3VCL , 4U1H , 4U1K , 5EO1 , 5EO0 ,%%s 1AGB , 1AGC , 1AGD , 1AGE , 1AGF , 1M05 , 1MI5 , 3FFC , 3SJV , 3SKM , 3SKO , 3SPV , 3X13 , 3X14 , 4QRP , 4QRQ , 4QRS , 4QRT , 4QRU ,%%s 4O2C , 4O2E , 4O2F ,%%s 3LN4 , 3LN5 ,%%s 4U1J , 4U1M , 4U1N ,%%s 4U1I , 4U1L , 4U1S ,%%s 1HSA , 1JGD , 1JGE , 1K5N , 1OF2 , 1OGT , 1UXS , 1UXW , 1W0V , 1W0W , 2A83 , 2BSR , 2BSS , 2BST , 3B3I , 3B6S , 3BP4 , 3BP7 , 3CZF , 3D18 , 3DTX , 3HCV , 3LV3 , 4G8G , 4G8I , 4G9D , 4G9F , 5DEF , 5DEG ,%%s 1A1N , 1A9B , 1A9E , 1CG9 , 1XH3 , 1ZHK , 1ZHL , 1ZSD , 2AK4 , 2AXF , 2AXG , 2H6P , 2NW3 , 2NX5 , 3BW9 , 3BWA , 3KWW , 3KXF , 3LKN , 3LKO , 3LKP , 3LKQ , 3LKR , 3LKS , 3MV7 , 3MV8 , 3MV9 , 3VFS , 3VFT , 3VFU , 3VFV , 3VFW , 4LNR , 4PR5 , 4PRN , 4QRR ,%%s 1A1M , 1A1O ,%%s 2BVO , 2BVP , 2BVQ , 2HJL , 2RFX , 2YPK , 2YPL , 3UPR , 3VH8 , 3VRI , 3VRJ , 3WUW , 3X11 , 3X12 , 5B39 , 5B38 ,%%s 4JQV , 4XXC ,%%s 1XR8 , 1XR9 , 3C9N ,%%s 4LCY ,%%s 1M6O , 1N2R , 1SYV , 3DX6 , 3DX7 , 3DX8 , 3DXA , 3KPL , 3KPM , 3KPN , 3KPO , 3KPP , 3KPQ , 3KPR , 3KPS , 3L3D , 3L3G , 3L3I , 3L3J , 4JQX ,%%s 1E27 , 1E28 , 4MJI ,%%s 3W39
143-421: 3106 n/a ENSG00000232126 n/a P01889 n/a NM_005514 n/a NP_005505 n/a HLA-B ( major histocompatibility complex, class I, B ) is a human gene that provides instructions for making a protein that plays a critical role in the immune system . HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish
286-415: A multi-layered network of cooperating, distinct, or even competing social groups – from families and peer groups to corporations and political states . As such, social interactions between humans have established a wide variety of values, social norms , languages , and traditions (collectively termed institutions ), each of which bolsters human society . Humans are also highly curious , with
429-612: A population genetic study, Singapore is "the country with the biggest proportion of Han Chinese" in Southeast Asia. Singapore is the only nation in the world where Overseas Chinese constitute a majority of the population and remain the country's cultural, economic and politically dominant arbiters vis-à-vis their non-Han minority counterparts. Up until the past few decades, overseas Han communities originated predominantly from areas in Eastern and Southeastern China (mainly from
572-668: A theory of mind . The human mind is capable of introspection , private thought , imagination , volition , and forming views on existence . This has allowed great technological advancements and complex tool development through complex reasoning and the transmission of knowledge to subsequent generations through language . Humans have had a dramatic effect on the environment . They are apex predators , being rarely preyed upon by other species. Human population growth , industrialization, land development, overconsumption and combustion of fossil fuels have led to environmental destruction and pollution that significantly contributes to
715-443: A consequence of better nutrition, healthcare, and living conditions. The average mass of an adult human is 59 kg (130 lb) for females and 77 kg (170 lb) for males. Like many other conditions, body weight and body type are influenced by both genetic susceptibility and environment and varies greatly among individuals. Humans have a far faster and more accurate throw than other animals. Humans are also among
858-446: A culturally, economically and politically dominant majority vis-à-vis the non-Han minorities throughout most of China's recorded history. Han Chinese are almost the majority in every Chinese province, municipality and autonomous region except for the autonomous regions of Xinjiang (38% or 40% in 2010) and Tibet Autonomous Region (8% in 2014), where Uighurs and Tibetans are the majority, respectively. Han Chinese also constitute
1001-419: A few other places), saw the emergence of agriculture and permanent human settlement ; in turn, this led to the development of civilization and kickstarted a period of continuous (and ongoing) population growth and rapid technological change . Since then, a number of civilizations have risen and fallen, while a number of sociocultural and technological developments have resulted in significant changes to
1144-463: A great capacity for altering their habitats by means of technology, irrigation , urban planning , construction, deforestation and desertification . Human settlements continue to be vulnerable to natural disasters , especially those placed in hazardous locations and with low quality of construction. Grouping and deliberate habitat alteration is often done with the goals of providing protection, accumulating comforts or material wealth, expanding
1287-530: A group of related inflammatory joint diseases. Some of these diseases are associated with a common skin condition called psoriasis or chronic inflammatory bowel disorders ( Crohn's disease and ulcerative colitis ). One of the spondyloarthropathies, reactive arthritis , is typically triggered by bacterial infections of the gastrointestinal or genital tract. Following an infection, affected individuals may develop arthritis, back pain, and eye inflammation. Like ankylosing spondylitis, many factors probably contribute to
1430-612: A higher body fat percentage. At puberty , humans develop secondary sex characteristics . Females are capable of pregnancy , usually between puberty, at around 12 years old, and menopause , around the age of 50. As omnivorous creatures, they are capable of consuming a wide variety of plant and animal material, and have used fire and other forms of heat to prepare and cook food since the time of Homo erectus . Humans can survive for up to eight weeks without food and several days without water . Humans are generally diurnal , sleeping on average seven to nine hours per day. Childbirth
1573-475: A human can lose personhood (such as by going into a persistent vegetative state ). Humans are apes ( superfamily Hominoidea ). The lineage of apes that eventually gave rise to humans first split from gibbons (family Hylobatidae) and orangutans (genus Pongo ), then gorillas (genus Gorilla ), and finally, chimpanzees and bonobos (genus Pan ). The last split, between the human and chimpanzee–bonobo lineages, took place around 8–4 million years ago, in
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#17327835202201716-581: A more barrel-shaped chests in contrast to the funnel shape of other apes, an adaptation for bipedal respiration. Apart from bipedalism and brain size, humans differ from chimpanzees mostly in smelling , hearing and digesting proteins . While humans have a density of hair follicles comparable to other apes, it is predominantly vellus hair , most of which is so short and wispy as to be practically invisible. Humans have about 2 million sweat glands spread over their entire bodies, many more than chimpanzees, whose sweat glands are scarce and are mainly located on
1859-504: A much clearer picture of life at the time. Between the 8th and 6th century BCE, Europe entered the classical antiquity age, a period when ancient Greece and ancient Rome flourished. Around this time other civilizations also came to prominence. The Maya civilization started to build cities and create complex calendars . In Africa, the Kingdom of Aksum overtook the declining Kingdom of Kush and facilitated trade between India and
2002-505: A resemblance to the areas they had left behind in China, regardless of whether they arrived in the north or south of Taiwan. Hoklo immigrants from Quanzhou settled in coastal regions and those from Zhangzhou tended to gather on inland plains, while the Hakka inhabited hilly areas. Clashes and tensions between the two groups over land, water, ethno-racial, and cultural differences led to
2145-451: A result, humans are a cosmopolitan species found in almost all regions of the world, including tropical rainforest , arid desert , extremely cold arctic regions , and heavily polluted cities; in comparison, most other species are confined to a few geographical areas by their limited adaptability. The human population is not, however, uniformly distributed on the Earth 's surface, because
2288-429: A rich history that spans thousands of years, with their historical roots dating back to the days of ancient China . Throughout Han history, China has been governed by dynasties , with periods during which it has seen cycles of expansion, contraction, unity, and fragmentation. Due to the overwhelming numerical and cultural dominance of Han culture in China, most of the written history of China can be read as "a history of
2431-413: A severe skin disorder called Stevens–Johnson syndrome in response to carbamazepine (a drug used to treat seizures). Another version, HLA-B*5801, is associated with an increased risk of severe skin reactions in people treated with allopurinol (a drug used to treat gout , which is a form of arthritis caused by uric acid in the joints). Among people with human immunodeficiency virus (HIV) infection,
2574-639: A similar species. Migrating out of Africa , they gradually replaced and interbred with local populations of archaic humans. Multiple hypotheses for the extinction of archaic human species such as Neanderthals include competition, violence , interbreeding with Homo sapiens , or inability to adapt to climate change . Humans began exhibiting behavioral modernity about 160,000–60,000 years ago. For most of their history, humans were nomadic hunter-gatherers. The Neolithic Revolution , which began in Southwest Asia around 13,000 years ago (and separately in
2717-515: A simple linear or branched progression but involved interbreeding between related species . Genomic research has shown that hybridization between substantially diverged lineages was common in human evolution. DNA evidence suggests that several genes of Neanderthal origin are present among all non sub-Saharan-African populations, and Neanderthals and other hominins, such as Denisovans , may have contributed up to 6% of their genome to present-day non sub-Saharan-African humans. Human evolution
2860-451: A successful labor increased significantly during the 20th century in wealthier countries with the advent of new medical technologies. In contrast, pregnancy and natural childbirth remain hazardous ordeals in developing regions of the world, with maternal death rates approximately 100 times greater than in developed countries. Both the mother and the father provide care for human offspring, in contrast to other primates, where parental care
3003-526: A version of HLA-B designated HLA-B*5701 is associated with an extreme sensitivity to abacavir . This drug is a treatment for HIV-1 that slows the spread of the virus in the body. People with abacavir hypersensitivity often develop a fever, chills, rash, upset stomach, and other symptoms when treated with this drug. Several other variations of the HLA-B gene appear to play a role in the progression of HIV infection to acquired immunodeficiency syndrome ( AIDS ). AIDS
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#17327835202203146-497: A wide range of foreign invaders. Hundreds of versions (alleles) of HLA-B are known, each of which is given a particular number (such as HLA-B27 ). Closely related alleles are categorized together; for example, at least 28 very similar alleles are subtypes of HLA-B27. These subtypes are designated as HLA-B*2701 to HLA-B*2728. The HLA-B gene is located on the short (p) arm of chromosome 6 at cytoband 21.3, from base pair 31,353,871 to 31,357,211 Ankylosing spondylitis : A version of
3289-406: A wide variety of plant and animal material. Human groups have adopted a range of diets from purely vegan to primarily carnivorous . In some cases, dietary restrictions in humans can lead to deficiency diseases ; however, stable human groups have adapted to many dietary patterns through both genetic specialization and cultural conventions to use nutritionally balanced food sources. The human diet
3432-511: Is 38 weeks, but a normal pregnancy can vary by up to 37 days. Embryonic development in the human covers the first eight weeks of development; at the beginning of the ninth week the embryo is termed a fetus . Humans are able to induce early labor or perform a caesarean section if the child needs to be born earlier for medical reasons. In developed countries, infants are typically 3–4 kg (7–9 lb) in weight and 47–53 cm (19–21 in) in height at birth. However, low birth weight
3575-435: Is a disease that damages the immune system, preventing it from effectively defending the body against infections. The signs and symptoms of AIDS may not appear until 10 years or more after infection with HIV. Studies suggest that people with HIV infection who have HLA-B27 or HLA-B57 tend to progress more slowly than usual to AIDS. On the other hand, researchers believe that HIV-positive individuals who have HLA-B35 tend to develop
3718-485: Is a mixture of the two parental sets. Among the 23 pairs of chromosomes, there are 22 pairs of autosomes and one pair of sex chromosomes . Like other mammals, humans have an XY sex-determination system , so that females have the sex chromosomes XX and males have XY. Genes and environment influence human biological variation in visible characteristics, physiology, disease susceptibility and mental abilities. The exact influence of genes and environment on certain traits
3861-424: Is a population decline in the winter months of this realm. Humans established nation-states in the other seven realms, such as South Africa , India , Russia , Australia , Fiji , United States and Brazil (each located in a different biogeographical realm). By using advanced tools and clothing , humans have been able to extend their tolerance to a wide variety of temperatures, humidities , and altitudes. As
4004-402: Is characterized by a number of morphological , developmental , physiological , and behavioral changes that have taken place since the split between the last common ancestor of humans and chimpanzees . The most significant of these adaptations are hairlessness , obligate bipedalism, increased brain size and decreased sexual dimorphism ( neoteny ). The relationship between all these changes
4147-456: Is common in developing countries, and contributes to the high levels of infant mortality in these regions. Compared with other species, human childbirth is dangerous, with a much higher risk of complications and death. The size of the fetus's head is more closely matched to the pelvis than in other primates. The reason for this is not completely understood, but it contributes to a painful labor that can last 24 hours or more. The chances of
4290-648: Is complicated by the absence of contemporary records, the discovery of archaeological sites has enabled a succession of Neolithic cultures to be identified along the Yellow River. Along the middle and lower reaches of the Yellow River were the Cishan culture ( c. 6500–5000 BCE ), the Yangshao culture ( c. 5000–3000 BCE ), the Longshan culture ( c. 3000–2000 BCE ) and
4433-421: Is dangerous, with a high risk of complications and death . Often, both the mother and the father provide care for their children, who are helpless at birth . Humans have a large, highly developed, and complex prefrontal cortex , the region of the brain associated with higher cognition. Humans are highly intelligent and capable of episodic memory ; they have flexible facial expressions, self-awareness , and
HLA-B - Misplaced Pages Continue
4576-479: Is generally aging, with the median age around 40 years. In the developing world , the median age is between 15 and 20 years. While one in five Europeans is 60 years of age or older, only one in twenty Africans is 60 years of age or older. In 2012, the United Nations estimated that there were 316,600 living centenarians (humans of age 100 or older) worldwide. Humans are omnivorous , capable of consuming
4719-443: Is inherited only from the mother, geneticists have concluded that the last female common ancestor whose genetic marker is found in all modern humans, the so-called mitochondrial Eve , must have lived around 90,000 to 200,000 years ago. Most human reproduction takes place by internal fertilization via sexual intercourse , but can also occur through assisted reproductive technology procedures. The average gestation period
4862-408: Is mostly done by the mother. Helpless at birth , humans continue to grow for some years, typically reaching sexual maturity at 15 to 17 years of age. The human life span has been split into various stages ranging from three to twelve. Common stages include infancy , childhood , adolescence , adulthood and old age . The lengths of these stages have varied across cultures and time periods but
5005-521: Is not well understood. While no humans – not even monozygotic twins – are genetically identical, two humans on average will have a genetic similarity of 99.5%-99.9%. This makes them more homogeneous than other great apes, including chimpanzees. This small variation in human DNA compared to many other species suggests a population bottleneck during the Late Pleistocene (around 100,000 years ago), in which
5148-593: Is prominently reflected in human culture and has led to the development of food science . Han Chinese The Han Chinese or the Han people , or simply the Chinese , are an East Asian ethnic group native to Greater China . With a global population of over 1.4 billion, the Han Chinese are the world's largest ethnic group , making up about 17.5% of the global population . The Han Chinese represent 92% of
5291-557: Is said to have sent several hundred thousand men and fifteen thousand women to form agricultural and military settlements in Lingnan (present day Guangxi and Guangdong), under the leadership of a general named Zhao Tuo. The famous Han emperor, Han Wu Di, ordered another two hundred thousand men to build ships to attack and colonialize the Lingnan region, thus adding to the population in Guangdong and Guangxi. The first urban conurbations in
5434-570: Is the Xia dynasty (c. 2070–1600 BCE), established by Yu the Great after Emperor Shun abdicated leadership to reward Yu's work in taming the Great Flood . Yu's son, Qi , managed to not only install himself as the next ruler, but also dictated his sons as heirs by default, making the Xia dynasty the first in recorded history where genealogical succession was the norm. The civilizational prosperity of
5577-445: Is the subject of ongoing debate. Hylobatidae ( gibbons ) Pongo abelii Pongo tapanuliensis Pongo pygmaeus Gorilla gorilla Gorilla beringei Pan troglodytes Pan paniscus Homo sapiens (humans) Until about 12,000 years ago, all humans lived as hunter-gatherers . The Neolithic Revolution (the invention of agriculture ) first took place in Southwest Asia and spread through large parts of
5720-747: Is traditionally credited to have united with the neighbouring Shennong tribes after defeating their leader, the Yan Emperor , at the Battle of Banquan . The newly merged Yanhuang tribes then combined forces to defeat their common enemy from the east, Chiyou of the Jiuli ( 九黎 ) tribes, at the Battle of Zhuolu and established their cultural dominance in the Central Plain region. To this day, modern Han Chinese refer themselves as " Descendants of Yan and Huang ". Although study of this period of history
5863-654: Is typified by an unusually rapid growth spurt during adolescence. Human females undergo menopause and become infertile at around the age of 50. It has been proposed that menopause increases a woman's overall reproductive success by allowing her to invest more time and resources in her existing offspring, and in turn their children (the grandmother hypothesis ), rather than by continuing to bear children into old age. The life span of an individual depends on two major factors, genetics and lifestyle choices. For various reasons, including biological/genetic causes, women live on average about four years longer than men. As of 2018 ,
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6006-633: The An Lu Shan rebellion during the Tang dynasty (755–763 AD), and the Jingkang incident (1127 AD) and Jin-Song wars . These events caused widespread devastation, and even depopulated the north, resulting in the complete social and political breakdown and collapse of central authority in the Central Plains, triggering massive, sustained waves of Han Chinese migration into South China, leading to
6149-548: The British Empire expanded to become the world's largest empire . A tenuous balance of power among European nations collapsed in 1914 with the outbreak of the First World War , one of the deadliest conflicts in history. In the 1930s, a worldwide economic crisis led to the rise of authoritarian regimes and a Second World War , involving almost all of the world's countries . The war's destruction led to
6292-580: The Caral–Supe civilization is the oldest complex civilization in the Americas. Astronomy and mathematics were also developed and the Great Pyramid of Giza was built. There is evidence of a severe drought lasting about a hundred years that may have caused the decline of these civilizations, with new ones appearing in the aftermath. Babylonians came to dominate Mesopotamia while others, such as
6435-511: The Church would provide centralized authority and education. In the Middle East, Islam became the prominent religion and expanded into North Africa. It led to an Islamic Golden Age , inspiring achievements in architecture , the revival of old advances in science and technology, and the formation of a distinct way of life. The Christian and Islamic worlds would eventually clash, with
6578-718: The Erlitou culture ( c. 1900–1500 BCE ). These cultures are believed to be related to the origins of the Sino-Tibetan languages and later the Sinitic languages . They were the foundation for the formation of Old Chinese and the founding of the Shang dynasty , China's first confirmed dynasty. Early ancient Chinese history is largely legendary, consisting of mythical tales intertwined with sporadic annals written centuries to millennia later. Sima Qian's Records of
6721-474: The Homo genus. The name " Homo sapiens " means 'wise man' or 'knowledgeable man'. There is disagreement if certain extinct members of the genus, namely Neanderthals , should be included as a separate species of humans or as a subspecies of H. sapiens . Human is a loanword of Middle English from Old French humain , ultimately from Latin hūmānus , the adjectival form of homō ('man' – in
6864-635: The Huaxia that lived along the Guanzhong and Yellow River basins in Northern China. In addition, numerous ethnic groups were assimilated and absorbed by the Han Chinese at various points in China's history. Like many modern ethnic groups, the ethnogenesis of Han Chinese was a lengthy process that involved the expansion of the successive Chinese dynasties and their assimilation of various non-Han ethnic groups that became sinicised over
7007-616: The Hundred Schools of Thought ) and Confucianism , Taoism and Legalism are among the most important surviving philosophies from this era. The chaotic Warring States period of the Eastern Zhou dynasty came to an end with the unification of China by the western state of Qin after its conquest of all other rival states under King Ying Zheng . King Zheng then gave himself a new title " First Emperor of Qin " ( Chinese : 秦始皇帝 ; pinyin : Qín Shǐ Huángdì ), setting
7150-579: The Kingdom of England , the Kingdom of France and the Holy Roman Empire declaring a series of holy wars to regain control of the Holy Land from Muslims . In the Americas, between 200 and 900 CE Mesoamerica was in its Classic Period , while further north, complex Mississippian societies would arise starting around 800 CE. The Mongol Empire would conquer much of Eurasia in the 13th and 14th centuries. Over this same time period,
7293-854: The Mali Empire in Africa grew to be the largest empire on the continent, stretching from Senegambia to Ivory Coast . Oceania would see the rise of the Tuʻi Tonga Empire which expanded across many islands in the South Pacific. By the late 15th century, the Aztecs and Inca had become the dominant power in Mesoamerica and the Andes , respectively. The early modern period in Europe and
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#17327835202207436-569: The Northern and Southern period and was inspired by the Han dynasty , which is considered to be one of the first golden ages in Chinese history . As a unified and cohesive empire that succeeded the short-lived Qin dynasty, Han China established itself as the center of the East Asian geopolitical order at the time, projecting its power and influence unto Asian neighbors. It was comparable with
7579-587: The Old World over the following millennia. It also occurred independently in Mesoamerica (about 6,000 years ago), China, Papua New Guinea , and the Sahel and West Savanna regions of Africa. Access to food surplus led to the formation of permanent human settlements , the domestication of animals and the use of metal tools for the first time in history. Agriculture and sedentary lifestyle led to
7722-598: The Pearl River Delta . These mass migrations over the centuries inevitably led to the demographic expansion, economic prosperity, agricultural advancements, and cultural flourishing of Southern China, which remained relatively peaceful unlike its northern counterpart. The vast majority of Han Chinese – over 1.2 billion – live in the People's Republic of China (PRC), where they constitute about 90% of its overall population. Han Chinese in China have been
7865-601: The Poverty Point culture , Minoans and the Shang dynasty , rose to prominence in new areas. The Late Bronze Age collapse around 1200 BCE resulted in the disappearance of a number of civilizations and the beginning of the Greek Dark Ages . During this period iron started replacing bronze, leading to the Iron Age . In the 5th century BCE, history started being recorded as a discipline , which provided
8008-668: The Uprising of the Five Barbarians triggered the first massive movement of Han Chinese dominated by civilians rather than soldiers to the south, being led principally by the aristocracy and the Jin elite. Thus, Jiangnan, comprising Hangzhou's coastal regions and the Yangtze valley were settled in the 4th century AD by families descended from Chinese nobility. Special " commanderies of immigrants" and "white registers" were created for
8151-795: The colonization of the Americas and the Columbian Exchange . This expansion led to the Atlantic slave trade and the genocide of Native American peoples . This period also marked the Scientific Revolution , with great advances in mathematics , mechanics , astronomy and physiology . The late modern period (1800–present) saw the Technological and Industrial Revolution bring such discoveries as imaging technology , major innovations in transport and energy development . Influenced by Enlightenment ideals,
8294-518: The Americas and Europe experienced a period of political revolutions known as the Age of Revolution . The Napoleonic Wars raged through Europe in the early 1800s, Spain lost most of its colonies in the New World , while Europeans continued expansion into Africa – where European control went from 10% to almost 90% in less than 50 years – and Oceania. In the 19th century,
8437-535: The Central Plains by Han Wu Di, was now repopulated by Han Chinese settlers and colonists from the Chinese heartland. The "Eight Great Surnames" were eight noble families who migrated from the Central Plains to Fujian - these were the Hu, He, Qiu, Dan, Zheng, Huang, Chen and Lin clans, who remain there until this very day. In the wake of the An Lushan rebellion , a further wave of Han migrants from northern China headed
8580-598: The Dugu and Yuwen families. The Sui (581–618) and Tang (618–907) dynasties saw continuing emigration from the Central Plains to the south-eastern coast of what is now China proper, including the provinces of Fujian , Guangdong , and Hainan . This was especially true in the latter part of the Tang era and the Five Dynasties period that followed; the relative stability of the south coast made it an attractive destination for refugees fleeing continual warfare and turmoil in
8723-672: The Grand Historian recorded a period following the Battle of Zhuolu, during the reign of successive generations of confederate overlords ( Chinese : 共主 ) known as the Three Sovereigns and Five Emperors (c. 2852–2070 BCE), who, allegedly, were elected to power among the tribes. This is a period for which scant reliable archaeological evidence exists – these sovereigns are largely regarded as cultural heroes . The first dynasty to be described in Chinese historical records
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#17327835202208866-487: The HLA-B gene called HLA-B27 increases the risk of developing ankylosing spondylitis. It is uncertain how HLA-B27 causes this increased risk. Researchers speculate that HLA-B27 may abnormally display to the immune system peptides that trigger arthritis. Other research suggests that joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of
9009-471: The Han Chinese from Northern China to Southern China, leading to a further increase in the Han Chinese population across southern Chinese provinces. The formation of the Hainanese and Hakka people can be attributed to the chaos of this period. The Mongol conquest of China during the thirteenth century once again caused a surging influx of Northern Han Chinese refugees to move south to settle and develop
9152-487: The Han Chinese population in the south far outstripped that of the Bai Yue. Guangdong and Fujian both experienced a significant influx of Northern Han Chinese settlers, leading many Cantonese, Hokkien and Teochew individuals to identify themselves as Tangren , which has served as a means to assert and acknowledge their ethnic and cultural origin and identity. The Jin–Song Wars caused yet another wave of mass migration of
9295-418: The Han Chinese," hinted and tinged with only passing references to its ethnic non-Han minority counterparts . The prehistory of the Han Chinese is closely intertwined with both archaeology, biology, historical textual records, and mythology. The ethnic stock to which the Han Chinese originally trace their ancestry from were confederations of late Neolithic and early Bronze Age agricultural tribes known as
9438-632: The Han dynasty, ancient Chinese scholars used the term Huaxia ( 華夏 ; 华夏 ; Huáxià ) in texts to describe China proper , while the Chinese populace were referred to as either the 'various Hua' ( 諸華 ; 诸华 ; Zhūhuá ) or 'various Xia' ( 诸夏 ; 諸夏 ; Zhūxià ). This gave rise to two term commonly used nowadays by Overseas Chinese as an ethnic identity for the Chinese diaspora – Huaren ( 華人 ; 华人 ; Huárén ; 'ethnic Chinese people') and Huaqiao ( 华侨 ; 華僑 ; Huáqiáo ; 'the Chinese immigrant'), meaning Overseas Chinese . It has also given rise to
9581-776: The Mediterranean. In West Asia, the Achaemenid Empire 's system of centralized governance became the precursor to many later empires, while the Gupta Empire in India and the Han dynasty in China have been described as golden ages in their respective regions. Following the fall of the Western Roman Empire in 476, Europe entered the Middle Ages . During this period, Christianity and
9724-832: The Near East ( c. 1450 –1800) began with the final defeat of the Byzantine Empire , and the rise of the Ottoman Empire . Meanwhile, Japan entered the Edo period , the Qing dynasty rose in China and the Mughal Empire ruled much of India. Europe underwent the Renaissance , starting in the 15th century, and the Age of Discovery began with the exploring and colonizing of new regions. This included
9867-402: The People's Republic of China and once publicised by the Republic of China, was historicially used specifically to refer to the Han Chinese. In Article Observations on the Chinese ethnic groups in History , Liang Qichao , who coined the term Zhonghua minzu , wrote "the present-day Zhonghua minzu generally refers to what is commonly known as the Han Chinese." It was only after the founding of
10010-441: The Society for the Great Unity of Zhonghua minzu of the Republic of China in 1912 that the term began to officially include ethnic minorities from all regions in China. Han Chinese can be divided into various subgroups based on the variety of Chinese that they speak. Waves of migration have occurred throughout China's long history and vast geographical expanse, engendering the emergence of Han Chinese subgroups found throughout
10153-421: The Sui and Tang dynasties, led by the Han Chinese families of the Yang (杨) and Li (李) surnames respectively. Both the Sui and Tang dynasties are seen as high points of Han Chinese civilization. These dynasties both emphasized their aristocratic Han Chinese pedigree and enforced the restoration of Central Plains culture, even the founders of both dynasties had already intermarried with non-Han or partly-Han women from
10296-557: The Wu and Min varieties of Chinese originate from the way Chinese was spoken during the Jin, while the Yue and Hakka from the way Chinese was spoken in the Tang and Song, about half-a-millenia later. The presence of Tai-Kradai substrates in these dialects may have been due to the assimilation of the remaining groups of Bai Yue, integrating these lands into the Sinosphere proper. The chaos of
10439-517: The Xia dynasty at this time is thought to have given rise to the name "Huaxia" ( simplified Chinese : 华夏 ; traditional Chinese : 華夏 ; pinyin : Huá Xià , "the magnificent Xia"), a term that was used ubiquitously throughout history to define the Chinese nation. Conclusive archaeological evidence predating the 16th century BCE is, however, rarely available. Recent efforts of the Xia–Shang–Zhou Chronology Project drew
10582-478: The available food, improving aesthetics , increasing knowledge or enhancing the exchange of resources. Humans are one of the most adaptable species, despite having a low or narrow tolerance for many of the earth's extreme environments. Currently the species is present in all eight biogeographical realms , although their presence in the Antarctic realm is very limited to research stations and annually there
10725-561: The best long-distance runners in the animal kingdom, but slower over short distances. Humans' thinner body hair and more productive sweat glands help avoid heat exhaustion while running for long distances. Compared to other apes, the human heart produces greater stroke volume and cardiac output and the aorta is proportionately larger. Like most animals, humans are a diploid and eukaryotic species. Each somatic cell has two sets of 23 chromosomes , each set received from one parent; gametes have only one set of chromosomes, which
10868-552: The body's own proteins from proteins made by foreign invaders such as viruses and bacteria . HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I , class II , and class III . In humans, the HLA-B gene and two related genes, HLA-A and HLA-C , are the major genes in MHC class I. MHC class I genes provide instructions for making proteins that are present on
11011-487: The centres of Han Chinese culture and wealth moved from the Yellow River Basin to Jiangnan, and to a lesser extent also, to Fujian and Guangdong. At various points in Chinese history, collapses of central authority in the face of barbarian uprisings or invasions and the loss of control of the Chinese heartland triggered mass migratory waves which transformed the demographic composition and cultural identity of
11154-547: The centuries. During the Western Zhou and Han dynasties, Han Chinese writers established genealogical lineages by drawing from legendary materials originating from the Shang dynasty , while the Han dynasty historian Sima Qian 's Records of the Grand Historian places the reign of the Yellow Emperor , the legendary leader of Youxiong tribes ( 有熊氏 ), at the beginning of Chinese history. The Yellow Emperor
11297-665: The collapse of most global empires, leading to widespread decolonization. Following the conclusion of the Second World War in 1945, the United States and the USSR emerged as the remaining global superpowers . This led to a Cold War that saw a struggle for global influence, including a nuclear arms race and a space race , ending in the collapse of the Soviet Union. The current Information Age , spurred by
11440-787: The combined eastern and western Roman Empire in the 4th century AD. Bubonic plagues , first recorded in the 6th century AD, reduced the population by 50%, with the Black Death killing 75–200 million people in Eurasia and North Africa alone. Human population is believed to have reached one billion in 1800. It has since then increased exponentially, reaching two billion in 1930 and three billion in 1960, four in 1975, five in 1987 and six billion in 1999. It passed seven billion in 2011 and passed eight billion in November 2022. It took over two million years of human prehistory and history for
11583-402: The confines of these agricultural settlements and military outposts. The genesis of the modern Han people and their subgroups cannot be understood apart from their historical migrations to the south, resulting in a depopulation of the Central Plains, a fission between those that remained and those that headed south, and their subsequent fusion with aboriginal tribes south of the Yangtze, even as
11726-520: The connection between the Erlitou culture and the Xia dynasty, but scholars could not reach a consensus regarding the reliability of such history. The Xia dynasty was overthrown after the Battle of Mingtiao , around 1600 BCE, by Cheng Tang , who established the Shang dynasty ( c. 1600 –1046 BCE). The earliest archaeological examples of Chinese writing date back to this period – from characters inscribed on oracle bones used for divination – but
11869-417: The contemporary Roman Empire in population size, geographical extent, and cultural reach. The Han dynasty's prestige and prominence led many of the ancient Huaxia to identify themselves as 'Han people'. Similarly, the Chinese language also came to be named and alluded to as the "Han language" ( 漢語 ; 汉语 ; Hànyǔ ) ever since and the Chinese script is referred to as " Han characters ." Prior to
12012-478: The continent, gradually replacing or interbreeding with local populations of archaic humans. Humans began exhibiting behavioral modernity about 160,000–70,000 years ago, and possibly earlier. This development was likely selected amidst natural climate change in Middle to Late Pleistocene Africa. The "out of Africa" migration took place in at least two waves, the first around 130,000 to 100,000 years ago,
12155-423: The desire to understand and influence phenomena having motivated humanity's development of science , technology , philosophy , mythology , religion , and other frameworks of knowledge ; humans also study themselves through such domains as anthropology , social science , history , psychology , and medicine . There are estimated to be more than eight billion living humans . Although some scientists equate
12298-572: The development and growth of Chinese civilization. Originating from the Central Plains , the Han Chinese trace their ancestry to the Huaxia people, a confederation of agricultural tribes that lived along the middle and lower reaches of the Yellow River in north central plains of China. The Huaxia are the progenitors of Chinese civilization and the ancestors of modern Han Chinese. Han Chinese people and culture spread south from
12441-525: The development of reactive arthritis and other spondyloarthropathies. A large number of studies have shown an association between HLA-B51 And Behçet's disease . Other disorders: Several variations of the HLA-B gene are associated with adverse reactions to certain drugs. For example, two specific versions of this gene are related to increased drug sensitivity among the Han Chinese population. Individuals who have HLA-B*1502 are more likely to experience
12584-516: The development of the Internet and Artificial Intelligence systems, sees the world becoming increasingly globalized and interconnected. Early human settlements were dependent on proximity to water and – depending on the lifestyle – other natural resources used for subsistence , such as populations of animal prey for hunting and arable land for growing crops and grazing livestock. Modern humans, however, have
12727-640: The early 20th century, there has been continuous human presence in Antarctica through research stations and, since 2000, in space through habitation on the International Space Station . All modern humans are classified into the species Homo sapiens , coined by Carl Linnaeus in his 1735 work Systema Naturae . The generic name " Homo " is a learned 18th-century derivation from Latin homō , which refers to humans of either sex. The word human can refer to all members of
12870-685: The emergence of early civilizations . An urban revolution took place in the 4th millennium BCE with the development of city-states , particularly Sumerian cities located in Mesopotamia . It was in these cities that the earliest known form of writing, cuneiform script , appeared around 3000 BCE. Other major civilizations to develop around this time were Ancient Egypt and the Indus Valley Civilisation . They eventually traded with each other and invented technology such as wheels, plows and sails. Emerging by 3000 BCE,
13013-533: The ensuing civil wars and succeeded in establishing a much longer-lasting dynasty. It continued many of the institutions created by the Qin dynasty, but adopted a more moderate rule. Under the Han dynasty, art and culture flourished, while the Han Empire expanded militarily in all directions . Many Chinese scholars such as Ho Ping-ti believe that the concept ( ethnogenesis ) of Han ethnicity, although being ancient,
13156-517: The etymological origin of the modern English word "China". The reign of the first imperial dynasty was short-lived. Due to the First Emperor's autocratic rule and his massive labor projects, which fomented rebellion among his population, the Qin dynasty fell into chaos soon after his death. Under the corrupt rule of his son and successor Huhai , the Qin dynasty collapsed a mere three years later. The Han dynasty (206 BC–220 CE) then emerged from
13299-474: The far south. At the same time, most of the nomads in northern China came to be sinicized as they ruled over large Chinese populations and adopted elements of their culture and administration. Of note, the Xianbei rulers of Northern Wei ordered a policy of systematic sinicization, adopting Han surnames , institutions, and culture, so the Xianbei became Han Chinese. Sui and Tang Han Chinese rule resumed during
13442-825: The formation of distinct Han lineages, who also likely assimilated the by-now partially sinicized Bai Yue in their midst. Modern Han Chinese subgroups, such as the Cantonese , the Hakka , the Henghua , the Hainanese , the Hoklo peoples, the Gan , the Xiang , the Wu-speaking peoples, all claim Han Chinese ancestry pointing to official histories and their own genealogical records to support such claims. Linguists hypothesize that
13585-416: The frontiers. In effect, he established a centralized bureaucratic state to replace the old feudal confederation system of preceding dynasties, making Qin the first imperial dynasty in Chinese history. This dynasty, sometimes phonetically spelt as the "Ch'in dynasty", has been proposed in the 17th century by Martino Martini and supported by later scholars such as Paul Pelliot and Berthold Laufer to be
13728-566: The genomes of 1,184 individuals from 11 populations and identified 1.6 million single nucleotide polymorphisms . African populations harbor the highest number of private genetic variants. While many of the common variants found in populations outside of Africa are also found on the African continent, there are still large numbers that are private to these regions, especially Oceania and the Americas . By 2010 estimates, humans have approximately 22,000 genes. By comparing mitochondrial DNA , which
13871-595: The global average life expectancy at birth of a girl is estimated to be 74.9 years compared to 70.4 for a boy. There are significant geographical variations in human life expectancy, mostly correlated with economic development – for example, life expectancy at birth in Hong Kong is 87.6 years for girls and 81.8 for boys, while in the Central African Republic , it is 55.0 years for girls and 50.6 for boys. The developed world
14014-443: The human lifestyle. Genes and the environment influence human biological variation in visible characteristics, physiology , disease susceptibility, mental abilities, body size, and life span. Though humans vary in many traits, humans are among the least genetically diverse species. Any two humans are at least 99.5% genetically similar. Humans are sexually dimorphic : generally, males have greater body strength and females have
14157-555: The human population to reach one billion and only 207 years more to grow to 7 billion. The combined biomass of the carbon of all the humans on Earth in 2018 was estimated at 60 million tons, about 10 times larger than that of all non-domesticated mammals. In 2018, 4.2 billion humans (55%) lived in urban areas, up from 751 million in 1950. The most urbanized regions are Northern America (82%), Latin America (81%), Europe (74%) and Oceania (68%), with Africa and Asia having nearly 90% of
14300-517: The human population was reduced to a small number of breeding pairs. The forces of natural selection have continued to operate on human populations, with evidence that certain regions of the genome display directional selection in the past 15,000 years. The human genome was first sequenced in 2001 and by 2020 hundreds of thousands of genomes had been sequenced. In 2012 the International HapMap Project had compared
14443-459: The influence of the new Han migrants. The term is used in everyday colloquial discourse and is also an element in one of the words for Chinatown : 'streets of Tang people' ( 唐人街 ; Tángrénjiē ; Tong4 jan4 gaai1 ). The phrase Huábù ( 華埠 ; 华埠 ) is also used to refer to Chinatowns. The term Zhonghua minzu (中華民族; 中华民族; Zhōnghuámínzú), literally meaning the Chinese nation, currently used as an supra-ethnic concept publicised by
14586-567: The late Miocene epoch. During this split, chromosome 2 was formed from the joining of two other chromosomes, leaving humans with only 23 pairs of chromosomes, compared to 24 for the other apes. Following their split with chimpanzees and bonobos, the hominins diversified into many species and at least two distinct genera. All but one of these lineages – representing the genus Homo and its sole extant species Homo sapiens – are now extinct. The genus Homo evolved from Australopithecus . Though fossils from
14729-459: The literary name for China – Zhonghua ( 中華 ; 中华 ; Zhōnghuá ; 'Central China'). While the general term Zhongguo ren ( 中國人 ; 中国人 ) refers to any Chinese citizen or Chinese national regardless of their ethnic origins and does not necessary imply Han ancestry, the term huaren in its narrow, classical usages implies Central Plains or Han ancestry. Among some southern Han Chinese varieties such as Cantonese , Hakka and Minnan ,
14872-466: The main inhabitants of the fertile lowland areas and cities of southern China, with minority tribes occupying the highlands. The term "Han" not only refers to a specific ethnic collective, but also points to a shared ancestry, history, and cultural identity . The term "Huaxia" was used by the ancient Chinese philosopher Confucius 's contemporaries during the Warring States period to elucidate
15015-606: The majority in both of the special administrative regions of the PRC – about 92.2% and 88.4% of the population of Hong Kong and Macau , respectively. The Han Chinese in Hong Kong and Macau have been culturally, economically and politically dominant majority vis-à-vis the non-Han minorities. There are over 22 million people of Han Chinese ancestry in living in Taiwan. At first, these migrants chose to settle in locations that bore
15158-602: The massive number of Han Chinese immigrating during this period which included notable families such as the Wang and the Xie. A religious group known as the Celestial Masters contributed to the movement. Jiangnan became the most populous and prosperous region of China. The Uprising of the Five Barbarians , also led to the resettlement of Fujian. The province of Fujian - whose aboriginal inhabitants had been deported to
15301-501: The most common and widespread species of primate , and the last surviving species of the genus Homo . They are great apes characterized by their hairlessness , bipedalism , and high intelligence . Humans have large brains , enabling more advanced cognitive skills that enable them to thrive and adapt in varied environments, develop highly complex tools , and form complex social structures and civilizations . Humans are highly social , with individual humans tending to belong to
15444-618: The most successful of which was the Northern Wei established by the Xianbei . From this period, the native population of China proper was referred to as Hanren, or the "People of Han" to distinguish them from the nomads from the steppe. Warfare and invasion led to one of the first great migrations of Han populations in history, as they fled south to the Yangzi and beyond, shifting the Chinese demographic center and speeding up sinicization of
15587-418: The northern heartland in the Yellow River valley, driven by large and sustained waves of migration during successive periods of Chinese history (e.g. the Qin and Han dynasties), leading to a demographic and economic tilt towards the south, and to the absorption of various non-Han ethnic groups over the centuries at various points in Chinese history. By the time of the Tang and Song dynasties, Han Chinese were
15730-559: The ongoing mass extinction of other forms of life. Within the last century, humans have explored challenging environments such as Antarctica , the deep sea , and outer space . Human habitation within these hostile environments is restrictive and expensive, typically limited in duration, and restricted to scientific , military , or industrial expeditions. Humans have visited the Moon and made their presence known on other celestial bodies through human-made robotic spacecraft . Since
15873-442: The only primates to have short, relatively flush canine teeth . Humans have characteristically crowded teeth, with gaps from lost teeth usually closing up quickly in young individuals. Humans are gradually losing their third molars , with some individuals having them congenitally absent. Humans share with chimpanzees a vestigial tail, appendix , flexible shoulder joints, grasping fingers and opposable thumbs . Humans also have
16016-474: The palm of the hand and on the soles of the feet. It is estimated that the worldwide average height for an adult human male is about 171 cm (5 ft 7 in), while the worldwide average height for adult human females is about 159 cm (5 ft 3 in). Shrinkage of stature may begin in middle age in some individuals but tends to be typical in the extremely aged . Throughout history, human populations have universally become taller, probably as
16159-521: The parasite that causes malaria. HLA-B is one of three major HLAs that should be matched between donors and recipients. They are HLA-A, HLA-B, (both Class I MHCs) and HLA-DR (a Class II MHC). If the two tissues have the same genes coding for these three HLAs, the likelihood and severity of rejection is minimized. This article incorporates public domain text from The U.S. National Library of Medicine Human Humans ( Homo sapiens , meaning "thinking man" or "wise man") or modern humans are
16302-625: The peripheries of the Zhou kingdoms. Overseas Chinese who possess non-Chinese citizenship are commonly referred as "Hua people" ( 华人 ; 華人 ; Huárén ) or Huazu ( 华族 ; 華族 ; Huázú ). The two respective aforementioned terms are applied solely to those with a Han background that is semantically distinct from Zhongguo ren ( 中国人 ; 中國人 ) which has connotations and implications limited to being citizens and nationals of China, especially with regard to ethnic minorities in China . The name "Han people" ( 漢人 ; 汉人 ; Hànrén ) first appeared during
16445-515: The population density varies from one region to another, and large stretches of surface are almost completely uninhabited, like Antarctica and vast swathes of the ocean. Most humans (61%) live in Asia; the remainder live in the Americas (14%), Africa (14%), Europe (11%), and Oceania (0.5%). Estimates of the population at the time agriculture emerged in around 10,000 BC have ranged between 1 million and 15 million. Around 50–60 million people lived in
16588-503: The population in China and 97% of the population in Taiwan . Han Chinese form large diaspora populations throughout Southeast Asia, comprising large minorities in countries such as Thailand, Malaysia, and Indonesia. In Singapore, people of Han Chinese or Chinese descent make up around 75% of the country's population. The Han Chinese have exerted the primary formative influence in shaping
16731-607: The power of the Zhou kings fragmented not long afterwards, and many autonomous vassal states emerged. This dynasty is traditionally divided into two eras – the Western Zhou (1046–771 BCE) and the Eastern Zhou (770–256 BCE) – with the latter further divided into the Spring and Autumn (770–476 BCE) and the Warring States (476–221 BCE) periods. It was a period of significant cultural and philosophical diversification (known as
16874-544: The precedent for the next two millennia. To consolidate administrative control over the newly conquered parts of the country, the First Emperor decreed a nationwide standardization of currency, writing scripts and measurement units, to unify the country economically and culturally. He also ordered large-scale infrastructure projects such as the Great Wall , the Lingqu Canal and the Qin road system to militarily fortify
17017-422: The protein on the cell surface. Although most patients with ankylosing spondylitis have the HLA-B27 variation, many people with this particular variation never develop the disorder. Other genetic and environmental factors are likely to affect the chances of developing ankylosing spondylitis and influence its progression. In addition to Ankylosing spondylitis, HLA-B27 is associated with other spondyloarthropathies ,
17160-955: The provinces of Fujian , Guangdong and Hainan , and to a lesser extent, Guangxi , Yunnan and Zhejiang ). There are 60 million Overseas Chinese people worldwide. Overseas Han Chinese have settled in numerous countries across the globe, particularly within the Western World where nearly 4 million people of Han Chinese descent live in the United States (about 1.5% of the population), over 1 million in Australia (5.6%) and about 1.5 million in Canada (5.1%), nearly 231,000 in New Zealand (4.9%), and as many as 750,000 in Sub-Saharan Africa. The Han Chinese have
17303-445: The region, for example, Panyu, were created by Han settlers rather than the Bai Yue, who preferred to maintain small settlements subsisting on swidden agriculture and rice farming. Later on, Guangdong, Northern Vietnam, and Yunnan all experienced a surge in Han Chinese migrants during Wang Mang 's reign. The demographic composition and culture of these regions during this period, could however scarcely be said to have been Sinitic outside
17446-531: The relocation of some communities and over time, varying degrees of intermarriage and assimilation took place. In Taiwan, Han Chinese (including both the earlier Han Taiwanese settlers and the recent Chinese that arrived in Taiwan with Chiang Kai-shek in 1949) constitute over 95% of the population. They have also been a politically, culturally and economically dominant majority vis-à-vis the non-Han indigenous Taiwanese peoples . Nearly 30 to 40 million people of Han Chinese descent live in Southeast Asia. According to
17589-404: The second ( Southern Dispersal ) around 70,000 to 50,000 years ago. H. sapiens proceeded to colonize all the continents and larger islands, arriving in Eurasia 125,000 years ago, Australia around 65,000 years ago, the Americas around 15,000 years ago, and remote islands such as Hawaii , Easter Island , Madagascar , and New Zealand in the years 300 to 1280 CE. Human evolution was not
17732-547: The sense of humanity). The native English term man can refer to the species generally (a synonym for humanity ) as well as to human males. It may also refer to individuals of either sex. Despite the fact that the word animal is colloquially used as an antonym for human , and contrary to a common biological misconception , humans are animals . The word person is often used interchangeably with human , but philosophical debate exists as to whether personhood applies to all humans or all sentient beings , and further if
17875-526: The shared ethnicity of all Chinese; Chinese people called themselves Hua ren . The Warring States period led to the emergence of the Zhou-era Chinese referring to themselves as being Huaxia (literally 'the beautiful grandeur'): under the Hua–Yi distinction , a "Hua" culture (often translated as 'civilized') was contrasted to that of peoples perceived as "Yi" (often translated as ' barbarian ') living on
18018-499: The signs and symptoms of AIDS more quickly than usual. Other factors also influence the progression of HIV to AIDS. Another version of the HLA-B gene, HLA-B53, has been shown to help protect against severe malaria. HLA-B53 is most common in West African populations, where malaria is a frequent cause of death in children. Researchers suggest that this version of the HLA-B gene may help the immune system respond more effectively to
18161-474: The south. At the start of the rebellion in 755 there were 52.9 million registered inhabitants of the Tang Empire, and after its end in 764, only 16.9 million were recorded. It is likely that the difference in census figures was due to the complete breakdown in administrative capabilities, as well as the widespread escape from the north by the Han Chinese and their mass migration to the south. By now,
18304-480: The south. This process of sustained mass migration has been known as "garments and headdresses moving south" 衣冠南渡 (yì guān nán dù), on account of it first being led by the aristocratic classes. Such migratory waves were numerous and triggered by such events such as the Uprising of the Five Barbarians during the Jin dynasty (304–316 AD) in which China was completely overrun by minority groups previously serving as vassals and servants to Sima (the royal house of Jin),
18447-613: The sparsely populated regions of south China were inhabited by tribes known only as the Bai Yue or Hundred Yue. Many of these tribes developed into kingdoms under rulers and nobility of Han Chinese ethnicity but retained a Bai Yue majority for several centuries. Yet others were forcibly brought into the Sinosphere by the imperial ambitions of emperors such as Qin Shi Huangdi and Han Wu Di, both of whom settled hundreds of thousands of Chinese in these lands to form agricultural colonies and military garrisons. Even then, control over these lands
18590-468: The surface of almost all cells. On the cell surface, these proteins are bound to protein fragments ( peptides ) that have been exported from within the cell. MHC class I proteins display these peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it responds by destroying the infected cell. The HLA-B gene has many different normal variations, allowing each person's immune system to react to
18733-400: The term Tangren ( 唐人 ; Tángrén ; 'people of Tang'), derived from the name of the later Tang dynasty (618–907) that oversaw what is regarded as another golden age of China . The self-identification as Tangren is popular in south China, because it was at this time that massive waves of migration and settlement led to a shift in the center of gravity of the Chinese nation away from
18876-433: The term "humans" with all members of the genus Homo , in common usage it generally refers to Homo sapiens , the only extant member. All other members of the genus Homo , which are now extinct, are known as archaic humans , and the term "modern human" is used to distinguish Homo sapiens from archaic humans. Anatomically modern humans emerged around 300,000 years ago in Africa, evolving from Homo heidelbergensis or
19019-401: The throne – fled to Wu and settled there. Three generations later, King Wu of the Zhou dynasty defeated King Zhou (the last Shang king), and enfeoffed the descendants of Taibo in Wu – mirroring the later history of Nanyue , where a Chinese king and his soldiers ruled a non-Han population and mixed with locals, who were sinicized over time. After the Battle of Muye , the Shang dynasty
19162-427: The transition are scarce, the earliest members of Homo share several key traits with Australopithecus . The earliest record of Homo is the 2.8 million-year-old specimen LD 350-1 from Ethiopia , and the earliest named species are Homo habilis and Homo rudolfensis which evolved by 2.3 million years ago. H. erectus (the African variant is sometimes called H. ergaster ) evolved 2 million years ago and
19305-445: The tumult of the Central Plains to the peaceful lands south of the Yangtze and on the southeastern coast, leading to the earnest settlement by Chinese of lands hitherto regarded as part of the empire's sparsely populated frontier or periphery. Guangdong and Fujian, hitherto regarded as backwater regions populated by the descendants of garrison soldiers, exiles and refugees, became new centers and representatives of Han Chinese culture under
19448-414: The various regions of modern China today with distinct regional features. The expansion of the Han people outside their linguistic homeland in the Yellow River is an important part of their historical consciousness and ethnogenesis, and accounts for their present-day diversity. There were several periods of mass migration of Han people to Southeastern and Southern China throughout history. Initially,
19591-520: The well-developed characters hint at a much earlier origin of writing in China. During the Shang dynasty, people of the Wu area in the Yangtze River Delta were considered a different tribe, and described as being scantily dressed, tattooed and speaking a distinct language. Later, Taibo , elder uncle of Ji Chang – on realising that his younger brother, Jili, was wiser and deserved to inherit
19734-440: The world's 3.4 billion rural population. Problems for humans living in cities include various forms of pollution and crime , especially in inner city and suburban slums . Most aspects of human physiology are closely homologous to corresponding aspects of animal physiology. The dental formula of humans is: 2.1.2.3 2.1.2.3 . Humans have proportionately shorter palates and much smaller teeth than other primates. They are
19877-537: Was a brief period of prosperity under the native Han Chinese dynasty known as the Jin (266–420 BC), although protracted struggles within the ruling house of Sima (司馬) sparked off a protracted period of fragmentation, rebellion by immigrant tribes that served as slaves and indentured servants, and extended non-native rule. Non-native rule During this time, areas of northern China were overrun by various non-Han nomadic peoples , which came to establish kingdoms of their own,
20020-407: Was formally entrenched in the Han dynasty. The Han dynasty is considered one of the golden ages of Chinese history, with the modern Han Chinese people taking their ethnic name from this dynasty and the Chinese script being referred to as " Han characters ". The fall of the Han dynasty was followed by an age of fragmentation and several centuries of disunity amid warfare among rival kingdoms. There
20163-540: Was overthrown by Zhou (led by Ji Fa ), which had emerged as a western state along the Wei River in the 2nd millennium BCE. The Zhou dynasty shared the language and culture of the Shang people, and extended their reach to encompass much of the area north of the Yangtze River . Through conquest and colonization, much of this area came under the influence of sinicization and this culture extended south. However,
20306-464: Was tenuous, and Bai Yue cultural identity remained strong until sustained waves of Han Chinese emigration in the Jin, Tang and Song dynasties altered the demographic balance completely. Chinese language (or Chinese languages) can be divided to 10 primary dialects (or languages). Each Han Chinese subgroup (民系) can be identified through their dialects: The first emperor Qin Shih Huang Di
20449-402: Was the first archaic human species to leave Africa and disperse across Eurasia. H. erectus also was the first to evolve a characteristically human body plan . Homo sapiens emerged in Africa around 300,000 years ago from a species commonly designated as either H. heidelbergensis or H. rhodesiensis , the descendants of H. erectus that remained in Africa. H. sapiens migrated out of
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