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International HapMap Project

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The International HapMap Project was an organization that aimed to develop a haplotype map ( HapMap ) of the human genome , to describe the common patterns of human genetic variation . HapMap is used to find genetic variants affecting health, disease and responses to drugs and environmental factors. The information produced by the project is made freely available for research.

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178-575: The International HapMap Project is a collaboration among researchers at academic centers, non-profit biomedical research groups and private companies in Canada , China (including Hong Kong ), Japan , Nigeria , the United Kingdom , and the United States . It officially started with a meeting on October 27 to 29, 2002, and was expected to take about three years. It comprises three phases;

356-451: A high nominal per capita income globally and its advanced economy ranks among the largest in the world by nominal GDP , relying chiefly upon its abundant natural resources and well-developed international trade networks . Recognized as a middle power , Canada's strong support for multilateralism and internationalism has been closely related to its foreign relations policies of peacekeeping and aid for developing countries . Canada

534-549: A megacity like Lagos and other major Nigerian cities which are linked with economic development, population growth and the inability of municipal councils to manage the resulting rise in industrial and domestic waste. This waste management problem is also attributable to unsustainable environmental management lifestyles of Kubwa community in the Federal Capital Territory, where there are habits of indiscriminate disposal of waste, dumping of waste along or into

712-467: A parliamentary system within the context of a constitutional monarchy —the monarchy of Canada being the foundation of the executive, legislative , and judicial branches. The reigning monarch is also monarch of 14 other sovereign Commonwealth countries and Canada's 10 provinces . The monarch appoints a representative, the governor general , on the advice of the prime minister , to carry out most of their ceremonial royal duties. The monarchy

890-662: A 10-metre (33 ft) cross bearing the words, "long live the King of France", and took possession of the territory New France in the name of King Francis I . The early 16th century saw European mariners with navigational techniques pioneered by the Basque and Portuguese establish seasonal whaling and fishing outposts along the Atlantic coast. In general, early settlements during the Age of Discovery appear to have been short-lived due to

1068-471: A civilian government but not before appointing Ernest Shonekan head of an interim national government . Babangida's regime has been considered the most corrupt and responsible for creating a culture of corruption in Nigeria. Shonekan's interim government, the shortest in the political history of the country, was overthrown in a coup d'état of 1993 led by General Sani Abacha , who used military force on

1246-642: A combination of the harsh climate, problems with navigating trade routes and competing outputs in Scandinavia. In 1583, Sir Humphrey Gilbert , by the royal prerogative of Queen Elizabeth I , founded St John's, Newfoundland , as the first North American English seasonal camp . In 1600, the French established their first seasonal trading post at Tadoussac along the Saint Lawrence. French explorer Samuel de Champlain arrived in 1603 and established

1424-567: A constitutional amending formula and the Canadian Charter of Rights and Freedoms . The Charter guarantees basic rights and freedoms that usually cannot be overridden by any government; a notwithstanding clause allows Parliament and the provincial legislatures to override certain sections of the Charter for a period of five years. Canada's judiciary interprets laws and has the power to strike down acts of Parliament that violate

1602-506: A distinguishing element of Canada's political culture. Peace, order, and good government , alongside an Implied Bill of Rights , are founding principles of Canadian federalism . At the federal level, Canada has been dominated by two relatively centrist parties practising "brokerage politics": the centre-left leaning Liberal Party of Canada and the centre-right leaning Conservative Party of Canada (or its predecessors ). The historically predominant Liberals position themselves at

1780-516: A formally independent federation on 1 October 1960. It experienced a civil war from 1967 to 1970, followed by a succession of military dictatorships and democratically elected civilian governments until achieving a stable government in the 1999 Nigerian presidential election , with the election of Olusegun Obasanjo of the Peoples Democratic Party . However, the country frequently experiences electoral fraud , and corruption

1958-692: A given region of interest is also provided. These data can also be directly accessed from the widely used Haploview program. Canada Canada is a country in North America . Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean , making it the world's second-largest country by total area , with the world's longest coastline . Its border with

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2136-489: A large re-sequencing project to discover millions of additional SNPs. These were submitted to the public dbSNP database. As a result, by August 2006, the database included more than ten million SNPs, and more than 40% of them were known to be polymorphic . By comparison, at the start of the project, fewer than 3 million SNPs were identified, and no more than 10% of them were known to be polymorphic. During Phase II, more than two million additional SNPs were genotyped throughout

2314-432: A river system. The river system of the northeast is also a major river system. In addition, Nigeria has numerous coastal rivers. Over the last million years, Lake Chad in the far north-east of Nigeria has dried up several times for a few thousand years and just as often growing to many times its current size. In recent decades its surface area has been reduced considerably, which may also be due to humans taking water from

2492-455: A shortcut. Although any two unrelated people share about 99.5% of their DNA sequence, their genomes differ at specific nucleotide locations. Such sites are known as single nucleotide polymorphisms (SNPs), and each of the possible resulting gene forms is called an allele . The HapMap project focuses only on common SNPs, those where each allele occurs in at least 1% of the population. Each person has two copies of all chromosomes , except

2670-559: A successful jihad against the Hausa Kingdoms , founding the centralised Sokoto Caliphate . This empire, with Arabic as its official language, grew rapidly under his rule and that of his descendants , who sent out invading armies in every direction. The vast landlocked empire connected the east with the western Sudan region and made inroads down south conquering parts of the Oyo Empire (modern-day Kwara ), and advanced towards

2848-805: A team led by David Altshuler and Mark Daly at the Broad Institute in Cambridge, USA (chromosomes 4q, 7q, 18p, Y and mitochondrion ), a team led by Richard Gibbs at the Baylor College of Medicine in Houston (chromosome 12), and a team led by Pui-Yan Kwok at the University of California, San Francisco (chromosome 7p). To obtain enough SNPs to create the Map, the Consortium funded

3026-431: A temperate climate, with a mild and rainy winter. On the east and west coasts, average high temperatures are generally in the low 20s °C (70s °F), while between the coasts, the average summer high temperature ranges from 25 to 30 °C (77 to 86 °F), with temperatures in some interior locations occasionally exceeding 40 °C (104 °F). Much of Northern Canada is covered by ice and permafrost . The future of

3204-572: A triumvirate of three brigadier generals whose decisions could be vetoed by a Supreme Military Council . For this triumvirate, they convinced General Murtala Muhammed to become military head of state, with General Olusegun Obasanjo as his second-in-command, and General Theophilus Danjuma as the third. Together, the triumvirate introduced austerity measures to stem inflation, established a Corrupt Practices Investigation Bureau, replaced all military governors with new officers, and launched "Operation Deadwood" through which they fired 11,000 officials from

3382-706: A wide scale to suppress the continuing civilian unrest. In 1995, the government hanged environmentalist Ken Saro-Wiwa on trumped-up charges in the deaths of four Ogoni elders, which caused Nigerian's suspension from the Commonwealth . Lawsuits under the American Alien Tort Statute against Royal Dutch Shell and Brian Anderson, the head of Shell's Nigerian operation, settled out of court with Shell continuing to deny liability. Several hundred million dollars in accounts traced to Abacha were discovered in 1999. The regime came to an end in 1998 when

3560-429: Is English , chosen to facilitate linguistic unity at the national level. Nigeria's constitution ensures de jure freedom of religion , and it is home to some of the world's largest Muslim and Christian populations. Nigeria is divided roughly in half between Muslims , who live mostly in the north part of the country, and Christians , who live mostly in the south; indigenous religions , such as those native to

3738-524: Is a better model of UK British individuals than is CEU alone. It was expensive in the 1990s to sequence patients’ whole genomes. So the National Institutes of Health embraced the idea for a "shortcut", which was to look just at sites on the genome where many people have a variant DNA unit. The theory behind the shortcut was that, since the major diseases are common, so too would be the genetic variants that caused them. Natural selection keeps

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3916-551: Is considered to be the foundation of Igbo culture . Nri and Aguleri , where the Igbo creation myth originates, are in the territory of the Umeuri clan. Members of the clan trace their lineages back to the patriarchal king-figure Eri . In West Africa, the oldest bronzes made using the lost wax process were from Igbo-Ukwu , a city under Nri influence. The Yoruba kingdoms of Ife and Oyo in southwestern Nigeria became prominent in

4094-554: Is divided into 15 terrestrial and five marine ecozones . These ecozones encompass over 80,000 classified species of Canadian wildlife , with an equal number yet to be formally recognized or discovered. Although Canada has a low percentage of endemic species compared to other countries , due to human activities, invasive species , and environmental issues in the country , there are currently more than 800 species at risk of being lost . About 65 percent of Canada's resident species are considered "Secure". Over half of Canada's landscape

4272-1026: Is intact and relatively free of human development. The boreal forest of Canada is considered to be the largest intact forest on Earth, with approximately 3,000,000 km (1,200,000 sq mi) undisturbed by roads, cities or industry. Since the end of the last glacial period , Canada has consisted of eight distinct forest regions . Approximately 12.1 percent of the nation's landmass and freshwater are conservation areas , including 11.4 percent designated as protected areas . Approximately 13.8 percent of its territorial waters are conserved, including 8.9 percent designated as protected areas. Canada's first National Park , Banff National Park established in 1885 spans 6,641 square kilometres (2,564 sq mi). Canada's oldest provincial park, Algonquin Provincial Park , established in 1893, covers an area of 7,653.45 square kilometres (2,955.01 sq mi). Lake Superior National Marine Conservation Area

4450-559: Is now Canada for thousands of years. Beginning in the 16th century, British and French expeditions explored and later settled along the Atlantic coast. As a consequence of various armed conflicts , France ceded nearly all of its colonies in North America in 1763. In 1867, with the union of three British North American colonies through Confederation , Canada was formed as a federal dominion of four provinces. This began an accretion of provinces and territories resulting in

4628-457: Is part of multiple international organizations and forums . While a variety of theories have been postulated for the etymological origins of Canada , the name is now accepted as coming from the St. Lawrence Iroquoian word kanata , meaning "village" or "settlement". In 1535, Indigenous inhabitants of the present-day Quebec City region used the word to direct French explorer Jacques Cartier to

4806-564: Is plains of tall grass interrupted by trees. Sudan savannah is similar but with shorter grasses and shorter trees. Sahel savannah consists of patches of grass and sand, found in the northeast. Nigeria is divided into two main catchment areas - that of Lake Chad and that of the Niger. The Niger catchment area covers about 63% of the country. The main tributary of the Niger is the Benue, whose tributaries extend beyond Cameroon into Cameroon into Chad and

4984-462: Is rampant in various levels of Nigerian politics. Nigeria is a multinational state inhabited by more than 250 ethnic groups speaking 500 distinct languages , all identifying with a wide variety of cultures. The three largest ethnic groups are the Hausa in the north , Yoruba in the west , and Igbo in the east , together constituting over 60% of the total population. The official language

5162-687: Is solely a federal responsibility and is uniform throughout Canada. Law enforcement, including criminal courts, is officially a provincial responsibility, conducted by provincial and municipal police forces. In most rural and some urban areas, policing responsibilities are contracted to the federal Royal Canadian Mounted Police . Canadian Aboriginal law provides certain constitutionally recognized rights to land and traditional practices for Indigenous groups in Canada. Various treaties and case laws were established to mediate relations between Europeans and many Indigenous peoples. The role of Aboriginal law and

5340-399: Is the second-largest country . By land area alone, Canada ranks fourth , due to having the world's largest area of fresh water lakes . Stretching from the Atlantic Ocean in the east, along the Arctic Ocean to the north, and to the Pacific Ocean in the west, the country encompasses 9,984,670 km (3,855,100 sq mi) of territory. Canada also has vast maritime terrain, with

5518-521: Is the source of sovereignty and authority in Canada. However, while the governor general or monarch may exercise their power without ministerial advice in rare crisis situations , the use of the executive powers (or royal prerogative ) is otherwise directed by the Cabinet , a committee of ministers of the Crown responsible to the elected House of Commons and chosen and headed by the prime minister,

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5696-562: Is the world's largest freshwater protected area, spanning roughly 10,000 square kilometres (3,900 sq mi). Canada's largest national wildlife region is the Scott Islands Marine National Wildlife Area which spans 11,570.65 square kilometres (4,467.45 sq mi). Canada is described as a " full democracy ", with a tradition of liberalism , and an egalitarian , moderate political ideology. An emphasis on social justice has been

5874-666: The Canada Elections Act limits this to four years with a "fixed" election date in October; general elections still must be called by the governor general and can be triggered by either the advice of the prime minister or a lost confidence vote in the House. The 105 members of the Senate, whose seats are apportioned on a regional basis, serve until age 75. Canadian federalism divides government responsibilities between

6052-705: The Dominion Lands Act to regulate settlement and established the North-West Mounted Police to assert authority over the territory. This period of westward expansion and nation building resulted in the displacement of many Indigenous peoples of the Canadian Prairies to " Indian reserves ", clearing the way for ethnic European block settlements . This caused the collapse of the Plains Bison in western Canada and

6230-775: The Battle of the Scheldt in 1944. Canada provided asylum for the Dutch monarchy while that country was occupied and is credited by the Netherlands for major contributions to its liberation from Nazi Germany . The Canadian economy boomed during the war as its industries manufactured military materiel for Canada, Britain, China , and the Soviet Union . Despite another Conscription Crisis in Quebec in 1944, Canada finished

6408-502: The Bight of Benin , and Bonny Island on the Bight of Biafra. The majority of those taken to these ports were captured in raids and wars. Usually, the captives were taken back to the conquerors' territory as forced labour ; they were sometimes gradually acculturated and absorbed into the conquerors' society. Slave routes were established throughout Nigeria linking the hinterland areas with

6586-746: The Bornu Empire gave rise to the British-controlled Borno Emirate which established Abubakar Garbai of Borno as ruler. In 1903, the British victory in the Battle of Kano gave them a logistical edge in pacifying the heartland of the Sokoto Caliphate and parts of the former Bornu Empire. On 13 March 1903, at the grand market square of Sokoto, the last vizier of the caliphate officially conceded to British rule. The British appointed Muhammadu Attahiru II as

6764-612: The COVID-19 pandemic in Canada began on January 27, 2020, with widespread social and economic disruption. In 2021, the possible graves of hundreds of Indigenous people were discovered near the former sites of Canadian Indian residential schools . Administered by various Christian churches and funded by the Canadian government from 1828 to 1997, these boarding schools attempted to assimilate Indigenous children into Euro-Canadian culture . By total area (including its waters), Canada

6942-649: The Canada Act 1982 , the patriation of Canada's constitution from the United Kingdom, concurrent with the creation of the Canadian Charter of Rights and Freedoms . Canada had established complete sovereignty as an independent country under its own monarchy . In 1999, Nunavut became Canada's third territory after a series of negotiations with the federal government. At the same time, Quebec underwent profound social and economic changes through

7120-826: The Canadian Shield , the interior plains , the Great Lakes-St. Lawrence Lowlands , the Appalachian region , the Western Cordillera , Hudson Bay Lowlands , and the Arctic Archipelago . Boreal forests prevail throughout the country, ice is prominent in northern Arctic regions and through the Rocky Mountains , and the relatively flat Canadian Prairies in the southwest facilitate productive agriculture. The Great Lakes feed

7298-666: The Eastern Region . In May 1967, Governor of the Eastern Region Lt. Colonel Emeka Ojukwu declared the region independent from the federation as a state called the Republic of Biafra , as a result of the continuous and systematically planned attacks against Igbos and those of Eastern extraction popularly known as 1966 pogroms . This declaration precipitated the Nigerian Civil War , which began as

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7476-582: The Igbo and Yoruba ethnicities, are in the minority. Nigeria is a regional power in Africa and a middle power in international affairs. Nigeria's economy is the fourth-largest in Africa , the 53rd-largest in the world by nominal GDP , and 27th-largest by PPP . Nigeria is often referred to as the Giant of Africa owing to its large population and economy , and is considered to be an emerging market by

7654-669: The Lagos Treaty of Cession . British missionaries expanded their operations and travelled further inland. In 1864, Samuel Ajayi Crowther became the first African bishop of the Anglican Church . In 1885, British claims to a West African sphere of influence received recognition from other European nations at the Berlin Conference . The following year, it chartered the Royal Niger Company under

7832-769: The Meech Lake Accord failed in 1990. This led to the formation of the Bloc Québécois in Quebec and the invigoration of the Reform Party of Canada in the West. A second referendum followed in 1995, in which sovereignty was rejected by a slimmer margin of 50.6 to 49.4 percent. In 1997, the Supreme Court ruled unilateral secession by a province would be unconstitutional, and the Clarity Act

8010-571: The Muslim world . There are early historical references by medieval Arab and Muslim historians and geographers which refer to the Kanem–Bornu Empire as the region's major centre for Islamic civilization. The Kingdom of Nri of the Igbo people consolidated in the 10th century and continued until it lost its sovereignty to the British in 1911. Nri was ruled by the Eze Nri , and the city of Nri

8188-589: The Niger River running through the country. This name was coined on 8 January 1897, by the British journalist Flora Shaw . The neighboring Republic of Niger takes its name from the same river. The origin of the name Niger , which originally applied to only the middle reaches of the Niger River, is uncertain. The word is likely an alteration of the Tuareg name egerew n-iger ewen used by inhabitants along

8366-564: The Nigerian Political Bureau which made recommendations for the transition to the Third Nigerian Republic. In 1989, Babangida started making plans for the transition to the Third Nigerian Republic. Babangida survived the 1990 Nigerian coup d'état attempt , then postponed a promised return to democracy to 1992. Babangida legalized the formation of political parties and formed the two-party system with

8544-602: The Northern Nigeria Protectorate into the Colony and Protectorate of Nigeria . Administratively, Nigeria remained divided into the Northern and Southern Protectorates and Lagos Colony . Inhabitants of the southern region sustained more interaction, economic and cultural, with the British and other Europeans owing to the coastal economy. Christian missions established Western educational institutions in

8722-413: The Oka Crisis of 1990, the first of a number of violent confrontations between provincial governments and Indigenous groups. Canada joined the Gulf War in 1990 and was active in several peacekeeping missions in the 1990s, including operations in the Balkans during and after the Yugoslav Wars , and in Somalia , resulting in an incident that has been described as " the darkest era in the history of

8900-446: The Parliament of Canada and the commissioners represent the King in his federal Council , rather than the monarch directly. The powers flowing from the Constitution Act, 1867 , are divided between the federal government and the provincial governments to exercise exclusively and any changes to that arrangement require a constitutional amendment , while changes to the roles and powers of the territories may be performed unilaterally by

9078-425: The Quiet Revolution of the 1960s, giving birth to a secular nationalist movement. The radical Front de libération du Québec (FLQ) ignited the October Crisis with a series of bombings and kidnappings in 1970, and the sovereigntist Parti Québécois was elected in 1976, organizing an unsuccessful referendum on sovereignty-association in 1980. Attempts to accommodate Quebec nationalism constitutionally through

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9256-401: The Social Democratic Party and National Republican Convention ahead of the 1992 general elections . He urged all Nigerians to join either of the parties, which Chief Bola Ige referred to as "two leper hands". The 1993 presidential election held on 12 June was the first since the military coup of 1983. The results, though not officially declared by the National Electoral Commission, showed

9434-584: The St. Lawrence River (in the southeast) where the lowlands host much of Canada's economic output. Canada has over 2,000,000 lakes—563 of which are larger than 100 km (39 sq mi)—containing much of the world's fresh water . There are also fresh-water glaciers in the Canadian Rockies , the Coast Mountains , and the Arctic Cordillera . Canada is geologically active , having many earthquakes and potentially active volcanoes . Average winter and summer high temperatures across Canada vary from region to region. Winters can be harsh in many parts of

9612-400: The Westminster tradition . The country's head of government is the prime minister , who holds office by virtue of their ability to command the confidence of the elected House of Commons and is appointed by the governor general , representing the monarch of Canada , the ceremonial head of state . The country is a Commonwealth realm and is officially bilingual (English and French) in

9790-430: The World Bank . Nigeria is a founding member of the African Union and a member of many international organizations, including the United Nations , the Commonwealth of Nations , NAM , the Economic Community of West African States , Organisation of Islamic Cooperation and OPEC . It is also a member of the informal MINT group of countries and is one of the Next Eleven economies. The name Nigeria derives from

9968-409: The Yoruba heartland of Ibadan , to reach the Atlantic Ocean. The territory controlled by the empire included much of modern-day northern and central Nigeria. The sultan sent out emirs to establish suzerainty over the conquered territories and promote Islamic civilization; the emirs in turn became increasingly rich and powerful through trade and slavery. By the 1890s, the largest slave population in

10146-400: The displacement of Indigenous populations , and a process of increasing autonomy from the United Kingdom. This increased sovereignty was highlighted by the Statute of Westminster, 1931 , and culminating in the Canada Act 1982 , which severed the vestiges of legal dependence on the Parliament of the United Kingdom . Canada is a parliamentary democracy and a constitutional monarchy in

10324-441: The head of government . To ensure the stability of government, the governor general will usually appoint as prime minister the individual who is the current leader of the political party that can obtain the confidence of a majority of members in the House. The Prime Minister's Office (PMO) is one of the most powerful institutions in government, initiating most legislation for parliamentary approval and selecting for appointment by

10502-449: The sex chromosomes in males . For each SNP, the combination of alleles a person has is called a genotype . Genotyping refers to uncovering what genotype a person has at a particular site. The HapMap project chose a sample of 269 individuals and selected several million well-defined SNPs, genotyped the individuals for these SNPs, and published the results. The alleles of nearby SNPs on a single chromosome are correlated. Specifically, if

10680-507: The world's sixth-most populous country . Nigeria borders Niger in the north , Chad in the northeast , Cameroon in the east , and Benin in the west . Nigeria is a federal republic comprising 36 states and the Federal Capital Territory , where its capital, Abuja , is located. The largest city in Nigeria is Lagos , one of the largest metropolitan areas in the world and the largest in Africa . Nigeria has been home to several indigenous pre-colonial states and kingdoms since

10858-410: The 10th century. With the spread of Islam from the 7th century AD, the area became known as Sudan or as Bilad Al Sudan (English: Land of the Blacks). Since the populations were partially affiliated with the Arab Muslim culture of North Africa , they began trans-Saharan trade and were referred to by the Arabic speakers as Al-Sudan (meaning "The Blacks") as they were considered an extended part of

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11036-413: The 12th and 14th centuries, respectively. The oldest signs of human settlement at Ife's current site date back to the 9th century, and its material culture includes terracotta and bronze figures. In the 16th century, Portuguese explorers were the first Europeans to begin important, direct trade with the peoples of southern Nigeria, at the port they named Lagos (formerly Eko) and in Calabar along

11214-412: The 1713 Treaty of Utrecht and Canada and most of New France came under British rule in 1763 after the Seven Years' War. The Royal Proclamation of 1763 established First Nation treaty rights, created the Province of Quebec out of New France, and annexed Cape Breton Island to Nova Scotia. St John's Island (now Prince Edward Island ) became a separate colony in 1769. To avert conflict in Quebec ,

11392-424: The 2007 general elections, Umaru Yar'Adua of the People's Democratic Party came to power. The international community, which had observed the Nigerian elections to promote a free and fair process, condemned these elections as seriously flawed. Yar'Adua died on 5 May 2010, and Vice President Goodluck Jonathan had been sworn in by the Senate three months earlier as acting president to succeed Yar'Adua. Jonathan won

11570-449: The 2011 presidential election; the polls went smoothly and with relatively little violence or electoral fraud. Jonathan's tenure saw an economic recovery that made Nigeria the leading economic power in Africa. The Jonathan administration also saw an increase in unparalleled corruption, with as many as 20 billion US dollars said to have been lost to the Nigerian state through the national oil company. Above all, however, Jonathan's tenure saw

11748-405: The British Parliament passed the Quebec Act 1774, expanding Quebec's territory to the Great Lakes and Ohio Valley . More importantly, the Quebec Act afforded Quebec special autonomy and rights of self-administration at a time when the Thirteen Colonies were increasingly agitating against British rule. It re-established the French language, Catholic faith, and French civil law there, staving off

11926-467: The British government moved Nigeria toward self-government on a representative and increasingly federal basis. By the eve of independence in 1960, regional differences in modern educational access were marked. The legacy, though less pronounced, continues to the present day. The balance between north and south was also expressed in Nigeria's political life. For instance, northern Nigeria did not outlaw slavery until 1936 whilst in other parts of Nigeria, slavery

12104-458: The CEPH collection); CHB (Han Chinese in Beijing, China); CHD (Chinese in Metropolitan Denver, Colorado); GIH (Gujarati Indians in Houston, Texas); JPT (Japanese in Tokyo, Japan); LWK (Luhya in Webuye, Kenya); MEX (Mexican ancestry in Los Angeles, California); MKK (Maasai in Kinyawa, Kenya); TSI (Tuscans in Italy); YRI (Yoruba in Ibadan, Nigeria). Three combined panels have also been created, which allow better identification of SNPs in groups outside

12282-466: The Canadian military ". Canada sent troops to Afghanistan in 2001 , resulting in the largest amount of Canadian deaths for any single military mission since the Korean War in the early 1950s. In 2011, Canadian forces participated in the NATO-led intervention into the Libyan Civil War and also became involved in battling the Islamic State insurgency in Iraq in the mid-2010s. The country celebrated its sesquicentennial in 2017, three years before

12460-409: The Chad Basin, where the course of the El Beid River forms the border with Cameroon, from the Mandara Mountains to Lake Chad. The Komadugu Yobe river system gives rise to the internationally important Hadejia-Nguru wetlands and Ox-bow lakes around Lake Nguru in the rainy season. Other rivers of the northeast include the Ngadda and the Yedseram, both of which flow through the Sambisa swamps, thus forming

12638-423: The Crown the governor general, lieutenant governors , senators, federal court judges, and heads of Crown corporations and government agencies. The leader of the party with the second-most seats usually becomes the leader of the Official Opposition and is part of an adversarial parliamentary system intended to keep the government in check. The Parliament of Canada passes all federal statute laws. It comprises

12816-771: The First Nations to education, government and legal rights. Because Britain still maintained control of Canada's foreign affairs under the British North America Act, 1867, its declaration of war in 1914 automatically brought Canada into the First World War . Volunteers sent to the Western Front later became part of the Canadian Corps , which played a substantial role in the Battle of Vimy Ridge and other major engagements of

12994-502: The HapMap: 30 adult-and-both-parents Yoruba trios from Ibadan , Nigeria (YRI), 30 trios of Utah residents of northern and western European ancestry (CEU), 44 unrelated Japanese individuals from Tokyo , Japan (JPT) and 45 unrelated Han Chinese individuals from Beijing , China (CHB). Although the haplotypes revealed from these populations should be useful for studying many other populations, parallel studies are currently examining

13172-590: The Kwankwassiya of Rabiu Kwankwaso , former governor of Kano State in the Northwest. Bola Tinubu , of the ruling party, won the disputed election with 36.61% of the vote, but both runners-up claimed victory and litigation is ongoing in an election tribunal. Bola Tinubu's inauguration was held on 29 May 2023. Problems with widespread kidnapping in Nigeria continued. On 29 May 2024, Tinubu signed into law an act readopting Nigeria, We Hail Thee , which

13350-652: The Métis' grievances ignited the Red River Rebellion and the creation of the province of Manitoba in July 1870. British Columbia and Vancouver Island (which had been united in 1866) joined the confederation in 1871 on the promise of a transcontinental railway extending to Victoria in the province within 10 years, while Prince Edward Island joined in 1873. In 1898, during the Klondike Gold Rush in

13528-600: The Niger and the Cross Rivers has lost most of its forest because of development and harvesting by increased population and has been replaced by grassland . Everything in between the far south and the far north is savannah (insignificant tree cover, with grasses and flowers located between trees). Rainfall is more limited to between 500 and 1,500 millimetres (20 and 60 in) per year. The savannah zone's three categories are Guinean forest-savanna mosaic , Sudan savannah, and Sahel savannah. Guinean forest-savanna mosaic

13706-587: The Nigerian government, with Nigeria utilizing air support from Egyptian pilots provided by Gamal Abdel Nasser , while France and Israel aided the Biafrans. The Congolese government, under President Joseph-Désiré Mobutu , took an early stand on the Biafran secession, voicing strong support for the Nigerian federal government and deploying thousands of troops to fight against the secessionists . Following

13884-540: The Norse built a small short-lived encampment that was occupied sporadically for perhaps 20 years at L'Anse aux Meadows on the northern tip of Newfoundland . No further European exploration occurred until 1497, when seafarer John Cabot explored and claimed Canada's Atlantic coast in the name of Henry VII of England . In 1534, French explorer Jacques Cartier explored the Gulf of Saint Lawrence where, on July 24, he planted

14062-735: The Northwest Territories, Parliament created the Yukon Territory. Alberta and Saskatchewan became provinces in 1905. Between 1871 and 1896, almost one quarter of the Canadian population emigrated south to the US. To open the West and encourage European immigration, the Government of Canada sponsored the construction of three transcontinental railways (including the Canadian Pacific Railway ), passed

14240-708: The Parliament of Canada. Nigeria Nigeria , officially the Federal Republic of Nigeria , is a country in West Africa . It is situated between the Sahel to the north and the Gulf of Guinea to the south in the Atlantic Ocean . It covers an area of 923,769 square kilometres (356,669 sq mi). With a population of more than 230 million, it is the most populous country in Africa , and

14418-593: The Saint Lawrence River. Following the British conquest of New France , this area was known as the British Province of Quebec from 1763 to 1791. In 1791, the area became two British colonies called Upper Canada and Lower Canada . These two colonies were collectively named the Canadas until their union as the British Province of Canada in 1841. Upon Confederation in 1867 , Canada

14596-739: The Sharie catchment area. In the Sahel region, rain is less than 500 millimetres (20 in) per year, and the Sahara Desert is encroaching. In the dry northeast corner of the country lies Lake Chad , on a shared water boundary delimitation with Niger, Chad and Cameroon. The Chad Basin is fed from the north-eastern quarter of Nigeria. The Bauchi Plateau forms the watershed between the Niger/Benue and Komadugu Yobe river systems. The flat plains of north-eastern Nigeria are geographically part of

14774-709: The United Kingdom. The delay underscored Canada's independence. The first Canadian Army units arrived in Britain in December 1939. In all, over a million Canadians served in the armed forces during the Second World War . Canadian troops played important roles in many key battles of the war, including the failed 1942 Dieppe Raid , the Allied invasion of Italy , the Normandy landings , the Battle of Normandy , and

14952-601: The United States is the world's longest international land border. The country is characterized by a wide range of both meteorologic and geological regions. With a population of just over 41   million people, it has widely varying population densities, with the majority residing in urban areas and large areas of the country being sparsely populated. Canada's capital is Ottawa and its three largest metropolitan areas are Toronto , Montreal , and Vancouver . Indigenous peoples have continuously inhabited what

15130-642: The United States in 1846 ended the Oregon boundary dispute , extending the border westward along the 49th parallel . This paved the way for British colonies on Vancouver Island (1849) and in British Columbia (1858) . The Anglo-Russian Treaty of Saint Petersburg (1825) established the border along the Pacific coast, but, even after the US Alaska Purchase of 1867, disputes continued about

15308-473: The abortive Rebellions of 1837 . The Durham Report subsequently recommended responsible government and the assimilation of French Canadians into English culture. The Act of Union 1840 merged the Canadas into a united Province of Canada and responsible government was established for all provinces of British North America east of Lake Superior by 1855. The signing of the Oregon Treaty by Britain and

15486-484: The allele of one SNP for a given individual is known, the alleles of nearby SNPs can often be predicted, a process known as genotype imputation . This is because each SNP arose in evolutionary history as a single point mutation , and was then passed down on the chromosome surrounded by other, earlier, point mutations. SNPs that are separated by a large distance on the chromosome are typically not very well correlated, because recombination occurs in each generation and mixes

15664-507: The allele sequences of the two chromosomes. A sequence of consecutive alleles on a particular chromosome is known as a haplotype . To find the genetic factors involved in a particular disease, one can proceed as follows. First a certain region of interest in the genome is identified, possibly from earlier inheritance studies. In this region one locates a set of tag SNPs from the HapMap data; these are SNPs that are very well correlated with all

15842-552: The border with Cameroon , where the montane land is part of the Bamenda Highlands of Cameroon. The far south is defined by its tropical rainforest climate , where annual rainfall is 1,500 to 2,000 millimetres (60 to 80 in) per year. In the southeast stands the Obudu Plateau . Coastal plains are found in both the southwest and the southeast. Mangrove swamps are found along the coast. The area near

16020-593: The border with Cameroon close to the coast is rich rainforest and part of the Cross-Sanaga-Bioko coastal forests ecoregion , an important centre for biodiversity . It is a habitat for the drill primate , which is found in the wild only in this area and across the border in Cameroon. The areas surrounding Calabar , Cross River State, also in this forest, are believed to contain the world's largest diversity of butterflies. The area of southern Nigeria between

16198-405: The caliphate and the central Sokoto administration to prevent any defence as he worked towards the capital. As the British approached the city of Sokoto , Sultan Muhammadu Attahiru I organized a quick defence of the city and fought the advancing British-led forces. The British force quickly won, sending Attahiru I and thousands of followers on a Mahdist hijra . In the northeast, the decline of

16376-477: The canals, sewerage systems that are channels for water flows, and the like. Haphazard industrial planning, increased urbanisation, poverty and lack of competence of the municipal government are seen as the major reasons for high levels of waste pollution in major cities of the country. Some of the solutions have been disastrous to the environment, resulting in untreated waste being dumped in places where it can pollute waterways and groundwater . In 2005, Nigeria had

16554-743: The centre of the political scale. Five parties had representatives elected to the Parliament in the 2021 election —the Liberals, who formed a minority government; the Conservatives, who became the Official Opposition ; the New Democratic Party (occupying the left ); the Bloc Québécois ; and the Green Party . Far-right and far-left politics have never been a prominent force in Canadian society. Canada has

16732-565: The civil service. Colonel Buka Suka Dimka launched a February 1976 coup attempt , during which General Murtala Muhammed was assassinated. Dimka lacked widespread support among the military, and his coup failed, forcing him to flee. After the coup attempt, General Olusegun Obasanjo was appointed military head of state. Obasanjo vowed to continue Murtala's policies. Aware of the danger of alienating northern Nigerians, Obasanjo brought General Shehu Yar'Adua as his replacement and second-in-command as Chief of Staff, Supreme Headquarters completing

16910-695: The complete data obtained in Phase I were published on 27 October 2005. The analysis of the Phase II dataset was published in October 2007. The Phase III dataset was released in spring 2009 and the publication presenting the final results published in September 2010. Unlike with the rarer Mendelian diseases, combinations of different genes and the environment play a role in the development and progression of common diseases (such as diabetes , cancer , heart disease , stroke , depression , and asthma ), or in

17088-555: The constitution. The Supreme Court of Canada is the highest court, final arbiter, and has been led since 2017 by Richard Wagner , the Chief Justice of Canada . The governor general appoints the court's nine members on the advice of the prime minister and minister of justice . The federal Cabinet also appoints justices to superior courts in the provincial and territorial jurisdictions. Common law prevails everywhere except Quebec, where civil law predominates. Criminal law

17266-516: The continent during the North American fur trade . These early European interactions with First Nations would change from friendship and peace treaties to the dispossession of Indigenous lands through treaties . From the late 18th century, European Canadians forced Indigenous peoples to assimilate into a western Canadian society. Settler colonialism reached a climax in the late 19th and early 20th centuries. A period of redress began with

17444-576: The country and consists of written text and unwritten conventions. The Constitution Act, 1867 (known as the British North America Act, 1867 prior to 1982), affirmed governance based on parliamentary precedent and divided powers between the federal and provincial governments. The Statute of Westminster, 1931 , granted full autonomy, and the Constitution Act, 1982 , ended all legislative ties to Britain, as well as adding

17622-421: The country, particularly in the interior and Prairie provinces, which experience a continental climate , where daily average temperatures are near −15  °C (5  °F ), but can drop below −40 °C (−40 °F) with severe wind chills . In non-coastal regions, snow can cover the ground for almost six months of the year, while in parts of the north snow can persist year-round. Coastal British Columbia has

17800-490: The cultural and political differences were sharp among Nigeria's dominant ethnic groups: the Hausa in the north, Igbo in the east and Yoruba in the west. The Westminster system of government was retained, and thus the President 's powers were generally ceremonial. The parliamentary system of government had Abubakar Tafawa Balewa as Prime Minister and Nnamdi Azikiwe as the ceremonial president. The founding government

17978-570: The dictator died in the villa. He looted money to offshore accounts in Western European banks and defeated coup plots by arresting and bribing generals and politicians. His successor, General Abdulsalami Abubakar , adopted a new constitution on 5 May 1999, which provided for multiparty elections. On 29 May 1999, Abubakar handed over power to the winner of the 1999 presidential election, former military ruler General Olusegun Obasanjo , as President of Nigeria. Obasanjo had been in prison under

18156-516: The dictatorship of Abacha. Obasanjo's inauguration heralded the beginning of the Fourth Nigerian Republic, ending a 39-year period of short-lived democracies, civil war and military dictatorship. Although the elections that brought Obasanjo to power and allowed him to run for a second term in the 2003 presidential elections were condemned as unfree and unfair, Nigeria made significant progress in democratization under Obasanjo. In

18334-622: The direct control of the British government and established the Southern Nigeria Protectorate as a British protectorate and part of the British Empire . By 1902, the British had begun plans to move north into the Sokoto Caliphate. British General Lord Frederick Lugard was tasked by the Colonial Office to implement the agenda. Lugard used rivalries between many of the emirs in the southern reach of

18512-561: The duo of Moshood Abiola and Baba Gana Kingibe of the Social Democratic Party defeated Bashir Tofa and Sylvester Ugoh of the National Republican Convention by over 2.3 million votes. However, Babangida annulled the elections, leading to massive civilian protests that effectively shut down the country for weeks. In August 1993, Babangida finally kept his promise to relinquish power to

18690-723: The earliest known sculptures in sub-Saharan Africa and smelted iron by about 550 BC and possibly a few centuries earlier. Evidence of iron smelting has also been excavated at sites in the Nsukka region of southeast Nigeria: dating to 2000 BC at the site of Lejja and to 750 BC and at the site of Opi . The Kano Chronicle highlights an ancient history dating to around 999 AD of the Hausa Sahelian city-state of Kano , with other major Hausa cities (or Hausa Bakwai ) of Daura , Hadeija , Kano , Katsina , Zazzau , Rano , and Gobir all having recorded histories dating back to

18868-597: The early 1930s saw an economic downturn, leading to hardship across the country. In response to the downturn, the Co-operative Commonwealth Federation (CCF) in Saskatchewan introduced many elements of a welfare state (as pioneered by Tommy Douglas ) in the 1940s and 1950s. On the advice of Prime Minister William Lyon Mackenzie King , war with Germany was declared effective September 10, 1939, by King George VI , seven days after

19046-633: The emergence of a new Canadian identity , marked by the adoption of the maple leaf flag in 1965, the implementation of official bilingualism (English and French) in 1969, and the institution of official multiculturalism in 1971. Socially democratic programs were also instituted, such as Medicare , the Canada Pension Plan , and Canada Student Loans ; though, provincial governments, particularly Quebec and Alberta, opposed many of these as incursions into their jurisdictions. Finally, another series of constitutional conferences resulted in

19224-792: The emergence of a wave of terror by the Boko Haram insurgency , such as the Gwoza massacre and Chibok schoolgirls kidnapping in 2014. Ahead of the general election of 2015 , a merger of the biggest opposition parties in Nigeria – the Action Congress of Nigeria , the Congress for Progressive Change , the All Nigeria Peoples Party , a faction of the All Progressives Grand Alliance and

19402-693: The exact demarcation of the Alaska–Yukon and Alaska–BC border. Following three constitutional conferences, the British North America Act, 1867 officially proclaimed Canadian Confederation on July 1, 1867, initially with four provinces: Ontario , Quebec, Nova Scotia, and New Brunswick. Canada assumed control of Rupert's Land and the North-Western Territory to form the Northwest Territories , where

19580-416: The federal government and the 10 provinces. Provincial legislatures are unicameral and operate in parliamentary fashion similar to the House of Commons. Canada's three territories also have legislatures, but these are not sovereign, have fewer constitutional responsibilities than the provinces, and differ structurally from their provincial counterparts. The Constitution of Canada is the supreme law of

19758-488: The federal jurisdiction. It is very highly ranked in international measurements of government transparency, quality of life, economic competitiveness, innovation, education and human rights. It is one of the world's most ethnically diverse and multicultural nations, the product of large-scale immigration . Canada's long and complex relationship with the United States has had a significant impact on its history , economy , and culture . A developed country , Canada has

19936-546: The first permanent year-round European settlements at Port Royal (in 1605) and Quebec City (in 1608). Among the colonists of New France, Canadiens extensively settled the Saint Lawrence River valley and Acadians settled the present-day Maritimes , while fur traders and Catholic missionaries explored the Great Lakes , Hudson Bay , and the Mississippi watershed to Louisiana . The Beaver Wars broke out in

20114-522: The first time since the return of democracy, no former military ruler ran for president, marking a strengthening of democracy and faith in the multiparty constitution . The election also saw the rise of metonymic supporters of the new candidates, the Obidient movement of Peter Obi , previously governor of Anambra State, widely appealed to young, urban voters and has his core base in the Southeast; and

20292-416: The forest zone's most southerly portion, especially around the Niger River and Cross River deltas, is mangrove swamp . North of this is a freshwater swamp, containing different vegetation from the saltwater mangrove swamps, and north of that is a rainforest. The savannah zone's three categories are divided into Guinean forest-savanna mosaic , made up of plains of tall grass which are interrupted by trees,

20470-499: The formation of a reconciliation commission by the Government of Canada in 2008. This included acknowledgment of cultural genocide , settlement agreements , and betterment of racial discrimination issues, such as addressing the plight of missing and murdered Indigenous women . It is believed that the first documented European to explore the east coast of Canada was Norse explorer Leif Erikson . In approximately 1000 AD,

20648-541: The fur trade, conflicts with the colonial authorities and settlers, and the loss of Indigenous lands to settlers and the subsequent collapse of several nations' self-sufficiency. Although not without conflict, European Canadians ' early interactions with First Nations and Inuit populations were relatively peaceful. First Nations and Métis peoples played a critical part in the development of European colonies in Canada , particularly for their role in assisting European coureurs des bois and voyageurs in their explorations of

20826-485: The genome by David R. Cox, Kelly A. Frazer and others at Perlegen Sciences and 500,000 by the company Affymetrix . All of the data generated by the project, including SNP frequencies, genotypes and haplotypes , were placed in the public domain and are available for download. This website also contains a genome browser which allows to find SNPs in any region of interest, their allele frequencies and their association to nearby SNPs. A tool that can determine tag SNPs for

21004-609: The growth of an independence movement in contrast to the Thirteen Colonies. The Proclamation and the Quebec Act in turn angered many residents of the Thirteen Colonies, further fuelling anti-British sentiment in the years prior to the American Revolution . After the successful American War of Independence, the 1783 Treaty of Paris recognized the independence of the newly formed United States and set

21182-591: The highest rate of deforestation in the world, according to the Food and Agriculture Organization of the United Nations . That year, 12.2%, the equivalent of 11,089,000 hectares, had been forested in the country. Between 1990 and 2000, Nigeria lost an average of 409,700 hectares of forest every year equal to an average annual deforestation rate of 2.4%. Between 1990 and 2005, in total Nigeria lost 35.7% of its forest cover or around 6,145,000 hectares. Nigeria had

21360-602: The human genome free of variants that damage health before children are grown, the theory held, but fails against variants that strike later in life, allowing them to become quite common (In 2002 the National Institutes of Health started a $ 138 million project called the HapMap to catalog the common variants in European, East Asian and African genomes). For the Phase I, one common SNP was genotyped every 5,000 bases. Overall, more than one million SNPs were genotyped. The genotyping

21538-456: The individual response to pharmacological agents. To find the genetic factors involved in these diseases, one could in principle do a genome-wide association study : obtain the complete genetic sequence of several individuals, some with the disease and some without, and then search for differences between the two sets of genomes. At the time, this approach was not feasible because of the cost of full genome sequencing . The HapMap project proposed

21716-407: The inlets to irrigate agricultural land. Nigeria is covered by three types of vegetation: forests (where there is significant tree cover), savannahs (insignificant tree cover, with grasses and flowers located between trees), and montane land (least common and mainly found in the mountains near the Cameroon border). Both the forest zone and the savannah zone are divided into three parts. Some of

21894-521: The introduction of European cattle farms and wheat fields dominating the land. The Indigenous peoples saw widespread famine and disease due to the loss of the bison and their traditional hunting lands. The federal government did provide emergency relief, on condition of the Indigenous peoples moving to the reserves. During this time, Canada introduced the Indian Act extending its control over

22072-415: The leadership of Sir George Taubman Goldie . By the late 19th and early 20th centuries, the company had vastly succeeded in subjugating the independent southern kingdoms along the Niger River , the British conquered Benin in 1897, and, in the Anglo-Aro War (1901–1902), defeated other opponents. The defeat of these states opened up the Niger area to British rule. In 1900, the company's territory came under

22250-410: The location of a large area of Central African mangroves . Nigeria's most expansive topographical region is that of the valleys of the Niger and Benue river valleys (which merge and form a Y-shape). To the southwest of the Niger is a "rugged" highland . To the southeast of the Benue are hills and mountains, which form the Mambilla Plateau , the highest plateau in Nigeria. This plateau extends through

22428-539: The main front in the War of 1812 between the United States and the United Kingdom . Peace came in 1815; no boundaries were changed. Immigration resumed at a higher level, with over 960,000 arrivals from Britain between 1815 and 1850. New arrivals included refugees escaping the Great Irish Famine as well as Gaelic -speaking Scots displaced by the Highland Clearances . Infectious diseases killed between 25 and 33 percent of Europeans who immigrated to Canada before 1891. The desire for responsible government resulted in

22606-454: The major coastal ports. Some of the more prolific slave-trading kingdoms who participated in the Atlantic slave trade were linked with the Edo's Benin Empire in the south, Oyo Empire in the southwest, and the Aro Confederacy in the southeast. Benin's power lasted between the 15th and 19th centuries. Oyo, at its territorial zenith in the late 17th to early 18th centuries, extended its influence from western Nigeria to modern-day Togo . In

22784-436: The mid-17th century over control of the North American fur trade. The English established additional settlements in Newfoundland in 1610 along with settlements in the Thirteen Colonies to the south. A series of four wars erupted in colonial North America between 1689 and 1763; the later wars of the period constituted the North American theatre of the Seven Years' War . Mainland Nova Scotia came under British rule with

22962-406: The middle reaches of the river around Timbuktu before 19th-century European colonialism . Before Flora Shaw suggested the name Nigeria , other proposed names included Royal Niger Company Territories , Central Sudan , Niger Empire , Niger Sudan , and Hausa Territories . Kainji Dam excavations showed ironworking by the 2nd century BC. The transition from Neolithic times to the Iron Age

23140-418: The military triumvirate, with Obasanjo as head of state and General Theophilus Danjuma as Chief of Army Staff , the three went on to re-establish control over the military regime and organized the military's transfer of power programme: states creation and national delimitation , local government reforms and the constitutional drafting committee for a new republic. The military carefully planned

23318-514: The monarch, the House of Commons, and the Senate . While Canada inherited the British concept of parliamentary supremacy , this was later, with the enactment of the Constitution Act, 1982, all but completely superseded by the American notion of the supremacy of the law . Each of the 338 members of Parliament in the House of Commons is elected by simple plurality in an electoral district or riding. The Constitution Act, 1982 , requires that no more than five years pass between elections, although

23496-403: The most common across the country; Sudan savannah, with short grasses and short trees; and Sahel savannah patches of grass and sand, found in the northeast. Waste management including sewage treatment , the linked processes of deforestation and soil degradation , and climate change or global warming are the major environmental problems in Nigeria. Waste management presents problems in

23674-582: The name of the national holiday was changed from Dominion Day to Canada Day . The first inhabitants of North America are generally hypothesized to have migrated from Siberia by way of the Bering land bridge and arrived at least 14,000 years ago. The Paleo-Indian archeological sites at Old Crow Flats and Bluefish Caves are two of the oldest sites of human habitation in Canada. The characteristics of Indigenous societies included permanent settlements, agriculture, complex societal hierarchies, and trading networks. Some of these cultures had collapsed by

23852-461: The new PDP (a faction of serving governors of the ruling People's Democratic Party) – formed the All Progressives Congress led by current president Bola Ahmed Tinubu. At the time, it was the most expensive election ever to be held on the African continent (being surpassed only by the elections of 2019 and 2023 ). The new mega-opposition party chose as their candidate for the election former military dictator Muhammadu Buhari. Buhari's campaign in 2015

24030-434: The new caliph. Lugard abolished the caliphate but retained the title sultan as a symbolic position in the newly organized Northern Nigeria Protectorate . This remnant became known as " Sokoto Sultanate Council ". In June 1903, the British defeated the remaining northern forces of Attahiru. By 1906, all resistance to British rule had ended. On 1 January 1914, the British formally united the Southern Nigeria Protectorate and

24208-410: The nine homogenous samples: CEU+TSI (Combined panel of Utah residents with Northern and Western European ancestry from the CEPH collection and Tuscans in Italy); JPT+CHB (Combined panel of Japanese in Tokyo, Japan and Han Chinese in Beijing, China) and JPT+CHB+CHD (Combined panel of Japanese in Tokyo, Japan, Han Chinese in Beijing, China and Chinese in Metropolitan Denver, Colorado). CEU+TSI, for instance,

24386-419: The north, the incessant fighting amongst the Hausa city-states and the decline of the Bornu Empire allowed the Fulani people to gain headway into the region. Until this point, the Fulani, a nomadic ethnic group, primarily traversed the semi-desert Sahelian region north of Sudan with cattle and avoided trade and intermingling with the Sudanic peoples. At the beginning of the 19th century, Usman dan Fodio led

24564-400: The official Nigerian government side attacked Biafra on 6 July 1967, at Garkem. The 30-month war, with a long blockade of Biafra and its isolation from trade and international relief, ended in January 1970. Estimates of the number of dead in the former Eastern Region during the 30-month civil war range from one to three million. Britain and the Soviet Union were the main military backers of

24742-538: The other SNPs in the region. Using these, genotype imputation can be used to determine (impute) the other SNPs and thus the entire haplotype with high confidence. Next, one determines the genotype for these tag SNPs in several individuals, some with the disease and some without. By comparing the two groups, one determines the likely locations and haplotypes that are involved in the disease. Haplotypes are generally shared between populations, but their frequency can differ widely. Four populations were selected for inclusion in

24920-404: The permafrost is uncertain because the Arctic has been warming at three times the global average as a result of climate change in Canada . Canada's annual average temperature over land has risen by 1.7 °C (3.1 °F), with changes ranging from 1.1 to 2.3 °C (2.0 to 4.1 °F) in various regions, since 1948. The rate of warming has been higher across the North and in the Prairies. In

25098-466: The plotters struggled to form a central government. Senate President Nwafor Orizu handed over government control to the Army , under the command of another Igbo officer, Major General Johnson Aguiyi-Ironsi . Later, the counter-coup of 1966, supported primarily by Northern military officers, facilitated the rise of Yakubu Gowon as military head of state. Tension rose between north and south; Igbos in northern cities suffered persecution and many fled to

25276-443: The protectorates. Under Britain's policy of indirect rule and validation of Islamic legitimist tradition, the Crown did not encourage the operation of Christian missions in the northern, Islamic part of the country. By the mid-20th century following World War II , a wave for independence was sweeping across Africa, in response to the growth of Nigerian nationalism and demands for independence, successive constitutions legislated by

25454-488: The provinces collect more revenue than the federal government, equalization payments are made by the federal government to ensure reasonably uniform standards of services and taxation are kept between the richer and poorer provinces. The major difference between a Canadian province and a territory is that provinces receive their sovereignty from the Crown and power and authority from the Constitution Act, 1867 , whereas territorial governments have powers delegated to them by

25632-404: The region Slave Coast . Europeans traded goods with peoples at the coast; coastal trade with Europeans also marked the beginnings of the Atlantic slave trade . The port of Calabar on the historical Bight of Biafra (now commonly referred to as the Bight of Bonny) became one of the largest slave-trading posts in West Africa in this era. Other major slaving ports were located in Badagry , Lagos on

25810-428: The resettlement of slaves freed by Britain in North America after the American Revolutionary War . Britain intervened in the Lagos kingship power struggle by bombarding Lagos in 1851, deposing the slave-trade-friendly Oba Kosoko , helping to install the amenable Oba Akitoye and signing the Treaty between Great Britain and Lagos on 1   January 1852. Britain annexed Lagos as a crown colony in August 1861 with

25988-405: The return to civilian rule putting in place measures to ensure that political parties had broader support than witnessed during the first republic. In 1979, five political parties competed in a series of elections in which Alhaji Shehu Shagari of the National Party of Nigeria (NPN) was elected president. All five parties won representation in the National Assembly. On 1 October 1979, Shehu Shagari

26166-736: The rights they support were reaffirmed by section 35 of the Constitution Act, 1982 . These rights may include provision of services, such as healthcare through the Indian Health Transfer Policy , and exemption from taxation. Canada is a federation composed of 10 federated states , called provinces, and three federal territories . These may be grouped into four main regions : Western Canada , Central Canada , Atlantic Canada , and Northern Canada ( Eastern Canada refers to Central Canada and Atlantic Canada together). Provinces and territories have responsibility for social programs such as healthcare , education , and social programs , as well as administration of justice (but not criminal law). Although

26344-480: The second millennium BC, with the Nok civilization in the 15th century BC marking the first internal unification. The modern state originated with British colonialization in the 19th century, taking its present territorial shape with the merging of the Southern Nigeria Protectorate and the Northern Nigeria Protectorate in 1914. The British set up administrative and legal structures while practicing indirect rule through traditional chiefdoms . Nigeria became

26522-426: The separatist Ambazonia ) 1,690 km or 1,050 mi. Its coastline is at least 853 km (530 mi). Nigeria lies between latitudes 4° and 14°N , and longitudes 2° and 15°E . The highest point in Nigeria is Chappal Waddi at 2,419 m (7,936 ft). The main rivers are the Niger and the Benue , which converge and empty into the Niger Delta . This is one of the world's largest river deltas and

26700-585: The southeast. Canada is also home to the world's northernmost settlement, Canadian Forces Station Alert , on the northern tip of Ellesmere Island —latitude 82.5°N—which lies 817 kilometres (508 mi) from the North Pole. In latitude, Canada's most northerly point of land is Cape Columbia in Nunavut at 83°6′41″N, with its southern extreme at Middle Island in Lake Erie at 41°40′53″N. In longitude, Canada's land extends from Cape Spear , Newfoundland, at 52°37'W, to Mount St. Elias , Yukon Territory, at 141°W. Canada can be divided into seven physiographic regions:

26878-422: The southern regions of Canada, air pollution from both Canada and the United States—caused by metal smelting, burning coal to power utilities, and vehicle emissions—has resulted in acid rain , which has severely impacted waterways, forest growth, and agricultural productivity. Canada is one of the largest greenhouse gas emitters globally , with emissions increased by 16.5 percent between 1990 and 2022. Canada

27056-438: The terms of peace, ceding British North American territories south of the Great Lakes and east of the Mississippi River to the new country. The American war of independence also caused a large out-migration of Loyalists , the settlers who had fought against American independence. Many moved to Canada, particularly Atlantic Canada, where their arrival changed the demographic distribution of the existing territories. New Brunswick

27234-403: The threshold of power in the country. As oil production and revenue rose, the Nigerian government became increasingly dependent on oil revenues and international commodity markets for budgetary and economic concerns. The coup in July 1975 , led by Generals Shehu Musa Yar'Adua and Joseph Garba , ousted Gowon, who fled to Britain. The coup plotters wanted to replace Gowon's autocratic rule with

27412-446: The time European explorers arrived in the late 15th and early 16th centuries and have only been discovered through archeological investigations. Indigenous peoples in present-day Canada include the First Nations , Inuit , and Métis , the last being of mixed descent who originated in the mid-17th century when First Nations people married European settlers and subsequently developed their own identity. The Indigenous population at

27590-446: The time of the first European settlements is estimated to have been between 200,000 and two million, with a figure of 500,000 accepted by Canada's Royal Commission on Aboriginal Peoples . As a consequence of European colonization, the Indigenous population declined by forty to eighty percent. The decline is attributed to several causes, including the transfer of European diseases , to which they had no natural immunity, conflicts over

27768-555: The usefulness of including additional populations in the project. All samples were collected through a community engagement process with appropriate informed consent. The community engagement process was designed to identify and attempt to respond to culturally specific concerns and give participating communities input into the informed consent and sample collection processes. In phase III, 11 global ancestry groups have been assembled: ASW (African ancestry in Southwest USA); CEU (Utah residents with Northern and Western European ancestry from

27946-410: The village of Stadacona . Cartier later used the word Canada to refer not only to that particular village but to the entire area subject to Donnacona (the chief at Stadacona); by 1545, European books and maps had begun referring to this small region along the Saint Lawrence River as Canada . From the 16th to the early 18th century, Canada referred to the part of New France that lay along

28124-423: The war with a large army and strong economy. The financial crisis of the Great Depression led the Dominion of Newfoundland to relinquish responsible government in 1934 and become a Crown colony ruled by a British governor. After two referendums , Newfoundlanders voted to join Canada in 1949 as a province. Canada's post-war economic growth, combined with the policies of successive Liberal governments, led to

28302-413: The war, Nigeria enjoyed an oil boom in the 1970s, during which the country joined OPEC and received huge oil revenues. Despite these revenues, the military government did little to improve the standard of living , help small and medium businesses, or invest in infrastructure. As oil revenues fueled the rise of federal subsidies to states, the federal government became the centre of political struggle and

28480-428: The war. The Conscription Crisis of 1917 erupted when the Unionist Cabinet's proposal to augment the military's dwindling number of active members with conscription was met with vehement objections from French-speaking Quebecers. In 1919, Canada joined the League of Nations independently of Britain, and the Statute of Westminster, 1931 , affirmed Canada's independence. The Great Depression in Canada during

28658-502: The waters of this country". In August 1983, Shagari and the NPN were returned to power in a landslide victory, with a majority of seats in the National Assembly and control of 12 state governments. But the elections were marred by violence, and allegations of widespread vote-rigging and electoral malfeasance led to legal battles over the results. There were also uncertainties, such as in the first republic, that political leaders may be unable to govern properly. The 1983 military coup d'état

28836-419: The widespread cultivation of agricultural products, such as the palm, for use in European industry. The slave trade continued after the ban, as illegal smugglers purchased slaves along the coast from native slavers. Britain's West Africa Squadron sought to intercept the smugglers at sea. The rescued slaves were taken to Freetown , a colony in West Africa originally established by Lieutenant John Clarkson for

29014-410: The world's longest coastline of 243,042 kilometres (151,019 mi). In addition to sharing the world's largest land border with the United States —spanning 8,891 km (5,525 mi) —Canada shares a land border with Greenland (and hence the Kingdom of Denmark ) to the northeast, on Hans Island , and a maritime boundary with France 's overseas collectivity of Saint Pierre and Miquelon to

29192-491: The world, about two million, was concentrated in the territories of the Sokoto Caliphate . The use of slave labour was extensive, especially in agriculture. By the time of its break-up in 1903 into various European colonies, the Sokoto Caliphate was one of the largest pre-colonial African states. A changing legal imperative (the outlawing of the Atlantic slave trade in 1807) and economic imperative (a desire for political and social stability) led most European powers to support

29370-408: Was a coalition of conservative parties: the Northern People's Congress led by Sir Ahmadu Bello , a party dominated by Muslim northerners, and the Igbo and Christian-dominated National Council of Nigeria and the Cameroons led by Nnamdi Azikiwe . The opposition consisted of the comparatively liberal Action Group , which was largely dominated by the Yoruba and led by Obafemi Awolowo . An imbalance

29548-425: Was abolished soon after colonialism. Nigeria gained a degree of self-rule in 1954, and full independence from the United Kingdom on 1 October 1960, as the Federation of Nigeria with Abubakar Tafawa Balewa as its Prime Minister , while retaining the British monarch , Elizabeth II , as nominal head of state and Queen of Nigeria . Azikiwe replaced the colonial governor-general in November 1960. At independence,

29726-567: Was accomplished without intermediate bronze production. Some have suggested the technology moved west from the Nile Valley . But the Iron Age in the Niger River valley and the forest region appears to predate the introduction of metallurgy in the upper savanna by more than 800 years, as well as predating it in the Nile Valley. More recent research suggests that iron metallurgy was developed independently in sub-Saharan Africa . The Nok civilization thrived between 1,500 BC and AD 200. It produced life-sized terracotta figures that are some of

29904-427: Was adopted as the legal name for the new country at the London Conference and the word dominion was conferred as the country's title. By the 1950s, the term Dominion of Canada was no longer used by the United Kingdom, which considered Canada a "realm of the Commonwealth". The Canada Act 1982 , which brought the Constitution of Canada fully under Canadian control, referred only to Canada . Later that year,

30082-525: Was carried out by 10 centres using five different genotyping technologies. Genotyping quality was assessed by using duplicate or related samples and by having periodic quality checks where centres had to genotype common sets of SNPs. The Canadian team was led by Thomas J. Hudson at McGill University in Montreal and focused on chromosomes 2 and 4p. The Chinese team was led by Huanming Yang in Beijing and Shanghai , and Lap-Chee Tsui in Hong Kong and focused on chromosomes 3, 8p and 21. The Japanese team

30260-403: Was coordinated by key officers of the Nigerian military and led to the overthrow of the government and the installation of Major General Muhammadu Buhari as head of state. The military coup of Muhammadu Buhari shortly after the regime's re-election in 1984 was generally viewed as a positive development. In 1985, Ibrahim Babangida overthrew Buhari in a coup d'état. In 1986, Babangida established

30438-412: Was created in the polity as the result of the 1961 plebiscite . Southern Cameroons opted to join the Republic of Cameroon while Northern Cameroons chose to join Nigeria. The northern part of the country became larger than the southern part. The disequilibrium and perceived corruption of the electoral and political process led to two military coups in 1966. The first coup was in January 1966 and

30616-507: Was in turn split from Nova Scotia as part of a reorganization of Loyalist settlements in the Maritimes, which led to the incorporation of Saint John, New Brunswick , as Canada's first city. To accommodate the influx of English-speaking Loyalists in Central Canada, the Constitutional Act of 1791 divided the province of Canada into French-speaking Lower Canada (later Quebec ) and English-speaking Upper Canada (later Ontario ), granting each its own elected legislative assembly. The Canadas were

30794-413: Was led by Yusuke Nakamura at the University of Tokyo and focused on chromosomes 5, 11, 14, 15, 16, 17 and 19. The British team was led by David R. Bentley at the Sanger Institute and focused on chromosomes 1, 6, 10, 13 and 20. There were four United States' genotyping centres: a team led by Mark Chee and Arnold Oliphant at Illumina Inc. in San Diego (studying chromosomes 8q, 9, 18q, 22 and X),

30972-404: Was led mostly by soldiers under Majors Emmanuel Ifeajuna (of the Igbo tribe), Chukwuma Kaduna Nzeogwu ( Northerner of Eastern extraction) and Adewale Ademoyega (a Yoruba from the West). The coup plotters succeeded in assassinating Sir Ahmadu Bello and Sir Abubakar Tafawa Balewa alongside prominent leaders of the Northern Region and Premier Samuel Akintola of the Western Region , but

31150-430: Was passed by Parliament, outlining the terms of a negotiated departure from Confederation. In addition to the issues of Quebec sovereignty, a number of crises shook Canadian society in the late 1980s and early 1990s. These included the explosion of Air India Flight 182 in 1985, the largest mass murder in Canadian history; the École Polytechnique massacre in 1989, a university shooting targeting female students; and

31328-418: Was popular and built around his image as a staunch anti-corruption fighter—he won the election by over two million votes. Observers generally praised the election as being fair. The election marked the first time an incumbent president had lost re-election in Nigeria. In the 2019 presidential election , Buhari was re-elected. Four candidates vied for the presidency in the 2023 presidential election . For

31506-440: Was sworn in as the first President and Commander-in-Chief of the Federal Republic of Nigeria. Obasanjo peacefully transferred power to Shagari, becoming the first head of state in Nigerian history to willingly step down. The Shagari government became viewed as corrupt by virtually all sectors of Nigerian society. In 1983, the inspectors of the state-owned Nigerian National Petroleum Corporation began to notice "the slow poisoning of

31684-501: Was the country's national anthem from 1960 to 1978, as its national anthem, replacing Arise, O Compatriots . Nigeria is located in western Africa on the Gulf of Guinea and has a total area of 923,768 km (356,669 sq mi), making it the world's 32nd-largest country . Its borders span 4,047 kilometres (2,515 mi), and it shares borders with Benin (773 km or 480 mi), Niger (1,497 km or 930 mi), Chad (87 km or 54 mi), and Cameroon (including

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