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107-798: Rostov-on-Don is a port city and the administrative centre of Rostov Oblast and the Southern Federal District of Russia . It lies in the southeastern part of the East European Plain on the Don River , 32 kilometers (20 mi) from the Sea of Azov , directly north of the North Caucasus . The southwestern suburbs of the city lie above the Don river delta . Rostov-on-Don has a population of over one million people and

214-404: A chef-lieu ( French pronunciation: [ʃɛfljø] , plural form chefs-lieux , literally 'chief place' or 'main place'), is a town or city that is important from an administrative perspective. The capital of an Algerian province is called a chef-lieu . The capital of a district , the next largest division, is also called a chef-lieu , whilst the capital of the lowest division,

321-501: A stool test , or a rapid dipstick test , although the dipstick test is less accurate. Prevention methods against cholera include improved sanitation and access to clean water . Cholera vaccines that are given by mouth provide reasonable protection for about six months, and confer the added benefit of protecting against another type of diarrhea caused by E. coli . In 2017, the US Food and Drug Administration (FDA) approved

428-436: A temperate bacteriophage called CTXφ . Microbiologists have studied the genetic mechanisms by which the V. cholerae bacteria turn off the production of some proteins and turn on the production of other proteins as they respond to the series of chemical environments they encounter, passing through the stomach, through the mucous layer of the small intestine, and on to the intestinal wall. Of particular interest have been

535-684: A "port of five seas" (reachable from the Black Sea , the Sea of Azov , the Caspian Sea , the White Sea , and the Baltic Sea ). See the article Port of Rostov-on-Don In modern times, Rostov-on-Don has experienced economic growth. Numerous start-up companies have established headquarters in the city, the median income is increasing, and the city is being transformed into a modern, industrial and technology-rich hub. For instance, Rostov-on-Don

642-477: A central city as chef-lieu of delegation . In the United Kingdom it is the centre of a local authority , which is distinct from a historic county with a county town. Cholera Cholera ( / ˈ k ɒ l ər ə / ) is an infection of the small intestine by some strains of the bacterium Vibrio cholerae . Symptoms may range from none, to mild, to severe. The classic symptom

749-409: A district ( liwa ), or a governorate ( muhafazah ). Luxembourg is divided into two judicial arrondissements (Luxembourg City, Diekirch), four electoral circonscriptions (constituencies), twelve cantons , as well as 100 communes (municipalities; Luxembourgish: Gemengen ). Arrondissements, districts and cantons have each a chef-lieu and are named after it. The same is true for each commune which

856-539: A field of wheat. In 1928, the two towns were merged. The former town border lies beneath the Teatralnaya Square of central Rostov-on-Don. By 1928, following the incorporation of the hitherto neighbouring city of Nakhichevan-on-Don, Rostov had become the third-largest city in Russia. In the early 20th century, epidemics of cholera during the summer months were not uncommon. During World War I Rostov-on-Don

963-439: A fishy odor. An untreated person with cholera may produce 10 to 20 litres (3 to 5 US gal) of diarrhea a day. Severe cholera, without treatment, kills about half of affected individuals. If the severe diarrhea is not treated, it can result in life-threatening dehydration and electrolyte imbalances. Estimates of the ratio of asymptomatic to symptomatic infections have ranged from 3 to 100. Cholera has been nicknamed

1070-428: A greatly reduced pathogen count—though it will not necessarily be perfectly safe, it is an improvement for poor people with limited options. In Bangladesh this practice was found to decrease rates of cholera by nearly half. It involves folding a sari four to eight times. Between uses the cloth should be rinsed in clean water and dried in the sun to kill any bacteria on it. A nylon cloth appears to work as well but

1177-534: A massive inoculation program in British India . Persons who survive an episode of cholera have long-lasting immunity for at least 3 years (the period tested.) A number of safe and effective oral vaccines for cholera are available. The World Health Organization (WHO) has three prequalified oral cholera vaccines (OCVs): Dukoral, Sanchol, and Euvichol. Dukoral , an orally administered, inactivated whole-cell vaccine , has an overall efficacy of about 52% during

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1284-567: A negotiated settlement with the Russian government and military, the Wagner Group withdrew from the city. Within the framework of administrative divisions , it is incorporated as Rostov-na-Donu Urban Okrug —an administrative unit with the status equal to that of the districts . As a municipal division , this administrative unit also has urban okrug status. Rostov-on-Don is divided into eight city districts: The 2021 census recorded

1391-541: A non-toxic B-subunit of cholera toxin and providing protection against V. cholerae O1; and two vaccines developed using the same transfer of technology—ShanChol (Shantha Biotec) and Euvichol (EuBiologics Co.), which have bivalent O1 and O139 oral killed cholera vaccines. Oral cholera vaccination could be deployed in a diverse range of situations from cholera-endemic areas and locations of humanitarian crises, but no clear consensus exists. Developed for use in Bangladesh ,

1498-408: A one-million fold increase in numbers of V. cholerae in the environment. The source of the contamination is typically other people with cholera when their untreated diarrheal discharge is allowed to get into waterways, groundwater or drinking water supplies. Drinking any contaminated water and eating any foods washed in the water, as well as shellfish living in the affected waterway , can cause

1605-430: A person to contract an infection. Cholera is rarely spread directly from person to person . V. cholerae also exists outside the human body in natural water sources, either by itself or through interacting with phytoplankton , zooplankton , or biotic and abiotic detritus. Drinking such water can also result in the disease, even without prior contamination through fecal matter. Selective pressures exist however in

1712-513: A rapid increase in population, with 119,500 residents registered in Rostov by the end of the nineteenth century along with approximately 140 industrial businesses. The harbour was one of the largest trade hubs in southern Russia, especially for the export of wheat , timber , and iron ore . In 1779, Rostov-on-Don became associated with a settlement of Armenian refugees from Crimea at Nakhichevan-on-Don . The two settlements were separated by

1819-530: A result of transmission by food, while in developing countries it is more often water. Food transmission can occur when people harvest seafood such as oysters in waters infected with sewage , as Vibrio cholerae accumulates in planktonic crustaceans and the oysters eat the zooplankton . People infected with cholera often have diarrhea, and disease transmission may occur if this highly liquid stool, colloquially referred to as "rice-water", contaminates water used by others. A single diarrheal event can cause

1926-421: A severe case if they become infected. Any individual, even a healthy adult in middle age, can undergo a severe case, and each person's case should be measured by the loss of fluids, preferably in consultation with a professional health care provider . The cystic fibrosis genetic mutation known as delta-F508 in humans has been said to maintain a selective heterozygous advantage : heterozygous carriers of

2033-742: A single-dose, live, oral cholera vaccine called Vaxchora for adults aged 18–64 who are travelling to an area of active cholera transmission. It offers limited protection to young children. People who survive an episode of cholera have long-lasting immunity for at least three years (the period tested). The primary treatment for affected individuals is oral rehydration salts (ORS), the replacement of fluids and electrolytes by using slightly sweet and salty solutions. Rice-based solutions are preferred. In children, zinc supplementation has also been found to improve outcomes. In severe cases, intravenous fluids , such as Ringer's lactate , may be required, and antibiotics may be beneficial. The choice of antibiotic

2140-533: A site called Zmievskaya Balka . On 19 March 2016, Flydubai Flight 981 , a Boeing 737-800 operating from Dubai to Rostov-on-Don in Russia, crashed during a go-around in inclement weather at Rostov-on-Don Airport , killing all 62 people (55 passengers and 7 crew) on board. Rostov-on-Don hosted several matches of the 2018 FIFA World Cup . Rostov-on-Don is the location of the Russian Southern Military District , which includes

2247-987: A synagogue , a mosque , and the Diamond Way Buddhist Center of the Karma Kagyu Tradition. There are also several Armenian and Greek Orthodox churches in the city, with one of the Armenian churches being the oldest standing building in Rostov. All of the Armenian churches are in the Nakhichevan-on-Don district of the city. See also List of synagogues in Russia and History of the Jews in Rostov-on-Don Administrative centre In countries with French as administrative language (such as Belgium, Luxembourg, Switzerland and many African countries),

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2354-442: A year (uncertainty range: 21,000–143,000) as of 2015 . This occurs mainly in the developing world. In the early 1980s, death rates are believed to have still been higher than three million a year. It is difficult to calculate exact numbers of cases, as many go unreported due to concerns that an outbreak may have a negative impact on the tourism of a country. As of 2004, cholera remained both epidemic and endemic in many areas of

2461-596: Is endemic . If people are immunized broadly, herd immunity results, with a decrease in the amount of contamination in the environment. WHO recommends that oral cholera vaccination be considered in areas where the disease is endemic (with seasonal peaks), as part of the response to outbreaks, or in a humanitarian crisis during which the risk of cholera is high. Oral Cholera Vaccine (OCV) has been recognized as an adjunct tool for prevention and control of cholera. The World Health Organization (WHO) has prequalified three bivalent cholera vaccines—Dukoral (SBL Vaccines), containing

2568-521: Is a center for helicopter and farm machinery manufacturing. The "Tebodin" engineering company opened its fourth office in Rostov-on-Don in June 2010. Public transport in Rostov-on-Don includes buses, trolleybuses, trams, and marshrutkas (routed minibus, usually a 17-passenger Mercedes Sprinter). The Rostov Metro was planned in the early 1990s and later in the 2000s and 2010s. At the end of 2021,

2675-422: Is a common problem. Stool and swab samples collected in the acute stage of the disease, before antibiotics have been administered, are the most useful specimens for laboratory diagnosis. If an epidemic of cholera is suspected, the most common causative agent is V. cholerae O1. If V. cholerae serogroup O1 is not isolated, the laboratory should test for V. cholerae O139. However, if neither of these organisms

2782-524: Is a major shipping lane connecting southwestern Russia with the north. Rostov-on-Don is a trading port for Russian, Italian, Greek and Turkish merchants selling, for example, wool, wheat and oil. It is also an important river port for passengers. The Rostov-on-Don agricultural region produces one-third of Russia's vegetable oil from sunflowers. With the construction of the Volga-Don Shipping Canal in 1952, Rostov-on-Don has become known as

2889-506: Is a term commonly ascribed to the settlement that serves as a municipal administrative centre. This level handles the local administrative and political tasks of the surrounding settlements. Since central place theory was the guiding principle during the municipal reform 1962–1977, most municipalities were dominated by a larger urban area where the political seat was located. Most municipalities are named for their central locality, but there are several exceptions. There are many deviations from

2996-559: Is aided by antibiotic sensitivity testing . Cholera continues to affect an estimated 3–5 million people worldwide and causes 28,800–130,000 deaths a year. To date, seven cholera pandemics have occurred, with the most recent beginning in 1961, and continuing today. The illness is rare in high-income countries , and affects children most severely. Cholera occurs as both outbreaks and chronically in certain areas . Areas with an ongoing risk of disease include Africa and Southeast Asia . The risk of death among those affected

3103-566: Is an important cultural, educational, economic and logistical centre of Southern Russia . From ancient times, the area around the mouth of the Don River has held cultural and commercial importance. Ancient indigenous inhabitants included the Scythian and Sarmatian tribes. It was the site of Tanais , an ancient Greek colony , Fort Tana under the Genoese , and Fort Azak in the time of

3210-442: Is available to determine the presence of V. cholerae . In those samples that test positive, further testing should be done to determine antibiotic resistance. In epidemic situations, a clinical diagnosis may be made by taking a patient history and doing a brief examination. Treatment via hydration and over-the-counter hydration solutions can be started without or before confirmation by laboratory analysis, especially where cholera

3317-478: Is caused by a number of types of Vibrio cholerae , with some types producing more severe disease than others. It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. Undercooked shellfish is a common source. Humans are the only known host for the bacteria . Risk factors for the disease include poor sanitation , insufficient clean drinking water , and poverty . Cholera can be diagnosed by

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3424-599: Is composed of more than one town or village. Usually (with a few exceptions), the commune is named after the communal chef-lieu. In Russia , several million-plus cities in federal districts have the official status of an administrative centre: Moscow (as the main city of the Central Federal District ), Vladivostok , Volgograd , Yekaterinburg , Nizhny Novgorod , Novosibirsk , Pyatigorsk , Rostov-on-Don and St. Petersburg . The main cities of regions and municipal districts are also called unofficially

3531-446: Is effective for adults aged 18–64 as a single dose. One injectable vaccine was found to be effective for two to three years. The protective efficacy was 28% lower in children less than five years old. However, as of 2010 , it has limited availability. Work is under way to investigate the role of mass vaccination. The WHO recommends immunization of high-risk groups, such as children and people with HIV , in countries where this disease

3638-416: Is increasing within cholera bacteria. In Bangladesh , for example, most cases are resistant to tetracycline , trimethoprim-sulfamethoxazole , and erythromycin . Rapid diagnostic assay methods are available for the identification of multi-drug resistant cases. New generation antimicrobials have been discovered which are effective against cholera bacteria in in vitro studies. A rapid dipstick test

3745-487: Is isolated, it is necessary to send stool specimens to a reference laboratory. Infection with V. cholerae O139 should be reported and handled in the same manner as that caused by V. cholerae O1. The associated diarrheal illness should be referred to as cholera and must be reported in the United States. The World Health Organization (WHO) recommends focusing on prevention, preparedness, and response to combat

3852-438: Is large amounts of watery diarrhea lasting a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance . This may result in sunken eyes , cold skin, decreased skin elasticity, and wrinkling of the hands and feet. Dehydration can cause the skin to turn bluish . Symptoms start two hours to five days after exposure. Cholera

3959-460: Is less in those with lowered gastric acidity (for instance those using proton pump inhibitors ). Children are also more susceptible, with two- to four-year-olds having the highest rates of infection. Individuals' susceptibility to cholera is also affected by their blood type , with those with type O blood being the most susceptible. Persons with lowered immunity , such as persons with AIDS or malnourished children, are more likely to develop

4066-754: Is maintained. The WHO only recommends antibiotics in those with severe dehydration. Doxycycline is typically used first line, although some strains of V. cholerae have shown resistance . Testing for resistance during an outbreak can help determine appropriate future choices. Other antibiotics proven to be effective include cotrimoxazole , erythromycin , tetracycline , chloramphenicol , and furazolidone . Fluoroquinolones , such as ciprofloxacin , also may be used, but resistance has been reported. Antibiotics improve outcomes in those who are both severely and not severely dehydrated. Azithromycin and tetracycline may work better than doxycycline or ciprofloxacin . In Bangladesh zinc supplementation reduced

4173-469: Is not as affordable. Continued eating speeds the recovery of normal intestinal function. The WHO recommends this generally for cases of diarrhea no matter what the underlying cause. A CDC training manual specifically for cholera states: "Continue to breastfeed your baby if the baby has watery diarrhea, even when traveling to get treatment. Adults and older children should continue to eat frequently." The most common error in caring for patients with cholera

4280-442: Is rapid and thready, and urine output decreases with time. Muscle cramping and weakness, altered consciousness, seizures , or even coma due to electrolyte imbalances are common, especially in children. Cholera bacteria have been found in shellfish and plankton . Transmission is usually through the fecal-oral route of contaminated food or water caused by poor sanitation . Most cholera cases in developed countries are

4387-406: Is rare. For example, the last major outbreak of cholera in the United States occurred in 1910–1911. Cholera is mainly a risk in developing countries in those areas where access to WASH (water, sanitation and hygiene) infrastructure is still inadequate. Effective sanitation practices, if instituted and adhered to in time, are usually sufficient to stop an epidemic. There are several points along

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4494-787: Is recorded. The decoration is worn over the suit on a large chain. The mayor returns the decoration to the Duma on his or her retirement from office. The Emblem of the Don Host Oblast was introduced in July ;5 (18), 1878. The flag of the All Great Don Army was introduced in May 1918 on the "Circle of the Don Saving". Rostov's favourable geographical position at trading crossroads promotes economic development. The Don River

4601-490: Is taken out of the building only on Victory Day and Rostov-on-Don Day by a guard of honour. In 1870, an oval-shaped mayoral decoration wrought from precious or semi-precious white metal was introduced. On the front is written "Rostov-on-Don" at the top, the Rostov-on-Don coat-of-arms is in the center and the inscription, "Mayor of the City" is written at the bottom. On its reverse side, the day of its adoption, April 9, 1996,

4708-586: Is the preferred solution, often with added potassium. Large volumes and continued replacement until diarrhea has subsided may be needed. Ten percent of a person's body weight in fluid may need to be given in the first two to four hours. This method was first tried on a mass scale during the Bangladesh Liberation War , and was found to have much success. Despite widespread beliefs, fruit juices and commercial fizzy drinks like cola are not ideal for rehydration of people with serious infections of

4815-404: Is to underestimate the speed and volume of fluids required. In most cases, cholera can be successfully treated with oral rehydration therapy (ORT), which is highly effective, safe, and simple to administer. Rice-based solutions are preferred to glucose-based ones due to greater efficiency. In severe cases with significant dehydration, intravenous rehydration may be necessary. Ringer's lactate

4922-553: Is usually less than 5%, given improved treatment, but may be as high as 50% without such access to treatment. Descriptions of cholera are found as early as the 5th century BC in Sanskrit . In Europe, cholera was a term initially used to describe any kind of gastroenteritis, and was not used for this disease until the early 19th century. The study of cholera in England by John Snow between 1849 and 1854 led to significant advances in

5029-605: The 58th Combined Arms Army . As such, it was a key logistical hub during the 2022 Russian invasion of Ukraine and the 2023 Ukrainian counteroffensive . On 23 June 2023, amid the war, the Wagner Group , a private military company fighting on behalf of the Russian Federation , declared a rebellion against the Russian Ministry of Defence and took control of Rostov-on-Don. On June 24, after reaching

5136-449: The Gs alpha subunit of the heterotrimeric G protein . This results in constitutive cAMP production, which in turn leads to the secretion of water, sodium, potassium, and bicarbonate into the lumen of the small intestine and rapid dehydration. The gene encoding the cholera toxin was introduced into V. cholerae by horizontal gene transfer . Virulent strains of V. cholerae carry a variant of

5243-703: The Ottoman Empire . In 1749, a custom house was established on the Temernik River , a tributary of the Don, by edict of the Empress Elizabeth , the daughter of Peter the Great , in order to control trade with Turkey . It was co-located with a fortress named for Dimitry of Rostov , a metropolitan bishop of the old northern town of Rostov the Great . Azov , a town closer to the Sea of Azov on

5350-604: The Russian Empire , the settlement lost much of its militarily strategic importance as a frontier post. In 1796, the settlement was chartered and in 1797, it became the seat of Rostovsky Uyezd within Novorossiysk Governorate . In 1806, it was officially renamed Rostov-on-Don. During the 19th century, due to its river connections with Russia's interior, Rostov developed into a major trade centre and communications hub. A railway connection with Kharkiv

5457-501: The Stockholm metropolitan area . The term central locality has no legal standing and it is unclear how it should be applied to these municipalities. Some municipalities appointing one or several localities to be the central locality. A residence city (Swedish: "residensstad") is the town or city which is the political and administrative seat of the county . This level handles the more regional political and administrative tasks of

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5564-512: The Västra Götaland Region . The term chef-lieu is applied to the capital of each Swiss canton . In 16 of the 26 cantons, the territory is subdivided into districts. Every district also has a location nominated as chef-lieu and each has a prefect. The term chef-lieu is used to designate the capital of each gouvernorat (department). Each of the 24 gouvernorats is subdivided into delegations (districts) which each have

5671-406: The human stomach . The few surviving bacteria conserve their energy and stored nutrients during the passage through the stomach by shutting down protein production. When the surviving bacteria exit the stomach and reach the small intestine , they must propel themselves through the thick mucus that lines the small intestine to reach the intestinal walls where they can attach and thrive. Once

5778-473: The municipalities , is called agglomération de chef-lieu (chef-lieu agglomeration ) and is abbreviated as A.C.L. The chef-lieu in Belgium is the administrative centre of each of the ten provinces of Belgium . Three of these cities also give their name to their province ( Antwerp , Liège and Namur ). The chef-lieu of a département is known as the préfecture . This is the town or city where

5885-479: The potassium level may be normal, even though large losses have occurred. As the dehydration is corrected, potassium levels may decrease rapidly, and thus need to be replaced. This is best done by Oral Rehydration Solution (ORS). Antibiotic treatments for one to three days shorten the course of the disease and reduce the severity of the symptoms. Use of antibiotics also reduces fluid requirements. People will recover without them, however, if sufficient hydration

5992-469: The prefect of the department (and all services under their control) are situated, in a building known as the prefecture . In every French region , one of the departments has pre-eminence over the others, and the prefect carries the title of Prefect of region X..., Prefect of Department Z... and the city where the regional prefect is found is known as chef-lieu of the region or, more commonly, Regional prefecture . The services are, however, controlled by

6099-515: The "blue death" because a person's skin may turn bluish-gray from extreme loss of fluids. Fever is rare and should raise suspicion for secondary infection. Patients can be lethargic and might have sunken eyes, dry mouth, cold clammy skin, or wrinkled hands and feet. Kussmaul breathing , a deep and labored breathing pattern, can occur because of acidosis from stool bicarbonate losses and lactic acidosis associated with poor perfusion . Blood pressure drops due to dehydration, peripheral pulse

6206-411: The "sari filter" is a simple and cost-effective appropriate technology method for reducing the contamination of drinking water. Used sari cloth is preferable but other types of used cloth can be used with some effect, though the effectiveness will vary significantly. Used cloth is more effective than new cloth, as the repeated washing reduces the space between the fibers. Water collected in this way has

6313-480: The 1990s, the chef-lieu has transitioned from the location of the Governor, Commandant, or Prefect and their staff, to the location of Commune, Cercles of Mali / Departments of Niger , and Regional Councils and a variety of decentralized bodies. The chefs-lieux of a Region, Cercle or Département, is usually also a Communal chef-lieu. Both nations collect these councils in a "High Council of Collectivites" seated at

6420-689: The Academic Drama Theater named after Maxim Gorky works Mikhail Bushnov, who is the national artist of the USSR and an honorary citizen of Rostov-on-Don. The small collections of the Art Gallery and the Museum of Arts include some works by Repin, Surikov, Perov, Levitan and Aivazovsky as well as modern Rostov artists. Other facilities include seven stadiums, a Palace of Sports, a circus, a zoo botanical gardens and parks. Rostov-on-Don hosts

6527-539: The City Duma. The flag of Rostov-on-Don was approved by the Duma on September 20, 1864. At the end of the 19th and beginning of the 20th centuries the home guard regiments, which defended the Southern borders of Russia, were raised under this flag. The "Flag of Rostov" is kept in the town's municipal building under glass. Its length is 1,370 millimeters (54 in) and width, 850 millimeters (33 in). The flag

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6634-417: The Don, gradually lost its commercial importance in the region to the new fortress, but it remains an important historical center. In 1756, the "Russian commercial and trading company of Constantinople" was founded at the "merchants' settlement" (Kupecheskaya Sloboda) on the high bank of the Don. Towards the end of the eighteenth century, with the incorporation of previously Ottoman Black Sea territories into

6741-665: The German First Panzer Army in the Battle of Rostov , and then for seven months from 24 July 1942 to 14 February 1943. The town was of strategic importance as a railway junction and a river port accessing the Caucasus , a region rich in oil and minerals. It took ten years to restore the city from the damage during World War II. In 1942 up to 30,000 Russian Jews were massacred by the German military in Rostov-on-Don at

6848-680: The Government of the Rostov Region and the Sinara company signed an agreement on the creation of a high-speed tramway in Rostov-on-Don on a concession basis. This happened at the international forum Transport Week 2021 in Moscow. By signing this agreement, the regional government put an end to the idea of developing the metro in the city in favour of the tram. The Rostov-on-Don Airport caters for domestic travel, as well as flights to and from

6955-739: The North Caucasian Science Center and research institutes. The city is also home to a Starbucks coffee chain, a true rarity in this geographical area of Russia. The Administration of Rostov and Novocherkassk Eparchy of the Russian Orthodox Church is located in Rostov. Other religious facilities in Rostov-on-Don are the Roman Catholic "Church of the Lord's Supper", the Old Believers ' temple,

7062-838: The South of Russia, Rostovsoсbank , was opened in Rostov-on-Don. The bank existed from 1989 to 1998, and before the withdrawal of the banking license it made a full return of deposits to all depositors. The largest bank in the Rostov region is Center-Invest . In total, there are about 50 banks and their branches, 17% local banks, 80% representative offices of federal banks, and 4% representative offices of foreign banks. Rostov-on-Don hosts higher educational establishments, including universities, academies, secondary schools of vocational training including colleges, technical schools, specialized schools, and elementary schools of vocational training including lyceums, professional colleges and schools of general education. The largest educational establishments in

7169-499: The administration being devolved usually to the Secretary-general of the departmental prefecture , who functions as sub-prefect for the arrondissement. The chef-lieu of a canton is usually the biggest city or town within the canton, but has only a nominal role. No specific services are controlled by it. In past decades, there was always a Gendarmerie , a treasurer and a justice of the peace. The chef-lieu indicates

7276-430: The administrative centre or simply the centre. The only exception to this rule is the republics , for which the term " capital " is used to refer to the seat of government. The capital of Russia is also an entity to which the term "administrative centre" does not apply. In Sweden there are two levels of administrative centre; the local municipal and the regional county . Central locality ( Swedish : "centralort")

7383-501: The administrative subdivisions down to the Commune level each have a formal place of administrative headquarters, titled the chef-lieu. The larger portion of the terminology of administrative division is inherited from colonial rule as part of French West Africa , and has survived and been somewhat modified over time. In both nations there have been remarkably parallel histories. With the decentralization process begun in both nations in

7490-474: The aquatic environment that may reduce the virulence of V. cholerae . Specifically, animal models indicate that the transcriptional profile of the pathogen changes as it prepares to enter an aquatic environment. This transcriptional change results in a loss of ability of V. cholerae to be cultured on standard media, a phenotype referred to as ' viable but non-culturable ' (VBNC) or more conservatively ' active but non-culturable ' (ABNC). One study indicates that

7597-450: The central locality principle. Some municipalities are dominated by two or more towns of similar size, and sometimes they share the municipal administration, with the municipality having its official address in one of the towns. For example, both Skillingaryd and Vaggeryd are central localities of Vaggeryd Municipality . Conversely, there are municipalities within metropolitan areas . For example, there are twenty-six municipalities within

7704-422: The cholera bacteria reach the intestinal wall, they no longer need the flagella to move. The bacteria stop producing the protein flagellin to conserve energy and nutrients by changing the mix of proteins that they express in response to the changed chemical surroundings. On reaching the intestinal wall, V. cholerae start producing the toxic proteins that give the infected person a watery diarrhea. This carries

7811-612: The cholera transmission path at which its spread may be halted: Handwashing with soap or ash after using a toilet and before handling food or eating is also recommended for cholera prevention by WHO Africa. Surveillance and prompt reporting allow for containing cholera epidemics rapidly. Cholera exists as a seasonal disease in many endemic countries, occurring annually mostly during rainy seasons . Surveillance systems can provide early alerts to outbreaks, therefore leading to coordinated response and assist in preparation of preparedness plans. Efficient surveillance systems can also improve

7918-409: The cities of Rostov-on-Don, Novocherkassk , Taganrog , Aksay , Bataysk , and Azov . In 1929, the first automatic telephone exchange in Russia with a capacity of 6,000 numbers commenced in Rostov-on-Don. Since 2004, standard telephone numbers in Rostov-on-Don have been seven digits in length. Since 2009, city numbers have begun with "2". The city dialing code is "863". The first commercial bank in

8025-701: The city include: There is also a French cultural centre (Alliance Francaise), a British Council and German Goethe Institute (DAAD and Bosch foundation), and a Korean Cultural Centre. The most conspicuous architectural feature of the central part of the city is the Cathedral of the Nativity of the Blessed Virgin Mary (1860–1887), designed by Konstantin Thon . Rostov-on-Don's libraries include: In

8132-594: The coat-of-arms is kept in the regional local history museum but its accuracy and authenticity are uncertain. In June 1996, the Rostov-on-Don City Duma adopted a variant of the coat-of-arms in which a tower represents the St. Dimitry Rostovsky Fortress. The ancient Russian arms reference the role Rostov played in the defense of Russia's borders. The coat-of-arms adorns the mayor's decoration but all other cases of its use are first considered for approval by

8239-504: The county, such as healthcare and public transport . The name comes from that this is the town or city where the governor ( Swedish : "landshövding") have their residence . There are some exceptions to this, however. In the newer amalgamated "greater counties", often referred to as "regions", the administrative centre is placed in one of the older residence cities . Examples of this is Malmö in Region Scania and Gothenburg in

8346-424: The culturability of V. cholerae drops 90% within 24 hours of entering the water, and furthermore that this loss in culturability is associated with a loss in virulence. Both toxic and non-toxic strains exist. Non-toxic strains can acquire toxicity through a temperate bacteriophage . About 100   million bacteria must typically be ingested to cause cholera in a normal healthy adult. This dose, however,

8453-433: The duration and severity of diarrhea in children with cholera when given with antibiotics and rehydration therapy as needed. It reduced the length of disease by eight hours and the amount of diarrhea stool by 10%. Supplementation appears to be also effective in both treating and preventing infectious diarrhea due to other causes among children in the developing world. If people with cholera are treated quickly and properly,

8560-633: The east and crosses the Don River in the Aksay city area. The "Rostov-Novoshakhtinsk" starts from the Northern housing block area of the city running north to connect with the M-4 "Don" route between Shakhty and Novoshakhtinsk. The Ministry of Regional Development of Russia has prepared a program to create eight multimillion conglomerate population centees or 'super cities'. The Rostov Oblast will be one of these. "The Greater Rostov" metropolitan area will include

8667-443: The field of epidemiology because of his insights about transmission via contaminated water, and a map of the same was the first recorded incidence of epidemiological tracking. The primary symptoms of cholera are profuse diarrhea and vomiting of clear fluid. These symptoms usually start suddenly, half a day to five days after ingestion of the bacteria. The diarrhea is frequently described as "rice water" in nature and may have

8774-489: The first to immunize humans against a bacterial disease. His vaccine and inoculation was rather controversial and was rejected by his peers and several investigation commissions but it ended up demonstrating its effectiveness and being recognized for it: out of the 30 thousand people he vaccinated only 54 died. Russian-Jewish bacteriologist Waldemar Haffkine also developed a human cholera vaccine in July 1892. He conducted

8881-480: The first year after being given and 62% in the second year, with minimal side effects. It is available in over 60 countries. However, it is not currently recommended by the Centers for Disease Control and Prevention (CDC) for most people traveling from the United States to endemic countries. The vaccine that the US Food and Drug Administration (FDA) recommends, Vaxchora , is an oral attenuated live vaccine , that

8988-470: The former C.I.S., Europe, Africa and Asia. Its IATA code is "ROV". Donavia airlines (formerly "Aeroflot Don") has its head office in Rostov-on-Don. The Bataysk military aerodrome (which is located 5.0 miles (8.0 km) northwest of the city center) may be developed into a new airport hub for Southern Russia. Platov International Airport was opened in late 2017 as part of preparations for the 2018 FIFA World Cup . The international river port specializes in

9095-420: The genetic mechanisms by which cholera bacteria turn on the protein production of the toxins that interact with host cell mechanisms to pump chloride ions into the small intestine, creating an ionic pressure which prevents sodium ions from entering the cell. The chloride and sodium ions create a salt-water environment in the small intestines, which through osmosis can pull up to six liters of water per day through

9202-462: The genetic structure. Two clusters have been identified: Cluster I and Cluster II. For the most part, Cluster I consists of strains from the 1960s and 1970s, while Cluster II largely contains strains from the 1980s and 1990s, based on the change in the clone structure. This grouping of strains is best seen in the strains from the African continent. In many areas of the world, antibiotic resistance

9309-466: The intestinal cells, creating the massive amounts of diarrhea. The host can become rapidly dehydrated unless treated properly. By inserting separate, successive sections of V. cholerae DNA into the DNA of other bacteria, such as E. coli that would not naturally produce the protein toxins, researchers have investigated the mechanisms by which V. cholerae responds to the changing chemical environments of

9416-400: The intestines, and their excessive sugar content may even harm water uptake. If commercially produced oral rehydration solutions are too expensive or difficult to obtain, solutions can be made. One such recipe calls for 1 liter of boiled water, 1/2 teaspoon of salt, 6 teaspoons of sugar, and added mashed banana for potassium and to improve taste. As there frequently is initially acidosis ,

9523-505: The mortality rate is less than 1%; however, with untreated cholera, the mortality rate rises to 50–60%. For certain genetic strains of cholera, such as the one present during the 2010 epidemic in Haiti and the 2004 outbreak in India, death can occur within two hours of becoming ill. Cholera affects an estimated 2.8 million people worldwide, and causes approximately 95,000 deaths

9630-448: The multiplying new generations of V. cholerae bacteria out into the drinking water of the next host if proper sanitation measures are not in place. The cholera toxin (CTX or CT) is an oligomeric complex made up of six protein subunits : a single copy of the A subunit (part A), and five copies of the B subunit (part B), connected by a disulfide bond . The five B subunits form a five-membered ring that binds to GM1 gangliosides on

9737-400: The mutation (who are not affected by cystic fibrosis) are more resistant to V. cholerae infections. In this model, the genetic deficiency in the cystic fibrosis transmembrane conductance regulator channel proteins interferes with bacteria binding to the intestinal epithelium , thus reducing the effects of an infection. When consumed, most bacteria do not survive the acidic conditions of

9844-644: The nation's capital. Smaller sub-divisions in Mali's Communes (Villages, Tribal councils, Quarters) are administered from or identified as a Place / Site ( Site in French), so the chef-lieu is literally the Chief-Place even at the lowest level. In the Hashemite Kingdom of Jordan , the administrative centres are known as "chief towns" or nahias . Nahias may be in charge of a sub-district ( qda ),

9951-452: The packaging and freighting of minerals and timber. Shipping information is published online. The main railway stations in Rostov-on-Don are " Rostov-Glavny " and "Rostov-Prigorodny". The "St. Petersburg-Rostov-Caucasus" railway crosses the territory of Rostov-on-Don. The North Caucasus Railway Administration Building is in Rostov-on-Don. Several highways of federal and regional significance cross Rostov. The M-4 "Don" route passes Rostov to

10058-789: The population of Rostov-on-Don at 1,142,162 making it the 11th most populous city in Russia . At the time of the official 2010 Census, the ethnic makeup of the city's population whose ethnicity was known (1,066,523) was: Albert Parry , born in 1901 in Rostov-on-Don, wrote of the summers of his childhood: Rostov-on-Don lies in a humid continental climate ( Köppen : Dfa ). The winter is moderately cold, with an average January temperature of −3.0 °C (26.6 °F). The lowest recorded temperature of −31.9 °C (−25.4 °F) occurred in January 1940. Summers are warm and humid; July temperatures average +23.4 °C (74.1 °F). The city's highest recorded temperature of +40.2 °C (104.4 °F)

10165-405: The prefecture of the department. The chef-lieu of an arrondissement , commonly known as the sous-préfecture is the city or town where the sub-prefect of the arrondissement (and the services directly under their control) are situated, in a building called the sub-prefecture . The arrondissement where the département prefecture is located does not normally have a sub-prefect or sub-prefecture,

10272-469: The principal city of the provinces of New Caledonia. So Nouméa is the chef-lieu of South Province. But the chef-lieu can also mean the principal area within a town. So Wé is part of the town of Lifou , but is the chef-lieu of Lifou. In the Loyalty Islands and the other islands, the name of the chef-lieu differs from that of the name of the town. For the towns of the mainland, the chef-lieu has

10379-399: The risk assessment for potential cholera outbreaks. Understanding the seasonality and location of outbreaks provides guidance for improving cholera control activities for the most vulnerable. For prevention to be effective, it is important that cases be reported to national health authorities. Spanish physician Jaume Ferran i Clua developed the first successful cholera inoculation in 1885,

10486-596: The same name as the town. Nouméa is a town composed only of Nouméa. Many of the West African states which gained independence from France in the mid-20th century also inherited the French administrative structure of Departments and Communes, headed by a Chief-Lieu . States still using Chief-Lieu to identify the administrative headquarters of a government subdivision include Senegal , Burkina Faso , Benin , Mali , and Niger . Taking Niger and Mali as examples,

10593-406: The spread of cholera. They also stress the importance of an effective surveillance system. Governments can play a role in all of these areas. Although cholera may be life-threatening, prevention of the disease is normally straightforward if proper sanitation practices are followed. In developed countries , due to their nearly universal advanced water treatment and sanitation practices, cholera

10700-646: The stomach, mucous layers, and intestinal wall. Researchers have discovered a complex cascade of regulatory proteins controls expression of V. cholerae virulence determinants. In responding to the chemical environment at the intestinal wall, the V. cholerae bacteria produce the TcpP/TcpH proteins, which, together with the ToxR/ToxS proteins, activate the expression of the ToxT regulatory protein. ToxT then directly activates expression of virulence genes that produce

10807-613: The surface of the intestinal epithelium cells. The A1 portion of the A subunit is an enzyme that ADP-ribosylates G proteins , while the A2 chain fits into the central pore of the B subunit ring. Upon binding, the complex is taken into the cell via receptor-mediated endocytosis . Once inside the cell, the disulfide bond is reduced, and the A1 subunit is freed to bind with a human partner protein called ADP-ribosylation factor 6 (Arf6). Binding exposes its active site, allowing it to permanently ribosylate

10914-410: The toxins, causing diarrhea in the infected person and allowing the bacteria to colonize the intestine. Current research aims at discovering "the signal that makes the cholera bacteria stop swimming and start to colonize (that is, adhere to the cells of) the small intestine." Amplified fragment length polymorphism fingerprinting of the pandemic isolates of V. cholerae has revealed variation in

11021-451: The world. Recent major outbreaks are the 2010s Haiti cholera outbreak and the 2016–2022 Yemen cholera outbreak . In October 2016, an outbreak of cholera began in war-ravaged Yemen . WHO called it "the worst cholera outbreak in the world". In 2019, 93% of the reported 923,037 cholera cases were from Yemen (with 1911 deaths reported). Between September 2019 and September 2020, a global total of over 450,000 cases and over 900 deaths

11128-970: Was briefly occupied by the German Empire in 1918. During the Russian Civil War , the Whites and the Reds contested Rostov-on-Don, then the most heavily industrialized city of South Russia. By 1928, the regional government had moved from the old Cossack capital of Novocherkassk to Rostov-on-Don. In the Soviet years, the Bolsheviks demolished two of Rostov-on-Don's principal landmarks: St. Alexander Nevsky Cathedral (1908) and St. George Cathedral (1783–1807). During World War II , Nazi German forces occupied Rostov-on-Don, at first from 19/20 November to 2 December 1941, after attacks by

11235-460: Was completed in 1870, with further links following in 1871 to Voronezh and in 1875 to Vladikavkaz . Concurrent with improvements in communications, heavy industry developed. Coal from the Donets Basin and iron ore from Krivoy Rog supported the establishment of an iron foundry in 1846. In 1859, the production of pumps and steam boilers began. Industrial growth was accompanied by

11342-487: Was reported on 7 July 2020. The mean annual precipitation is 643 millimeters (25.3 in), the average wind speed is 2.7 m/s, and the average air humidity is 72%. In December 1996, Rostov-on-Don adopted a coat of arms, a flag and a mayoral decoration as the symbols of the town. The first coat of arms of Rostov-on-Don was designed in 1811 and approved by the Tsar. In 1904, some changes were made. One lasting oil painting of

11449-629: Was reported; however, the accuracy of these numbers suffer from over-reporting from countries that report suspected cases (and not laboratory confirmed cases), as well as under-reporting from countries that do not report official cases (such as Bangladesh, India and Philippines). Although much is known about the mechanisms behind the spread of cholera, researchers still do not have a full understanding of what makes cholera outbreaks happen in some places and not others. Lack of treatment of human feces and lack of treatment of drinking water greatly facilitate its spread. Bodies of water have been found to serve as

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