Vĩnh Phúc is a province in the Red River Delta of northern Vietnam .
103-450: Vĩnh Phúc is subdivided into 8 district-level sub-divisions: They are further subdivided into 12 commune-level towns (or townlets), 112 communes, and 13 wards. Tay Dinh banh gio: also known as sun cake, is a famous Vinh Phuc specialty for a long time. This is an indispensable dish in traditional Tet holidays and some other holidays of the people of Tay Dinh - Vinh Phuc like banh chung. With long-standing accumulated experience, accompanied by
206-641: A Creative City by UNESCO , in the field of design. Wuhan is classified as a Beta- (global second tier) city together with seven other cities in China, including Changsha , Dalian , Jinan , Shenyang , Xiamen , Xi'an and Zhengzhou by the Globalization and World Cities Research Network . Wuhan is also one of the world's top 100 financial centers, according to the Global Financial Centres Index . The name "Wuhan" comes from
309-476: A bat-borne virus . Research is ongoing as to whether SARS‑CoV‑2 came directly from bats or indirectly through any intermediate hosts. The virus shows little genetic diversity , indicating that the spillover event introducing SARS‑CoV‑2 to humans is likely to have occurred in late 2019. Epidemiological studies estimate that in the period between December 2019 and September 2020 each infection resulted in an average of 2.4–3.4 new infections when no members of
412-525: A busy city port for commerce and trading with some crucial influences on Chinese history . The name "Wuhan" came from the city's historical origin from the conglomeration of Wuchang , Hankou , and Hanyang , which are collectively known as the "Three Towns of Wuhan" ( 武汉三镇 ). Wuhan lies in the eastern Jianghan Plain , at the confluence of the Yangtze river and its largest tributary, the Han River , and
515-782: A center for the arts (especially poetry) and for intellectual studies. Cui Hao , a celebrated poet of the Tang dynasty , visited the Yellow Crane Tower in the early 8th century; his poem made it the most celebrated building in southern China. In spring 877, Wang Xianzhi captured E Prefecture ( 鄂州 , in modern Wuhan). He then returned north, joining forces with Huang again, and they surrounded Song Wei at Song Prefecture ( 宋州 , in modern Shangqiu , Henan ). In winter 877, Huang Chao pillaged Qi and Huang ( 黃州 , in modern Wuhan) Prefectures. Before Kublai Khan arrived in 1259, word reached him that Möngke had died. Kublai decided to keep
618-771: A central event in the Romance of the Three Kingdoms —the Battle of Red Cliffs —took place near the Yangtze River , with the cliffs near Wuhan identified as one of the potential locations. Around that time, walls were built to protect Hanyang (AD 206) and Wuchang (AD 223). The latter event marks the foundation of Wuhan. In AD 223, the Yellow Crane Tower , one of the Four Great Towers of China ,
721-474: A family of viruses. By 12 January 2020, five genomes of SARS‑CoV‑2 had been isolated from Wuhan and reported by the Chinese Center for Disease Control and Prevention (CCDC) and other institutions; the number of genomes increased to 42 by 30 January 2020. A phylogenetic analysis of those samples showed they were "highly related with at most seven mutations relative to a common ancestor ", implying that
824-780: A great many students for study overseas, which well promoted the development of China's modern education. Furthermore, he trained a modern military and organized a modern army including a zhen and a xie (both zhen and xie are military units in the Qing dynasty) in Hubei. Originally known as the Hubei Arsenal, the Hanyang Arsenal was founded in 1891, who diverted funds from the Nanyang Fleet in Guangdong to build
927-693: A membrane protein that regulates the renin–angiotensin system. During the initial outbreak in Wuhan , China, various names were used for the virus; some names used by different sources included "the coronavirus" or "Wuhan coronavirus". In January 2020, the World Health Organization (WHO) recommended "2019 novel coronavirus" (2019-nCoV) as the provisional name for the virus. This was in accordance with WHO's 2015 guidance against using geographical locations, animal species, or groups of people in disease and virus names. On 11 February 2020,
1030-413: A mink euthanasia campaign rendering it virtually extinct. Each SARS-CoV-2 virion is 60–140 nanometres (2.4 × 10 –5.5 × 10 in) in diameter; its mass within the global human populace has been estimated as being between 0.1 and 10 kilograms. Like other coronaviruses, SARS-CoV-2 has four structural proteins, known as the S ( spike ), E ( envelope ), M ( membrane ), and N ( nucleocapsid ) proteins;
1133-919: A new City of Wuchang, but in October 1946 were separated into the City of Wuchang (including Wuchang only) and the County of Hanyang. Hankou became a centrally controlled municipality in August 1947. Militarily, the Wuhan Forward Headquarters was established in Wuhan, headed by Bai Chongxi . During the later stages of the Chinese Civil War, Bai sought to broker peace, proposing that the Communist Party could rule northern China while
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#17327937563981236-421: A range of animals—such as cats, ferrets, hamsters, non-human primates, minks, tree shrews, raccoon dogs, fruit bats, and rabbits—that are susceptible and permissive to SARS-CoV-2 infection. Some institutions have advised that those infected with SARS‑CoV‑2 restrict their contact with animals. On 1 February 2020, the World Health Organization (WHO) indicated that "transmission from asymptomatic cases
1339-590: A rural community of over 10,600 in Bình Xuyên District - for fourteen days as an effort to contain the disease caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) virus. Seven of the total of sixteen people contracted the virus in Vietnam are residents of Sơn Lôi Commune - including a three-month-old girl. Authorities have established mobile shops and provided food and face masks to
1442-430: A single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ~34%). SARS-CoV-2 is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and
1545-412: A site. The furin cleavage site PRRAR↓ is highly similar to that of the feline coronavirus , an alphacoronavirus 1 strain. Viral genetic sequence data can provide critical information about whether viruses separated by time and space are likely to be epidemiologically linked. With a sufficient number of sequenced genomes , it is possible to reconstruct a phylogenetic tree of the mutation history of
1648-507: Is contagious in humans. SARS‑CoV‑2 is a strain of the species Betacoronavirus pandemicum (SARSr-CoV), as is SARS-CoV-1 , the virus that caused the 2002–2004 SARS outbreak . There are animal-borne coronavirus strains more closely related to SARS-CoV-2, the most closely known relative being the BANAL-52 bat coronavirus. SARS-CoV-2 is of zoonotic origin; its close genetic similarity to bat coronaviruses suggests it emerged from such
1751-477: Is another possible cause of infection. Preliminary research indicates that the virus may remain viable on plastic ( polypropylene ) and stainless steel ( AISI 304 ) for up to three days, but it does not survive on cardboard for more than one day or on copper for more than four hours. The virus is inactivated by soap, which destabilizes its lipid bilayer . Viral RNA has also been found in stool samples and semen from infected individuals. The degree to which
1854-425: Is approximately 30,000 bases in length, relatively long for a coronavirus—which in turn carry the largest genomes among all RNA families. Its genome consists nearly entirely of protein-coding sequences, a trait shared with other coronaviruses. A distinguishing feature of SARS‑CoV‑2 is its incorporation of a polybasic site cleaved by furin , which appears to be an important element enhancing its virulence. It
1957-541: Is headquartered in Wuhan. The city is home to multiple notable institutes of higher education, including Wuhan University and the Huazhong University of Science and Technology . Wuhan is a major city in the world by scientific research outputs and it ranks 9th globally and 5th in the Asia-Pacific & China (after Beijing , Shanghai , Nanjing and Guangzhou ). In 2017, Wuhan was designated as
2060-533: Is known as "Nine Provinces' Thoroughfare" ( 九省通衢 ). Wuhan was the site of the 1911 Wuchang Uprising against the Qing dynasty which ended 2,000 years of dynastic rule . Wuhan was briefly a capital of China twice, in 1927 under a left wing Kuomintang (KMT) government , and in 1937 as a provisional wartime capital during World War II . In 1938, during the Second Sino-Japanese War , the city
2163-401: Is likely not a major driver of transmission". One meta-analysis found that 17% of infections are asymptomatic, and asymptomatic individuals were 42% less likely to transmit the virus. However, an epidemiological model of the beginning of the outbreak in China suggested that "pre-symptomatic shedding may be typical among documented infections" and that subclinical infections may have been
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#17327937563982266-510: Is the protein responsible for allowing the virus to attach to and fuse with the membrane of a host cell; specifically, its S1 subunit catalyzes attachment, the S2 subunit fusion. Wuhan Wuhan is the capital of Hubei , China. With a population of over eleven million, it is the most populous city in Hubei and the seventh-most-populous city in China. It is also one of the nine national central cities . Wuhan historically served as
2369-662: The Beijing–Hankou railway with the Guangdong–Hankou railway into the Beijing–Guangzhou railway , making Wuhan a 'thoroughfare to nine provinces' ( 九省通衢 ) in name and in fact. After Chengdu Conference, Mao went to Chongqing and Wuhan in April to inspect the countryside and factories. In Wuhan, he called all the leaders of provinces and municipalities who had not attended Chengdu Conference to report their work. Tian Jiaying,
2472-636: The Erligang culture ( c. 1510 – c. 1460 BC) (being sparsely populated during the earlier Erlitou period ), is located in modern-day Huangpi District of Wuhan. During the Western Zhou the State of E , which gives its name to the single character abbreviation for Hubei province, controlled the present-day Wuchang area south of the Yangtze River. After the conquest of
2575-725: The International Committee on Taxonomy of Viruses adopted the official name "severe acute respiratory syndrome coronavirus 2" (SARS‑CoV‑2). To avoid confusion with the disease SARS , the WHO sometimes refers to SARS‑CoV‑2 as "the COVID-19 virus" in public health communications and the name HCoV-19 was included in some research articles. Referring to COVID-19 as the "Wuhan virus" has been described as dangerous by WHO officials, and as xenophobic by many journalists and academics. Human-to-human transmission of SARS‑CoV‑2
2678-553: The Northern and Southern dynasties period, the Wuhan area was part of the successive Southern dynasty states Liu Song (420–479), Southern Qi (479–502), Liang , and Western Liang . In fall 550, Hou Jing sent Ren Yue to attack both Xiao Daxin and Xiao Fan's son Xiao Si ( 蕭嗣 ). Ren killed Xiao Si in battle, and Xiao Daxin, unable to resist, surrendered, allowing Hou to take his domain under control. Meanwhile, Xiao Guan, who had by now settled at Jiangxia ( 江夏 , in modern Wuhan),
2781-538: The Soviet Volunteer Group in both planes and personnel, as U.S. support in war materials waned. As the battle raged on through 1938, Wuhan and the surrounding region had become the site of the Battle of Wuhan . After being taken by the Japanese in late 1938, Wuhan became a major Japanese logistics center for operations in southern China. In early October 1938, Japanese troops moved east and north in
2884-577: The Yangtze River in Wuhan to collect the information needed for opening the trading port in Wuhan. In the spring of 1861, Counselor Harry Smith Parkes and Admiral Herbert were sent to Wuhan to open a trading port. On the basis of the Convention of Peking , Parkes concluded the Hankou Lend-Lease Treaty with Guan Wen, the governor-general of Hunan and Hubei. It brought an area of 30.53 square kilometers (11.79 sq mi) along
2987-469: The index case ". The authors later published a correction that showed that shedding began earlier than first estimated, four to five days before symptoms appear. There is uncertainty about reinfection and long-term immunity. It is not known how common reinfection is, but reports have indicated that it is occurring with variable severity. The first reported case of reinfection was a 33-year-old man from Hong Kong who first tested positive on 26 March 2020,
3090-483: The nasal cavity is seemingly the dominant initial site of infection, with subsequent aspiration -mediated virus-seeding into the lungs in SARS‑CoV‑2 pathogenesis. They found that there was an infection gradient from high in proximal towards low in distal pulmonary epithelial cultures, with a focal infection in ciliated cells and type 2 pneumocytes in the airway and alveolar regions respectively. Studies have identified
3193-418: The provisional name 2019 novel coronavirus ( 2019-nCoV ), and has also been called human coronavirus 2019 ( HCoV-19 or hCoV-19 ). First identified in the city of Wuhan , Hubei, China, the World Health Organization designated the outbreak a public health emergency of international concern from January 30, 2020, to May 5, 2023. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that
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3296-611: The train ferries for crossing the Yangtze River in Wuhan. The project of building the Wuhan Yangtze River Bridge , also known as the First Yangtze River Bridge, was regarded as one of the key projects during the first five-year plan. On October 25, 1955, construction began on the bridge proper. The same day in 1957, the whole project was completed and an opening-to-traffic ceremony was held on October 15. The First Yangtze River Bridge united
3399-589: The 11th, the revolutionary army took the whole city of Wuchang, but leaders such as Jiang Yiwu and Sun Wu disappeared. Thus the leaderless revolutionary army recommended Li Yuanhong , the assistant governor of the Qing army, as the commander-in-chief. Li founded the Hubei Military Government, proclaimed the abolition of the Qing rule in Hubei, the founding of the Republic of China and published an open telegram calling for other provinces to join
3502-647: The Communists within the party, which marked the end of the First United Front , and Chiang Kai-shek briefly stepped down as the commander of the National Revolutionary Army. In June 1927, Stalin sent a telegram to the Communists in Wuhan, calling for the mobilization of an army of workers and peasants. This alarmed Wang Jingwei, who decided to break with the Communists and come to terms with Chiang Kai-shek. The Wuhan coup
3605-535: The E state in 863 BC, the present-day Wuhan area was controlled by the State of Chu for the rest of the Western Zhou and Eastern Zhou periods. After the State of Huang was conquered by State of Chu in the summer of 648 BC, the people of Huang were moved into the area in and around present-day Wuhan. Local geographical terms including the name of Wuhan's Huangpi District were named after the State of Huang. Chu
3708-571: The KMT gunboat Zhongshan came up against six Japanese aircraft. Though two were eventually shot down, the Zhongshan sank with 25 casualties. Raised from the bottom of the Yangtze River in 1997, and restored at a local shipyard, the Zhongshan has been moved to a purpose-built museum in Wuhan's suburban Jiangxia District , which opened on September 26, 2011. As a key center on the Yangtze, Wuhan
3811-495: The N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope . Coronavirus S proteins are glycoproteins and also type I membrane proteins (membranes containing a single transmembrane domain oriented on the extracellular side). They are divided into two functional parts (S1 and S2). In SARS-CoV-2, the spike protein, which has been imaged at the atomic level using cryogenic electron microscopy ,
3914-537: The Nationalist government retained southern China. This was rejected, and on May 15, 1949, Bai and the Wuhan garrison retreated from the city. People's Liberation Army troops entered Wuhan on the afternoon of Monday, May 16, 1949. The Communists redeveloped industry in Wuhan, which had damaged by war. During the PRC's first decade, it became an important center of industry again. Hundreds of factories were built in
4017-718: The Northern Expedition was interrupted by the political split in the Kuomintang following the formation of the Nanjing faction in April 1927 against the existing faction in Wuhan. Members of the Chinese Communist Party , who had survived the April 12 massacre, met at Wuhan and reelected Chen Duxiu (Ch'en Tu-hsiu) as the Party's Secretary General. The split was partially motivated by the purge of
4120-491: The Russian concession. Japanese immigrants, mainly traders, also started arriving in 1874. In 1889, Zhang Zhidong was transferred from Viceroy of Liangguang ( Guangdong and Guangxi provinces) to Viceroy of Huguang ( Hunan and Hubei provinces). He governed the province for 18 years, until 1907. During this period, he elucidated the theory of "Chinese learning as the basis, Western learning for application," known as
4223-401: The SARS‑CoV‑2 genome (matches above 90 percent may sound high, but in genomic terms it is a wide evolutionary gap ). In addition, despite similarities in a few critical amino acids, pangolin virus samples exhibit poor binding to the human ACE2 receptor. SARS‑CoV‑2 belongs to the broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with
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4326-801: The Wuhan area was controlled for many years by rebel forces and the Yellow Crane Tower, Xingfu Temple , Zhuodaoquan Temple and other buildings were repurposed or damaged. During the Second Opium War (known in the West as the Arrow War, 1856–1860), the government of the Qing dynasty was defeated by the western powers and signed the Treaties of Tianjin and the Convention of Peking , which stipulated eleven cities or regions (including Hankou) as trading ports. In December 1858, James Bruce, 8th Earl of Elgin , High Commissioner to China, led four warships up
4429-802: The Xinhai year on the Chinese calendar. The city has several museums and memorials to the revolution and the thousands of martyrs who died defending the revolution. With the northern extension of the Northern Expedition , the center of the Great Revolution shifted from the Pearl River basin to the Yangtze River basin. On November 26, the Kuomintang Central Political Committee decided to move
4532-454: The Yangtze River (from latter-day Jianghan Road to Hezuo Road) to become a British Concession and permitted Britain to set up its consulate in the concession. In 1862, Russian tea merchants arrived in the treaty port of Hankou. Russians in Hankou established four factories using assembly lines and machinery to produce brick tea, and became the city's richest industrialists in what would become
4635-646: The Yangtze River boom town, was "the St. Louis and Chicago of China." On October 10, 1911, Sun Yat-sen 's followers launched the Wuchang Uprising , which led to the collapse of the Qing state and 2,000 years of dynastic rule, as well as the establishment of the Republic of China . The Wuchang Uprising of October 1911, which overthrew the Qing dynasty, originated in Wuhan. Before the uprising, anti-Qing secret societies were active in Wuhan. In September 1911,
4738-496: The Yangtze River. In 1926, the Northern Expedition reached the Wuhan area and it was decided to merge Hankou, Wuchang and Hanyang into one city in order to make a new capital for Nationalist China. On January 1, 1927, the resulting city was proclaimed as ' 武漢 ' (the traditional Chinese characters for 'Wuhan'), which was later simplified as ' 武汉 ' (also 'Wuhan'). The Wuhan area has been settled for 3,500 years. Panlongcheng , an archaeological site primarily associated with
4841-598: The amino acid sequence P RR A . This sequence is upstream of an arginine and serine which forms the S1/S2 cleavage site ( P RR A R ↓ S ) of the spike protein. Although such sites are a common naturally-occurring feature of other viruses within the Subfamily Orthocoronavirinae, it appears in few other viruses from the Beta-CoV genus, and it is unique among members of its subgenus for such
4944-491: The arsenal. It cost about 250,000 pounds sterling and was built in 4 years. On April 23, 1894, construction was completed and the arsenal, occupying some 40 acres (160,000 m ), could start production of small-caliber cannons. It built magazine-fed rifles, Gruson quick fire guns, and cartridges. In 1896, the Russian Empire also acquired a concession in Hankou. By 1900, according to Collier's magazine, Hankou,
5047-430: The capital from Guangzhou to Wuhan. In mid-December, most of the KMT central executive commissioners and national government commissioners arrived in Wuhan, set up the temporary joint conference of central executive commissioners and National Government commissioners, performed the top functions of central party headquarters and National Government, declared they would work in Wuhan on January 1, 1927, and decided to combine
5150-514: The city and connecting to other major cities. Because of its key role in domestic transportation, Wuhan is sometimes referred to as "the Chicago of China" by foreign sources. The "Golden Waterway" of the Yangtze River and the Han River traverse the urban area and divide Wuhan into the three districts of Wuchang , Hankou , and Hanyang . The Wuhan Yangtze River Bridge crosses the Yangtze in
5253-624: The city, including most prominently Wuhan Iron and Steel , which opened in 1958. The Changjiang Water Resources Commission was reestablished in February 1950 with its headquarters in Wuhan. From June to September 1954, the Yangtze River Floods were a series of catastrophic floodings that occurred mostly in Hubei Province. Due to an unusually high volume of precipitation as well as an extraordinarily long rainy season in
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#17327937563985356-418: The city, making Wuhan an important transshipment point between rail and river traffic. Also during this period foreign powers extracted mercantile concessions, with the riverfront of Hankou being divided up into foreign-controlled merchant districts. These districts contained trading firm offices, warehouses, and docking facilities. The French had a concession in Hankou. During the Taiping Heavenly Kingdom ,
5459-419: The city, with 30,000 sheltering on a railway embankment in central Hankou. With little food and a complete breakdown in sanitation, thousands soon began to succumb to diseases. Jin Shilong, Senior Engineer at the Hubei Flood Prevention Agency, described the flooding: There was no warning, only a sudden great wall of water. Most of Wuhan's buildings in those days were only one story high, and for many people there
5562-786: The city. The Three Gorges Dam , the world's largest power station in terms of installed capacity , is located nearby. Historically, Wuhan has suffered risks of flooding, prompting the government to alleviate the situation by introducing ecologically friendly absorption mechanisms. While Wuhan has been a traditional manufacturing hub for decades, it is also one of the areas promoting modern industrial changes in China. Wuhan has three national development zones, four scientific and technological development parks, over 350 research institutes, 1,656 high tech enterprises, numerous enterprise incubators and investments from 230 Fortune Global 500 firms. It produced GDP (nominal) of US$ 274 billion in 2021. The Dongfeng Motor Corporation , an automobile manufacturer,
5665-458: The community were immune and no preventive measures were taken. However, some subsequent variants have become more infectious. The virus is airborne and primarily spreads between people through close contact and via aerosols and respiratory droplets that are exhaled when talking, breathing, or otherwise exhaling, as well as those produced from coughs and sneezes. It enters human cells by binding to angiotensin-converting enzyme 2 (ACE2),
5768-416: The community. This article about a location in Vĩnh Phúc Province , Vietnam is a stub . You can help Misplaced Pages by expanding it . Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2 ( SARS‑CoV‑2 ) is a strain of coronavirus that causes COVID-19 , the respiratory illness responsible for the COVID-19 pandemic . The virus previously had
5871-413: The creativity of Tay Dinh villagers, they have created a specialty with bold flavors and unique features of Tay Dinh banh gio. The cake has a beautiful golden brown color. When eating, we can feel the aroma of rice and the chewiness of the cake, combined with sugar or molasses to create a characteristic sweet and cool taste. On February 13, 2020, Vĩnh Phúc province has decided to lock down Sơn Lôi Commune -
5974-407: The death of his brother secret and continued the attack on the Wuhan area, near the Yangtze . The present-day Wuying Pagoda was constructed at the end of the Song dynasty between attacks by the Mongolian forces. Under the Mongol rulers ( Yuan dynasty ) (after 1301), the Wuchang prefecture , headquartered in the town, became the capital of Hubei province. Hankou, from the Ming to late Qing ,
6077-418: The differences between what was then called 2019-nCoV and the virus from the 2003 SARS outbreak were insufficient to make them separate viral species . Therefore, they identified 2019-nCoV as a virus of Severe acute respiratory syndrome–related coronavirus . In July 2020, scientists reported that a more infectious SARS‑CoV‑2 variant with spike protein variant G614 has replaced D614 as the dominant form in
6180-589: The first human infection occurred in November or December 2019. Examination of the topology of the phylogenetic tree at the start of the pandemic also found high similarities between human isolates. As of 21 August 2021, 3,422 SARS‑CoV‑2 genomes, belonging to 19 strains, sampled on all continents except Antarctica were publicly available. On 11 February 2020, the International Committee on Taxonomy of Viruses announced that according to existing rules that compute hierarchical relationships among coronaviruses based on five conserved sequences of nucleic acids,
6283-495: The first infection, but the mechanisms that could account for this are not known. No natural reservoir for SARS-CoV-2 has been identified. Prior to the emergence of SARS-CoV-2 as a pathogen infecting humans, there had been two previous zoonosis -based coronavirus epidemics, those caused by SARS-CoV-1 and MERS-CoV . The first known infections from SARS‑CoV‑2 were discovered in Wuhan, China. The original source of viral transmission to humans remains unclear, as does whether
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#17327937563986386-406: The height of the Cultural Revolution . Economic development was further disrupted by the Cultural Revolution. In 1981, the Wuhan City Government commenced reconstruction of the Yellow Crane Tower at a new location, about 1 km (0.62 mi) from the original site, and it was completed in 1985. In 1957, the Wuhan Yangtze River Bridge was built with one trestle of the bridge on the site of
6489-419: The middle stretch of the Yangtze River late in the spring of 1954, the river started to rise above its usual level in around late June. In 1969, a large stone monument was erected in the riverside park in Hankou honoring the heroic deeds in fighting the 1954 Yangtze River floods. Before construction of the Wuhan Yangtze River Bridge , Hunslet Engine Company built two extra heavy 0-8-0 locomotives for loading
6592-562: The much larger clades . Several different clade nomenclatures have been proposed. Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, S, G, GH, and GR). Several notable variants of SARS-CoV-2 emerged in late 2020. The World Health Organization has currently declared five variants of concern , which are as follows: Other notable variants include 6 other WHO-designated variants under investigation and Cluster 5 , which emerged among mink in Denmark and resulted in
6695-468: The natural reservoir of the virus that caused the 2002–2004 SARS outbreak has resulted in the discovery of many SARS-like bat coronaviruses , most originating in horseshoe bats . The closest match by far, published in Nature (journal) in February 2022, were viruses BANAL-52 (96.8% resemblance to SARS‑CoV‑2), BANAL-103 and BANAL-236, collected in three different species of bats in Feuang , Laos. An earlier source published in February 2020 identified
6798-469: The original SARS-CoV . Like the SARS-related coronavirus implicated in the 2003 SARS outbreak, SARS‑CoV‑2 is a member of the subgenus Sarbecovirus ( beta-CoV lineage B). Coronaviruses undergo frequent recombination. The mechanism of recombination in unsegmented RNA viruses such as SARS-CoV-2 is generally by copy-choice replication, in which gene material switches from one RNA template molecule to another during replication. The SARS-CoV-2 RNA sequence
6901-498: The outbreak of the protests in Sichuan forced the Qing authorities to send part of the New Army garrisoned in Wuhan to suppress the rebellion. On September 14 the Literary Society ( 文學社 ) and the Progressive Association ( 共進會 ), two local revolutionary organizations in Hubei, set up joint headquarters in Wuchang and planned for an uprising. On the morning of October 9, a bomb at the office of the political arrangement exploded prematurely and alerted local authorities. The proclamation for
7004-401: The outskirts of Wuhan. As a result, numerous companies and enterprises and large numbers of people had to withdraw from Wuhan to the west of Hubei and Sichuan. The KMT navy undertook the responsibility of defending the Yangtze River on patrol and covering the withdrawal. On October 24, while overseeing the waters of the Yangtze River near the town of Jinkou (Jiangxia District in Wuhan) in Wuchang,
7107-1698: The pandemic. Coronavirus genomes and subgenomes encode six open reading frames (ORFs). In October 2020, researchers discovered a possible overlapping gene named ORF3d , in the SARS‑CoV‑2 genome . It is unknown if the protein produced by ORF3d has any function, but it provokes a strong immune response. ORF3d has been identified before, in a variant of coronavirus that infects pangolins . A phylogenetic tree based on whole-genome sequences of SARS-CoV-2 and related coronaviruses is: ( Bat ) Rc-o319 , 81% to SARS-CoV-2, Rhinolophus cornutus , Iwate , Japan Bat SL-ZXC21 , 88% to SARS-CoV-2, Rhinolophus pusillus , Zhoushan , Zhejiang Bat SL-ZC45 , 88% to SARS-CoV-2, Rhinolophus pusillus , Zhoushan, Zhejiang Pangolin SARSr-CoV-GX, 85.3% to SARS-CoV-2, Manis javanica , smuggled from Southeast Asia Pangolin SARSr-CoV-GD, 90.1% to SARS-CoV-2, Manis javanica , smuggled from Southeast Asia Bat RshSTT182, 92.6% to SARS-CoV-2, Rhinolophus shameli , Steung Treng , Cambodia Bat RshSTT200, 92.6% to SARS-CoV-2, Rhinolophus shameli , Steung Treng, Cambodia (Bat) RacCS203 , 91.5% to SARS-CoV-2, Rhinolophus acuminatus , Chachoengsao , Thailand (Bat) RmYN02 , 93.3% to SARS-CoV-2, Rhinolophus malayanus , Mengla , Yunnan (Bat) RpYN06 , 94.4% to SARS-CoV-2, Rhinolophus pusillus , Xishuangbanna , Yunnan (Bat) RaTG13 , 96.1% to SARS-CoV-2, Rhinolophus affinis , Mojiang , Yunnan (Bat) BANAL-52 , 96.8% to SARS-CoV-2, Rhinolophus malayanus , Vientiane , Laos SARS-CoV-2 SARS-CoV-1 , 79% to SARS-CoV-2 There are many thousands of variants of SARS-CoV-2, which can be grouped into
7210-439: The revolution. As the revolution spread to other parts of the country, the Qing government concentrated loyalist military forces to suppress the uprising in Wuhan. From October 17 to December 1, the revolutionary army and local volunteers defended the city in the Battle of Yangxia against better armed and more numerous Qing forces commanded by Yuan Shikai . Huang Xing would arrive in Wuhan in early November to take command of
7313-415: The revolutionary army. After fierce fighting and heavy casualties, Qing forces seized Hankou and Hanyang. But Yuan agreed to halt the advance on Wuchang and participated in peace talks , which would eventually lead to the return of Sun Yat-sen from exile, founding of the Republic of China on January 1, 1912. Through the Wuchang Uprising, Wuhan is known as the birthplace of the Xinhai Revolution, named after
7416-523: The role of pangolins as an intermediate host was initially posited (a study published in July 2020 suggested that pangolins are an intermediate host of SARS‑CoV‑2-like coronaviruses ), subsequent studies have not substantiated their contribution to the spillover. Evidence against this hypothesis includes the fact that pangolin virus samples are too distant to SARS-CoV-2: isolates obtained from pangolins seized in Guangdong were only 92% identical in sequence to
7519-526: The secretary of Mao, said that Wuhan Conference was a supplement to Chengdu Conference. As the Third Front campaign shifted the focus of industrial development to China's hinterlands, Wuhan's development slowed. In July 1967, civil strife struck the city in the Wuhan Incident ("July 20th Incident"), an armed conflict between two hostile groups who were fighting for control over the city at
7622-509: The source of a majority of infections. That may explain how out of 217 on board a cruise liner that docked at Montevideo , only 24 of 128 who tested positive for viral RNA showed symptoms. Similarly, a study of ninety-four patients hospitalized in January and February 2020 estimated patients began shedding virus two to three days before symptoms appear and that "a substantial proportion of transmission probably occurred before first symptoms in
7725-558: The source. For a virus recently acquired through a cross-species transmission, rapid evolution is expected. The mutation rate estimated from early cases of SARS-CoV-2 was of 6.54 × 10 per site per year. Coronaviruses in general have high genetic plasticity , but SARS-CoV-2's viral evolution is slowed by the RNA proofreading capability of its replication machinery. For comparison, the viral mutation rate in vivo of SARS-CoV-2 has been found to be lower than that of influenza. Research into
7828-542: The ti-yong ideal. He set up many heavy industries, founded Hanyang Steel Plant, Daye Iron Mine, Pingxiang Coal Mine and Hubei Arsenal and set up local textile industries, boosting the flourishing modern industry in Wuhan. Meanwhile, he initiated education reform, opened dozens of modern educational organizations successively, such as Lianghu (Hunan and Hubei) Academy of Classical Learning, Civil General Institute, Military General Institute, Foreign Languages Institute and Lianghu (Hunan and Hubei) General Normal School, and selected
7931-585: The tower, which had been last destroyed in 1884. During the 1989 Tiananmen Square protests , students in Wuhan blocked the Yangtze River Railway bridge and another 4,000 gathered at the railway station. About one thousand students staged a railroad 'sit-in'. Rail traffic on the Beijing-Guangzhou and Wuhan-Dalian lines was interrupted. The students also urged employees of major state-owned enterprises to go on strike. The situation
8034-745: The towns of Wuchang, Hankou , and Hanyang into Wuhan City, called "Capital District". The new national government, later known as " Wuhan nationalist government ", was based in the Nanyang Building in Hankou, while the central party headquarters and other organizations chose their locations in Hankou or Wuchang. In March 1927, Mao Zedong appeared at the Third Plenum of the KMT Central Executive Committee in Wuhan, which sought to strip General Chiang of his power by appointing Wang Jingwei leader. The first phase of
8137-449: The two major cities on the banks of the Yangtze River that make up the Wuhan metropolis: "Wu" refers to the city of Wuchang ( Chinese : 武昌 ), which lies on the southern bank of the Yangtze, while "Han" refers to the city of Hankou ( Chinese : 汉口 ), which lies on the northern bank of the Yangtze. "Hankou" means "Mouth of the Han", from its position at the confluence of the Han with
8240-516: The uprising at the engineering barracks of Hubei New Army . They then led the New Army of all barracks to join the revolution. Under the guidance of Wu Zhaolin, Cai Jimin and others, this revolutionary army seized the official residence of the governor and government offices. Rui Cheng fled in panic into the Chuyu ship. Zhang Biao, the commander of the Qing army, also fled the city. On the morning of
8343-407: The uprising, beadroll and the revolutionaries’ official seal fell into the hands of Rui Cheng, the governor-general of Hunan and Hubei, who demolished the uprising headquarters the same day and set out to arrest the revolutionaries listed in the beadroll. This forced the revolutionaries to launch the uprising earlier than planned. On the night of October 10, the revolutionaries fired shots to signal
8446-598: The victims. During the Second Sino-Japanese War and following the fall of Nanking in December 1937, Wuhan had become the provisional capital of China's Kuomintang government, and became another focal point of pitched air battles beginning in early 1938 between modern monoplane bomber and fighter aircraft of the Imperial Japanese forces and the Chinese Air Force , which included support from
8549-498: The virus RaTG13 , collected in bats in Mojiang , Yunnan, China to be the closest to SARS‑CoV‑2, with 96.1% resemblance. None of the above are its direct ancestor. Bats are considered the most likely natural reservoir of SARS‑CoV‑2. Differences between the bat coronavirus and SARS‑CoV‑2 suggest that humans may have been infected via an intermediate host; although the source of introduction into humans remains unknown. Although
8652-550: The virus became pathogenic before or after the spillover event . Because many of the early infectees were workers at the Huanan Seafood Market , it has been suggested that the virus might have originated from the market. However, other research indicates that visitors may have introduced the virus to the market, which then facilitated rapid expansion of the infections. A March 2021 WHO-convened report stated that human spillover via an intermediate animal host
8755-484: The virus is infectious during the incubation period is uncertain, but research has indicated that the pharynx reaches peak viral load approximately four days after infection or in the first week of symptoms and declines thereafter. The duration of SARS-CoV-2 RNA shedding is generally between 3 and 46 days after symptom onset. A study by a team of researchers from the University of North Carolina found that
8858-587: The virus may be airborne as well, with aerosols potentially being able to transmit the virus. During human-to-human transmission, between 200 and 800 infectious SARS‑CoV‑2 virions are thought to initiate a new infection. If confirmed, aerosol transmission has biosafety implications because a major concern associated with the risk of working with emerging viruses in the laboratory is the generation of aerosols from various laboratory activities which are not immediately recognizable and may affect other scientific personnel. Indirect contact via contaminated surfaces
8961-422: The virus. Another case study described a 25-year-old man from Nevada who tested positive for SARS‑CoV‑2 on 18 April 2020 and on 5 June 2020 (separated by two negative tests). Since genomic analyses showed significant genetic differences between the SARS‑CoV‑2 variant sampled on those two dates, the case study authors determined this was a reinfection. The man's second infection was symptomatically more severe than
9064-440: Was a political shift made on July 15, 1927, by Wang Jingwei towards Chiang Kai-shek, and his Shanghai -based rival in the Kuomintang. The Wuhan Nationalist Government was established in Wuhan on February 21, 1927, and ended by August 19, 1927. After the end of the Northern Expedition, Hankou was elevated to a centrally-controlled municipality. In the 1931 China floods , one of the deadliest flood disasters in world history, Wuhan
9167-478: Was a refuge for flood victims from outlying areas, who had been arriving since the late spring. But when the city itself was inundated in the early summer, and after a catastrophic dike failure just before 6:00 AM on July 27, an estimated 782,189 urban citizens and rural refugees were left homeless. The flood covered an area of 32 square miles and the city was flooded under many feet of water for close to three months. Large numbers gathered on flood islands throughout
9270-414: Was an important base for Japanese operations in China. On December 18, 1944, in a planned strategic move, and as revenge for the torture and execution of three captured American pilots by Japanese soldiers in the city, Wuhan was bombed by 77 American bombers with the approval of Chiang Kai-Shek. This set off a firestorm that destroyed much of the military resources of the city. For the next three days, Wuhan
9373-566: Was bombed by the Americans, destroying all of the docks and warehouses of Wuhan, as well as the Japanese air bases in the city. The air raids also killed thousands of Chinese civilians. "According to casualty statistics compiled by Hankou city in 1946, more than 20,000 were killed or injured in the December bombings of 1944." Wuhan returned to Chinese control in September 1945. Administratively, Wuchang and Hanyang were initially combined into
9476-469: Was confirmed on 20 January 2020 during the COVID-19 pandemic . Transmission was initially assumed to occur primarily via respiratory droplets from coughs and sneezes within a range of about 1.8 metres (6 ft). Laser light scattering experiments suggest that speaking is an additional mode of transmission and a far-reaching one, indoors, with little air flow. Other studies have suggested that
9579-800: Was constructed on the Wuchang side of the Yangtze River by order of Sun Quan , leader of the Eastern Wu . The tower became a sacred site of Taoism . Due to tensions between the Eastern Wu and Cao Wei kingdoms, in the autumn of 228, Cao Rui , grandson of Cao Cao and the second emperor of the state of Cao Wei , ordered the general Man Chong to lead troops to Xiakou ( 夏口 ; in present-day Wuhan). In 279, Wang Jun and his army conquered strategic locations in Wu territory such as Xiling (in present-day Yichang , Hubei), Xiakou ( 夏口 ; present-day Hankou) and Wuchang ( 武昌 ; present-day Ezhou , Hubei). During
9682-452: Was discharged on 15 April 2020 after two negative tests, and tested positive again on 15 August 2020 (142 days later), which was confirmed by whole-genome sequencing showing that the viral genomes between the episodes belong to different clades . The findings had the implications that herd immunity may not eliminate the virus if reinfection is not an uncommon occurrence and that vaccines may not be able to provide lifelong protection against
9785-556: Was in turn conquered by Qin in 223 BC. During the Han dynasty , Hanyang became a fairly busy port. The Battle of Xiakou in AD ;203 and Battle of Jiangxia five years later were fought in the region over control of Jiangxia Commandery , territories of which included much of present-day eastern Hubei. In the winter of 208/9, one of the most famous battles in Chinese history and
9888-454: Was no escape – they died by the tens of thousands. ... I was just coming off duty at the company's main office, a fairly new three-story building near the center of town ... When I heard the terrible noise and saw the wall of water coming, I raced to the top story of the building. ... I was in one of the tallest and strongest buildings left standing. At that time no one knew whether the water would subside or rise even higher. The high-water mark
9991-433: Was planning to attack Hou, but this drew Xiao Yi's ire—believing that Xiao Guan was intending to contend for the throne—and he sent Wang to attack Xiao Guan. In summer 567, Chen Xu commissioned Wu Mingche as the governor of Xiang Province and had him command a major part of the troops against Hua, along with Chunyu Liang ( 淳于量 ). The opposing sides met at Zhuankou ( 沌口 , in modern Wuhan). The city has long been renowned as
10094-509: Was reached on August 19 at Hankou, with the water level exceeding 16 m (53 ft) above normal. In 1936, when natural disaster struck Central China with widespread flooding affecting Hebei , Hunan , Jiangxi , Wuhan and Chongqing caused by the Yangtze and Huai Rivers bursting their banks, Ong Seok Kim , as Chairman of the Sitiawan Fundraising and Disaster Relief Committee, raised money and materials in support of
10197-594: Was so tense that residents reportedly began a bank run and resorted to panic-buying. Wuhan was the first stop on Deng Xiaoping 's 1992 southern tour . In the wake of the United States bombing of the Chinese embassy in Belgrade on May 7, 1999, protests broke out throughout China, including in Wuhan. On June 22, 2000, a Wuhan Airlines flight from Enshi to Wuhan was forced to circle for 30 minutes due to thunderstorms. The aircraft eventually crashed on
10300-496: Was suggested that the acquisition of the furin-cleavage site in the SARS-CoV-2 S protein was essential for zoonotic transfer to humans. The furin protease recognizes the canonical peptide sequence R X[ R / K ] R ↓X where the cleavage site is indicated by a down arrow and X is any amino acid . In SARS-CoV-2 the recognition site is formed by the incorporated 12 codon nucleotide sequence CCT CGG CGG GCA which corresponds to
10403-597: Was the most likely explanation, with direct spillover from bats next most likely. Introduction through the food supply chain and the Huanan Seafood Market was considered another possible, but less likely, explanation. An analysis in November 2021, however, said that the earliest-known case had been misidentified and that the preponderance of early cases linked to the Huanan Market argued for it being
10506-479: Was the site of the Battle of Wuhan . On December 31, 2019, SARS-CoV-2 , a novel coronavirus that later caused the COVID-19 pandemic , was first discovered in Wuhan and the city was the location of the first lockdown of the pandemic in January 2020. Wuhan is considered the political, economic, financial, commercial, cultural, and educational center of Central China. It is a major transportation hub, with dozens of railways, roads, and expressways passing through
10609-527: Was under the administration of the local government in Hanyang , although it was already one of the four major national markets ( zh:四大名镇 ) of the Ming dynasty. Hanyang's Guiyuan Temple was completed in the 15th year of Shunzhi (1658). By the dawn of the 18th century, Hankou had become one of China's top four trading centers. In the late 19th century, railroads were extended on a north–south axis through
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