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NIH Intramural Research Program

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The NIH Intramural Research Program ( IRP ) is the internal research program of the National Institutes of Health (NIH), known for its synergistic approach to biomedical science . With 1,200 Principal Investigators and over 4,000 Postdoctoral Fellows conducting basic, translational , and clinical research, the NIH Intramural Research Program is the largest biomedical research institution on earth. The unique funding environment of the IRP facilitates opportunities to conduct both long-term and high-impact science that would otherwise be difficult to undertake. With rigorous external reviews ensuring that only the most outstanding research secures funding, the IRP is responsible for many scientific accomplishments, including the discovery of fluoride to prevent tooth decay, the use of lithium to manage bipolar disorder , and the creation of vaccines against hepatitis , Hemophilus influenzae (Hib), and human papillomavirus (HPV). In addition, the IRP has also produced or trained 21 Nobel Prize -winning scientists.

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72-695: Within the framework of the NIH mandate, the Intramural Research Program's mission is to: The NIH Intramural Research Program (IRP) traces its roots to 1887, when a one-room laboratory on Staten Island was created within the Marine Hospital Service, a predecessor agency to the U.S. Public Health Service . This laboratory evolved into the Hygienic Laboratory, which moved to Washington, D.C. , in 1891 and, with

144-655: A "temporary landfill" in 1947, the Fresh Kills Landfill was a repository of trash for the city of New York. The landfill, once the world's largest man-made structure, was closed in 2001, but it was briefly reopened for the debris from Ground Zero following the September 11 attacks in 2001. It is being converted into a park almost three times the size of Central Park and the largest park to be developed in New York City in over 100 years. Plans for

216-551: A compromise that established the maritime boundary in the middle of the Hudson River and gave Staten Island to New York. Ellis Island and Bedloe's Island , both uninhabited at the time, also became controlled by New Jersey. From 1800 to 1858, Staten Island was the location of the largest quarantine facility in the United States. Angry residents burned down the hospital compound in 1858 in a series of attacks known as

288-718: A department or center at an academic institution . Within these larger structures, Principal Investigators run Sections or Units devoted to their independent research goals. Core facilities, supported by staff scientists and clinicians, are among the shared resources available to IRP researchers. Scientific interests are not bound by the organizational structure. There exists a full spectrum of scientific interest groups (called SIGs) that brings researchers from different Institutes and Centers together around common areas of scientific interest where ideas can be shared and collaborations initiated. In addition, institutes come together to work cooperatively on major initiatives focused on unraveling

360-486: A local chronicler in Staten Island, was responsible for originating the legend in the mid-1800s. In 1683, the colony of New York was divided into ten counties. As part of this process, Staten Island, as well as several minor neighboring islands, was designated as Richmond County . The name derives from the title of Charles Lennox, 1st Duke of Richmond , an illegitimate son of King Charles II . In 1687 and 1688,

432-483: A long list of medical milestones, including the development of chemotherapy ; the first use of an immunotoxin to treat a malignancy ; identification of the genes that cause kidney cancer , leading to the development of six new, targeted treatments for advanced kidney cancer; the discovery that lithium helps depression ; the first gene therapy ; the first AIDS treatment; and the development of tests to detect AIDS/ HIV and hepatitis viruses in blood, which led to

504-564: A model institution that has, since 1953, transformed scientific advances into innovative therapies and provided high-quality care to patients and recognizes the Clinical Center's rich history of medical discovery through clinical research. At the NIH Clinical Center, clinical research participants—more than 480,000 since the hospital opened in 1953—are active partners in medical discovery. This partnership has resulted in

576-411: A safer blood supply. The NIH Clinical Center sees 10,000 new research participants a year from around the world. Staten Island Staten Island ( / ˈ s t æ t ən / STAT -ən ) is the southernmost borough of New York City , coextensive with Richmond County and situated at the southernmost point of New York . The borough is separated from the adjacent state of New Jersey by

648-722: A whole is subject to periodic review by Blue Ribbon Panels . These panels, made up of expert external reviewers appointed by the NIH Director, ensure that the program's overall objectives are current, relevant, distinctive, and appropriate to the unique research environment of the IRP. Blue Ribbon Panel reports are addressed to the NIH Director, the Advisory Committee of the Director, and the IC Director. In addition to

720-448: Is extremely sparse, however, and most historians conclude that it is entirely apocryphal. In 2007, The New York Times addressed the issue in a news article, which concluded that this event was heavily embellished over the years and almost certainly originated in local folklore. YouTuber CGP Grey addressed the story of the Staten Island race and its historical discrepancies in a 2019 video, in which he concluded that Gabriel Disosway,

792-405: Is home to the 2 + 1 ⁄ 2 -mile (4-kilometer) FDR Boardwalk , the world's fourth-longest boardwalk . The South Shore , site of the 17th-century Dutch and French Huguenot settlement, developed rapidly beginning in the 1960s and 1970s and is now very suburban. The West Shore is the island's least populated and most industrial part. Motor traffic can reach the borough from Brooklyn by

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864-697: Is taking advantage of the special features of the NIH intramural scientific environment and employing useful collaborative arrangements. As a result of these reviews, recommendations for altering allocated resources are prepared by the BSC for the Scientific Director, the Institute or Center Director, the NIH Deputy Director for Intramural Research, and the Institute or Center (IC) National Advisory Council or Board. Additionally, each IRP as

936-485: Is the largest pre-European burial ground in New York City. Bodies have been reported unearthed at Burial Ridge from 1858 onward. After conducting independent research, which included unearthing bodies interred at the site, ethnologist and archaeologist George H. Pepper was contracted in 1895 to conduct paid archaeological research at Burial Ridge by the American Museum of Natural History . The burial ground today

1008-570: Is the only borough without a New York City Department of Correction major detention center. The construction of the Verrazzano-Narrows Bridge , along with the other three major Staten Island bridges, created a new way for commuters and tourists to travel from New Jersey to Brooklyn, Manhattan, and areas farther east on Long Island . The network of highways running between the bridges has effectively carved up many of Staten Island's old neighborhoods. The bridge opened many areas of

1080-637: Is the third-smallest county in New York by land area and fourth-smallest by total area. Although Staten Island is a borough of New York City, the island is geographically part of New Jersey. Staten Island is separated from Long Island by the Narrows and from mainland New Jersey by the Arthur Kill and the Kill Van Kull. Staten Island is positioned at the center of New York Bight , a sharp bend in

1152-544: Is unmarked and lies within Conference House Park . The first recorded European contact on the island was in 1524 by Italian explorer Giovanni da Verrazzano who sailed through The Narrows on the ship La Dauphine and anchored for one night. The Dutch did not establish a permanent settlement on Staaten Eylandt for many decades. Its name derived from the Staten Generaal , the parliament of

1224-595: The Arthur Kill and the Kill Van Kull and from the rest of New York by New York Bay . With a population of 495,747 in the 2020 Census , Staten Island is the least populated New York City borough but the third largest in land area at 58.5 sq mi (152 km ); it is also the least densely populated and most suburban borough in the city. A home to the Lenape Native American's,

1296-877: The Hudson River in Palisades Interstate Park . The sill extends southward beyond the cliffs in Jersey City beneath the Upper New York Harbor and resurfaces on Staten Island. The Palisades sill date from the Early Jurassic period, 192 to 186 million years ago. Staten Island has been at the southern terminus of various periods of glaciation . The most recent, the Wisconsin glaciation , ended approximately 12,000 years ago. The accumulated rock and sediment deposited at

1368-414: The Kill Van Kull was frozen over, Lord Stirling led an unsuccessful Patriot raid from New Jersey on the western shore of Staten Island. It was repulsed in part by troops led by British Commander Francis Rawdon-Hastings, 1st Marquess of Hastings . In June 1780, Wilhelm von Knyphausen , commander of Britain's Hessian auxiliaries , led many raids and a full assault into New Jersey from Staten Island with

1440-529: The New York City Board of Estimate , which had given equal representation to the five boroughs. Dinkins and the city government opposed a non-binding secession referendum, contending that the vote should not be permitted by the state unless the city issued a home rule message supporting it, which the city would not. Governor Mario Cuomo disagreed, and the vote went forward in 1993. Ultimately, 65% of Staten island residents voted to secede through

1512-599: The Ransdell Act of 1930, became the National Institute of Health. Several of the IRP's initial Institutes were established over the next two decades and, after World War II, Vannevar Bush , director of the Office of Scientific Research and Development , outlined a program for postwar scientific research that affirmed the contributions of "remote and unexpected fields of medicine and the underlying sciences" in

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1584-628: The Republic of the Seven United Netherlands . From 1639 to 1655, Cornelis Melyn and David de Vries made three separate attempts to establish one there, but each time the settlement was destroyed in conflicts between the Dutch and the local tribe. In 1661, the first permanent Dutch settlement was established at Oude Dorp (Dutch for "Old Village") by a small group of Dutch, Walloon , and French Huguenot families, just south of

1656-671: The Rose and Crown Tavern , near the junction of present New Dorp Lane and Richmond Road. There the representatives of the British government reportedly received their first notification of the Declaration of Independence . In August 1776, the British forces crossed the Narrows to Brooklyn and outflanked the American forces at the Battle of Long Island , resulting in the British control of

1728-665: The Staten Island Quarantine War . In 1860, parts of Castleton and Southfield were made into a new town, Middletown . The Village of New Brighton in the town of Castleton was incorporated in 1866, and in 1872 the Village of New Brighton annexed all the remainder of the Town of Castleton and became coterminous with the town. An 1887 movement to incorporate Staten Island as a city ended up resulting in nothing. The towns of Staten Island were dissolved in 1898 with

1800-659: The Unami division of the Lenape . In Lenape , one of the Algonquian languages , Staten Island was called Aquehonga Manacknong , meaning "as far as the place of the bad woods", or Eghquhous , meaning "the bad woods". The name is spelled as Eghquaons in the deed to Lubbertus van Dincklage for the purchase of Staten Island, 1657. The area was part of the Lenape homeland known as Lenapehoking . The Lenape were later called

1872-665: The Verrazzano-Narrows Bridge and from New Jersey by the Outerbridge Crossing , Goethals Bridge and Bayonne Bridge . Staten Island has Metropolitan Transportation Authority (MTA) bus lines and an MTA rapid transit line, the Staten Island Railway , which runs from the ferry terminal at St. George to Tottenville . Staten Island is the only borough not connected to the New York City Subway system. The free Staten Island Ferry connects

1944-527: The city government and the media. It has also been referred to as the "borough of parks" due to its 12,300 acres of protected parkland and over 170 parks. The North Shore —especially the neighborhoods of St. George , Tompkinsville , Clifton , and Stapleton —is the island's most urban area. It contains the designated St. George Historic District and the St. Paul's Avenue-Stapleton Heights Historic District, which feature large Victorian houses. The East Shore

2016-524: The "Delaware" by the English colonists because they inhabited both shores of what the English named the Delaware River . The island was laced with Native American foot trails, one of which followed the south side of the ridge near the course of present-day Richmond Road and Amboy Road . The Lenape did not live in fixed encampments but moved seasonally, using slash and burn agriculture. Shellfish

2088-513: The Charleston section of the island. Various Clovis artifacts have been discovered since then, on property owned by Mobil Oil . The island was probably abandoned later, possibly because of the extirpation of large mammals on the island. Evidence of the first permanent Native American settlements and agriculture are thought to date from about 5,000 years ago, although early archaic habitation evidence has been found in multiple locations on

2160-475: The Declaration of Independence, and the conference ended without an agreement. On August 22, 1777, the Battle of Staten Island occurred between the British forces and several companies of the 2nd Canadian Regiment fighting alongside other American companies. The battle was inconclusive, though both sides surrendered over a hundred troops as prisoners. The Americans finally withdrew. In early 1780, while

2232-559: The Dutch settlements, the English resurveyed Oude Dorp (which became known as 'Old Town') and expanded the lots along the shore to the south. These lots were settled primarily by Dutch families and became known as Nieuwe Dorp (meaning 'New Village'), which later became anglicized as New Dorp . Captain Christopher Billopp , after years of distinguished service in the Royal Navy, came to America in 1674 along with

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2304-469: The English divided the island into four administrative divisions based on natural features: the 5,100-acre (21 km ) manorial estate of colonial governor Thomas Dongan in the northeastern hills known as the "Lordship or Manor of Cassiltown", along with the North, South, and West divisions. These divisions later evolved into the four towns of Castleton , Northfield , Southfield , and Westfield . In 1698,

2376-486: The IRP consists of individual programs housed in 23 of the NIH Institutes and Centers, creating a network of multi-disciplinary, federally funded laboratories with an emphasis on translational research . The National Institutes of Health Clinical Center , the world's largest clinical research hospital, is designed to foster smooth transitions between laboratory work, patient studies, and bedside cures, facilitating

2448-494: The Intramural Research Program (IRP). The IRP includes the United States National Library of Medicine , an international resource for researchers, and the NIH Clinical Center, the world's largest clinical research hospital. Intramural researchers are affiliated with individual Laboratories, Branches or Centers, which are typically organized around common thematic research goals and approaches, much like

2520-598: The Narrows near South Beach. Many French Huguenots had gone to the Netherlands as refugees from the religious wars in France, suffering persecution for their Protestant faith, and some joined the emigration to New Netherland. At one point nearly a third of the residents of the Island spoke French. The last vestige of Oude Dorp is the name of the present-day neighborhood of Old Town adjacent to Old Town Road. Staten Island

2592-546: The aim of defeating George Washington and the Continental Army . Although the raids were successful in the Newark and Elizabeth areas, the advance was halted at Connecticut Farms (Union) and the Battle of Springfield . British forces remained on Staten Island for the remainder of the war. Most Patriots fled after the British occupation, and the sentiment of those who remained was predominantly Loyalist . Even so,

2664-673: The approval of a new city charter making Staten Island an independent city , but implementation was blocked in the State Assembly . In the 1980s, the United States Navy had a base on Staten Island called Naval Station New York . It had two sections: a Strategic Homeport in Stapleton and a larger section near Fort Wadsworth , where the Verrazzano-Narrows Bridge enters the island. The base

2736-464: The borough to Manhattan across New York Harbor . It provides views of the Statue of Liberty , Ellis Island , and Lower Manhattan . As in much of North America, human habitation appeared on the island fairly rapidly after the Wisconsin glaciation . Archaeologists have recovered tool evidence of Clovis culture activity dating from about 14,000 years ago. This evidence was first discovered in 1917 in

2808-431: The borough to residential and commercial development from the 1960s onward, especially in the central and southern parts of the borough, which had been largely undeveloped. Staten Island's population doubled from 221,991 in 1960 to 443,728 in 2000. Nevertheless, Staten Island remained less developed than the rest of the city. A New York Times article in 1972 stated that despite the borough having 333,000 residents, parts of

2880-458: The captain could circumnavigate it in one day, which he did. This story is most likely untrue, due to conflicting information on the time Christopher Billopp took to complete the race and whether he received a personal prize or not. Mayor Michael Bloomberg perpetuated the myth by referring to it at a news conference in Brooklyn on February 20, 2007. Reliable historical documentation of the event

2952-541: The collision zone and now forms the oldest bedrock strata of Staten Island, the serpentinite . This strata of the Lower Paleozoic (approximately 430 million years old) consists predominantly of the serpentine minerals, antigorite , chrysotile , and lizardite ; it also contains asbestos and talc . At the end of the Paleozoic era (248 million years ago) all major continental masses were joined into

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3024-655: The colonies, residents of the island were so uninterested that no representatives were sent to the First Continental Congress , the only county in New York to not send anyone. This had economic repercussions in the months up through 1776, where New Jersey towns such as Elizabethport, Woodbridge , and Dover instituted boycotts on doing business with islanders. On March 17, 1776, the British forces under Sir William Howe evacuated Boston and sailed for Halifax, Nova Scotia . From Halifax, Howe prepared to attack New York City, which then consisted entirely of

3096-458: The complexities of disease. The Center for Human Immunology, Autoimmunity and Inflammation (CHI) is one example of this trans-NIH cooperative research approach. As with all biomedical research, the scientific programs of the IRP's 1,200 Principal Investigators are subject to periodic scientific review. Each Principal Investigator must be peer-reviewed at least once every four years by an external Board of Scientific Counselors (BSC). The BSC evaluates

3168-613: The consolidation of the City of Greater New York , as Richmond County became one of the five boroughs of the expanded city. Although consolidated into the City of Greater New York in 1898, the county sheriff of Staten Island maintained control of the jail system, unlike the other boroughs, which had gradually transferred control of the jails to the Department of Correction. The jail system was not transferred until January 1, 1942. Staten Island

3240-675: The continent of Laurentia and the plate containing the continent of Gondwanaland were converging, the Iapetus Ocean that separated the two continents gradually closed, and the resulting collision between the plates formed the Appalachian Mountains . During the early stages of this mountain building known as the Taconic orogeny , a piece of ocean crust from the Iapetus Ocean broke off and became incorporated into

3312-469: The course of the Hudson River have placed it alternatively through the present course of the Raritan River , south of the island, or through present-day Flushing Bay and Jamaica Bay . According to the U.S. Census Bureau , Richmond County has a total area of 102.5 square miles (265 km ), of which 58.5 square miles (152 km ) is land and 44.0 square miles (114 km ) (43%) is water. It

3384-569: The eastern edge of New Jersey was located at the Hudson River 's shoreline during high tide, which would give New York control of all the docks and wharves on the Hudson River. New Jersey argued that the maritime boundary should be down the middle of the Hudson River and then continue out to the Atlantic Ocean, which would give New Jersey control of the docks and wharves as well as Staten Island. Vice President Martin Van Buren negotiated

3456-728: The external NIH Boards of Scientific Counselors and Blue Ribbon Panels, the NIH IRP receives regular and periodic independent evaluations by the following external bodies: Nina F. Schor , M.D. is the Deputy Director for Intramural Research and heads the Office of Intramural Research (OIR). In this role, he is responsible for oversight and coordination of all intramural research, training and technology transfer activities. The Lister Hill National Center for Biomedical Communications (LHNCBC) conducts and supports research and development with

3528-542: The family of Canadian historian Peter Fisher , John Dunn, who founded St. Andrews, New Brunswick , and Abraham Jones , fled to Canada, and their estates were subdivided and sold. Staten Island was occupied by the British longer than any single part of the Thirteen Colonies. On July 4, 1827, the end of slavery in New York state was celebrated at Swan Hotel, in the West Brighton neighborhood. Rooms at

3600-430: The goal of improving access to high quality biomedical information for individuals around the world. The National Institutes of Health Clinical Center , the world's largest hospital entirely devoted to clinical research , is a national resource that enables the rapid translation of scientific observations and laboratory discoveries into new approaches for diagnosing, treating and preventing disease. Due to its position on

3672-552: The harbor and the capture of New York City shortly afterwards. Three weeks later, on September 11, 1776, Sir William's brother, Lord Howe , received a delegation of Americans consisting of Benjamin Franklin , Edward Rutledge , and John Adams at the Conference House on the southwestern tip of the island on the former estate of Christopher Billopp. The Americans refused a peace offer from Howe in exchange for withdrawing

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3744-422: The hotel were reserved months in advance as local abolitionists, including prominent free blacks, prepared for the festivities. Speeches, pageants, picnics, and fireworks marked the celebration, which lasted for two days. In the early 19th century, New Jersey and New York disputed the location of their maritime boundary. The original charters were of no help because they were worded ambiguously. New York argued that

3816-408: The island still maintained a bucolic atmosphere with woods and marshes. Throughout the 1980s, a movement to secede from the city steadily grew in popularity, notably championed by longtime New York state senator and former Republican Party mayoral nominee John J. Marchi . The campaign reached its peak during the mayoral term of David Dinkins (1990–1993), after the U.S. Supreme Court invalidated

3888-401: The island was settled by Dutch colonists in the 17th century. It was one of the 12 original counties of New York state. Staten Island was consolidated with New York City in 1898 . It was formerly known as the Borough of Richmond until 1975, when its name was changed to Borough of Staten Island. Staten Island has sometimes been called "the forgotten borough" by inhabitants who feel neglected by

3960-420: The island. Rossville points are distinct arrowheads that define a Native American cultural period from the Archaic period to the Early Woodland period , dating from about 1500 to 100 BC. They are named for the Rossville section of Staten Island, where they were first found near the old Rossville Post Office building. At the time of European contact, the island was inhabited by the Raritan band of

4032-512: The islanders found the demands of supporting the troops to be heavy. The British army kept headquarters in neighborhoods such as Bulls Head . Many buildings and churches were destroyed for their materials, and the military's demand for resources resulted in an extensive deforestation by the end of the war. The British army again used the island as a staging ground for its final evacuation of New York City on December 5, 1783. After their departure, many Loyalist landowners, such as Christopher Billop ,

4104-405: The main campus in Bethesda, Maryland , the Institutes and Centers of the IRP are able to mobilize clinical resources quickly and effectively to respond to emerging scientific challenges and opportunities. The NIH Clinical Center is the 2011 recipient of the Lasker-Bloomberg Public Service Award , given by the Albert and Mary Lasker Foundation . This award honors the Clinical Center for serving as

4176-431: The newly appointed royal governor of New York and the Jerseys Sir Edmund Andros, in charge of a company of infantry. The following year, he settled on Staten Island, where he was granted a patent for 932 acres (3.8 km ) of land. According to one version of an oft-repeated but apocryphal tale, Captain Billopp's seamanship secured Staten Island to New York, rather than to New Jersey: the island would belong to New York if

4248-403: The park include a bird-nesting island, public roads, boardwalks, soccer and baseball fields, bridle paths, and a 5,000-seat stadium. Today, freshwater and tidal wetlands, fields, birch thickets, and a coastal oak maritime forest, as well as areas dominated by non-native plant species, are all within the boundaries of Fresh Kills.   During the Paleozoic Era , the tectonic plate containing

4320-463: The population was 727. The government granted land patents in rectangular blocks of 80 acres (320,000 m ), with the most desirable lands along the coastline and inland waterways. By 1708, the entire island had been divided up in this fashion, creating 166 small farms and two large manorial estates, the Dongan estate and a 1,600 acres (6.5 km ) parcel on the southwestern tip of the island belonging to Christopher Billopp. The first county seat

4392-470: The progress against disease and the benefits of cooperative endeavors with industry and academia. The disease orientation and categorical structure of the IRP had its genesis in the establishment of the National Cancer Institute (NCI) in 1944. In 1948, Congress passed the National Heart Act, which created the National Heart Institute, and soon after established institutes for research on mental health, oral diseases, neurological problems, and blindness. Today,

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4464-466: The promised goods for the land a few months later. At the end of the Second Anglo-Dutch War in 1667, the Dutch ceded New Netherland to England in the Treaty of Breda , and the Dutch Staaten Eylandt , anglicized as "Staten Island", became part of the new English colony of New York . In 1670, the Native Americans ceded all claims to Staten Island to the English in a deed to Governor Francis Lovelace . In 1671, in order to encourage an expansion of

4536-399: The quality of research, the resources that should be allocated to scientists, and the promise of tenure-track investigators for future success in their careers. These evaluations are based on the Principal Investigator's past accomplishments, objectives met, and future plans. The review criteria mirror those used by extramural peer review with the addition of considering whether the investigator

4608-430: The shoreline between New Jersey and Long Island. The region is considered vulnerable to sea-level rise. On October 29, 2012, the island experienced severe damage and loss of life along with the destruction of many homes during Hurricane Sandy . In addition to the main island, the borough and county also include several small uninhabited islands: Blue Ribbon Panel Too Many Requests If you report this error to

4680-502: The southern end of Manhattan Island . General George Washington led the entire Continental Army to New York City in anticipation of the British attack. Howe used the strategic location of Staten Island as a staging ground for the invasion. Over 140 British ships arrived over the summer of 1776 and anchored off the shores of Staten Island at the entrance to New York Harbor. The British soldiers and Hessian mercenaries numbered about 30,000. Howe established his headquarters in New Dorp at

4752-412: The supercontinent of Pangaea . The Palisades Sill has been designated a National Natural Landmark , being "the best example of a thick diabase sill in the United States". It underlies a portion of northwest Staten Island, with a visible outcropping in Travis , off Travis Road in the William T. Davis Wildlife Refuge . This is the same formation that appears in New Jersey and upstate New York along

4824-408: The terminus of the glacier is known as the terminal moraine present along the central portion of the island. The evidence of these glacial periods is visible in the remaining wooded areas of Staten Island in the form of glacial erratics and kettle ponds . At the retreat of the ice sheet, Staten Island was connected by land to Long Island, as the Narrows had not yet formed. Geologists' reckonings of

4896-400: The translation of laboratory findings to new approaches for the prevention and cure of human diseases. The National Institutes of Health (NIH) is composed of 27 Institutes and Centers, most of which include research programs led by a Scientific Director and conducted by federal researchers and their trainees at one of several NIH campus locations. Collectively, these research programs encompass

4968-442: Was a staple of their diet, including the Eastern oyster ( Crassostrea virginica ) abundant in the waterways throughout the present-day New York City region. Evidence of their habitation can still be seen in shell middens along the shore in the Tottenville section, where oyster shells larger than 12 inches (300 mm) are sometimes found. Burial Ridge , a Lenape burial ground on a bluff overlooking Raritan Bay in Tottenville ,

5040-424: Was closed in 1994 through the Base Realignment and Closure process because of its small size and the expense of basing personnel there. Fresh Kills and its tributaries are part of the largest tidal wetland ecosystem in the region. Its creeks and wetlands have been designated a Significant Coastal Fish and Wildlife Habitat by the New York State Department of Environmental Conservation . Opened along Fresh Kills as

5112-536: Was established in New Dorp in what was called Stony Brook at the time. In 1729, the county seat was moved to the village of Richmond Town, located at the headwaters of the Fresh Kills near the center of the island. By 1771, the island's population had grown to 2,847. Staten Islanders were solidly supportive of the Crown, and the island played a significant role in the American Revolutionary War . General George Washington once called Islanders "our most inveterate enemies". As support of independence spread throughout

5184-530: Was not spared the bloodshed that culminated in Kieft's War . In the summer of 1641 and in 1642, Native American tribes laid waste to Old Town. On July 10, 1657, the Native Americans signed a deed to Lubbertus van Dincklage, attorney of Henrick van der Capelle tho Ryssel, for the purchase of all indigenous lands on Staten Island. However, this deed was annulled when the Dutch purchasers failed to deliver

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