199-624: Dr. Reddy's Laboratories is an Indian multinational pharmaceutical company based in Hyderabad . The company was founded by Kallam Anji Reddy , who previously worked in the mentor institute Indian Drugs and Pharmaceuticals Limited . Dr. Reddy manufactures and markets a wide range of pharmaceuticals in India and overseas. The company produces over 190 medications, 60 active pharmaceutical ingredients (APIs) for drug manufacture, diagnostic kits, critical care , and biotechnology . Dr. Reddy's began as
398-463: A Danish pharmaceutical company. It strengthened its Indian manufacturing operations by acquiring American Remedies Ltd. in 1999. This acquisition made Reddy's the third largest pharmaceutical company in India, after Ranbaxy and Glaxo (I) Ltd., with a full spectrum of pharmaceutical products, which included bulk drugs, intermediates, finished dosages, chemical synthesis, diagnostics and biotechnology. Reddy's also started exploiting Para 4 filing as
597-560: A compound annual growth rate (CAGR) of 1.8% given the results of recent events (which includes the COVID-19 pandemic ). In historical terms, a pharmaceutical industry as an intellectual concept arose within the middle to late 1800s inside of certain nation-states with developed economies such as Germany , Switzerland , and the United States given that multiple businesses engaging in synthetic organic chemistry , such as
796-477: A "musty" or "moldy" smell. On 24 June 2014, the New York Times published an article "Warning Unheeded, Heart Drugs Are Recalled" in which it said another large Indian manufacturer and "Dr. Reddy's Laboratories, have announced recalls over the past two months totalling more than 100,000 bottles" of "a widely used heart drug, Toprol XL" "because their products were not dissolving properly". In December 2014
995-492: A 20% drop in those for which antibiotics were not effective. The report concluded that "it appears that the use of antibiotics, early diagnosis, and other factors have limited the epidemic spread and thus the number of these diseases which have occurred". The study further examined mortality rates for eight common diseases for which antibiotics offered effective therapy (syphilis, tuberculosis, dysentery, scarlet fever, whooping cough, meningococcal infections, and pneumonia), and found
1194-509: A 43% stake in Perlecan for an estimated $ 22.5 million. However, the company was forced to buy back the Perlecan shares from ICICI and Citigroup due to doubts regarding the commercial viability of the drug candidates that were in Perlecan's pipeline. At that point, Perlecan became a wholly owned subsidiary. In the board meeting of 23 October 2008, the company chose to amalgamate/absorb Perlecan, thereby making it an in-house research facility, as it
1393-517: A 56% decline over the same period. Notable among these was a 75% decline in deaths due to tuberculosis. During the years 1940–1955, the rate of decline in the U.S. death rate accelerated from 2% per year to 8% per year, then returned to the historical rate of 2% per year. The dramatic decline in the immediate post-war years has been attributed to the rapid development of new treatments and vaccines for infectious disease that occurred during these years. Vaccine development continued to accelerate, with
1592-411: A Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum , as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials , however a long-term study in dogs found toxic effects at higher doses and as
1791-616: A Jewish-American factory superintendent, was convicted of the murder of a 13-year-old girl in a highly publicized trial. He was sentenced to death but the governor commuted his sentence to life. An enraged and organized lynch mob took him from jail in 1915 and hanged him in Marietta . The Jewish community in Atlanta and across the country were horrified. On May 21, 1917, the Great Atlanta Fire destroyed 1,938 buildings in what
1990-447: A blacksmith shop, a grocery store, and nothing else". A year later, the area around the milepost had developed into a settlement, first known as Terminus , and later Thrasherville , after a local merchant who built homes and a general store in the area. By 1842, the town had six buildings and 30 residents and was renamed Marthasville to honor Governor Wilson Lumpkin's daughter Martha. Later, John Edgar Thomson , Chief Engineer of
2189-614: A city of the " New South " that would be based upon a modern economy and less reliant on agriculture. By 1885, the founding of the Georgia School of Technology (now the Georgia Institute of Technology ) and the Atlanta University Center , a consortium of historically Black colleges made up of units for men and women, had established Atlanta as a center for higher education. In 1895, Atlanta hosted
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#17327761549962388-414: A compound is identified as a potential drug in order to establish its suitability as a medication. Objectives of drug development are to determine appropriate formulation and dosing , as well as to establish safety . Research in these areas generally includes a combination of in vitro studies, in vivo studies, and clinical trials . The cost of late stage development has meant it is usually done by
2587-492: A decreasing portion of the population, from a high of 67% in 1990 to 54% in 2010. From 2000 to 2010, Atlanta gained 22,763 white residents, 5,142 Asian residents, and 3,095 Hispanic residents, while the city's Black population decreased by 31,678. Much of the city's demographic change during the decade was driven by young, college-educated professionals: from 2000 to 2009, the three-mile radius surrounding Downtown Atlanta gained 9,722 residents aged 25 to 34 and holding at least
2786-472: A drug could be sold, and explicitly prohibited false therapeutic claims. The aftermath of World War II saw an explosion in the discovery of new classes of antibacterial drugs including the cephalosporins (developed by Eli Lilly based on the seminal work of Giuseppe Brotzu and Edward Abraham ), streptomycin (discovered during a Merck-funded research program in Selman Waksman's laboratory ),
2985-433: A foundation for drug discovery. Development of speciality generics was an important step for the company's growing interest in the development of new chemical entities. The elements involved in creating a speciality generic, such as innovation in the laboratory, developing the compound, and sending the sales team to the market, are also stages in the development of a new speciality drug. Starting with speciality generics allowed
3184-413: A founding member in an effort to promote the development of generic drugs in India. The company's first international move took it to Russia in 1992. There, Dr. Reddy's formed a joint venture with the country's biggest pharmaceuticals producer, Biomed . They pulled out in 1995 amid accusations of scandal, involving "a significant material loss due to the activities of Moscow's branch of Reddy's Labs with
3383-587: A four-year degree, an increase of 61%. This was similar to the tendency in other cities for young, college educated, single or married couples to live in downtown areas. Between the mid-1990s and 2010, stimulated by funding from the HOPE VI program and under leadership of CEO Renee Lewis Glover (1994–2013), the Atlanta Housing Authority demolished nearly all of its public housing, a total of 17,000 units and about 10% of all housing units in
3582-541: A generic version of atorvastatin , marketed by Pfizer as Lipitor , an anti- cholesterol medication. Reddy's was already linked to UK pharmaceuticals multinational Glaxo Smithkline . In September 2020, the company partnered with the Russian Direct Investment Fund to conduct phase 3 trials of the Sputnik V COVID-19 vaccine in India, and manufacture and distribute up to 100 million doses of
3781-558: A heart attack were reduced by 42%. In 1995, Zocor and Mevacor both made Merck over US$ 1 billion. Endo was awarded the 2006 Japan Prize , and the Lasker-DeBakey Clinical Medical Research Award in 2008. For his "pioneering research into a new class of molecules" for "lowering cholesterol," Since several decades, biologics have been rising in importance in comparison with small molecules treatments. The biotech subsector, animal health and
3980-507: A highly toxic solvent that is now widely used as antifreeze. Under the laws extant at that time, prosecution of the manufacturer was possible only under the technicality that the product had been called an "elixir", which literally implied a solution in ethanol. In response to this episode, the U.S. Congress passed the Federal Food, Drug, and Cosmetic Act of 1938 , which for the first time required pre-market demonstration of safety before
4179-524: A licensing pact with XenoPort for their experimental treatment to treat plaque psoriasis . As per the agreement, Dr. Reddy's will be granted exclusive US rights to develop and commercialise XP23829 for all indications for an upfront payment of $ 47.5 million. In March 2024, Dr. Reddy's Laboratories partnered with Pharmazz Inc . to bring life-saving Centhaquine (Lyfaquin) to India. In 2001, Reddy's completed its US initial public offering of $ 132.8 million, secured by American Depositary Receipts . At that time
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#17327761549964378-690: A major role in Atlanta's economy, as the city claims the nation's third-largest concentration of Fortune 500 companies (tied for third with Chicago ). It also hosts the global headquarters of several corporations such as The Coca-Cola Company , The Home Depot , Delta Air Lines , Arby's , AT&T Mobility , Georgia-Pacific , Chick-fil-A , Church's Chicken , Dunkin Donuts , Norfolk Southern Railway , Mercedes-Benz USA , NAPA Auto Parts , Papa Johns , Porsche AG , Newell Brands , Rollins, Inc. , Marble Slab Creamery , and UPS . Over 75% of Fortune 1000 companies conduct business operations in
4577-521: A manufacturing and technology hub. During the 1950s and 1960s, it became a major organizing center of the American civil rights movement , with Martin Luther King Jr. , Ralph Abernathy , and many other locals becoming prominent figures in the movement's leadership. In the modern era, Atlanta has remained a major center of transportation, with Hartsfield-Jackson International Airport becoming
4776-534: A marketing agreement with Eurodrug Laboratories, a pharmaceutical company based in Netherlands , for improving its product portfolio for respiratory diseases. It introduced a second-generation xanthine bronchodilator, doxofylline , which is used for the treatment of asthma and COPD patients. In 2004, Reddy's acquired Trigenesis Therapeutics Inc; a US-based private dermatology company. This acquisition gave Reddy's access to proprietary products and technologies in
4975-469: A number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897, John Abel of Johns Hopkins University identified the active principle as epinephrine , which he isolated in an impure state as the sulfate salt. Industrial chemist Jōkichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke-Davis . Parke-Davis marketed epinephrine under
5174-479: A number of firms generating dyestuffs derived from coal tar on a large scale, sought out new applications of their artificial materials in terms of human health . This trend to increased capital investment occurred in tandem with the scholarly study of pathology as a field advancing significantly, and a variety of businesses set up cooperative relationships with academic laboratories evaluating human injury and disease. Examples of industrial companies with
5373-572: A period of 5 years. The company elected to expand globally, and acquired other entities. In March 2002, Dr. Reddy's acquired BMS Laboratories, Beverley , and its wholly owned subsidiary Meridian Healthcare, for 14.81 million Euros . These companies deal in oral solids, liquids and packaging, with manufacturing facilities in London and Beverley in the UK. Recently, Dr. Reddy's entered into an R&D and commercialisation agreement with Argenta Discovery Ltd.,
5572-493: A pharmaceutical focus that have endured to this day after such distant beginnings include Bayer (based out of Germany) and Pfizer (based out of the U.S.). The modern era of pharmaceutical industry began with local apothecaries that expanded for their traditional role of distributing botanical drug s such as morphine and quinine to wholesale manufacture in the mid-1800s, and from discoveries resulting from applied research. Intentional drug discovery from plants began with
5771-409: A postwar suburban layout. These include Collier Heights and Cascade Heights , historically home to much of the city's upper middle-class African-American population . Northwest Atlanta contains the areas of the city to west of Marietta Boulevard and to the north of Martin Luther King Jr. Drive, including those neighborhoods remote to downtown, such as Riverside, Bolton and Whittier Mill. The latter
5970-482: A private drug development company based in the UK, for the treatment of chronic obstructive pulmonary disease (COPD). Dr. Reddy's entered into a 10-year agreement with Rheoscience A/S of Denmark for the joint development and commercialisation of Balaglitazone (DRF-2593), a molecule for the treatment of type-2 diabetes . Rheoscience holds this product's marketing rights for the European Union and China, while
6169-499: A protocol to discontinue their use. A series of experiments performed from the late 1800s to the early 1900s revealed that diabetes is caused by the absence of a substance normally produced by the pancreas. In 1869, Oskar Minkowski and Joseph von Mering found that diabetes could be induced in dogs by surgical removal of the pancreas. In 1921, Canadian professor Frederick Banting and his student Charles Best repeated this study and found that injections of pancreatic extract reversed
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6368-467: A push for revisions of the FD&;C Act emerged from Congressional hearings led by Senator Estes Kefauver of Tennessee in 1959. The hearings covered a wide range of policy issues, including advertising abuses, questionable efficacy of drugs, and the need for greater regulation of the industry. While momentum for new legislation temporarily flagged under extended debate, a new tragedy emerged that underscored
6567-504: A reduction in initial public offerings being floated. A 2022 article articulated this notion succinctly by saying "In the business of drug development, deals can be just as important as scientific breakthroughs", typically referred to as pharmaceutical M&A (for mergers and acquisitions). It highlighted that some of the most impactful of the remedies of the early 21st Century were only made possible through M&A activities, specifically noting Keytruda and Humira . Drug discovery
6766-400: A result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs. P. Roy Vagelos , chief scientist and later CEO of Merck & Co , was interested, and made several trips to Japan starting in 1975. By 1978, Merck had isolated lovastatin (mevinolin, MK803) from
6965-431: A series of such compounds, and was found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis , a disease untl then had been incurable and led inexorably to severe skin ulceration, neurological damage, and death. Ehrlich's approach of systematically varying the chemical structure of synthetic compounds and measuring the effects of these changes on biological activity
7164-568: A sleep aid beginning in 1904. Systematic investigations of the effect of structural changes on potency and duration of action led to the discovery of phenobarbital at Bayer in 1911 and the discovery of its potent anti-epileptic activity in 1912. Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014, remains on the World Health Organizations list of essential medications. The 1950s and 1960s saw increased awareness of
7363-492: A small fraction are eventually approved in most nations by government-appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001,
7562-696: A strategic hub for the distribution of military supplies. In 1864, the Union Army moved southward following the capture of Chattanooga and began its invasion of north Georgia . The region surrounding Atlanta was the location of several major army battles, culminating with the Battle of Atlanta and a four-month-long siege of the city by the Union Army under the command of General William Tecumseh Sherman . On September 1, 1864, Confederate General John Bell Hood decided to retreat from Atlanta, and he ordered
7761-501: A strategy in bringing new drugs to the market at a faster pace. In 1999 it submitted a Para 4 application for omeprazole , the drug that had been the cornerstone of its success in India. In December 2000, Reddy's had undertaken its first commercial launch of a generic product in the US, and its first product with market exclusivity was launched there in August 2001. The same year, it also became
7960-399: A strong manufacturing base which itself was a result of inorganic growth through acquisition of international and national facilities. Reddy's merged Cheminor Drug Limited (CDL) with the primary aim of supplying active pharmaceutical ingredients to the technically demanding markets of North America and Europe . This merger also gave Reddy's an entry into the value-added generics business in
8159-612: A supplier to Indian drug manufacturers, but it soon started exporting to other less-regulated markets that had the advantage of not having to spend time and money on a manufacturing plant that would gain approval from a drug licensing body such as the U.S. Food and Drug Administration (FDA). By the early 1990s, the expanded scale and profitability from these unregulated markets enabled the company to begin focusing on getting approval from drug regulators for their formulations and bulk drug manufacturing plants – in more-developed economies. This allowed their movement into regulated markets such as
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8358-531: A survey by the Williams Institute , Atlanta ranked third among major American cities, behind San Francisco and slightly behind Seattle , with 12.8% of the city's total population identifying as LGB. The Midtown and Cheshire Bridge areas have historically been the epicenters of LGBT culture in Atlanta. Atlanta formed a reputation for being a place inclusive to LGBT people after former mayor Ivan Allen Jr. dubbed it "the city too busy to hate" in
8557-470: A telegram to the state's Board of Regents requesting Georgia Tech not to engage in racially integrated events, Georgia Tech's president Blake R. Van Leer rejected the request and threatened to resign. The game went on as planned. In the 1960s, Atlanta became a major organizing center of the civil rights movement , with Martin Luther King Jr. , Ralph Abernathy , and students from Atlanta's historically Black colleges and universities playing major roles in
8756-473: A terminus east of the Chattahoochee River , which would be linked to Savannah. After engineers surveyed various possible locations for the terminus, the "zero milepost" was driven into the ground in what is now Foundry Street, Five Points . When asked in 1837 about the future of the little village, Stephen Harriman Long , the railroad's chief engineer said the place would be good "for one tavern,
8955-561: A third of the global pharmaceutical market, with $ 340 billion in annual sales followed by the EU and Japan. Emerging markets such as China, Russia, South Korea and Mexico outpaced that market, growing a huge 81 percent. The top ten best-selling drugs of 2013 totaled $ 75.6 billion in sales, with the anti-inflammatory drug Humira being the best-selling drug worldwide at $ 10.7 billion in sales. The second and third best selling were Enbrel and Remicade, respectively. The top three best-selling drugs in
9154-443: Is 21 miles (34 km) southeast of Marietta , 27 miles (43 km) southwest of Alpharetta , 146 miles (235 km) southwest of Greenville, South Carolina , 147 miles (237 km) east of Birmingham, Alabama , and 245 miles (394 km) southwest of Charlotte, North Carolina . Despite having lost significant tree canopy coverage between 1973 and 1999, Atlanta now has the densest urban tree coverage of any major city in
9353-618: Is a growing population of Mexican ancestry throughout the region, with notable concentrations along the Buford Highway and I-85 corridor, and now extending into Gwinnett County. In 2013, Metro Atlanta had the 19th largest Hispanic population in the United States. The Atlanta area also has a fast growing Asian American population. The largest groups of Asian origin are those of Indian, Vietnamese, Chinese, Korean, Filipino, Pakistani and Japanese descent. Pew Research Center ranks
9552-406: Is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA reviews the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted. A fourth phase of post-approval surveillance is also often required due to
9751-446: Is an industry involved in medicine that discovers, develops, produces, and markets pharmaceutical goods for use as drugs that function by being administered to (or self-administered by) patients using such medications with the goal of curing or preventing disease (as well as possibly alleviating symptoms of illness or injury ). Pharmaceutical companies may deal in " generic " medications and medical devices without
9950-470: Is dominant. The eastside is marked by historic streetcar suburbs , built from the 1890s to the 1930s as havens for the upper middle class. These neighborhoods, many of which contain their own villages encircled by shaded, architecturally distinct residential streets, include the Victorian Inman Park , Bohemian East Atlanta , and eclectic Old Fourth Ward . On the westside and along
10149-561: Is metro Atlanta's largest employer. UPS , the world's largest courier company, operates an air cargo hub at Hartsfield-Jackson, and has their headquarters in neighboring Sandy Springs . Media is also an important aspect of Atlanta's economy. In the 1980s, media mogul Ted Turner founded the Cable News Network (CNN), Turner Network Television (TNT), HLN (HLN), Turner Classic Movies (TCM), The Cartoon Network, Inc. and its namesake television network , TruTV (truTV) and
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#173277615499610348-454: Is not associated with cancer in people. Other notable new vaccines of the period include those for measles (1962, John Franklin Enders of Children's Medical Center Boston, later refined by Maurice Hilleman at Merck), Rubella (1969, Hilleman, Merck) and mumps (1967, Hilleman, Merck) The United States incidences of rubella, congenital rubella syndrome, measles, and mumps all fell by >95% in
10547-624: Is now the Old Fourth Ward , resulting in one fatality and the displacement of 10,000 people. On December 15, 1939, Atlanta hosted the premiere of Gone with the Wind , the epic film based on the best-selling novel by Atlanta's Margaret Mitchell . The gala event at Loew's Grand Theatre was attended by the film's legendary producer, David O. Selznick , and the film's stars Clark Gable , Vivien Leigh , and Olivia de Havilland , but Oscar winner Hattie McDaniel , an African-American actress,
10746-427: Is one of Atlanta's designated Landmark Historical Neighborhoods. Vine City, though technically Northwest, adjoins the city's Downtown area and has recently been the target of community outreach programs and economic development initiatives. Gentrification of the city's neighborhoods is one of the more controversial and transformative forces shaping contemporary Atlanta. The gentrification of Atlanta has its origins in
10945-465: Is presently licensed by Merck & Co. to sell an authorised generic version of the popular drug simvastatin ( Zocor ) in the USA. Since Dr. Reddy's has a licence from Merck, it was not subject to the exclusivity period on generic simvastatin, which ended in 2006. As of 2006, Dr. Reddy's Laboratories exceeded US$ 500 million in revenues, flowing from their APIs, branded formulations and generics segments;
11144-462: Is ranked 87th with a net worth of $ 3.67 billion. Dr. Reddy's originally launched in 1984 producing active pharmaceutical ingredients . In 1986, Reddy's started operations on branded formulations. Within a year Reddy's had launched Norilet, the company's first recognised brand in India. Soon, Dr. Reddy's obtained another success with Omez, its branded omeprazole – gastrointestinal ulcer and reflux oesophagitis medication – launched at half
11343-430: Is the core guide for pharmacists and clinicians. In many non-US western countries, a 'fourth hurdle' of cost effectiveness analysis has developed before new technologies can be provided. This focuses on the 'efficacy price tag' (in terms of, for example, the cost per QALY ) of the technologies in question. In England and Wales NICE decides whether and in what circumstances drugs and technologies will be made available by
11542-498: Is the most important risk factor for cardiovascular morbidity and mortality , in industrialized countries . Prior to 1940 approximately 23% of all deaths among persons over age 50 were attributed to hypertension. Severe cases of hypertension were treated by surgery. Early developments in the field of treating hypertension included quaternary ammonium ion sympathetic nervous system blocking agents, but these compounds were never widely used due to their severe side effects, because
11741-595: Is the process by which potential drugs are discovered or designed. In the past, most drugs have been discovered either by isolating the active ingredient from traditional remedies or by serendipitous discovery. Modern biotechnology often focuses on understanding the metabolic pathways related to a disease state or pathogen , and manipulating these pathways using molecular biology or biochemistry . A great deal of early-stage drug discovery has traditionally been carried out by universities and research institutions. Drug development refers to activities undertaken after
11940-415: Is the value of the publicly traded companies. Small Molecules modality had 58.2% of the valuation share down from 84.6% in 2003. Biologics was up at 30.5% from 14.5%. The valuation share of Chinese Pharma grew from 2003 to 2021 from 1% to 12% overtaking Switzerland who is now ranked number 3 with 7.7%. The United States had still by far the most valued pharmaceutical industry with 40% of global valuation. 2023
12139-676: Is water. The city is situated in the Deep South of the southeastern United States among the foothills of the Appalachian Mountains . At 1,050 feet (320 m) above mean sea level, Atlanta has the highest elevation among major cities east of the Mississippi River . Atlanta straddles the Eastern Continental Divide . Rainwater that falls on the south and east side of the divide flows into
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#173277615499612338-602: The American Civil War , it served a strategically important role for the Confederacy until it was captured in 1864. The city was almost entirely burned to the ground during General William T. Sherman 's March to the Sea . However, the city rebounded dramatically in the post-war period and quickly became a national industrial center and the unofficial capital of the " New South ". After World War II , it also became
12537-511: The BeltLine on the eastside , former warehouses and factories have been converted into housing, retail space, and art galleries, transforming the once-industrial areas such as West Midtown into model neighborhoods for smart growth , historic rehabilitation, and infill construction. In southwest Atlanta, neighborhoods closer to downtown originated as streetcar suburbs, including the historic West End , while those farther from downtown retain
12736-530: The Cotton States and International Exposition , which attracted nearly 800,000 attendees and successfully promoted the New South's development to the world. During the first decades of the 20th century, Atlanta enjoyed a period of unprecedented growth. In three decades' time, Atlanta's population tripled as the city limits expanded to include nearby streetcar suburbs. The city's skyline grew taller with
12935-781: The Equitable Building (1892–1971), Terminal Station (1905–1972), and the Carnegie Library (1902–1977). In the mid-1970s, the Fox Theatre , now a cultural icon of the city, would have met the same fate if not for a grassroots effort to save it. More recently, preservationists may have made some inroads. For example, in 2016 activists convinced the Atlanta City Council not to demolish the Atlanta-Fulton Central Library,
13134-601: The Four Seasons Hotel Atlanta (1992). Also completed during the era is the Portman-designed Bank of America Plaza built in 1992. At 1,023 feet (312 m), it is the tallest building in the city and the 14th-tallest in the United States. The city's embrace of modern architecture has often translated into an ambivalent approach toward historic preservation, leading to the destruction of many notable architectural landmarks. These include
13333-520: The Georgia Railroad , suggested the town be renamed Atlanta , supposedly a feminine version of the word "Atlantic", referring to the Western and Atlantic Railroad. The residents approved, and the town was incorporated as Atlanta on December 29, 1847. By 1860, Atlanta's population had grown to 9,554. During the American Civil War , the nexus of multiple railroads in Atlanta made the city
13532-519: The Nobel Prize in Medicine for this discovery. Nonetheless, the dramatic decrease in deaths from infectious diseases that occurred prior to World War II was primarily the result of improved public health measures such as clean water and less crowded housing, and the impact of anti-infective drugs and vaccines was significant mainly after World War II. In 1928, Alexander Fleming discovered
13731-665: The North to the Atlanta area. It has long been known as a center of African-American political power, education, entrepreneurship, and culture, often called a Black mecca . However, in the 1990s, Atlanta started to experience Black flight . African Americans have moved to the suburbs seeking a lower cost of living or better public schools. The African-American share of Atlanta's population has declined faster than that of any racial group. The city's share of Black residents shrank from 67% in 1990 to 47% in 2020. Blacks made up nine percent of new Atlanta residents between 2010 and 2020. At
13930-781: The Pew Research Center in 2014, but in recent decades the Roman Catholic Church has increased in numbers and influence because of new migrants to the region. Metro Atlanta also has numerous ethnic or national Christian congregations, including Korean and Indian churches. Per the Public Religion Research Institute in 2020, overall, 73% of the population identify with some tradition or denomination of Christianity ; despite continuing religious diversification, historically African-American Protestant churches continue prevalence in
14129-497: The Turner Broadcasting System (TBS) in the city. Around the same time, Cox Enterprises , now the nation's third-largest cable television service and the publisher of over a dozen American newspapers, moved its headquarters to the city. Notable sports networks headquartered in Atlanta include Warner Bros. Discovery Sports , NBA TV , Bally Sports South , and Bally Sports Southeast . The Weather Channel
14328-577: The birth control movement and the efforts of activists Margaret Sanger , Mary Dennett , and Emma Goldman . Based on fundamental research performed by Gregory Pincus and synthetic methods for progesterone developed by Carl Djerassi at Syntex and by Frank Colton at G.D. Searle & Co. , the first oral contraceptive, Enovid , was developed by G.D. Searle & Co. and approved by the FDA in 1960. The original formulation incorporated vastly excessive doses of hormones, and caused severe side effects. Nonetheless, by 1962, 1.2 million American women were on
14527-487: The densest urban tree coverage of any major city in the United States. Atlanta was originally founded as the terminus of a major state-sponsored railroad, but it soon became the convergence point among several railroads, spurring its rapid growth. The largest was the Western and Atlantic Railroad , from which the name "Atlanta" is derived, signifying the city's growing reputation as a major hub of transportation. During
14726-434: The dermatology sector. Dr. Reddy's Para 4 application strategy for generic business received a severe setback when Reddy's lost the patent challenge in the case of Pfizer ’s drug Norvasc ( amlodipine maleate ), a drug indicated for the treatment of hypertension and angina . The cost involved in patent litigation as well as the unexpected loss of the patent challenge affected Reddy's plans to start speciality business in
14925-477: The opportunity cost of investing capital many years before revenues are realized (see Time-value of money ). Because of the very long time needed for discovery, development, and approval of pharmaceuticals, these costs can accumulate to nearly half the total expense. A direct consequence within the pharmaceutical industry value chain is that major pharmaceutical multinationals tend to increasingly outsource risks related to fundamental research, which somewhat reshapes
15124-644: The world's busiest airport by passenger traffic in 1998 (a position it has held every year since, except for 2020), with an estimated 93.7 million passengers in 2022. With a nominal gross domestic product (GDP) of $ 473 billion in 2021, Atlanta has the 11th-largest economy among cities in the U.S. and the 22nd-largest in the world. Its economy is considered diverse, with dominant sectors in industries including transportation, aerospace, logistics, healthcare, news and media operations, film and television production, information technology, finance, and biomedical research and public policy. Atlanta established itself on
15323-480: The "city too busy to hate." Desegregation of the public sphere came in stages, with public transportation desegregated by 1959, the restaurant at Rich's department store by 1961, movie theaters by 1963, and public schools by 1973 (nearly 20 years after the US Supreme Court ruled that segregated public schools were unconstitutional). In 1960, Whites comprised 61.7% of the city's population. During
15522-400: The 1950s–70s, suburbanization and White flight from urban areas led to a significant demographic shift. By 1970, African Americans were the majority of the city's population and exercised their recently enforced voting rights and political influence by electing Atlanta's first Black mayor, Maynard Jackson , in 1973. Under Mayor Jackson's tenure, Atlanta's airport was modernized, strengthening
15721-586: The 1960s (referring to racial relations). Atlanta has consistently scored 100% on the Human Rights Campaign's Municipal Equality Index that measures how inclusive a city's laws, policies and services are for LGBT people who live or work there. Religion in Atlanta, while historically centered on Protestant Christianity , now encompasses many faiths, as a result of the city and metro area's increasingly international population. Some 63% of residents identified as some type of Protestant according to
15920-498: The 1970s, after many of Atlanta's neighborhoods had declined and suffered the urban decay that affected other major American cities in the mid-20th century. When neighborhood opposition successfully prevented two freeways from being built through the city's east side in 1975, the area became the starting point for Atlanta's gentrification . After Atlanta was awarded the Olympic games in 1990, gentrification expanded into other parts of
16119-587: The Atlanta area among the top 10 U.S. metropolitan areas by Indian population in 2019. Early immigrants in the Atlanta area were mostly Jews and Greeks . Since 2010, the Atlanta area has experienced notable immigration from India, China, South Korea, and Jamaica. Other notable source countries of immigrants are Vietnam, Eritrea, Nigeria, the Arabian gulf, Ukraine and Poland. Within a few decades, and in keeping with national trends, immigrants from England, Ireland, and German-speaking central Europe were no longer
16318-681: The Atlantic Ocean, while rainwater on the north and west side of the divide flows into the Gulf of Mexico . Atlanta developed on a ridge south of the Chattahoochee River , which is part of the ACF River Basin . The river borders the far northwestern edge of the city, and much of its natural habitat has been preserved, in part by the Chattahoochee River National Recreation Area . Atlanta
16517-689: The Beltline has stimulated new and related development along its path. Under the Köppen classification , Atlanta has a humid subtropical climate ( Cfa ) with generous precipitation year-round, typical for the Upland South ; the city is situated in USDA Plant Hardiness Zone 8a, with the northern and western suburbs, as well as part of Midtown transitioning to 7b. Summers are hot and humid, with temperatures somewhat moderated by
16716-458: The Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials , as well as a commitment to ongoing safety monitoring . Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account,
16915-494: The Chinese pharmaceutical sector have also grown substantially. On the organisational side, big international pharma corporations have experienced a substantial decline of their value share. Also, the core generic sector (substitutions for off-patent brands) has been downvalued due to competition. Torreya estimated the pharmaceutical industry to have a market valuation of US$ 7.03 trillion by February 2021 from which US$ 6.1 trillion
17114-670: The Civil War ended in 1865, Atlanta was gradually rebuilt during the Reconstruction era . The work attracted many new residents. Due to the city's superior rail transportation network, the state capital was moved from Milledgeville to Atlanta in 1868. In the 1880 Census, Atlanta had surpassed Savannah as Georgia's largest city. Beginning in the 1880s, Henry W. Grady , the editor of the Atlanta Constitution newspaper, promoted Atlanta to potential investors as
17313-406: The FDA issued a Form 483 letter over concerns discovered during an inspection of its Srikakulam facility. No specific violations were mentioned in the letter. In 2019, Dr. Reddy's recalled all ranitidine products in the US market due to contamination with the carcinogen N-nitrosodimethylamine (NDMA). Months later, all brands of ranitidine were recalled and it was taken off the US market, as
17512-594: The Foundation set up an American laboratory in Atlanta , dedicated to discovery and design of novel therapeutics. The laboratory is called Reddy US Therapeutics Inc (RUSTI) and its main aim is the discovery of next-generation drugs using genomics and proteomics . Reddy's research thrust focused on large niche areas in western markets – anti- cancer , anti- diabetes , cardiovascular and anti-infection drugs. Reddy's international marketing successes were built on
17711-518: The Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize
17910-847: The NHS, whilst similar arrangements exist with the Scottish Medicines Consortium in Scotland, and the Pharmaceutical Benefits Advisory Committee in Australia. A product must pass the threshold for cost-effectiveness if it is to be approved. Treatments must represent 'value for money' and a net benefit to society. There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases involving fewer than 200,000 patients in
18109-723: The Orange Book site. In the UK, the Medicines and Healthcare products Regulatory Agency approves and evaluates drugs for use. Normally an approval in the UK and other European countries comes later than one in the USA. Then it is the National Institute for Health and Care Excellence (NICE), for England and Wales, who decides if and how the National Health Service (NHS) will allow (in the sense of paying for) their use. The British National Formulary
18308-520: The Reddy's brand name represented a significant step in the company's efforts to build a strong and sustainable US generic business. It was the first step in building Reddy's fully-fledged distribution network in the US market. In 2015, Dr. Reddy's Laboratories bought the established brands of Belgian drugmaker UCB SA in South Asia for ₹ 8 billion ($ 128.38 million). Dr. Reddy's Laboratories also signed
18507-508: The U.S. obtained exclusivity for all of the approved dosage forms (10 mg, 20 mg) except one (40 mg), which was obtained by Reddy's. Lilly had numerous other patents surrounding the drug compound and had already enjoyed a long period of patent protection. The case to allow generic sales was heard twice by the Federal Circuit Court , and Reddy's won both hearings. Reddy's generated nearly $ 70 million in revenue during
18706-463: The US and Europe . By 2007, Dr. Reddy's had seven FDA plants producing active pharmaceutical ingredients in India and seven FDA -inspected and ISO 9001 (quality) and ISO 14001 (environmental management) certified plants making patient-ready medications – five of them in India and two in the UK. As per Forbes list of India’s 100 richest tycoons, dated 9 October 2024, the Reddy Family
18905-638: The US generic markets. In March 2006, Dr. Reddy's acquired Betapharm Arzneimittel GmbH from 3i for 480 million Euros. Betapharm is Germany's fourth-largest generics pharmaceutical company, with a 3.5% market share , including 150 active pharmaceutical ingredients. Reddy's has promoted India's first integrated drug development company Perlecan Pharma Pvt Ltd together with ICICI ventures capital fund management company Ltd and Citigroup Venture Capital International growth partnership Mauritius Ltd. The combined entity will undertake clinical development and out-licensing of new chemical entity assets. Dr. Reddy's
19104-458: The US market. The FDA received authority to regulate advertising of prescription drugs and to establish good manufacturing practices . The law required that all drugs introduced between 1938 and 1962 had to be effective. An FDA - National Academy of Sciences collaborative study showed that nearly 40 percent of these products were not effective. A similarly comprehensive study of over-the-counter products began ten years later. In 1971, Akira Endo ,
19303-561: The US). Atlanta's dialect has traditionally been a variation of Southern American English . The Chattahoochee River long formed a border between the Coastal Southern and Southern Appalachian dialects. Because of the development of corporate headquarters in the region, attracting migrants from other areas of the country, by 2003, Atlanta magazine concluded that Atlanta had become significantly "de-Southernized". A Southern accent
19502-481: The United Kingdom and Germany. Bosnian refugees settled in Atlanta. Vietnamese people, Cambodians, Ethiopians and Eritreans were the earliest refugees formally brought to the city. Of the total population five years and older, 83.3% spoke only English at home, while 8.8% spoke Spanish, 3.9% another Indo-European language, and 2.8% an Asian language. Among them, 7.3% of Atlantans were born abroad ( 86th in
19701-573: The United States according to the 2020 U.S. census . It is the principal city of the much larger Atlanta metropolitan area , the core of which includes Cobb , Clayton and Gwinnett counties, in addition to Fulton and DeKalb. Metro Atlanta is home to more than 6.3 million people (2023 estimate), making it the sixth-largest U.S. metropolitan area . Situated among the foothills of the Appalachian Mountains at an elevation of just over 1,000 feet (300 m) above sea level, Atlanta features unique topography that includes rolling hills, lush greenery, and
19900-546: The United States and is often called "City of Trees" or "The City in a Forest". Most of Atlanta was burned in the final months of the American Civil War, depleting the city of a large stock of its historic architecture. Yet architecturally, the city had never been traditionally "southern": Atlanta originated as a railroad town rather than a southern seaport dominated by the planter class, such as Savannah or Charleston . Because of its later development, many of
20099-526: The United States in 2013 were Abilify ($ 6.3 billion,) Nexium ($ 6 billion) and Humira ($ 5.4 billion). The best-selling drug ever, Lipitor , averaged $ 13 billion annually and netted $ 141 billion total over its lifetime before Pfizer's patent expired in November 2011. IMS Health publishes an analysis of trends expected in the pharmaceutical industry in 2007, including increasing profits in most sectors despite loss of some patents, and new 'blockbuster' drugs on
20298-690: The United States, or larger populations in certain circumstances are subject to the Orphan Drug Act. Because medical research and development of drugs to treat such diseases is financially disadvantageous, companies that do so are rewarded with tax reductions, fee waivers, and market exclusivity on that drug for a limited time (seven years), regardless of whether the drug is protected by patents. In 2011, global spending on prescription drugs topped $ 954 billion, even as growth slowed somewhat in Europe and North America. The United States accounts for more than
20497-492: The ability to relocate to the suburbs. As a result, the city began to make up an ever-smaller proportion of the metropolitan area's population. African-American veterans returned from World War II seeking full rights in their country and began heightened activism. In exchange for support by that portion of the Black community that could vote, in 1948 the mayor ordered the hiring of the first eight African-American police officers in
20696-495: The addictive properties and abuse potential of barbiturates and amphetamines and led to increasing restrictions on their use and growing government oversight of prescribers. Today, amphetamine is largely restricted to use in the treatment of attention deficit disorder and phenobarbital in the treatment of epilepsy . In 1958, Leo Sternbach discovered the first benzodiazepine , chlordiazepoxide (Librium). Dozens of other benzodiazepines have been developed and are in use, some of
20895-401: The antibacterial effects of penicillin , but its exploitation for the treatment of human disease awaited the development of methods for its large scale production and purification. These were developed by a U.S. and British government-led consortium of pharmaceutical companies during the world war. There was early progress toward the development of vaccines throughout this period, primarily in
21094-549: The area from 1802 to 1825. The Creek were forced to leave the area in 1821, under Indian Removal by the federal government, and European American settlers arrived the following year. In 1836, the Georgia General Assembly voted to build the Western and Atlantic Railroad in order to provide a link between the port of Savannah and the Midwest . The initial route was to run southward from Chattanooga to
21293-536: The arrival of European settlers in North Georgia , the indigenous Creek people and their ancestors inhabited the area. Standing Peachtree , a Creek village where Peachtree Creek flows into the Chattahoochee River , was the closest Native American settlement to what is now Atlanta. Through the early 19th century, European Americans systematically encroached on the Creek of northern Georgia, forcing them out of
21492-476: The biological effects of these structural changes. By the 1890s, the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and
21691-648: The carcinogen was an unavoidable byproduct. In 2020 Dr. Reddy's Laboratories (UK) Ltd recalled a specific batch of nitrofurantoin 50 mg tablets from pharmacies and wholesalers due to dissolution during routine stability testing and a specific batch of aripiprazole due to the potential for small particles of aripiprazole active material to be present which may affect the efficacy of the product. Dr. Reddy's has been accused of polluting agricultural land surrounding its plant in Nalgonda district of Telangana . Pharmaceutical industry The pharmaceutical industry
21890-433: The city approved the $ 2.8 billion BeltLine project. It was intended to convert a disused 22-mile freight railroad loop that surrounds the central city into an art-filled multi-use trail and light rail transit line, which would increase the city's park space by 40%. The project stimulated retail and residential development along the loop, but has been criticized for its adverse effects on some Black communities. In 2013,
22089-468: The city in the following decade. During the 2000s, the city of Atlanta underwent a profound physical, cultural , and demographic change. As some of the African-American middle and upper classes also began to move to the suburbs, a booming economy drew numerous new migrants from other cities in the United States, who contributed to changes in the city's demographics. African Americans made up
22288-402: The city's economy to this day. In 2021, major freight railroad Norfolk Southern moved their headquarters to Atlanta, and the city hosts major classification yards for Norfolk Southern and CSX . Hartsfield–Jackson Atlanta International Airport is the world's busiest airport , and the headquarters of Delta Air Lines . Delta operates the world's largest airline hub at Hartsfield-Jackson and
22487-629: The city's elevation. Winters are overall mild but variable, occasionally susceptible to snowstorms even if in small quantities on several occasions, unlike the central and southern portions of the state. Warm air from the Gulf of Mexico can bring spring-like highs while strong Arctic air masses can push lows into the teens °F (−7 to −12 °C). July averages 80.9 °F (27.2 °C), with high temperatures reaching 90 °F (32 °C) on an average of 47 days per year, though 100 °F (38 °C) readings are not seen most years. January averages 44.8 °F (7.1 °C), with temperatures in
22686-615: The city's landmarks share architectural characteristics with buildings in the Northeast or Midwest, as they were designed at a time of shared national architectural styles. During the late 20th century, Atlanta embraced the global trend of modern architecture , especially for commercial and institutional structures. Examples include the State of Georgia Building built in 1966, and the Georgia-Pacific Tower in 1982. Many of
22885-409: The city's metro area, and the region hosts offices of over 1,250 multinational corporations. Many corporations are drawn to the city by its educated workforce; as of 2014 , 45% of adults aged 25 or older residing in the city have at least four-year college degrees, compared to the national average of 28%. Atlanta was born as a railroad town, and logistics continue to represent an important part of
23084-617: The city's role as a transportation center. The opening of the Georgia World Congress Center in 1976 further confirmed Atlanta's rise as a convention city. Construction of the city's subway system began in 1975, with rail service commencing in 1979. Despite these improvements, Atlanta lost more than 100,000 residents between 1970 and 1990, over 20% of its population. At the same time, it developed new office space after attracting numerous corporations, with an increasing portion of workers from northern areas. Atlanta
23283-443: The city's uptown district, is eight miles (13 km) north of Downtown and the city's third-largest business district. The district is marked by an urbanized core along Peachtree Road , surrounded by suburban single-family neighborhoods situated among woods and rolling hills. Surrounding Atlanta's three high-rise districts are the city's low- and medium-density neighborhoods , where the craftsman bungalow single-family home
23482-495: The city, stimulated by infrastructure improvements undertaken in preparation for the games. New development post-2000 has been aided by the Atlanta Housing Authority 's eradication of the city's public housing. As noted above, it allowed development of these sites for mixed-income housing, requiring developers to reserve a considerable portion for affordable housing units. It has also provided for other former residents to be given vouchers to gain housing in other areas. Construction of
23681-480: The city. After reserving 2,000 units mostly for elderly, the AHA allowed redevelopment of the sites for mixed-use and mixed-income, higher density developments, with 40% of the units to be reserved for affordable housing. Two-fifths of previous public housing residents attained new housing in such units; the remainder received vouchers to be used at other units, including in suburbs. At the same time, in an effort to change
23880-634: The city. Much controversy preceded the 1956 Sugar Bowl , when the Pitt Panthers , with African-American fullback Bobby Grier on the roster, met the Georgia Tech Yellow Jackets . There had been controversy over whether Grier should be allowed to play due to his race, and whether Georgia Tech should even play at all due to Georgia's Governor Marvin Griffin 's opposition to racial integration. After Griffin publicly sent
24079-526: The company also became listed on the New York Stock Exchange . Funds raised from the initial public offering helped Reddy's move into international production and take over technology-based companies. In 2003, Reddy's also invested $ 5.25 million (USD) in equity capital into Bio Sciences Ltd. Auriegene Discovery Technologies, a contract research company , was established as a fully owned subsidiary of Reddy's in 2002. Auriegene's objective
24278-606: The company to gain experience with those steps before moving on to creating brand-new drugs. Reddy's invested heavily in establishing R&D labs and is the only Indian company to have significant R&D being undertaken overseas. Dr. Reddy's Research Foundation was established in 1992 and in order to do research in the area of new drug discovery. At first, the foundation's drug research strategy revolved around searching for analogues. Focus has since changed to innovative R&D, hiring new scientists, especially Indian students studying abroad on doctoral and post-doctoral courses. In 2000,
24477-526: The construction of the Equitable , Flatiron , Empire , and Candler buildings. Sweet Auburn emerged as a center of Black commerce. The period was also marked by strife and tragedy. Increased racial tensions led to the Atlanta Race Riot of 1906, when Whites attacked Blacks, leaving at least 27 people dead and over 70 injured, with extensive damage in Black neighborhoods. In 1913, Leo Frank ,
24676-404: The cost of developing a successful new drug ( new chemical entity , or NCE), has been estimated at US$ 1.3 billion (not including marketing expenses ). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades. Industry-wide research and investment reached a record $ 65.3 billion in 2009. While
24875-590: The cost of research in the U.S. was about $ 34.2 billion between 1995 and 2010, revenues rose faster (revenues rose by $ 200.4 billion in that time). A study by the consulting firm Bain & Company reported that the cost for discovering, developing and launching (which factored in marketing and other business expenses) a new drug (along with the prospective drugs that fail) rose over a five-year period to nearly $ 1.7 billion in 2003. According to Forbes, by 2010 development costs were between $ 4 billion to $ 11 billion per drug. Some of these estimates also take into account
25074-453: The culture of those receiving subsidized housing, the AHA imposed a requirement for such residents to work (or be enrolled in a genuine, limited-time training program). It is virtually the only housing authority to have created this requirement. To prevent problems, the AHA also gave authority to management of the mixed-income or voucher units to evict tenants who did not comply with the work requirement or who caused behavior problems. In 2005,
25273-455: The data supporting the safety of thalidomide was incomplete. The firm continued to pressure Kelsey and the FDA to approve the application until November 1961, when the drug was pulled off the German market because of its association with grave congenital abnormalities. Several thousand newborns in Europe and elsewhere suffered the teratogenic effects of thalidomide. Without approval from the FDA,
25472-413: The destruction of all public buildings and possible assets that could be of use to the Union Army. On the next day, Mayor James Calhoun surrendered Atlanta to the Union Army, and on September 7, Sherman ordered the city's civilian population to evacuate. On November 11, 1864, Sherman prepared for the Union Army's March to the Sea by ordering the destruction of Atlanta's remaining military assets. After
25671-409: The development of tricyclic antidepressants in the 1960s. In 1903, Hermann Emil Fischer and Joseph von Mering disclosed their discovery that diethylbarbituric acid, formed from the reaction of diethylmalonic acid, phosphorus oxychloride and urea, induces sleep in dogs. The discovery was patented and licensed to Bayer pharmaceuticals , which marketed the compound under the trade name Veronal as
25870-448: The extent that such laws did exist, enforcement was lax. In the United States, increased regulation of vaccines and other biological drugs was spurred by tetanus outbreaks and deaths caused by the distribution of contaminated smallpox vaccine and diphtheria antitoxin. The Biologics Control Act of 1902 required that federal government grant premarket approval for every biological drug and for the process and facility producing such drugs. This
26069-425: The fact that even the largest clinical trials cannot effectively predict the prevalence of rare side-effects. Postmarketing surveillance ensures that after marketing the safety of a drug is monitored closely. In certain instances, its indication may need to be limited to particular patient groups, and in others the substance is withdrawn from the market completely. The FDA provides information about approved drugs at
26268-686: The firm distributed Kevadon to over 1,000 physicians there under the guise of investigational use. Over 20,000 Americans received thalidomide in this "study," including 624 pregnant patients, and about 17 known newborns suffered the effects of the drug. The thalidomide tragedy resurrected Kefauver's bill to enhance drug regulation that had stalled in Congress, and the Kefauver-Harris Amendment became law on 10 October 1962. Manufacturers henceforth had to prove to FDA that their drugs were effective as well as safe before they could go on
26467-418: The first vaccine against Japanese Encephalitis . Hilleman later moved to Merck , where he played a key role in the development of vaccines against measles , mumps , chickenpox , rubella , hepatitis A , hepatitis B , and meningitis . Prior to the 20th century, drugs were generally produced by small scale manufacturers with little regulatory control over manufacturing or claims of safety and efficacy. To
26666-468: The first non-Japanese pharmaceutical company from the Asia-Pacific region to obtain a New York Stock Exchange listing. In 2001 Reddy's became the first Indian company to launch the generic drug, fluoxetine (a generic version of Eli Lilly and Company ’s Prozac ) with 180-day market exclusivity in the USA. Prozac had sales in excess of $ 1 billion per year in the late 1990s. Barr Laboratories of
26865-407: The form of academic and government-funded basic research directed toward the identification of the pathogens responsible for common communicable diseases. In 1885, Louis Pasteur and Pierre Paul Émile Roux created the first rabies vaccine . The first diphtheria vaccines were produced in 1914 from a mixture of diphtheria toxin and antitoxin (produced from the serum of an inoculated animal), but
27064-536: The former two segments account for almost 75% of revenues. Dr. Reddy's deals in and manages all the processes, from the development of the API to the submission of finished dosage dossiers to the regulatory agencies. In 2010, the family-controlled Dr Reddy's denied that it was in talks to sell its generics business in India to US pharmaceutical giant Pfizer , which had been suing the company for alleged patent infringement after Dr Reddy's announced that it intended to produce
27263-535: The fungus Aspergillus terreus , first marketed in 1987 as Mevacor. In April 1994, the results of a Merck-sponsored study, the Scandinavian Simvastatin Survival Study , were announced. Researchers tested simvastatin , later sold by Merck as Zocor, on 4,444 patients with high cholesterol and heart disease. After five years, the study concluded the patients saw a 35% reduction in their cholesterol, and their chances of dying of
27462-747: The help of Biomed's chief executive". Reddy's sold the joint venture to the Kremlin-friendly Sistema group. In 1993, Reddy's entered into a joint venture in the Middle East and created two formulation units there and in Russia. Reddy's exported bulk drugs to these formulation units, which then converted them into finished products. In 1994, Reddy's started targeting the US generic market by building state of art manufacturing facility. Reddy's path into new drug discovery involved targeting speciality generics products in western markets to create
27661-499: The horizon. Atlanta Atlanta ( / æ t ˈ l æ n t ə / at- LAN -tə ) is the capital and most populous city in the U.S. state of Georgia . It is the seat of Fulton County , and a portion of the city extends into neighboring DeKalb County . With a population of 510,823 living within the city limits, Atlanta is the eighth most populous city in the Southeast and 37th most populous city in
27860-401: The immediate aftermath of widespread vaccination. The first 20 years of licensed measles vaccination in the U.S. prevented an estimated 52 million cases of the disease, 17,400 cases of mental retardation , and 5,200 deaths. Hypertension is a risk factor for atherosclerosis, heart failure , coronary artery disease , stroke , renal disease , and peripheral arterial disease , and
28059-911: The industry ecosystem with biotechnology companies playing an increasingly important role, and overall strategies being redefined accordingly. Some approved drugs, such as those based on re-formulation of an existing active ingredient (also referred to as Line-extensions) are much less expensive to develop. In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III
28258-541: The initial six-month exclusivity period. With such high returns at stake, Reddy's was gambling on the success of the litigation; failure to win the case could have cost them millions of dollars, depending on the length of the trial. The fluoxetine marketing success was followed by the American launch of Reddy's house-branded ibuprofen tablets in 400, 600 and 800 mg strengths, in January 2003. Direct marketing under
28457-565: The involvement of intellectual property , in " brand " materials is specifically tied to a given company's history, or in both within different contexts. The industry's has various subdivisions (which include distinct areas such as manufacturing biologics ) are all subject to a variety of laws and regulations that govern entire financial processes including the patenting , efficacy testing, safety evaluation , and marketing of these drugs. The global pharmaceuticals market produced treatments worth $ 1,228.45 billion in 2020, in total, and this showed
28656-509: The isolation between 1803 and 1805 of morphine – an analgesic and sleep-inducing agent – from opium by the German apothecary assistant Friedrich Sertürner , who named this compound after the Greek god of dreams, Morpheus . Multinational corporations including Merck , Hoffman-La Roche , Burroughs-Wellcome (now part of Glaxo Smith Kline ), Abbott Laboratories , Eli Lilly and Upjohn (now part of Pfizer ) began as local apothecary shops in
28855-436: The isolation of tuberculosis-infected people were an ubiquitous feature of cities in developed countries, with 50% dying within 5 years of admission. A Federal Trade Commission report issued in 1958 attempted to quantify the effect of antibiotic development on American public health. The report found that over the period 1946–1955, there was a 42% drop in the incidence of diseases for which antibiotics were effective and only
29054-462: The larger pharmaceutical companies. The pharmaceuticals and biotechnology industry spends more than 15% of its net sales for Research & Development which is in comparison with other industries by far the highest share. Often, large multinational corporations exhibit vertical integration , participating in a broad range of drug discovery and development, manufacturing and quality control, marketing, sales, and distribution. Smaller organizations, on
29253-430: The last building designed by noted architect Marcel Breuer . Atlanta is divided into 242 officially defined neighborhoods . The city contains three major high-rise districts, which form a north–south axis along Peachtree : Downtown , Midtown , and Buckhead . Surrounding these high-density districts are leafy, low-density neighborhoods, most of which are dominated by single-family homes. Downtown Atlanta contains
29452-446: The launch of new patient friendly packaging for its top 25 best-selling brands, which will be rolled-out in a phased manner over the next six months. The packaging has been designed such that blister packs would have extra space for brand name which ensures easy identification at the pharmacy, a tab at the bottom with expiry date clearly mentioned, and a pictorial representation of the time the medicine needs to be taken. In case of bottles,
29651-413: The law to prosecute manufacturers for making unsupported claims of efficacy were undercut by a Supreme Court ruling restricting the federal government's enforcement powers to cases of incorrect specification of the drug's ingredients. In 1937 over 100 people died after ingesting " Elixir Sulfanilamide " manufactured by S.E. Massengill Company of Tennessee. The product was formulated in diethylene glycol ,
29850-513: The long-term health consequences of high blood pressure had not yet been established, and because they had to be administered by injection. In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine . A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time ( tachyphylaxis ). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of Merck and Co. discovered and developed chlorothiazide , which remains
30049-604: The longest paved trail surface in the U.S. totaling about 300 miles (480 km). Atlanta's cultural offerings expanded during the 2000s: the High Museum of Art doubled in size; the Alliance Theatre won a Tony Award ; and art galleries were established on the once-industrial Westside . The College Football Hall of Fame relocated to Atlanta and the National Center for Civil and Human Rights museum
30248-490: The majority of Atlanta's foreign-born population. The city's Italians included immigrants from northern Italy, many of whom had been in Atlanta since the 1890s; more recent arrivals from southern Italy; and Sephardic Jews from the Isle of Rhodes, which Italy had seized from Turkey in 1912. Europeans from Great Britain , Ireland and Germany settled in the city as early as the 1840s. Most of Atlanta's European population are from
30447-454: The measuring cup is now easy to read, and neck of the bottle has been modified to ensure minimal spillage. Purple Health also includes patient support services. For example, someone taking medicines for an advanced kidney condition would be supported by messages and counselling on diet, medicine and so on. In September 2005, Dr. Reddy's spun off its drug discovery and research wing into a separate company called Perlecan Pharma Private Limited. At
30646-453: The mid-1800s. By the late 1880s, German dye manufacturers had perfected the purification of individual organic compounds from tar and other mineral sources and had also established rudimentary methods in organic chemical synthesis . The development of synthetic chemical methods allowed scientists to systematically vary the structure of chemical substances, and growth in the emerging science of pharmacology expanded their ability to evaluate
30845-524: The more popular drugs being diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), and lorazepam (Ativan). Due to their far superior safety and therapeutic properties, benzodiazepines have largely replaced the use of barbiturates in medicine, except in certain special cases. When it was later discovered that benzodiazepines, like barbiturates, significantly lose their effectiveness and can have serious side effects when taken long-term, Heather Ashton researched benzodiazepine dependence and developed
31044-452: The most notable achievement of the period being Jonas Salk 's 1954 development of the polio vaccine under the funding of the non-profit National Foundation for Infantile Paralysis . The vaccine process was never patented but was instead given to pharmaceutical companies to manufacture as a low-cost generic . In 1960 Maurice Hilleman of Merck Sharp & Dohme identified the SV40 virus, which
31243-789: The most notable examples from this period were designed by world renowned Atlanta architect John Portman . Most of the buildings that define the downtown skyline were designed by Portman during this period, including the Westin Peachtree Plaza and the Atlanta Marriott Marquis . In the latter half of the 1980s, Atlanta became one of the early homes of postmodern buildings that reintroduced classical elements to their designs. Many of Atlanta's tallest skyscrapers were built in this period and style, displaying tapering spires or otherwise ornamented crowns, such as One Atlantic Center (1987), 191 Peachtree Tower (1991), and
31442-425: The most office space in the metro area, much of it occupied by government entities. Downtown is home to the city's sporting venues and many of its tourist attractions. Midtown Atlanta is the city's second-largest business district, containing the offices of many of the region's law firms. Midtown is known for its art institutions, cultural attractions, institutions of higher education, and dense form. Buckhead ,
31641-454: The most severe occurring on January 7, 1973. Tornadoes are rare in the city itself, but the March 14, 2008, EF2 tornado damaged prominent structures in downtown Atlanta. The 2020 United States census reported that Atlanta had a population of 498,715. The population density was 3,685.45 persons per square mile (1,422.95/ km ). The racial and ethnic makeup of Atlanta (including Hispanics)
31840-439: The most widely used antihypertensive drug today. This development was associated with a substantial decline in the mortality rate among people with hypertension. The inventors were recognized by a Public Health Lasker Award in 1975 for "the saving of untold thousands of lives and the alleviation of the suffering of millions of victims of hypertension". A 2009 Cochrane review concluded that thiazide antihypertensive drugs reduce
32039-479: The movement's leadership. While Atlanta in the postwar years had relatively minimal racial strife compared to other cities, Blacks were limited by discrimination, segregation, and continued disenfranchisement of most voters. In 1961, the city attempted to thwart blockbusting by realtors by erecting road barriers in Cascade Heights , countering the efforts of civic and business leaders to foster Atlanta as
32238-462: The need for more comprehensive regulation and provided the driving force for the passage of new laws. On 12 September 1960, an American licensee, the William S. Merrell Company of Cincinnati, submitted a new drug application for Kevadon ( thalidomide ), a sedative that had been marketed in Europe since 1956. The FDA medical officer in charge of reviewing the compound, Frances Kelsey , believed that
32437-500: The other hand, often focus on a specific aspect such as discovering drug candidates or developing formulations. Often, collaborative agreements between research organizations and large pharmaceutical companies are formed to explore the potential of new drug substances. More recently, multi-nationals are increasingly relying on contract research organizations to manage drug development. Drug discovery and development are very expensive; of all compounds investigated for use in humans only
32636-429: The pH of the extract allowed a relatively pure grade of insulin to be produced. Under pressure from Toronto University and a potential patent challenge by academic scientists who had independently developed a similar purification method, an agreement was reached for non-exclusive production of insulin by multiple companies. Prior to the discovery and widespread availability of insulin therapy the life expectancy of diabetics
32835-401: The pill, and by 1965 the number had increased to 6.5 million. The availability of a convenient form of temporary contraceptive led to dramatic changes in social mores including expanding the range of lifestyle options available to women, reducing the reliance of women on men for contraceptive practice, encouraging the delay of marriage, and increasing pre-marital co-habitation. In the U.S.,
33034-593: The population was living below the poverty line in 2022. Circa 2024, of the Atlanta residents, 391,711 of them lived in Fulton County and 28,292 of them lived in DeKalb County. In the 1920s, the Black population began to grow in Southern metropolitan cities like Atlanta, Birmingham , Houston , and Memphis . The New Great Migration brought an insurgence of African Americans from California and
33233-549: The price of other brands on the Indian market at that time. Within a year, Reddy's became the first Indian company to export the active ingredients for pharmaceuticals to Europe. In 1987, Reddy's started to transform itself from a supplier of pharmaceutical ingredients to other manufacturers into a manufacturer of pharmaceutical products. In 1999, Dr. Reddy's joined the Indian Pharmaceutical Alliance as
33432-604: The project received a federal grant of $ 18 million to develop the southwest corridor. In September 2019 the James M. Cox Foundation gave $ 6 Million to the PATH Foundation which will connect the Silver Comet Trail to The Atlanta BeltLine which is expected to be completed by 2022. Upon completion, the total combined interconnected trail distance around Atlanta for The Atlanta BeltLine and Silver Comet Trail will be
33631-414: The proportion of whites in the city had strong growth. In two decades, Atlanta's White population grew from 33% to 39% of the city's population. Whites made up the majority of new Atlanta residents between 2010 and 2020. The Hispanic and Latino populations of metro Atlanta have grown significantly in recent years. The largest Hispanic ancestries in Atlanta are Mexican , Puerto Rican and Cuban . There
33830-417: The regulated markets of APIs. By 1997, Reddy's made the transition from being an API and bulk drug supplier to regulated markets like the US and the UK, and a branded formulations supplier in unregulated markets like India and Russia, into producing generics, by filing an Abbreviated New Drug Application (ANDA) in the USA. The same year, Reddy's out-licensed a molecule for clinical trials to Novo Nordisk ,
34029-465: The rights for the US and the rest of the world will be held by Dr. Reddy's. Dr. Reddy's conducted clinical trials of its cardiovascular drug RUS 3108 in Belfast , Northern Ireland , in 2005. The trials were conducted to study the safety and the pharmacokinetic profiles of the drug, which is intended for the treatment of atherosclerosis, a major cause of cardiovascular disorders. Dr. Reddy's entered into
34228-486: The risk of death ( RR 0.89), stroke (RR 0.63), coronary heart disease (RR 0.84), and cardiovascular events (RR 0.70) in people with high blood pressure. In the ensuring years other classes of antihypertensive drug were developed and found wide acceptance in combination therapy, including loop diuretics (Lasix/ furosemide , Hoechst Pharmaceuticals , 1963), beta blockers ( ICI Pharmaceuticals , 1964) ACE inhibitors , and angiotensin receptor blockers . ACE inhibitors reduce
34427-479: The risk of new onset kidney disease [RR 0.71] and death [RR 0.84] in diabetic patients, irrespective of whether they have hypertension. Prior to the Second World war, birth control was prohibited in many countries, and in the United States even the discussion of contraceptive methods sometimes led to prosecution under Comstock laws . The history of the development of oral contraceptives is thus closely tied to
34626-654: The safety of the inoculation was marginal and it was not widely used. The United States recorded 206,000 cases of diphtheria in 1921, resulting in 15,520 deaths. In 1923, parallel efforts by Gaston Ramon at the Pasteur Institute and Alexander Glenny at the Wellcome Research Laboratories (later part of GlaxoSmithKline ) led to the discovery that a safer vaccine could be produced by treating diphtheria toxin with formaldehyde . In 1944, Maurice Hilleman of Squibb Pharmaceuticals developed
34825-401: The same time, Atlanta is home to a sizable foreign-born Black population, notably from Eritrea , Ethiopia , Ghana , Somalia , Liberia , and Nigeria . With many notable investments occurring in Atlanta initiated by the 1996 Summer Olympics , the non-Hispanic white population of Atlanta began to rebound after several decades of white flight to Atlanta's suburbs. Between 2000 and 2020,
35024-413: The suburbs slightly cooler due largely to the urban heat island effect. Lows at or below freezing can be expected 36 nights annually, but the last occurrences of temperatures below 10 °F (−12 °C) were December 24, 2022 , and January 2014 , eight years apart. Extremes range from −9 °F (−23 °C) on February 13, 1899 to 106 °F (41 °C) on June 30, 2012 . Average dewpoints in
35223-712: The summer range from 63.7 °F (17.6 °C) in June to 67.8 °F (19.9 °C) in July. Typical of the southeastern U.S., Atlanta receives abundant rainfall that is evenly distributed throughout the year, though late spring and early fall are somewhat drier. The average annual precipitation is 50.43 in (1,281 mm), while snowfall is typically light and rare with a normal of 2.2 inches (5.6 cm) per winter. The heaviest single snowfall occurred on January 23, 1940, with around 10 inches (25 cm) of snow. However, ice storms usually cause more problems than snowfall does,
35422-528: The symptoms produced by pancreas removal. Soon, the extract was demonstrated to work in people, but development of insulin therapy as a routine medical procedure was delayed by difficulties in producing the material in sufficient quantity and with reproducible purity. The researchers sought assistance from industrial collaborators at Eli Lilly and Co. based on the company's experience with large scale purification of biological materials. Chemist George B. Walden of Eli Lilly and Company found that careful adjustment of
35621-418: The tetracyclines (discovered at Lederle Laboratories, now a part of Pfizer ), erythromycin (discovered at Eli Lilly and Co.) and their extension to an increasingly wide range of bacterial pathogens. Streptomycin, discovered during a Merck-funded research program in Selman Waksman's laboratory at Rutgers in 1943, became the first effective treatment for tuberculosis. At the time of its discovery, sanitoriums for
35820-441: The time, this was hailed as an innovative move, but in 2008, the company had to be wound down due to funding constraints. Dr. Reddy's was the first Indian pharma company to attempt such an effort to de-couple risk of drug discovery from the parent company by creating a separate company with an external source of funding. Perlecan Pharma was partially funded by ICICI Venture Capital and Citigroup Venture International, both of which held
36019-494: The trade name Adrenalin . Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 ( Primatene Mist ). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion. While highly effective, the requirement for injection limited the use of epinephrine and orally active derivatives were sought. A structurally similar compound, ephedrine ,
36218-782: The vaccine in India via its subsidiary Hetero Biopharma once approved by the Drugs Controller General (DCGI). The vaccine moved to late-stage trials in January 2021, and was approved for emergency use on 12 April 2021 after phase 3 trials concluded with results comparable to the late-stage trial in Russia. In September 2016, Dr. Reddy's launched “Purple Health” in India, a patient centric platform to deliver solutions that address unmet needs of patients. Purple Health will address unmet needs of patients involving four segments: awareness, access (access to medication), adherence (adherence to therapy) and experience (simplified medication experience). The first step in this program will be
36417-406: The whole metropolitan area alongside historic Black Catholic churches. The larger non-Christian faiths according to both studies are Judaism , Islam , and Hinduism . Overall, there are over 1,000 places of worship within Atlanta. With a GDP of $ 385 billion, the Atlanta metropolitan area 's economy is the 8th-largest in the country and the 15th-largest in the world . Corporate operations play
36616-542: The world stage when it won and hosted the 1996 Summer Olympics . The Games impacted Atlanta's development growth into the 21st century, and significantly sparked investment in the city's universities, parks, and tourism industry. The gentrification of some of its neighborhoods has intensified in the 21st century with the growth of the Atlanta Beltline . This has altered its demographics , politics , aesthetics , and culture . For thousands of years prior to
36815-410: Was 51.0% Black or African American, 40.9% non-Hispanic white, 4.2% Asian and 0.3% Native American, and 1.0% from other races. 2.4% of the population reported two or more races . Hispanics and Latinos of any race made up 6.0% of the city's population. The median income for a household in the city was $ 77,655 in 2022. The per capita income for the city was $ 60,778 in 2022. Approximately 17.7% percent of
37014-439: Was a year of layoffs for at least 10,000 people across 129 public biotech firms globally, albeit most small firms; this was a significant increase in reductions versus 2022 was in part due to worsening global financial conditions and a reduction in investment by "generalist investors". Private firms also saw a significant reduction in venture capital investment in 2023, continuing a downward trend started in 2021, which also led to
37213-480: Was barred from the event due to racial segregation laws. Atlanta played a vital role in the Allied effort during World War II due to the city's war-related manufacturing companies, railroad network and military bases. The defense industries attracted thousands of new residents and generated revenues, resulting in rapid population and economic growth. In the 1950s, the city's newly constructed highway system, supported by federal subsidies, allowed middle class Atlantans
37412-455: Was before 2005. In 2009, the company did a U-turn and has handed over discovery research and related intellectual property to its Bangalore -based subsidiary, with the possibility of spinning it off as a different entity altogether. "The company may be hoping to find a strategic partner in the future to share the risks and research funding." In June 2011, certain lots of Dr. Reddy's generic Simvastatin tablets were recalled due to tablets having
37611-452: Was considered a handicap in some circumstances. In general, Southern accents are less prevalent among residents of the city and inner suburbs and among younger people; they are more common in the outer suburbs and among older people. At the same time, some residents of the city speak in Southern variations of African-American English . Atlanta has a thriving and diverse lesbian, gay, bisexual, and transgender (LGBT) community. According to
37810-424: Was constructed. The city of Atlanta was the subject of a massive cyberattack which began in March 2018. In December 2019, Atlanta hosted the Miss Universe 2019 pageant competition. On June 16, 2022, Atlanta was selected as a host city for the 2026 FIFA World Cup . Atlanta encompasses 134.0 square miles (347.1 km ), of which 133.2 square miles (344.9 km ) is land and 0.85 square miles (2.2 km )
38009-449: Was developed by Smith, Kline and French as a nasal decongestant under the trade name Benzedrine Inhaler. Amphetamine was eventually developed for the treatment of narcolepsy , post-encephalitic parkinsonism , and mood elevation in depression and other psychiatric indications. It received approval as a New and Nonofficial Remedy from the American Medical Association for these uses in 1937, and remained in common use for depression until
38208-403: Was followed in 1906 by the Pure Food and Drugs Act , which forbade the interstate distribution of adulterated or misbranded foods and drugs. A drug was considered misbranded if it contained alcohol, morphine, opium, cocaine, or any of several other potentially dangerous or addictive drugs, and if its label failed to indicate the quantity or proportion of such drugs. The government's attempts to use
38407-426: Was identified by Japanese chemists in the Ma Huang plant and marketed by Eli Lilly as an oral treatment for asthma. Following the work of Henry Dale and George Barger at Burroughs-Wellcome , academic chemist Gordon Alles synthesized amphetamine and tested it in asthma patients in 1929. The drug proved to have only modest anti-asthma effects but produced sensations of exhilaration and palpitations. Amphetamine
38606-418: Was later shown to cause tumors in many mammalian species. It was later determined that SV40 was present as a contaminant in polio vaccine lots that had been administered to 90% of the children in the United States. The contamination appears to have originated both in the original cell stock and in monkey tissue used for production. In 2004 the National Cancer Institute announced that it had concluded that SV40
38805-448: Was only a few months. The development of drugs for the treatment of infectious diseases was a major focus of early research and development efforts; in 1900, pneumonia, tuberculosis, and diarrhea were the three leading causes of death in the United States and mortality in the first year of life exceeded 10%. In 1911 arsphenamine , the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of
39004-535: Was pursued broadly by industrial scientists, including Bayer scientists Josef Klarer, Fritz Mietzsch, and Gerhard Domagk . This work, also based on the testing of compounds available from the German dye industry, led to the development of Prontosil , the first representative of the sulfonamide class of antibiotics . Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful for infections caused by pathogens such as streptococci . In 1939, Domagk received
39203-458: Was selected as the site for the 1996 Summer Olympic Games . Following the announcement , the city government undertook several major construction projects to improve Atlanta's parks, sporting venues, and transportation infrastructure; however, for the first time, none of the $ 1.7 billion cost of the games was governmentally funded. While the games experienced transportation and accommodation problems and, despite extra security precautions, there
39402-428: Was the Centennial Olympic Park bombing , the spectacle was a watershed event in Atlanta's history. For the first time in Olympic history, every one of the record 197 national Olympic committees invited to compete sent athletes, sending more than 10,000 contestants participating in a record 271 events. The related projects such as Atlanta's Olympic Legacy Program and civic effort initiated a fundamental transformation of
39601-490: Was to gain experience in drug discovery through contract research for other pharmaceutical companies. Reddy's entered into a venture investment agreement with ICICI Bank , an established Indian banking company. Under the terms of the agreement, ICICI Venture agreed to fund the development, registration and legal costs related to the commercialisation of ANDAs on a pre-determined basis. Upon commercialisation of these products, Dr. Reddy's pays ICICI Venture royalty on net sales for
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