatile agents such as sarin. Tactically, nonpersistent agents are very useful against targets that are to be taken over and controlled very quickly. Apart from the agent used, the delivery mode is very important. To achieve a nonpersistent deployment, the agent is dispersed into very small droplets comparable with
1008-517: A gas, and therefore present primarily a contact hazard. The droplet size used for persistent delivery goes up to 1 mm increasing the falling speed and therefore about 80% of the deployed agent reaches the ground, resulting in heavy contamination. Deployment of persistent agents is intended to constrain enemy operations by denying access to contaminated areas. Possible targets include enemy flank positions (averting possible counterattacks), artillery regiments, command posts or supply lines. Because it
1120-414: A given disorder (DiMascio, Soltys and Shader, 1970). These undesirable effects include anticholinergic effects, alpha-adrenergic blockade, and dopaminergic effects, among others. Toxicity can be measured by its effects on the target (organism, organ, tissue or cell). Because individuals typically have different levels of response to the same dose of a toxic substance, a population-level measure of toxicity
1232-586: A grenade with K-51 aerosol CS gas from an unmanned drone. Although crude chemical warfare has been employed in many parts of the world for thousands of years, "modern" chemical warfare began during World War I – see Chemical weapons in World War I . Initially, only well-known commercially available chemicals and their variants were used. These included chlorine and phosgene gas. The methods used to disperse these agents during battle were relatively unrefined and inefficient. Even so, casualties could be heavy, due to
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#17327939620421344-493: A hatter" and the "Mad Hatter" of the book Alice in Wonderland derive from the known occupational toxicity of hatters who used a toxic chemical for controlling the shape of hats. Exposure to chemicals in the workplace environment may be required for evaluation by industrial hygiene professionals. Hazards in the arts have been an issue for artists for centuries, even though the toxicity of their tools, methods, and materials
1456-613: A leaderless and decentralized way and that Sun was only later elected provisional president of the new Chinese republic. However, Sun did not have military power and ceded the provisional presidency of the republic to Yuan Shikai , who arranged for the abdication of Puyi , the last Emperor, on 12 February. On 25 August 1912, the Nationalist Party was established at the Huguang Guild Hall in Beijing , where
1568-451: A multitude of submunitions, so that a large number of small clouds of the chemical agent would form directly on the target. Thermal dissemination is the use of explosives or pyrotechnics to deliver chemical agents. This technique, developed in the 1920s, was a major improvement over earlier dispersal techniques, in that it allowed significant quantities of an agent to be disseminated over a considerable distance. Thermal dissemination remains
1680-763: A new method of non-toxic lithography . There are many environmental health mapping tools. TOXMAP is a Geographic Information System (GIS) from the Division of Specialized Information Services of the United States National Library of Medicine (NLM) that uses maps of the United States to help users visually explore data from the United States Environmental Protection Agency 's (EPA) Toxics Release Inventory and Superfund programs. TOXMAP
1792-399: A newly synthesized and previously unstudied chemical that is believed to be very similar in effect to another compound could be assigned an additional protection factor of 10 to account for possible differences in effects that are probably much smaller. This approach is very approximate, but such protection factors are deliberately very conservative, and the method has been found to be useful in
1904-432: A one- to three-letter " NATO weapon designation" in addition to, or in place of, a common name. Binary munitions , in which precursors for chemical warfare agents are automatically mixed in shell to produce the agent just prior to its use, are indicated by a "-2" following the agent's designation (for example, GB-2 and VX-2). Some examples are given below: The most important factor in the effectiveness of chemical weapons
2016-487: A physical toxicant if taken in extremely high doses because the concentration of vital ions decreases dramatically with too much water in the body. Asphyxiant gases can be considered physical toxicants because they act by displacing oxygen in the environment but they are inert, not chemically toxic gases. Radiation can have a toxic effect on organisms. Behavioral toxicity refers to the undesirable effects of essentially therapeutic levels of medication clinically indicated for
2128-700: A poorly planned and ill-supported armed rising to overthrow Yuan, and failed. Yuan, claiming subversiveness and betrayal, expelled adherents of the KMT from the parliament . Yuan dissolved the Nationalists, whose members had largely fled into exile in Japan, in November and dismissed the parliament early in 1914. Yuan Shikai proclaimed himself emperor in December 1915. While exiled in Japan in 1914, Sun established
2240-1250: A screening tool. Kuomintang Lai Ching-te ( DPP ) Hsiao Bi-khim ( DPP ) Cho Jung-tai ( DPP ) 11th Legislative Yuan Han Kuo-yu ( KMT ) Shieh Ming-yan acting Vacant Vacant Vacant Control Yuan Chen Chu Lee Hung-chun Local government Central Election Commission Kuomintang Democratic Progressive Party Taiwan People's Party Others New Power Party Taiwan Statebuilding Party People First Party Taiwan Solidarity Union New Party Non-Partisan Solidarity Union Newspapers United Daily News Liberty Times China Times Taipei Times Propaganda Censorship Film censorship Lin Chia-lung Cross-Strait relations Special state-to-state relations One Country on Each Side 1992 Consensus Taiwan consensus Chinese Taipei Australia–Taiwan relations Canada–Taiwan relations France–Taiwan relations Russia–Taiwan relations Taiwan–United Kingdom relations Taiwan–United States relations Republic of China (1912–1949) Chinese Civil War One-China policy China and
2352-446: A technique for delivery of phosgene in a non-explosive artillery shell. This technique overcame many of the risks of dealing with gas in cylinders. First, gas shells were independent of the wind and increased the effective range of gas, making any target within reach of guns vulnerable. Second, gas shells could be delivered without warning, especially the clear, nearly odorless phosgene—there are numerous accounts of gas shells, landing with
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#17327939620422464-562: A term that contrasts with conventional weapons . The use of chemical weapons in international armed conflicts is prohibited under international humanitarian law by the 1925 Geneva Protocol and the Hague Conventions of 1899 and 1907 . The 1993 Chemical Weapons Convention prohibits signatories from acquiring, stockpiling, developing, and using chemical weapons in all circumstances except for very limited purposes (research, medical, pharmaceutical or protective). Chemical warfare
2576-516: A toxic substance is safe for a laboratory rat, one might assume that one-tenth that dose would be safe for a human, allowing a safety factor of 10 to allow for interspecies differences between two mammals; if the data are from fish, one might use a factor of 100 to account for the greater difference between two chordate classes (fish and mammals). Similarly, an extra protection factor may be used for individuals believed to be more susceptible to toxic effects such as in pregnancy or with certain diseases. Or,
2688-451: A whole organism, such as an animal , bacterium , or plant , as well as the effect on a substructure of the organism, such as a cell ( cytotoxicity ) or an organ such as the liver ( hepatotoxicity ). Sometimes the word is more or less synonymous with poisoning in everyday usage. A central concept of toxicology is that the effects of a toxicant are dose -dependent; even water can lead to water intoxication when taken in too high
2800-400: A wide variety of applications. Assessing all aspects of the toxicity of cancer-causing agents involves additional issues, since it is not certain if there is a minimal effective dose for carcinogens , or whether the risk is just too small to see. In addition, it is possible that a single cell transformed into a cancer cell is all it takes to develop the full effect (the "one hit" theory). It
2912-585: Is considered chemical warfare under the provisions of the Chemical Weapons Convention (CWC). Under this convention, any toxic chemical, regardless of its origin, is considered a chemical weapon unless it is used for purposes that are not prohibited (an important legal definition known as the General Purpose Criterion ). About 70 different chemicals have been used or were stockpiled as chemical warfare agents during
3024-974: Is a centre-right to right-wing party and the largest in the Pan-Blue Coalition , one of the two main political groups in Taiwan. Its primary rival is the Democratic Progressive Party (DPP), the largest party in the Pan-Green Coalition . As of 2024, the KMT is the largest single party in the Legislative Yuan . The current chairman is Eric Chu . The party originated as the Revive China Society founded by Sun Yat-sen in 1894 in Honolulu . The party underwent reorganization before and after
3136-593: Is a resource funded by the US Federal Government. TOXMAP's chemical and environmental health information is taken from NLM's Toxicology Data Network (TOXNET) and PubMed , and from other authoritative sources. Aquatic toxicity testing subjects key indicator species of fish or crustacea to certain concentrations of a substance in their environment to determine the lethality level. Fish are exposed for 96 hours while crustacea are exposed for 48 hours. While GHS does not define toxicity past 100 mg/L,
3248-479: Is called a chemical warfare agent ( CWA ). About 70 different chemicals have been used or stockpiled as chemical warfare agents during the 20th and 21st centuries. These agents may be in liquid, gas or solid form. Liquid agents that evaporate quickly are said to be volatile or have a high vapor pressure . Many chemical agents are volatile organic compounds so they can be dispersed over a large region quickly. The earliest target of chemical warfare agent research
3360-441: Is different from the use of conventional weapons or nuclear weapons because the destructive effects of chemical weapons are not primarily due to any explosive force . The offensive use of living organisms (such as anthrax ) is considered biological warfare rather than chemical warfare; however, the use of nonliving toxic products produced by living organisms (e.g. toxins such as botulinum toxin , ricin , and saxitoxin )
3472-440: Is incurred and how long it remains; whether it is reversible and how many test subjects were affected. Skin corrosion from a substance must penetrate through the epidermis into the dermis within four hours of application and must not reverse the damage within 14 days. Skin irritation shows damage less severe than corrosion if: the damage occurs within 72 hours of application; or for three consecutive days after application within
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3584-543: Is more difficult to determine the toxicity of chemical mixtures than a pure chemical because each component displays its own toxicity, and components may interact to produce enhanced or diminished effects. Common mixtures include gasoline , cigarette smoke , and industrial waste . Even more complex are situations with more than one type of toxic entity, such as the discharge from a malfunctioning sewage treatment plant, with both chemical and biological agents. The preclinical toxicity testing on various biological systems reveals
3696-586: Is not necessary to deliver large quantities of the agent in a short period of time, a wide variety of weapons systems can be used. A special form of persistent agents are thickened agents. These comprise a common agent mixed with thickeners to provide gelatinous, sticky agents. Primary targets for this kind of use include airfields, due to the increased persistency and difficulty of decontaminating affected areas. Chemical weapons are agents that come in four categories: choking , blister , blood and nerve . The agents are organized into several categories according to
3808-448: Is often used which relates the probabilities of an outcome for a given individual in a population. One such measure is the LD 50 . When such data does not exist, estimates are made by comparison to known similar toxic things, or to similar exposures in similar organisms. Then, " safety factors " are added to account for uncertainties in data and evaluation processes. For example, if a dose of
3920-413: Is still difficult to achieve effective dispersion. The dissemination is highly dependent on atmospheric conditions because many chemical agents act in gaseous form. Thus, weather observations and forecasting are essential to optimize weapon delivery and reduce the risk of injuring friendly forces. Dispersion is placing the chemical agent upon or adjacent to a target immediately before dissemination, so that
4032-432: Is the efficiency of its delivery, or dissemination, to a target. The most common techniques include munitions (such as bombs, projectiles, warheads) that allow dissemination at a distance and spray tanks which disseminate from low-flying aircraft. Developments in the techniques of filling and storage of munitions have also been important. Although there have been many advances in chemical weapon delivery since World War I, it
4144-659: The 1911 Xinhai Revolution , which resulted in the collapse of the Qing dynasty and establishment of the Republic of China (ROC), with Sun as the first president. In 1919, Sun re-established the party under the name "Kuomintang" in the Shanghai French Concession . From 1926 to 1928, the KMT under Chiang Kai-shek successfully led the Northern Expedition against regional warlords and unified
4256-669: The 2016 election , but regained a legislative plurality in the 2024 election . The KMT is a member of the International Democracy Union . The party's guiding ideology is the Three Principles of the People , advocated by Sun Yat-sen and organized on a basis of democratic centralism . As the KMT strongly supports the ROC as the only representative of China, it strongly opposes both Chinese unification under
4368-515: The Industrial Age . It was not until the 19th century that the modern conception of chemical warfare emerged, as various scientists and nations proposed the use of asphyxiating or poisonous gasses. Multiple international treaties were passed banning chemical weapons based upon the alarm of nations and scientists. This however did not prevent the extensive use of chemical weapons in World War I . The development of chlorine gas , among others,
4480-630: The Kuomintang and Chinese communist troops, the People's Liberation Army . However, the Nazis did extensively use poison gas against civilians, mostly the genocide of European Jews , in The Holocaust . Vast quantities of Zyklon B gas and carbon monoxide were used in the gas chambers of Nazi extermination camps , resulting in the overwhelming majority of some three million deaths. This remains
4592-639: The Meiji Restoration , Chiang knew relatively little about the West. He also studied in Japan, but he was firmly rooted in his ancient Han Chinese identity and was steeped in Chinese culture . As his life progressed, he became increasingly attached to ancient Chinese culture and traditions. His few trips to the West confirmed his pro-ancient Chinese outlook and he studied the ancient Chinese classics and ancient Chinese history assiduously. In 1923, after
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4704-738: The Nanjing incident in March 1927, the NRA stormed the consulates of the United States, the United Kingdom and Imperial Japan , looted foreign properties and almost assassinated the Japanese consul. An American, two British, one French, an Italian and a Japanese were killed. These looters also stormed and seized millions of dollars' worth of British concessions in Hankou , refusing to hand them back to
4816-618: The Northern Expedition to suppress the warlords began. Chiang had to defeat three separate warlords and two independent armies. Chiang, with Soviet supplies, conquered the southern half of China in nine months. A split erupted between the Chinese Communist Party and the KMT, which threatened the Northern Expedition. Wang Jing Wei, who led the KMT leftist allies, took the city of Wuhan in January 1927. With
4928-763: The Tokyo subway sarin attack and the Matsumoto incident . See also chemical terrorism . In the 21st century, the Ba'athist regime in Syria has used chemical weapons against civilian populations, resulting in numerous deadly chemical attacks during the Syrian civil war . The Syrian government has used sarin, chlorine, and mustard gas in the Syrian civil war – mostly against civilians. Russia has used chemical weapons during its invasion of Ukraine . This has been done mainly by dropping
5040-511: The Tongmenghui and five smaller pro-revolution parties merged to contest the first national elections. Sun was chosen as the party chairman with Huang Xing as his deputy. The most influential member of the party was the third ranking Song Jiaoren , who mobilized mass support from gentry and merchants for the Nationalists to advocate a constitutional parliamentary democracy. The party opposed constitutional monarchists and sought to check
5152-522: The Tongmenghui days, was sent to Moscow for several months' military and political study. At the first party congress in 1924 in Guangzhou , Guangdong, which included non-KMT delegates such as members of the CCP, they adopted Sun's political theory, which included the Three Principles of the People : nationalism, democracy and people's livelihood. When Sun Yat-sen died in 1925, the political leadership of
5264-719: The Tongmenghui , a group committed to the overthrow of the Qing dynasty and to establish a republic in China. The group supported the Xinhai Revolution of 1911 and the founding of the Republic of China on 1 January 1912. Although Sun and the Tongmenghui are often depicted as the principal organizers of the Xinhai Revolution, this view is disputed by scholars who argue that the Revolution broke out in
5376-522: The lethal dose causes incapacitation, e.g., through nausea or visual problems. The distinction between lethal and incapacitating substances is not fixed, but relies on a statistical average called the LD 50 . Chemical warfare agents can be classified according to their persistency , a measure of the length of time that a chemical agent remains effective after dissemination. Chemical agents are classified as persistent or nonpersistent . Agents classified as nonpersistent lose effectiveness after only
5488-554: The national government relocated to Taiwan . Following the death of Sun Yat-sen, Chiang Kai-shek emerged as the KMT leader and launched the Northern Expedition to defeat the northern warlords and unite China under the party. With its power confirmed in the southeast, the Nationalist Government appointed Chiang Kai-shek commander-in-chief of the National Revolutionary Army (NRA), and
5600-652: The tear-producer ethyl bromoacetate , and was used in autumn 1914 – with little effect on the Germans. The German military contrarily tried to increase the effect of 10.5 cm shrapnel shells by adding an irritant – dianisidine chlorosulfonate . Its use against the British at Neuve Chapelle in October 1914 went unnoticed by them. Hans Tappen, a chemist in the Heavy Artillery Department of
5712-578: The 1990s. The Chinese Communist Party (CCP) was under Comintern instructions to cooperate with the KMT, and its members were encouraged to join while maintaining their separate party identities, forming the First United Front between the two parties. Mao Zedong and early members of the CCP also joined the KMT in 1923. Soviet advisers also helped the KMT to set up a political institute to train propagandists in mass mobilization techniques, and in 1923 Chiang Kai-shek, one of Sun's lieutenants from
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#17327939620425824-532: The 20th century. The entire class, known as Lethal Unitary Chemical Agents and Munitions , has been scheduled for elimination by the CWC. Under the convention, chemicals that are toxic enough to be used as chemical weapons, or that may be used to manufacture such chemicals, are divided into three groups according to their purpose and treatment: Chemical weapons are divided into three categories: Simple chemical weapons were used sporadically throughout antiquity and into
5936-560: The Chinese Revolutionary Party on 8 July 1914, but many of his old revolutionary comrades, including Huang Xing, Wang Jingwei , Hu Hanmin and Chen Jiongming , refused to join him or support his efforts in inciting armed uprising against Yuan. To join the Revolutionary Party, members had to take an oath of personal loyalty to Sun, which many old revolutionaries regarded as undemocratic and contrary to
6048-460: The EPA currently lists aquatic toxicity as "practically non-toxic" in concentrations greater than 100 ppm. Note: A category 4 is established for chronic exposure, but simply contains any toxic substance which is mostly insoluble, or has no data for acute toxicity. Toxicity of a substance can be affected by many different factors, such as the pathway of administration (whether the toxicant is applied to
6160-603: The Japanese factories and their supplies. Full-scale civil war between the Communists and the Nationalists erupted in 1946. The Communist Chinese armies, the People's Liberation Army (PLA), previously a minor faction, grew rapidly in influence and power due to several errors on the KMT's part. First, the KMT reduced troop levels precipitously after the Japanese surrender, leaving large numbers of able-bodied, trained fighting men who became unemployed and disgruntled with
6272-614: The KMT and its Canton government accepted aid from the Soviet Union after being denied recognition by the western powers. Soviet advisers—the most prominent of whom was Mikhail Borodin , an agent of the Comintern —arrived in China in 1923 to aid in the reorganization and consolidation of the KMT along the lines of the Russian Communist Party (Bolsheviks) , establishing a Leninist party structure that lasted into
6384-570: The KMT as prime recruits for the PLA. Second, the KMT government proved thoroughly unable to manage the economy, allowing hyperinflation to result. Among the most despised and ineffective efforts it undertook to contain inflation was the conversion to the gold standard for the national treasury and the Chinese gold yuan in August 1948, outlawing private ownership of gold, silver and foreign exchange, collecting all such precious metals and foreign exchange from
6496-480: The KMT fell to Wang Jingwei (" Reorganization Group ") and Hu Hanmin (" Western Hills Group "), respectively the left-wing and right-wing leaders of the party. However, the real power was in the hands of Chiang Kai-shek, who was in near complete control of the military as the superintendent of the Whampoa Military Academy . With their military superiority, the KMT confirmed their rule on Canton,
6608-468: The KMT government and military. Chiang was alarmed by the expansion of communist influence; he wanted to suppress internal conflicts before confronting foreign aggression. The KMT were aided by German military advisors. The CSR was destroyed in 1934 after a series of KMT offensives. The communists abandoned bases in southeast China for Shaanxi in a military retreat called the Long March ; less than 10% of
6720-695: The Nazis, despite the considerable efforts that had gone into developing new varieties, might have been a lack of technical ability or fears that the Allies would retaliate with their own chemical weapons. Those fears were not unfounded: the Allies made comprehensive plans for defensive and retaliatory use of chemical weapons, and stockpiled large quantities. Japanese forces, as part of the Axis, used them more widely, though only against their Asian enemies, as they also feared that using it on Western powers would result in retaliation. Chemical weapons were frequently used against
6832-559: The No Observed Adverse Effect Level (NOAEL) dose and is helpful for clinical studies. For substances to be regulated and handled appropriately they must be properly classified and labelled. Classification is determined by approved testing measures or calculations and has determined cut-off levels set by governments and scientists (for example, no-observed-adverse-effect levels , threshold limit values , and tolerable daily intake levels). Pesticides provide
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#17327939620426944-600: The PRC and formal Taiwan independence . As the KMT opposes non-peaceful means to resolve the cross-strait disputes while still strongly adhering to the ROC constitution , the party favors a closer relationship with the PRC and accepts the 1992 Consensus , which defines both sides of the Taiwan Strait as " one China " but maintains its ambiguity to different interpretations. It seeks to maintain Taiwan's status quo rather than
7056-539: The ROC losing its United Nations seat and most countries, including its ally the US, switching diplomatic recognition to the CCP-led People's Republic of China (PRC) in the 1970s. In the late 1980s, Chiang Ching-kuo , Chiang Kai-shek's son, lifted martial law and the ban on opposition parties. His successor Lee Teng-hui continued democratic reforms and was re-elected in 1996 through a direct presidential election ,
7168-673: The Russians at the Battle of Bolimów on January 31, 1915; the liquid failed to vaporize in the cold weather, and again the experiment went unnoticed by the Allies. The first effective use were when the German forces at the Second Battle of Ypres simply opened cylinders of chlorine and allowed the wind to carry the gas across enemy lines. While simple, this technique had numerous disadvantages. Moving large numbers of heavy gas cylinders to
7280-529: The Soviet Model. Chiang was also particularly committed to Sun's idea of "political tutelage". Sun believed that the only hope for a unified and better China lay in a military conquest, followed by a period of political tutelage that would culminate in the transition to democracy. Using this ideology, Chiang built himself into the dictator of the Republic of China, both in the Chinese mainland and after
7392-420: The UK government. Both Nationalists and Communist soldiers within the army participated in the rioting and looting of foreign residents in Nanjing. NRA took Beijing in 1928. The city was the internationally recognized capital, even when it was previously controlled by warlords. This event allowed the KMT to receive widespread diplomatic recognition in the same year. The capital was moved from Beijing to Nanjing,
7504-422: The United Nations Chinese unification Taiwan independence movement Taiwanese nationalism Tangwai movement The Kuomintang ( KMT ), also referred to as the Guomindang ( GMD ), the Nationalist Party of China ( NPC ) or the Chinese Nationalist Party ( CNP ), is a political party in the Republic of China , initially based on the Chinese mainland and then in Taiwan since 1949. The KMT
7616-413: The War Ministry, suggested to his brother, the Chief of the Operations Branch at German General Headquarters, the use of the tear-gases benzyl bromide or xylyl bromide . Shells were tested successfully at the Wahn artillery range near Cologne on January 9, 1915, and an order was placed for 15 cm howitzer shells, designated 'T-shells' after Tappen. A shortage of shells limited the first use against
7728-402: The communist army survived. A new base, the Shaan-Gan-Ning Border Region , was created with Soviet aid. KMT secret police persecuted suspected communists and political opponents with terror . In The Birth of Communist China , C.P. Fitzgerald describes China under the rule of the KMT thus: "the Chinese people groaned under a regime Fascist in every quality except efficiency." In 1936, Chiang
7840-417: The communists in the civil war. From 1949 to 1987, the KMT ruled Taiwan as an authoritarian one-party state after the February 28 incident . During this period, martial law was in effect and civil liberties were curtailed as part of its anti-communism efforts, with the period known as the White Terror . The party oversaw Taiwan's economic development , but experienced diplomatic setbacks , including
7952-464: The deadliest use of poison gas in history. The post-war era has seen limited, though devastating, use of chemical weapons. Some 100,000 Iranian troops were casualties of Iraqi chemical weapons during the Iran–Iraq War . Iraq used mustard gas and nerve agents against its own civilians in the 1988 Halabja chemical attack . The Cuban intervention in Angola saw limited use of organophosphates . Terrorist groups have also used chemical weapons, notably in
8064-424: The development of modern chemical warfare in World War I, nations have pursued research and development on chemical weapons that falls into four major categories: new and more deadly agents; more efficient methods of delivering agents to the target (dissemination); more reliable means of defense against chemical weapons; and more sensitive and accurate means of detecting chemical agents. The chemical used in warfare
8176-775: The effective toxicity is then a combination. In some cases, e.g. cholera toxin , the disease is chiefly caused by a nonliving substance secreted by the organism, rather than the organism itself. Such nonliving biological toxicants are generally called toxins if produced by a microorganism, plant, or fungus, and venoms if produced by an animal. Physical toxicants are substances that, due to their physical nature, interfere with biological processes. Examples include coal dust, asbestos fibres or finely divided silicon dioxide , all of which can ultimately be fatal if inhaled. Corrosive chemicals possess physical toxicity because they destroy tissues, but are not directly poisonous unless they interfere directly with biological activity. Water can act as
8288-594: The enemy time to protect themselves, though many soldiers found the sight of a creeping gas cloud unnerving. This made the gas doubly effective, as, in addition to damaging the enemy physically, it also had a psychological effect on the intended victims. Another disadvantage was that gas clouds had limited penetration, capable only of affecting the front-line trenches before dissipating. Although it produced limited results in World War I, this technique shows how simple chemical weapon dissemination can be. Shortly after this "open canister" dissemination, French forces developed
8400-460: The entire body, lethality to specific organs, major/minor damage, or cause cancer. These are globally accepted definitions of what toxicity is. Anything falling outside of the definition cannot be classified as that type of toxicant. Acute toxicity looks at lethal effects following oral, dermal or inhalation exposure. It is split into five categories of severity where Category 1 requires the least amount of exposure to be lethal and Category 5 requires
8512-419: The environment. These hazards can be physical or chemical, and present in air, water, and/or soil. These conditions can cause extensive harm to humans and other organisms within an ecosystem. The EPA maintains a list of priority pollutants for testing and regulation. Workers in various occupations may be at a greater level of risk for several types of toxicity, including neurotoxicity. The expression "Mad as
8624-583: The example of well-established toxicity class systems and toxicity labels . While currently many countries have different regulations regarding the types of tests, numbers of tests and cut-off levels, the implementation of the Globally Harmonized System has begun unifying these countries. Global classification looks at three areas: Physical Hazards (explosions and pyrotechnics), Health Hazards and environmental hazards . The types of toxicities where substances may cause lethality to
8736-423: The first time in the ROC history. The 2000 presidential election ended 72 years of KMT's dominance in the ROC. The KMT reclaimed power from 2008 to 2016, with the landslide victory of Ma Ying-jeou in the 2008 presidential election , whose presidency significantly loosened restrictions on economic and cultural exchanges with the People's Republic of China. The KMT lost the presidency and its legislative majority in
8848-497: The foreign powers and the Qing dynasty. The KMT government demanded that the foreign powers renegotiate the treaties on equal terms. Before the Northern Expedition, the KMT began as a heterogeneous group advocating American-inspired federalism and provincial autonomy. However, the KMT under Chiang's leadership aimed at establishing a centralized one-party state with one ideology. This was even more evident following Sun's elevation into
8960-464: The formal independence or the unification. The KMT traces its ideological and organizational roots to the work of Sun Yat-sen , a proponent of Chinese nationalism and democracy who founded the Revive China Society at the capital of the Republic of Hawaii , Honolulu , on 24 November 1894. On 20 August 1905, Sun joined forces with other anti-monarchist societies in Tokyo, Empire of Japan , to form
9072-656: The formation of the First United Front , Sun Yat-sen sent Chiang to spend three months in Moscow studying the political and military system of the Soviet Union. Although Chiang did not follow the Soviet Communist doctrine, he, like the Communist Party, sought to destroy warlordism and foreign imperialism in China , and upon his return established the Whampoa Military Academy near Guangzhou, following
9184-538: The fragmented nation , leading to the fall of the Beiyang government . KMT was the sole ruling party of the ROC in China from 1928 to 1949, however the party had no actual control over a lot of territory during this period due to the civil war with the Chinese Communist Party (CCP) and the war against Japanese aggression. The party retreated to Taiwan in December 1949, following its defeat by
9296-429: The front-line positions from where the gas would be released was a lengthy and difficult logistical task. Stockpiles of cylinders had to be stored at the front line, posing a great risk if hit by artillery shells. Gas delivery depended greatly on wind speed and direction. If the wind was fickle, as at the Battle of Loos , the gas could blow back, causing friendly casualties . Gas clouds gave plenty of warning, allowing
9408-433: The genetic makeup of an individual, an individual's overall health, and many others. Several of the terms used to describe these factors have been included here. Considering the limitations of the dose-response concept, a novel Abstract Drug Toxicity Index (DTI) has been proposed recently. DTI redefines drug toxicity, identifies hepatotoxic drugs, gives mechanistic insights, predicts clinical outcomes and has potential as
9520-405: The initial blast and by being forced onto the ground. Second, the sizes of the particles vary greatly because explosive dissemination produces a mixture of liquid droplets of variable and difficult to control sizes. Toxic properties Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism . Toxicity can refer to the effect on
9632-492: The mainly static troop positions which were characteristic features of trench warfare . Germany, the first side to employ chemical warfare on the battlefield, simply opened canisters of chlorine upwind of the opposing side and let the prevailing winds do the dissemination. Soon after, the French modified artillery munitions to contain phosgene – a much more effective method that became the principal means of delivery. Since
9744-419: The manner in which they affect the human body. The names and number of categories varies slightly from source to source, but in general, types of chemical warfare agents are as follows: Non-living biological proteins, such as: There are other chemicals used militarily that are not scheduled by the CWC, and thus are not controlled under the CWC treaties. These include: Most chemical weapons are assigned
9856-418: The material is most efficiently used. Dispersion is the simplest technique of delivering an agent to its target. The most common techniques are munitions, bombs, projectiles, spray tanks and warheads. World War I saw the earliest implementation of this technique. The actual first chemical ammunition was the French 26 mm cartouche suffocante rifle grenade , fired from a flare carbine . It contained 35g of
9968-481: The mist produced by an aerosol can. In this form not only the gaseous part of the agent (around 50%) but also the fine aerosol can be inhaled or absorbed through pores in the skin. Modern doctrine requires very high concentrations almost instantly in order to be effective (one breath should contain a lethal dose of the agent). To achieve this, the primary weapons used would be rocket artillery or bombs and large ballistic missiles with cluster warheads. The contamination in
10080-406: The most exposure to be lethal. The table below shows the upper limits for each category. Note: The undefined values are expected to be roughly equivalent to the category 5 values for oral and dermal administration. Skin corrosion and irritation are determined through a skin patch test analysis, similar to an allergic inflammation patch test . This examines the severity of the damage done; when it
10192-582: The occasional use of chemical weapons, mainly to put down rebellions. In Nazi Germany , much research went into developing new chemical weapons, such as potent nerve agents . However, chemical weapons saw little battlefield use in World War II . Both sides were prepared to use such weapons, but the Allied Powers never did, and the Axis used them only very sparingly. The reason for the lack of use by
10304-523: The original capital of the Ming dynasty , and thus a symbolic purge of the final Qing elements. This period of KMT rule in China between 1927 and 1937 was relatively stable and prosperous and is still known as the Nanjing decade . After the Northern Expedition in 1928, the Nationalist government under the KMT declared that China had been exploited for decades under the unequal treaties signed between
10416-474: The people and issuing the Gold Standard Scrip in exchange. As most farmland in the north were under CCP's control, the cities governed by the KMT lacked food supply and this added to the hyperinflation. The new scrip became worthless in only ten months and greatly reinforced the nationwide perception of the KMT as a corrupt or at best inept entity. Third, Chiang Kai-shek ordered his forces to defend
10528-578: The power of Yuan. The Nationalists won an overwhelming majority in the first National Assembly election in December 1912. However, Yuan soon began to ignore the parliament in making presidential decisions. Song Jiaoren was assassinated in Shanghai in 1913. Members of the Nationalists, led by Sun Yat-sen, suspected that Yuan was behind the plot and thus staged the Second Revolution in July 1913,
10640-544: The practice of making poison arrows was widespread in cultures as early as the paleolithic era. The San people of Southern Africa have managed to preserved this practice into the modern era, with the knowledge base to form complex mixtures from poisonous beetles and plant derived extracts, yielding an arrow-tip product with a shelf life beyond several months to a year. There are generally five types of toxicities: chemical, biological, physical, radioactive and behavioural. Disease-causing microorganisms and parasites are toxic in
10752-399: The principal method of disseminating chemical agents today. Most thermal dissemination devices consist of a bomb or projectile shell that contains a chemical agent and a central "burster" charge; when the burster detonates, the agent is expelled laterally. Thermal dissemination devices, though common, are not particularly efficient. First, a percentage of the agent is lost by incineration in
10864-487: The problem was the Livens Projector . This was effectively a large-bore mortar, dug into the ground that used the gas cylinders themselves as projectiles – firing a 14 kg cylinder up to 1500 m. This combined the gas volume of cylinders with the range of artillery. Over the years, there were some refinements in this technique. In the 1950s and early 1960s, chemical artillery rockets and cluster bombs contained
10976-516: The provincial capital of Guangdong . The Guangxi warlords pledged loyalty to the KMT. The KMT now became a rival government in opposition to the warlord Beiyang government based in Beijing . Chiang assumed leadership of the KMT on 6 July 1926. Unlike Sun Yat-sen, whom he admired greatly and who forged all his political, economic, and revolutionary ideas primarily from what he had learned in Hawaii and indirectly through Hong Kong and Japan under
11088-406: The skin, ingested, inhaled, injected), the time of exposure (a brief encounter or long term), the number of exposures (a single dose or multiple doses over time), the physical form of the toxicant (solid, liquid, gas), the concentration of the substance, and in the case of gases, the partial pressure (at high ambient pressure, partial pressure will increase for a given concentration as a gas fraction),
11200-456: The species-, organ- and dose-specific toxic effects of an investigational product. The toxicity of substances can be observed by (a) studying the accidental exposures to a substance (b) in vitro studies using cells/ cell lines (c) in vivo exposure on experimental animals. Toxicity tests are mostly used to examine specific adverse events or specific endpoints such as cancer, cardiotoxicity, and skin/eye irritation. Toxicity testing also helps calculate
11312-582: The spirit of the revolution. As a result, he became largely sidelined within the Republican movement during this period. Sun returned to China in 1917 to establish a military junta at Canton to oppose the Beiyang government but was soon forced out of office and exiled to Shanghai . There, with renewed support, he resurrected the KMT on 10 October 1919, under the name Kuomintang of China ( 中國國民黨 ) and established its headquarters in Canton in 1920. In 1923,
11424-794: The support of the Soviet agent Mikhail Borodin , Wang declared the National Government as having moved to Wuhan. Having taken Nanjing in March, Chiang halted his campaign and prepared a violent break with Wang and his communist allies. Chiang's expulsion of the CCP and their Soviet advisers, marked by the Shanghai massacre on 12 April, led to the beginning of the Chinese Civil War . Wang finally surrendered his power to Chiang. Once this split had been healed, Chiang resumed his Northern Expedition and managed to take Shanghai. During
11536-440: The target area is only low or not existent and after four hours sarin or similar agents are not detectable anymore. By contrast, persistent agents tend to remain in the environment for as long as several weeks, complicating decontamination. Defense against persistent agents requires shielding for extended periods of time. Nonvolatile liquid agents, such as blister agents and the oily VX nerve agent, do not easily evaporate into
11648-460: The urbanized cities. This decision gave CCP a chance to move freely through the countryside. At first, the KMT had the edge with the aid of weapons and ammunition from the United States (US). However, with the country suffering from hyperinflation , widespread corruption and other economic ills, the KMT continued to lose popular support. Some leading officials and military leaders of the KMT hoarded material, armament and military-aid funding provided by
11760-776: The war, the conflicts among the cliques would have a devastating effect on the survival of the KMT. Muslim Generals in Gansu waged war against the Guominjun in favor of the KMT during the conflict in Gansu in 1927–1930 . In 1931, Japanese aggression resumed with the Mukden Incident and occupation of Manchuria, and the CCP founded the Chinese Soviet Republic (CSR) in Jiangxi while secretly recruiting within
11872-595: Was kidnapped by Zhang Xueliang in the Xi'an Incident and forced into the Second United Front , an anti-Japanese alliance with the CCP; the Second Sino-Japanese War started the following year. The alliance brought little coordination and was treated as a temporary cease fire in the civil war. The New Fourth Army Incident in 1941 ended the alliance. Japan surrendered in 1945, and Taiwan
11984-458: Was not always adequately realized. Lead and cadmium, among other toxic elements, were often incorporated into the names of artist's oil paints and pigments, for example, "lead white" and "cadmium red". 20th-century printmakers and other artists began to be aware of the toxic substances, toxic techniques, and toxic fumes in glues, painting mediums, pigments, and solvents, many of which in their labelling gave no indication of their toxicity. An example
12096-434: Was not toxicity, but development of agents that can affect a target through the skin and clothing, rendering protective gas masks useless. In July 1917, the Germans employed sulfur mustard . Mustard agents easily penetrate leather and fabric to inflict painful burns on the skin. Chemical warfare agents are divided into lethal and incapacitating categories. A substance is classified as incapacitating if less than 1/100 of
12208-406: Was returned to the Republic of China on 25 October of that year. The brief period of celebration was soon shadowed by the possibility of a civil war between the KMT and CCP. The Soviet Union declared war on Japan just before it surrendered and occupied Manchuria , the north eastern part of China. The Soviet Union denied the KMT army the right to enter the region but allowed the CCP to take control of
12320-448: Was the use of xylol for cleaning silk screens . Painters began to notice the dangers of breathing painting mediums and thinners such as turpentine . Aware of toxicants in studios and workshops, in 1998 printmaker Keith Howard published Non-Toxic Intaglio Printmaking which detailed twelve innovative Intaglio -type printmaking techniques including photo etching , digital imaging , acrylic -resist hand-etching methods, and introducing
12432-409: Was used by both sides to try to break the stalemate of trench warfare . Though largely ineffective over the long run, it decidedly changed the nature of the war. In many cases the gasses used did not kill, but instead horribly maimed, injured, or disfigured casualties. Some 1.3 million gas casualties were recorded, which may have included up to 260,000 civilian casualties. The interwar years saw
12544-550: Was used to describe substances which had the ability of "causing death or serious debilitation or exhibiting symptoms of infection." The word draws its origins from the Greek noun τόξον toxon (meaning "arc"), in reference to the use of bows and poisoned arrows as weapons. English-speaking American culture has adopted several figurative usages for toxicity , often when describing harmful inter-personal relationships or character traits (e.g. " toxic masculinity "). Humans have
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